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1,947 results for “fate”
Raw and processed data for publication "Quantitative microscopy reveals dynamics and fate of clustered IRE1alpha"
<p>This dataset contains all raw and processed data for our PNAS paper titled "Quantitative microscopy reveals dynamics and fate of clustered IRE1alpha". Using the associated analysis code (10.5281/zenodo.3544482), all figures in the paper can be reproduced from the data in this upload.</p> <p>Abstract of the paper is included below:</p> <p>"The endoplasmic reticulum (ER) membrane-resident stress sensor IRE1 governs the most evolutionarily conserved branch of the unfolded protein response. Upon sensing an accumulation of unfolded proteins in the ER lumen, IRE1 activates its cytoplasmic kinase and ribonuclease (RNase) domains to transduce the signal. IRE1 activity correlates with its assembly into large clusters, yet the biophysical characteristics of IRE1 clusters remain poorly characterized. We combined super-resolution microscopy, single-particle tracking, fluorescence recovery and photoconversion to examine IRE1 clustering quantitatively in living human and mouse cells. Our results revealed that (1) by contrast to qualitative impressions gleaned from microscopic images, IRE1 clusters comprise only a small fraction (~5%) of the total IRE1 in the cell. (2) IRE1 clusters have complex topologies that display features of higher-order organization. (3) IRE1 clusters contain a diffusionally constrained core, indicating that they are not phase-separated liquid condensates. (4) IRE1 molecules in clusters remain diffusionally accessible to the free pool of IRE1 molecules in the general ER network. (5) When IRE1 clusters disappear at later timepoints of ER stress as IRE1 signaling attenuates, their constituent molecules are released back into the ER network and not degraded. (6) IRE1 cluster assembly and disassembly are mechanistically distinct. (7) IRE1 clusters’ mobility is nearly independent of cluster size. Taken together, these insights define the clusters as dynamic assemblies with unique properties. The analysis tools developed for this study will be widely applicable to investigations of clustering behaviors in other signaling proteins."</p>
Particle trajectories generated by the eDNA fate and transport model for the Atlantic bottlenose dolphin (Tursiops truncatus) -- Part I
<ul> <li>"release" includes particle trajectories generated by the eDNA fate and transport model, which was driven by the hydrodynamics simulated with the realistic wind and tidal forcings.</li> <li>The python codes used to read the particle trajectories and get the particle counts in each model grid cell can be found in https://github.com/Jilian0717/eDNA_fate_transport_model/tree/main/particle_density</li> </ul>
Particle trajectories generated by the eDNA fate and transport model for the Atlantic bottlenose dolphin (Tursiops truncatus) -- Part II
<ul> <li>"release_no_wind" includes particle trajectories generated by the eDNA fate and transport model, which was driven by the hydrodynamics simulated without wind forcing. The purpose is to diagnose the influence of wind on particle distributions.</li> <li>The python codes used to read the particle trajectories and get the particle counts in each model grid cell can be found in https://github.com/Jilian0717/eDNA_fate_transport_model/tree/main/particle_density</li> </ul>
The Fate of Nitrogen during Early Silicate Differentiation of Rocky Bodies Constrained by Experimental Mineral-Melt Partitioning
Open the record for dataset details and reuse information.
[PART 3] A twist of fate: the helix-turn-helix motif in Pseudomonas aeruginosa ExsA can allosterically stabilize the ligand-binding domain
<p>1273- ExsA - Dimer1 without DNA - alphaFold compact - 230ns/day 10x500ns<br>*1274- ExsA - Dimer2 without DNA - xtal extended (like 1026) - 10x1µs (not everything is 1 µs)<br>1275- ExsA - Dimer3 without DNA - made by hand / 150ns/day (reps 1-5 broken, reps 6-10 correct)<br>*1276- ExsA- monomer - Site1-PexoT - 240 ns/day - 10x1µs (some replicas have pieces missing)<br>*1277- ExsA- monomer - Site2-PexoT - 10x1µs<br>*1278- ExsA - Dimer2 with broken DNA - xtal extended (like 1026) - 5x200ns?</p>
[PART 2] A twist of fate: the helix-turn-helix motif in Pseudomonas aeruginosa ExsA can allosterically stabilize the ligand-binding domain
<p>1273- ExsA - Dimer1 without DNA - alphaFold compact <br>1274- ExsA - Dimer2 without DNA - xtal extended <br>1275- ExsA - Dimer3 without DNA - made by hand (reps 1-5 broken, reps 6-10 correct)<br>1276- ExsA- monomer - Site1-PexoT <br>1277- ExsA- monomer - Site2-PexoT<br>1278- ExsA - Dimer2 with broken DNA</p>
The moment of tooth: rate, fate, and pattern of Pacific lingcod dentition revealed by pulse-chase
<p>Tooth replacement rates of polyphyodont cartilaginous and bony fishes are hard to determine because of lack of obvious patterning, and maintaining specimens long enough to observe replacement. Pulse-chase is a fluorescent technique that differentially colours developing mineralized tissue. We present <i>in-situ </i>tooth replacement rate and position data for the oral and pharyngeal detentions of <i>Ophiodon elongatus</i> (Pacific lingcod). We assessed over 10,000 teeth, in 20 fish, and found a daily replacement rate of about two teeth (3.6% of the dentition). The average tooth is in the dental battery for 27 days. Replacement was higher in the lower pharyngeal jaw (LPJ). We found no difference between replacement rates of feeding and non-feeding fish, suggesting feeding was not a driver of tooth replacement. Lingcod teeth have both a size and location fate; smaller teeth at one spot will not grow into larger teeth, even if a large tooth nearby is lost. We also found increased rates of replacement at the posterior of the LPJ relative to the anterior. We propose that lingcod teeth do not migrate in the jaw as they develop; their teeth are fated in size and location, erupting in their functional position.</p>
Dataset for publication "Fate of charge order in overdoped La-based cuprates"
<p>Dataset providing the sourcedata of the main figures in the publication "Fate of charge order in overdoped La-based cuprates".</p>
Excalibur Fate (Low Poly)
I made this model. I hope you like it. :) **I do not own any rights for fate.** **This is just fanart** Source: Objaverse 1.0 / Sketchfab
Fasting Time Effects in Time-Restricted Eating (FaTE-TRE)
ClinicalTrials.gov study NCT04503005. IPD Sharing: NO. Countries: 1. Publications: 1.
Characterization of the Metabolic Fate of an Oral Arginine Form
ClinicalTrials.gov study NCT02352740. IPD Sharing: Not stated. Countries: 1. Publications: 61.
Fate of Nutrient-Derived Amino Acids, FONDAA
ClinicalTrials.gov study NCT02587156. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Promephy - Metabolic Fate of Plant-based Proteins
ClinicalTrials.gov study NCT05669612. IPD Sharing: NO. Countries: 1. Publications: 5.
FATE-NK100 as Monotherapy and in Combination With Monoclonal Antibody in Subjects With Advanced Solid Tumors
ClinicalTrials.gov study NCT03319459. IPD Sharing: NO. Countries: 1. Publications: 1.
Metabolic Fate Modifications of Saturated Fats After an Overfeeding
ClinicalTrials.gov study NCT00905892. IPD Sharing: Not stated. Countries: 1. Publications: 3.
FAiling HearT in the Elderly (FATE) Study
ClinicalTrials.gov study NCT06343233. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Mechanisms of Fate Evolution of Colorectal Adenocarcinoma Metastasis
ClinicalTrials.gov study NCT04714814. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of H. Pylori Eradication on the Fate of H. Pylori-associated Gastric Polyp
ClinicalTrials.gov study NCT03065868. IPD Sharing: NO. Countries: 1. Publications: 1.
L5-S1 Disc Fate in Thoracolumbar Arthrodesis Stopping at L5
ClinicalTrials.gov study NCT05566119. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Effect of Fasting and Refeeding on T-cell Fate
ClinicalTrials.gov study NCT02719899. IPD Sharing: Not stated. Countries: 1. Publications: 4.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.