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1,723 results for “Reactivation”
Raw Data for the article: Analysis of the Specific Immune Response after the Third Dose of mRNA COVID-19 Vaccines in Organ Transplant Recipients: Possible Spike-S1 Reactive IgA Signature in Protection from SARS-CoV-2 Infection
<p><strong>Background:</strong> Several studies have indicated that anti-SARS-CoV-2 mRNA vaccinations are less effective in inducing robust immune responses among solid organ transplant recipients (SOTRs) compared with the immunocompetent. The third dose of vaccine in SOTRs showed promising results of immunogenicity, even though clinical studies have suggested that immunocompromised subjects are less likely to build a protective immune response against SARS-CoV-2 resulting in lower vaccine efficacy for the prevention of severe COVID-19. <strong>Methods:</strong> Serological IgG and IgA were analyzed through CLIA or ELISA, respectively, while Spike-specific T cells were detected by ELISpot assay after the second and third dose of vaccine in 43 SOTRs. <strong>Results:</strong> The third dose induced an improvement in antibody response against SARS-CoV-2. We also reported a strong correlation between specific humoral and cellular responses after the third dose, even though we did not see significant changes in the magnitude of the SARS-CoV-2-specific T cell response. SOTRs who contracted the SARS-CoV-2 infection after the third dose, despite eliciting a positive IgG response, failed to mount an anti-Spike-S1 IgA response, both after the third dose and after SARS-CoV-2 infection. <strong>Conclusions:</strong> We can conclude that serum IgA detection can be helpful, along with IgG detection, for the evaluation of vaccine efficacy, principally in fragile subjects at high risk of infection.</p>
Data: Modification of ground state chemical reactivity via light-matter coherence in infrared cavities
<p>Data to reproduce Figures in paper "Modification of ground state chemical reactivity via light-matter coherence in infrared cavities" published in DOI:0000/0000000</p>
Isolation and Redox Reactivity of Cerium Complexes in Four Redox States
<p>This upload contains raw data (NMR, X-Ray, UV, EPR, electrochemistry and Elemental Analysis) files for the article</p>
Dataset for Optimal reactive nitrogen control pathways identified for cost-effective PM2.5 mitigation in Europe
<p>This folder includes six folders:</p> <p>The "Nr anthropogenic emissions" folder includes the anthropogenic Nr emissions used in the baseline simulations for January, April, July, and October 2015.</p> <p>The "Concentration" folder includes daily surface ammonia (NH<sub>3</sub>), nitric acid (HNO<sub>3</sub>), nitrate (NO<sub>3</sub><sup>-</sup>), ammonium (NH<sub>4</sub><sup>+</sup>), sulfate (SO<sub>4</sub><sup>2-</sup>), and fine particulate matter (PM<sub>2.5</sub>) concentrations for January, April, July, and October 2015 from WRF-Chem simulations (one BASE simulation and twelve sensitivity simulations as stated in Method).</p> <p>The "N-share" folder includes the N-share caused by anthropogenic Nr (NH<sub>3</sub> and NO<sub>x</sub>)/ NH<sub>3</sub>/NO<sub>x</sub> emissions in 2015.</p> <p>The "Health" folder includes the PM2.5-related premature deaths from WRF-Chem combined with GEMM simulations in 2015. </p> <p>The "Instant efficiency" folder includes the instant efficiency of Nr/ NH<sub>3</sub>/NO<sub>x</sub> emission controls from WRF-Chem simulations in 2015. </p> <p>The "G ratio" folder includes the G ratio from WRF-Chem simulations for the year 2015 and the indicator months (January, April, July, and October). </p> <p>For any questions, please contact Zehui Liu<br> Email: liuzh18@pku.edu.cn<br> </p>
Alkane dataset for reactive chemistry neural network potentials at DFT and CASPT2 level
<p>datasets used for training and evaluating neural networks in the following work: Neural Network Potentials for Reactive Chemistry: CASPT2 Quality Potential Energy Surfaces for Bond Breaking <a href="https://doi.org/10.26434/chemrxiv-2023-13cv6">https://doi.org/10.26434/chemrxiv-2023-13cv6</a></p>
Data from: Hemin treatment drives viral reactivation and plasma cell differentiation of EBV latently infected B cells
<p>Epstein-Barr virus (EBV) and <em>Plasmodium falciparum</em> have a well described role in the development of endemic Burkitt lymphoma (BL), yet the mechanisms involved remain unknown. A major hallmark of malarial disease is hemolysis and bystander eryptosis of red blood cells, which causes release of free heme in large quantities into peripheral blood. We hypothesized that heme released during malaria infection drives differentiation of latently infected EBV-positive B cells, resulting in viral reactivation and release of infectious virus. To test this hypothesis, we used the EBV-positive Mutu I B-cell line and treated with hemin (the oxidized form of heme) and evaluated for evidence of EBV reactivation. Hemin treatment resulted in the expression of EBV immediate early, early and late lytic gene transcripts. In addition, expression of CD138, a marker of plasma cells was co-expressed with the late lytic protein gp350 on hemin treated Mutu I cells. Finally, DNase-resistant EBV DNA indicative of virion production was detected in supernatant. To assess the transcriptional changes induced by hemin treatment, RNA sequencing was performed on mock- and hemin-treated Mutu I cells, and a shift from mature B cell transcripts to plasma cell transcripts was identified. To identify the mechanism of hemin-induced B cell differentiation, we measured levels of the plasma cell transcriptional repressor, BACH2, that contains specific heme binding sites. Hemin treatment caused significant degradation of BACH2 by 24 hours post-treatment in four BL cell lines (two EBV positive, two EBV negative). Knockdown of BACH2 in Mutu I cells using siRNAs significantly increased CD138+gp350+ cells to levels similar to treatment with hemin. This suggested that hemin induced BACH2 degradation was responsible for plasma cell differentiation and viral reactivation. Together, these data support a model where EBV reactivation can occur during malaria infection via heme modulation, providing a mechanistic link between malaria and EBV. </p>
Micro-macro model of multicomponent reactive transport in a multimineral system
<p>This SEM image is from this article "Quantification of mineral accessible surface area and flow-dependent fluid-mineral reactivity at the pore scale". https://doi.org/10.1016/j.chemgeo.2020.120042</p>
Original data for "Unsupervised Analysis of Optical Imaging Data for the Discovery of Reactivity Patterns in Metal Alloy" article
<p>This upload includes both original and supplementary data for the publication "Unsupervised Analysis of Optical Imaging Data for the Discovery of Reactivity Patterns in Metal Alloy" by R. Li, A. Makogon, T. Galochkina, J-F. Lemineur, F. Kanoufi, and V. Shkirskiy, published in the Small Methods journal. The preprint version of the paper is available on ChemRxiv (<a href="https://doi.org/10.26434/chemrxiv-2023-sgvt0">https://doi.org/10.26434/chemrxiv-2023-sgvt0</a>).</p> <p>The file "Data_processing.zip" contains the original optical image of the interface, maps of film evolution rates in acidic and salt environments, COMSOL data output in acidic and salt environments, as well as a Jupyter Lab file that demonstrates how to process this data.</p> <p>The file "Comparison_of_SEM_images.zip" includes the original SEM images used in the current study and in our previous work (<a href="https://doi.org/10.26434/chemrxiv-2022-rn77b-v3">https://doi.org/10.26434/chemrxiv-2022-rn77b-v3</a>), along with a Jupyter Lab file that illustrates the data processing procedure.</p> <p>The file "Original_data_in_npy_format.zip" contains all original data from SEM/EDX and RM experiments.</p> <p>We recommend opening the Jupyter Lab files in a Python 3 environment. PDF files in the root directory provide outputs of all uploaded Jupyter Lab files.</p>
Reactive Multiphase Flow in Porous Media at the Darcy Scale: a Benchmark proposal
<p>Description and data files for a "Reactive Two-phase flow Benchmark"</p> <p>Modeling reactive multiphase multicomponent flow in porous media leads to a highly nonlinear coupled system of degenerate partial differential equations and algebraic and/or ordinary differential equations, requiring special numerical treatment. The Benchmark consists of five test problems in total (both in 1D and in 2D), with varying degrees of difficulty, designed to verify the algorithms and<br> the codes dedicated to simulate coupled isothermal Hydro-Chemical processes during injection and storage of CO2 in the subsurface. It is intended to be used as a basis for comparing codes in order to better understand different couplings such as chemical reactions with two-phase flow, phase behavior with equilibrium reactions, dissolution and precipitation</p>
Isoacridone dyes with parallel reactivity from both singlet and triplet excited states for biphotonic catalysis and upconversion
<p>Raw data of the publication in Chem. Sci. titled "Isoacridone dyes with parallel reactivity from both singlet and triplet excited states for biphotonic catalysis and upconversion"</p>
Data to support: Implications of snowpack reactive bromine production for Arctic ice core bromine preservation
<p>Snowpack emissions are recognized as an important source of gas-phase reactive bromine in the Arctic and are necessary to explain ozone depletion events in spring caused by the catalytic destruction of ozone by halogen radicals. Quantifying bromine emissions from snowpack is essential for interpretation of ice-core bromine. We present ice-core bromine records since the pre-industrial (1750 CE) from six Arctic locations and examine potential post-depositional loss of snowpack bromine using a global chemical transport model. Trend analysis of the ice-core records shows that only the high-latitude coastal Akademii Nauk ice core from the Russian Arctic preserves significant trends since pre-industrial times that are consistent with trends in sea ice extent and anthropogenic emissions from source regions. Model simulations suggest that recycling of reactive bromine on the snow skin layer (top 1mm) results in 9–17% loss of deposited bromine across all six ice-core locations. Reactive bromine production from below the snow skin layer and within the snow photic zone is potentially more important, but the magnitude of this source is uncertain. Model simulations suggest that the Akademii Nauk core is most likely to preserve an atmospheric signal compared to five Greenland ice cores due to its high latitude location combined with a relatively high snow accumulation rate. Understanding the sources and amount of photochemically reactive snow bromide in the snow photic zone throughout the sunlit period in the high Arctic is essential for interpreting ice-core bromine, and warrants further lab studies and field observations at inland locations.</p>
Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production
<p>Dataset associated with publication "Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production"</p>
The Menopause Transition: Estrogen Variability, Stress Reactivity and Mood
ClinicalTrials.gov study NCT03003949. IPD Sharing: YES. Countries: 1. Publications: 1.
Pharmacogenetics, Emotional Reactivity and Smoking
ClinicalTrials.gov study NCT00507728. IPD Sharing: Not stated. Countries: 1. Publications: 16.
A Randomized Trial to Evaluated the Suppressive Effect of Acyclovir on Rapidly Cleared HSV-2 Reactivation
ClinicalTrials.gov study NCT00723229. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Positive Airway Pressure on Reducing Airway Reactivity in Patients With Asthma (CPAP)
ClinicalTrials.gov study NCT01629823. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Peanut Reactivity Reduced by Oral Tolerance in an Anti-IgE Clinical Trial
ClinicalTrials.gov study NCT01781637. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of Emotion-Focused Therapy (EFT) on Mood Awareness and Emotional Reactivity in Bipolar PatientsAwareness and Emotional Reactivity
ClinicalTrials.gov study NCT06721858. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Reactive Balance Training Targeting Both Slip- and Trip-Induced Falls
ClinicalTrials.gov study NCT04308239. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Modulation Of Airway Reactivity With Chronic Mechanical Strain
ClinicalTrials.gov study NCT02396849. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.