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287 results for “adenosine”
Data from: Early changes in transient adenosine during cerebral ischemia and reperfusion injury
Adenosine is an important neuromodulator in the central nervous system, and tissue adenosine levels increase during ischemic events, attenuating excitotoxic neuronal injury. Recently, our lab developed an electrochemical fast-scan cyclic voltammetry (FSCV) method that identified rapid, spontaneous changes in adenosine concentrations that last only about 3 seconds. Here, we investigated the effects of cerebral ischemia and reperfusion on the concentration and frequency of transient adenosine release in the caudate-putamen. In anesthetized rats, data were collected for four hours: two hours of normoxia, 30 min of cerebral ischemia induced by bilateral common carotid artery occlusion, and 90 min of reperfusion. Transient adenosine release was increased during the cerebral ischemia period and remained elevated during reperfusion. The total number of adenosine transients increased by 52% during cerebral ischemia and reperfusion compared to normoxia. The concentration of adenosine per event did not increase but the cumulative adenosine concentration during cerebral ischemia and reperfusion increased by 53% because of the higher frequency of events. Further, we evaluated the role of A2A antagonist, SCH442416, a putative neuroprotective agent to affect adenosine transients. SCH442416 significantly decreased the transient frequency during cerebral ischemia-reperfusion by 27% and the cumulative concentration by 31%. Our results demonstrate that this mode of rapid adenosine release increases during early cerebral ischemia-reperfusion injury. Rapid adenosine release could provide fast, local neuromodulation and neuroprotection during cerebral ischemia.
Datasets and supplemental data for 'Deep Learning-based Design and Screening of Benzimidazole-pyrazine derivatives as Adenosine A2B Receptor Antagonists'
<p><strong>This is the original datasets and supplemental data for '<em>Deep Learning-based Design and Screening of Benzimidazole-pyrazine derivatives as Adenosine A2B Receptor Antagonists</em>'.</strong></p> <ul> <li><strong>Training sets.zip: </strong>The training sets to train the generative model (A2B_lower_100nm) & QSAR model.</li> <li><strong>Trained models.zip: </strong>Trained models of the generative algorithm (A2B_60, ChemBL & DRD2)</li> <li><strong>Generated molecules.zip: </strong>All generated molecules of the given scaffolds.</li> <li><strong>Binding modes A2B.zip: </strong>The binding modes of 5 target molecules to A2BAR.</li> <li><strong>Homology model.pdb: </strong>The homology model of A2BAR.</li> </ul>
Dose-Response of Adenosine for Perioperative Pain
ClinicalTrials.gov study NCT00298636. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of [123I]MNI-420 and SPECT as a Marker of the Adenosine A2a Receptor in PD, HD and Healthy Subjects.
ClinicalTrials.gov study NCT00970229. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Oral Adenosine-triphosphate (ATP) on Human Muscle Performance
ClinicalTrials.gov study NCT01141504. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Impact of Epilepsy on the Brainstem Adenosine Pathway and Its Relation With Arousal and Respiratory Reactivity
ClinicalTrials.gov study NCT07249034. IPD Sharing: NO. Countries: 1. Publications: 0.
FFR and Inducible Myocardial Ischemia During Adenosine Stress Testing
ClinicalTrials.gov study NCT04401657. IPD Sharing: NO. Countries: 1. Publications: 0.
Hyperemic mYocardial Perfusion by adEnosine at diffeRent Doses
ClinicalTrials.gov study NCT06578234. IPD Sharing: NO. Countries: 1. Publications: 0.
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart
ClinicalTrials.gov study NCT02885740. IPD Sharing: NO. Countries: 1. Publications: 0.
A Comparison Study of Apadenoson and Adenosine to Treadmill Exercise Stress.
ClinicalTrials.gov study NCT00380198. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Hemodynamic Forces at Rest and Stress vs. Adenosine and Dobutamine Stress Cardiac Magnetic Resonance
ClinicalTrials.gov study NCT04247698. IPD Sharing: NO. Countries: 1. Publications: 0.
PV Reconnection After PVAI at Different Power Settings and Adenosine Provocation
ClinicalTrials.gov study NCT01672346. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Empagliflozin on Urinary Excretion of Adenosine and Osteocyte Function in Patients With Chronic Kidney Disease
ClinicalTrials.gov study NCT04961931. IPD Sharing: NO. Countries: 1. Publications: 0.
Rapid Measurement of Adenosine in Syncope Patients
ClinicalTrials.gov study NCT05782712. IPD Sharing: YES. Countries: 1. Publications: 0.
Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase, 2,3-Diphosphglycerate and Adenosine Triphosphate Activities in Red Blood Cells of People With Sickle Cell Disease
ClinicalTrials.gov study NCT03685721. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study Comparing Two Administration Pathways for Adenosine During Microvascular Function Assessment
ClinicalTrials.gov study NCT06269874. IPD Sharing: NO. Countries: 1. Publications: 0.
Role of Adenosine in the Release of VEGF and Cytokines
ClinicalTrials.gov study NCT00580905. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effects of Allergen Inhalation on Adenosine Receptor Expression in Sputum and Peripheral Blood
ClinicalTrials.gov study NCT00116311. IPD Sharing: Not stated. Countries: 1. Publications: 0.
cAMP (Cyclic Adenosine Monophosphate) Levels in the Nose
ClinicalTrials.gov study NCT01332825. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm
ClinicalTrials.gov study NCT00710255. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.