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Figure 1 in Pectoral-fin glands and delivery apparatus in the catfish genus Brachyrhamdia Myers, 1927 (Siluriformes: Heptapteridae)
Figure 1: Ventral view of the pectoral region of Brachyrhamdia species, exposed in situ axillary glands after the removal of skin, hypaxial musculature and loose connective tissue and adipose tissue. (A) Brachyrhamdia marthae, LIRP 10040, 31.4 mm SL. Both left and right axillary glands (arrow) are exposed, right gland limits highlighted by white dashed line. (B) Brachyrhamdia heteropleura, LIRP 7419, 33.4 mm SL. Right axillary gland is exposed (arrow), with its limits highlighted by white dashed line, and portion of left axillary gland can be seen near pectoral-fin base by transparency. Scale bar: 1 mm.
Figure 3 in Pectoral-fin glands and delivery apparatus in the catfish genus Brachyrhamdia Myers, 1927 (Siluriformes: Heptapteridae)
Figure 3. (A₁) Dorsal view of Brachyrhamdia marthae right pectoral-fin spine and girdle, USNM 305641, total spine length 5.8 mm; (A₂) Illustration of B. marthae right pectoral-fin spine in dorsal view. Black indicates the ossified portion of spine, while gray portion indicates the unossified spurious ray; (B₁) Dorsal view of B. heteropleura right pectoral-fin spine and girdle, USNM 226105, total spine length 4.6 mm; (B₂) Illustration of B. heteropleura right pectoral-fin spine in dorsal view. Black indicates the ossified portion of the spine, while the gray portion indicates the unossified spurious ray (completed according to left pectoral-fin spine). The proximal portion of spine cannot be observed when the spine is articulated, therefore illustrations of such portion were produced according to direct observation. Abbreviations: ad = anterior denticulation, clth = cleithrum, pcp = posterior cleithrum process, ps = posterior serration.
Figure 2 in Pectoral-fin glands and delivery apparatus in the catfish genus Brachyrhamdia Myers, 1927 (Siluriformes: Heptapteridae)
Figure 2. Longitudinal oblique section of B. heteropleura left pectoral fin girdle, LIRP 7419, 30.9 mm SL, indicating gland cells wrapped by connective tissue. Abbreviations: agc = axillary gland cells (including binucleated cells), musc = musculature, clth = cleithrum. Scale bar: 0.5 mm.
Figure 4 in Pectoral-fin glands and delivery apparatus in the catfish genus Brachyrhamdia Myers, 1927 (Siluriformes: Heptapteridae)
Figure 4: Histological preparations of the right pectoral-fin spine of Brachyrhamdia species, indicating gland cells between bony spine and epidermis. (A) B. marthae, LIRP 10040, 23.9 mm SL, transversal section: (A₁) General view of spine (A₂) Detail of posterior edge of spine. (B) B. heteropleura, LIRP 7419, 30.9 mm SL, oblique transversal section: (B₁) General view of spine; (B₂) Detail of posterior edge of spine. Abbreviations: ad = anterior denticulation, ep = epidermis, ps = posterior serration, sp = pectoral-fin spine, vgc = superficial pectoral-fin spine venom gland cells. Epidermal cells indicated in B. heteropleura morphologically resemble club cells. Scale bar: 0.05 mm.
RNAseq of salivary gland IL10 positive CD4+ Tcells versus IL10 negative CD4+ Tcells at day14 post MCMV infection
<p>Bulk RNAseq, DESeq2 (https://bioconductor.org/packages/release/bioc/html/DESeq2.html) output for salivary gland IL10 positive CD4+ Tcells versus IL10 negative CD4+ Tcells at day14 post MCMV infection.</p>
Data from: Sexy fingers: Pheromones in the glands of male dendrobatid frogs
<p>Our study investigates the role of the swollen fingers of two dendrobatid species, <em>Leucostethus brachistriatus, </em>and <em>Epipedobates anthonyi,</em> in pheromone production using whole-transcriptome sequencing (RNAseq). We examined differential gene expression in the swollen versus non-swollen fingers and toes. The overwhelming pattern of gene expression in both species was strong upregulation of sodefrin precursor-like factors (SPFs) in swollen fingers, a well-known pheromone system in salamanders. As part of the results, we include a fasta-file with the RNA-seq assemblies from each species, as well as their annotation and Differential expression (DE) analyses. Likewise, we include the alignment of some of the most highly expressed sodefrin precursor-like-factor (SPF) sequences</p>
Fig. 3 in Effect Of Zinc And Cadmium Ions On Histostructure Of Antennal Glands Of Marbled Crayfish Procambarus Fallax (Hagen, 1870) F. Virginalis (Decapoda)
Fig. 3. Antennal gland of marbled crayfish under influence of zink (40х).
Fig. 2 in Effect Of Zinc And Cadmium Ions On Histostructure Of Antennal Glands Of Marbled Crayfish Procambarus Fallax (Hagen, 1870) F. Virginalis (Decapoda)
Fig. 2. Histology of antennal gland of marbled crayfish control (40x).
FIGURE 1 in Is 7-Hydroxyphthalide A Natural Compound Of Oil Gland Secretions? - Evidence From Archegozetes Longisetosus (Acari, Oribatida)
FIGURE 1: Gas chromatographic pattern of components, 24 hours after extraction, stored at -20°C. This pattern is identical to chromatograms taken directly after extraction. The amount of the internal standard (6-methyl-5-heptene-2-one) corresponds to 5ng. Peaks: a: 2,6-HMBD; b: neral; c: geranial; d: neryl formate; e: γ-acaridial; f: tridecane; h: tetradecane (this in an artifact of unknown origin); i: pentadecene; j: pentadecane; k: heptadecadiene; l: heptadecene; m: heptadecane. The * peaks arise from contaminations of the capillary column.
FIGURE 4 in Is 7-Hydroxyphthalide A Natural Compound Of Oil Gland Secretions? - Evidence From Archegozetes Longisetosus (Acari, Oribatida)
FIGURE 4: Comparison of amounts of γ-acaridial and 7-hydroxyphthalide during the 24 hour time course at 23°C. When both are com-
FIGURE 3 in Is 7-Hydroxyphthalide A Natural Compound Of Oil Gland Secretions? - Evidence From Archegozetes Longisetosus (Acari, Oribatida)
FIGURE 3: Mass spectra of γ-acaridial (above) and 7-hydroxyphthalide (below), both with M+ at m/z 150. Note differences at peaks m/z 76/77, m/z 104/105, and relative differences at m/z 122.
FIGURE 2 in Is 7-Hydroxyphthalide A Natural Compound Of Oil Gland Secretions? - Evidence From Archegozetes Longisetosus (Acari, Oribatida)
FIGURE 2: Gas chromatographic patterns measured from a raw extract stored at 23°C, 1 hour, 4 hours and 24 hours after extraction. Peak
Transcriptome analysis of T47D cells and H2A.J-KO derivatives for the paper entitled: The histone variant H2A.J is enriched in luminal epithelial gland cells
<p>H2A.J is a poorly studied mammalian-specific variant of histone H2A. We used immunohistochemistry to study its localization in various human and mouse tissues. H2A.J showed cell-type specific expression with a striking enrichment in luminal epithelial cells of multiple glands including those of breast, prostate, pancreas, thyroid, stomach, and salivary glands. H2A.J was also highly expressed in many carcinoma cell lines and in particular, those derived from luminal breast and prostate cancer. H2A.J thus appears to be a novel marker for luminal epithelial cancers. Knocking-out the H2AFJ gene in T47D luminal breast cancer cells reduced the expression of several estrogen-responsive genes which may explain its putative tumorigenic role in luminal-B breast cancer.</p>
Effects of Atractylodes Macrocephala Rhizoma polysaccharide on intestinal microbiota composition in rats with mammary gland hyperplasia
<p class="MsoNormal"><strong><span>Background</span></strong><span>: In recent years, Mammary gland hyperplasia (MGH) </span><span>has been</span><span> considered to be one of the diseases caused by endocrine disorders. It has been shown that diseases caused by endocrine disorders can be treated by regulating intestinal microbial. As a commonly used medicine in clinical practice, <em>Atractylodes </em></span><em><span>M</span></em><em><span>acrocephala Rhizoma</span></em><span> has good functions in regulating intestinal homeostasis. Therefore, this paper studied the effect of <em>Atractylodes </em></span><em><span>M</span></em><em><span>acrocephala Rhizoma</span></em><span> polysaccharide (AMP), on the intestinal flora of MGH rats, providing a new idea for polysaccharide treatment of MGH.</span></p> <p class="MsoNormal"><strong><span>Materials and methods</span></strong><span>: </span><span>Eighteen</span><span> female SD rats were selected and randomly divided into three groups, blank control group (Con), model control group (Mod) and AMP group, six rats in each group. MGH rat models were established by estradiol-progesterone combination and treated with AMP gastric infusion. The levels of E<sub>2</sub>, P and PRL in the serum of rats were measured, the intestinal contents were collected, and 16s rRNA high-throughput sequencing technology was used to analyze the changes of intestinal flora in the MGH rats.</span></p> <p class="MsoNormal"><strong><span>Results</span></strong><span>: AMP has good therapeutic effects on MGH rats, decreasing estradiol (E<sub>2</sub>) and prolactin (PRL) levels and increasing progesterone (P) levels, at the same time, it can regulate the abundance and diversity of intestinal flora of MGH rats, improve the disorder of intestinal flora caused by MGH </span><span>and </span><span>change the community structure, increase the abundance of beneficial flora and decrease the abundance of pathogenic flora.</span></p> <p class="MsoNormal"><strong><span>Conclusion</span></strong><span>: AMP can improve the intestinal microbiological environment of MGH rats, maintain the microecological balance of intestinal microbial</span><span>, and improve MGH symptoms</span><span>.</span></p>
Construction of microneedle of Atractylodes macrocephala aqueous extract and effect on mammary gland hyperplasia based on intestinal flora
<p><strong><span>Background</span></strong><span>: </span><span>A </span><span>microneedle</span><span> patch loaded with <em>Atractylodes macrocephala</em> water extract was prepared for the treatment of mammary gland hyperplasia to explore the relationship between MGH and intestinal flora. </span></p> <p><strong><span>Materials and methods</span></strong><span>: </span><span>Preparation of the microneedle patch by micromolding method, the prescription of the microneedle was optimized by the Box-Behnken Design response surface test, and the micro-morphology, penetration, toughness, and brittleness were investigated. <em>In vitro</em> release of drug-loaded microneedles was measured by diffusion cell method. The rat model of mammary gland hyperplasia was prepared by the combination of estradiol benzoate-progesterone, and the microneedle patch of <em>Atractylodes macrocephala</em> aqueous extract was used for intervention treatment. The change of levels in E<sub>2</sub>, P, and PRL in rat serum was determined. The intestinal contents of rats were collected and the changes in intestinal flora in MGH rats were analyzed by 16s rRNA high-throughput sequencing. </span></p> <p><strong><span>Results</span></strong><span>: </span><span>The optimized microneedle formula is a PVA concentration of 6.0%, HA concentration of 15.5%, and PVPK30 concentration of 16.0%. The prepared microneedle tip loaded with <em>Atractylodes macrocephala</em> aqueous extract has complete, sharp, and no bubbles and the needle rate of the microneedle array is in the range of 95%~100%. The bending rate of the microneedle is about 12.7%, and it has good flexibility, and the microneedle can puncture 4 layers of Parafilm</span><span>Ⓡ</span><span> membrane smoothly, and the puncture rate is more than 96%. The <em>in vitro</em> release of the microneedle was characterized by rapid release. The results of animal experiments showed that <em>Atractylodes macrocephala</em> aqueous extract microneedle patch could significantly reduce the E<sub>2</sub> level, significantly reduce the PRL level, and significantly increase the P level. At the same time, it can regulate the abundance and diversity of intestinal flora in MGH rats, improve the intestinal flora disorder caused by mammary gland hyperplasia, and balance the community structure. </span></p> <p><strong><span>Conclusion</span></strong><span>: </span><span>The prepared microneedle containing <em>Atractylodes macrocephala</em> aqueous extract has good toughness and brittle strength, can penetrate the skin and enter the dermis, and effectively deliver drugs to play a role in the treatment of mammary gland hyperplasia.</span></p>
Data for: Negative but antagonistic effects of neonicotinoid insecticides and ectoparasitic mites Varroa destructor on Apis mellifera honey bee food glands
<p>Collaborative brood care by workers is essential for the functionality of eusocial honey bee, <em>Apis</em> <em>mellifera</em>, colonies. The hypopharyngeal food glands of workers play a crucial role in this context. Even though there is consensus that ubiquitous ectoparasitic mites <em>Varroa</em> <em>destructor</em> and widespread insecticides, such as neonicotinoids, are major stressors for honey bee health, their impact alone and in combination on the feeding glands of workers is poorly understood. Here, we show that both <em>V. destructor</em> and neonicotinoids reduce hypopharyngeal gland size, thereby potentially compromising collaborative brood care in colonies. In a fully-crossed laboratory experiment, the impact of mites and the neonicotinoids thiamethoxam and clothianidin alone and in combination on workers were evaluated. While the neonicotinoids did not impact survival and emergence body mass, the data confirm that <em>V. destructor</em> reduces both. Even though the interactions between both stressors were antagonistic and neutral, the clear detrimental effects of both stressors alone and in combination on worker longevity and food glands are remarkable. Besides reduced worker longevity, impaired brood care provided by workers exposed to <em>V. destructor</em> and neonicotinoids could be detrimental for honey bee colony functionality. Our findings highlight a mechanism to explain honey bee colonies losses globally.</p>
Microbubbles in human salivary glands
<p>Supplementary video: a video captured from the ultrasound machine, illustrating the variable penetration patterns of microbubbles into glandular tissue. Videos of (A) left parotid gland with complete homogeneous dense penetration of microbubbles. (B) Right submandibular gland (SMG) with complete, inhomogeneous dense penetration of microbubbles. (C) Right parotid gland with complete homogenous penetration of microbubbles with moderate density. (D) Left SMG with no penetration of microbubbles. Only the main duct is visible.</p>
Nivolumab plus ipilimumab in advanced salivary gland cancer: a phase 2 trial
<p>This is a de-identified dataset accompanying the <em>Nature Medicine</em> publication titled "<strong>Nivolumab plus ipilimumab in advanced salivary gland cancer: a phase 2 trial</strong>", by Vos <em>et al. </em>(DOI: https://doi.org/10.1038/s41591-023-02518-x). It contains the clinical features and processed data of 64 patients with salivary gland cancer, treated with nivolumab and ipilimumab immunotherapy. These data underlie results reported in the article. Raw whole-exome and RNA sequencing data generated in this study have been made publicly available at SRA under BioProject number PRJNA940989.</p>
TGF-β3 increases the severity of radiation-induced oral mucositis and salivary gland fibrosis in a mouse model
<p>This is a collection of results from a preclinical trial investigating the effects of TGF-B3 treatment on healthy tissue radiotoxicity in C57BL/6 mice after fractionated head and neck radiotherapy. Survival, body weight, oral mucositis, lip dermatitis, saliva volume, and salivary gland collagen deposition were monitored. This data set is used in the manuscript "TGF-β3 increases the severity of radiation-induced oral mucositis and salivary gland fibrosis in a mouse model". </p> <p> </p>
Supplement: In situ spatial reconstruction of distinct normal and pathological cell populations within the human adrenal gland
<p>Supplemental legends, figure, and table for In situ spatial reconstruction of distinct normal and pathological cell populations within the human adrenal gland.</p>
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