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Dataset results
522 results for “Lung function”
The bradykinin-2 receptor antagonist, icatibant, improves lung function in patients with SARS-CoV2 associated ARDS - First results of a prospective off-label use patient-related observational study.
<p>SARS-CoV2-associated adult respiratory distress syndrome (COVID19-ARDS) frequently leads to fatal respiratory failure in COVID19. Currently, there is no curative treatment option for severe COVID19-ARDS other than mechanical ventilation therapy and extracorporal membrane oxygenation (ECMO). We investigated whether modification of the kallikrein-kinin system in vivo attenuates the progression of SARS-CoV2-induced ARDS. The aim of the study was to investigate the effect of blockade of the B2R on the course of COVID19-ARDS. In an observational study including 53 COVID19-ARDS patients, patients received the bradykinin-2-receptor antagonist (B2RAg) icatibant. After icatibant substitution, respiratory rate in COVID19-ARDS reduced by a maximum of 32% (24.9/min to 16.8/min) with a concomitant reduction in oxygen substitution by 59% (6.1 LO<sub>2</sub>/min to 2.5 LO<sub>2</sub>/min). The data show that the use of icatibant in the early phase of COVID19-ARDS is suitable to stabilize pulmonary gas exchange. Furthermore, early icatibant substitution seems to be able to reduce the rate of necessary invasive ventilation in COVID19-ARDS. Observational data suggest that inhibition of bradykinin signalling leads to stabilization of lung function in SARS-CoV2-associated ARDS. Further prospective placebo-controlled studies are needed to investigate the impact of the kallikrein-kinin system on the development of COVID19-ARDS in vivo.</p>
A Trial of Adding Lung Protective Strategies to Existing Enhanced Recovery After Surgery (ERAS) Protocols and Its Effects on Improving Post-Operative Lung Function
ClinicalTrials.gov study NCT04411186. IPD Sharing: NO. Countries: 1. Publications: 0.
Lung Function and Patient Preference With QVA149 vs. Tiotropium in COPD Patients
ClinicalTrials.gov study NCT02125734. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Components of Mechanical Power on the Functional Lung in ARDS
ClinicalTrials.gov study NCT07171632. IPD Sharing: NO. Countries: 0. Publications: 11.
Effectiveness of Combined Manual Therapy and Pulmonary Exercises on Ventilatory Function in Patients with Restrictive Lung Diseases
ClinicalTrials.gov study NCT06681701. IPD Sharing: UNDECIDED. Countries: 0. Publications: 2.
Evaluation of Efficacy of Minimally Invasive Local Therapy for Lung Tumors and Its Impact on Breathing Function
ClinicalTrials.gov study NCT07272356. IPD Sharing: YES. Countries: 1. Publications: 0.
Hyperpolarized Xenon MRI for Assessment of Pulmonary Function in Lung Resection
ClinicalTrials.gov study NCT03417687. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study to Evaluate the Onset of Effect and Time Course of Change in Lung Function With Benralizumab in Severe, Uncontrolled Asthma Patients With Eosinophilic Inflammation
ClinicalTrials.gov study NCT02869438. IPD Sharing: Not stated. Countries: 6. Publications: 0.
Impact of Dyspnea, Regional Lung Ventilation, and Diaphragmatic Function During de Novo Acute Respiratory Failure
ClinicalTrials.gov study NCT04961437. IPD Sharing: NO. Countries: 1. Publications: 0.
Characterization of Lung Function Profile of Inhaled Tiotropium + Olodaterol Fixed Dose Combination Compared to Fluticasone Propionate + Salmeterol Fixed Dose Combination in COPD Patients
ClinicalTrials.gov study NCT01969721. IPD Sharing: Not stated. Countries: 8. Publications: 0.
A Crossover Study to Determine the 24 Hour Lung Function Profile of Indacaterol in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD)
ClinicalTrials.gov study NCT00622635. IPD Sharing: Not stated. Countries: 3. Publications: 0.
The Effect of Intravenous Lipids on Lung Function in Acute Respiratory Distress Syndrome (ARDS)
ClinicalTrials.gov study NCT01096771. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Assessment of Right Ventricular Function Among Children With Chronic Lung Disease
ClinicalTrials.gov study NCT06134947. IPD Sharing: Not stated. Countries: 0. Publications: 9.
A Trial of 2 Disease-Modifying Drugs (Metformin and N-acetylcysteine ) to Promote TB Lung Function Recovery
ClinicalTrials.gov study NCT07136987. IPD Sharing: YES. Countries: 0. Publications: 5.
Study to Evaluate the Effect on Lung Function and ECG When a Combination of Tiotropium Plus Olodaterol is Administered to Patients With COPD Either From a Single Inhaler or Each Compound is Administer
ClinicalTrials.gov study NCT02030535. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cross-Over Study in Subjects With COPD, Evaluating Lung Function Response After Treatment With Once Daily Umeclidinium 62.5mcg, Vilanterol 25mcg, and Umeclidinium/Vilanterol 62.5/25mcg
ClinicalTrials.gov study NCT01716520. IPD Sharing: YES. Countries: 2. Publications: 0.
The Effects of Drug Candidate CS1 on Lung Structure and Function Utilizing FRI
ClinicalTrials.gov study NCT06907693. IPD Sharing: NO. Countries: 1. Publications: 0.
Inhaled Corticosteroids Versus Observation for Patients With Decreased Lung Function Status
ClinicalTrials.gov study NCT00656916. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Cross-Over Study to Evaluate Lung Function Response After Treatment With Umeclidinium (UMEC) 62.5 Micrograms (mcg), Vilanterol (VI) 25 mcg, and Umeclidinium/Vilanterol (UMEC/VI) 62.5/25 mcg Once-Dai
ClinicalTrials.gov study NCT02014480. IPD Sharing: YES. Countries: 2. Publications: 0.
Impact of Chest Wall Mechanics on Lung and Cardiovascular Function During Delayed Sternal Closure
ClinicalTrials.gov study NCT05257525. IPD Sharing: YES. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.