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247
datasets available to search
ShareScore release 0.9.0
Dataset results
247 results for “adaptive immunity”
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome
GEO Series GSE51092. Homo sapiens. 222 samples. Type: Expression profiling by array.
SF2523: Dual PI3K/BRD4 inhibitor blocks tumor immunosuppression and promotes adaptive immune responses in cancer
GEO Series GSE123154. Mus musculus. 21 samples. Type: Expression profiling by high throughput sequencing.
An in vitro methodology demonstrates the five steps of trained immunity in mice: implications on biomarker discovery, adaptive immune responses, mouse strains, sample cryopreservation and genetic abla
GEO Series GSE290033. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells
GEO Series GSE186396. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Exercise sensitizes the pressure diuresis response: shifting immune landscapes underlie renal adaptations to exercise
GEO Series GSE297842. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response (Activated B cells, set 1)
GEO Series GSE158030. Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing.
mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection [HC]
GEO Series GSE247916. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing; Other.
Tractable mouse TNBC models capture the heterogeneous tumor immune microenvironment and adaptation to PD-L1 blockade
GEO Series GSE292146. Mus musculus. 38 samples. Type: Expression profiling by high throughput sequencing.
Data from: Selection for brain size impairs innate, but not adaptive immune responses
The brain and the immune system are both energetically demanding organs, and when natural selection favors increased investment into one, then the size or performance of the other should be reduced. While comparative analyses have attempted to test this potential evolutionary trade-off, the results remain inconclusive. To test this hypothesis, we compared the tissue graft rejection (an assay for measuring innate and acquired immune responses) in guppies (Poecilia reticulata) artificially selected for large and small relative brain size. Individual scales were transplanted between pairs of fish, creating reciprocal allografts, and the rejection reaction was scored over eight days (before acquired immunity develops). Acquired immune responses were tested two weeks later, when the same pairs of fish received a second set of allografts and were scored again. Compared to large-brained animals, small-brained animals of both sexes mounted a significantly stronger rejection response to the first allograft. The rejection response to the second set of allografts did not differ between large- and small-brained fish. Our results show that selection for large brain size reduced innate immune responses to an allograft, which supports the hypothesis that there is a selective trade-off between investing into brain size and innate immunity.
Adaptive immune responses to Omicron BA.4/BA.5-containing bivalent mRNA booster vaccination
<p>This repository contains the immunoSEQ T-cell receptor (TCR) and B-cell receptor (BCR) repertoire data used in the manuscript titled "Adaptive immune responses to Omicron BA.4/BA.5-containing bivalent mRNA booster vaccination". This data set is composed of the TCR/BCR repertoire clonotype sequences and abundances derived from human peripheral blood mononuclear cell (PBMC) samples sorted for CD4, CD8 and CD19 before and after bivalent COVID mRNA booster vaccination. In total, 84 TCR samples (CD4+/CD8+ T cell populations at pre-/post-vaccination from 21 subjects) and 42 BCR samples (CD19+ populations at at pre-/post-vaccination from 21 subjects) are present in the data set.</p> <ul> <li><em><strong>Delmonte_TCR_data_84samples.rds</strong></em><br>R object with the amino acid and nucleotide sequences, VDJ gene calls, and abundances of the TCR clonotypes.</li> <li><strong><em>Delmonte_BCR_data_42samples.rds </em></strong> <br>R object with the amino acid and nucleotide sequences, VDJ gene calls, and abundances of the BCR clonotypes.</li> <li><em><strong>Delmonte_TCR_data_compact_84samples.rds</strong></em><br>R object with the amino acid sequences, VDJ gene calls, and abundances of the TCR clonotypes.</li> <li><em><strong>Delmonte_BCR_data_compact_42samples.rds </strong></em><br>R object with the amino acid sequences, VDJ gene calls, and abundances of the BCR clonotypes.</li> <li><em><strong>sampleExport_TCR.zip</strong></em><br>Compressed folder that includes the individual sample level TCR repertoire files in .tsv format.</li> <li><em><strong>sampleExport_BCR.zip</strong></em><br>Compressed folder that includes the individual sample level BCR repertoire files in .tsv format.</li> </ul> <p><br><em>Funding statement: This work was supported by the Division of Intramural Research Programs of the National Institute of Allergy and Infectious Diseases and of the National Institute of Dental and Craniofacial Research, National Institutes of Health (grant AI001270).</em><br><br></p> <p> </p>
COVID-19 Vaccine Induced Adaptive Immune Responses
ClinicalTrials.gov study NCT04729374. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study to Evaluate the Immune Responses of Trivalent Cold-Adapted Influenza Vaccine (CAIV-T) Compared With (TIV)
ClinicalTrials.gov study NCT00111579. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Understanding Adaptive Immune Response After COVID-19 Vaccination Boosters to Improve Vaccination Strategies in Vulnerable Groups.
ClinicalTrials.gov study NCT06300853. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Temporal Cellular Landscape of the Adaptive Immune System in Patients With Acute Stroke
ClinicalTrials.gov study NCT04852445. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Adaptive and Trained Immunity in the Pathogenesis of IgG4-Related Disease
ClinicalTrials.gov study NCT06844864. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Biological Modulation of Bacterial QSSMs, Innate and Adaptive Immunity by Antibiotics, Probiotics and Prebiotics in Healthy Individuals
ClinicalTrials.gov study NCT01201577. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Role of Post-traumatic Inhibition of the Innate and Adaptive Immune System in the Development of Infectious Complications in Severely Injured Patients
ClinicalTrials.gov study NCT03489577. IPD Sharing: NO. Countries: 1. Publications: 0.
Effects of Tai Chi Exercise on Innate and Adaptive Immune Function
ClinicalTrials.gov study NCT00172679. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Adaptive Immune Response to COVID-19 Vaccination
ClinicalTrials.gov study NCT04826770. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Individually Adapted Immunosuppression in de Novo Renal Transplantation Based on Immune Function Monitoring: a Prospective Randomised Study
ClinicalTrials.gov study NCT00895206. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.