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Dataset results
878 results for “human factors”
Activated Recombinant Human Factor VII Following Cardiac Bypass Surgery for Paediatric Congenital Heart Disease
ClinicalTrials.gov study NCT01562574. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Preliminary Efficacy of Activated Recombinant Human Factor VII in Acute Intracerebral Haemorrhage
ClinicalTrials.gov study NCT01566786. IPD Sharing: Not stated. Countries: 9. Publications: 2.
Efficacy and Safety of Trastuzumab Emtansine in Chinese Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Locally Advanced or Metastatic Breast Cancer
ClinicalTrials.gov study NCT03084939. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Complement Component 3c and Tumor Necrosis Factor-α in Patients With Human Papillomavirus-Induced Cutaneous Warts
ClinicalTrials.gov study NCT04399577. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Bile Acids and Gut Microbiota as Potent Coronary Atheroma Risk Factors: a Prospective Study in Human
ClinicalTrials.gov study NCT02375893. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of RO5479599 Alone or in Combination With Cetuximab or Erlotinib in Participants With Metastatic and/or Locally Advanced Malignant Human Epidermal Growth Factor Receptor (HER3) Expressing Soli
ClinicalTrials.gov study NCT01482377. IPD Sharing: Not stated. Countries: 4. Publications: 1.
microRNA of Human Epidermal Growth Factor Receptor 2 （HER2）Positive Patient Treated With Herceptin
ClinicalTrials.gov study NCT02656589. IPD Sharing: Not stated. Countries: 1. Publications: 17.
Data from: Multiscale factors affecting human attitudes toward snow leopards and wolves
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Data from: Inbreeding within human Schistosoma mansoni: do host- specific factors shape the genetic composition of parasite populations?
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Data from: The relative contribution of natural landscapes and human-mediated factors on the connectivity of a noxious invasive weed
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Data from: Human cytomegalovirus epidemiology and relationship to tuberculosis and cardiovascular disease risk factors in a rural Ugandan cohort
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Single cell transcriptomic analyses reveal the impact of bHLH factors on human retinal organoid development
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Data from: Factors affecting carcass detection at wind farms using dogs and human searchers
<p>1. The use of detection dogs to effectively monitor bird and bat fatalities at wind farms is becoming increasingly popular. All studies to date agree that dogs outperform human searchers at finding bird and bat carcasses around wind turbines; however, it remains unclear how particular conditions during the search may influence carcass detection.</p> <p>2. We investigate the effect of carcass size, habitat characteristics and weather conditions on carcass detection probability, for both dogs and humans, using data from the monitoring program of a wind farm in Spain.</p> <p>3. A generalized linear model reveals a high performance of dogs (~80% detection probability), with no clear influence of any of the variables analysed. Humans, on the contrary, were markedly affected by the size of the carcass and to some extent, by the vegetation structure. Humans performed poorly at detecting small carcasses (~20% detection probability), more so in dense vegetation.</p> <p>4. Synthesis and applications. Our results provide evidence that dogs perform at a high level under a wide range of environmental conditions. They are particularly well-suited for the monitoring of fatalities of small, rare or inconspicuous species in cluttered environments. Humans, by contrast, are very poor at detecting all but the largest carcasses.16-Jun-2020</p>
Figure 2 from: Ilieva V, Kondeva-Burdina M, Georgieva T (2020) In vitro analysis of the activity of human monoamine oxidase type B (hMAOB), treated with the cyanotoxin anatoxin-a: supposed factor of neurodegenerative diseases. Pharmacia 67(2): 111-114. https://doi.org/10.3897/pharmacia.67.e50806
Figure 2 Results from hMAOB activity, treated with anatoxin-a. * P < 0.05; ** P < 0.01; *** P < 0.001 vs control (pure hMAOB).
Data from: Identification of candidate risk factor genes for human idelalisib toxicity using a collaborative cross approach
Idelalisib is a phosphatidylinositol 3-kinase inhibitor highly selective for the delta isoform that has shown good efficacy in treating chronic lymphocytic leukemia and follicular lymphoma. In clinical trials, however, idelalisib was associated with rare, but potentially serious liver and lung toxicities. In this study, we used the Collaborative Cross (CC) mouse population to identify genetic factors associated with the drug response that may inform risk management strategies for idelalisib in humans. Eight (8) male mice (4 matched pairs) from 50 CC lines were treated once daily for 14 days by oral gavage with either vehicle or idelalisib at a dose selected to achieve clinically-relevant peak plasma concentrations (150 mg/kg/day). The drug was well tolerated across all CC lines, and there were no observations of overt liver injury. Differences across CC lines were seen in drug concentration in plasma samples collected at the approximate Tmax on study Days 1, 7, and 14. There were also small but statistically significant treatment-induced alterations in plasma total bile acids and microRNA-122, and these may indicate early hepatocellular stress required for immune-mediated hepatotoxicity in humans. Idelalisib treatment further induced significant elevations in the total cell count of terminal bronchoalveolar lavage fluid, which may be analogous to pneumonitis observed in the clinic. Genetic mapping identified loci associated with interim plasma idelalisib concentration and the other three treatment-related endpoints. Thirteen (13) priority candidate quantitative trait genes identified in CC mice may now guide interrogation of risk factors for adverse drug responses associated with idelalisib in humans.
Data from: Human plague system associated with rodent diversity and other environmental factors
Plague remains a threat to public health and is considered as a re-emerging infectious disease today. Rodents play an important role as major hosts in plague persistence and driving plague outbreaks in natural foci; however, few studies have tested the association between host diversity in ecosystems and human plague risk. Here we use Zero-Inflated Generalized Additive Models to examine the association of species richness with human plague presence (where plague outbreaks could occur) and intensity (the average number of annual human cases when they occurred) in China during the Third Pandemic. We also account for transportation network density, annual precipitation levels, and human population size. We found rodent species richness, particularly of rodent plague hosts, is positively associated with the presence of human plague. Further investigation shows that species richness of both wild and commensal rodent plague hosts are positively correlated with the presence, but only the latter correlated with the intensity. Our results indicated a positive relationship between rodent diversity and human plague, which may provide suggestions for the plague surveillance system.
Data from: Do prevailing environmental factors influence human preferences for facial morphology?
Prevailing environmental factors influence preferences for attractive traits across many species. In humans, debate surrounds the role of environmental pathogens and economic development in determining facial attractiveness. We tested whether women and men's preferences for facial dimorphism, symmetry, skin tone, and adiposity differ among Melanesian participants from 3 islands (Espiritu Santo, Efate, and Tanna) in Vanuatu in the South West Pacific. These islands vary in their historical malarial pathogens respectively from pronounced to almost absent and are characterized by within and between island differences in economic development, ranging from urbanized market-based economies to remote rural horticultural communities. We found no support for the hypothesis that masculine male faces or feminine female faces are more attractive in environments with higher exposure to malarial pathogens or urban development. However, preferences for facial symmetry were highest in islands with higher malarial rates, possibly as symmetry indicates health and guides mate selection in disease rich environments. However, past evidence linking symmetry and health is weak, and we therefore interpret our findings cautiously. Women from peri-urban communities preferred male faces with lighter skin to rural and urban participants. Men from urban areas stated higher preferences for symmetry than peri-urban and rural male participants. All other effects were not statistically significant. While cross-cultural studies comparing preferences between disparate cultures provide evidence of associations between environmental effects and preferences for some facial traits, our results suggest these associations might not always persist at more fine-grain scales within small-scale societies.
Domain scanning results for a selected set of high-quality-annotation protein isoforms produced by human transcription factor genes
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Data from: Temporal factors and distance to human settlement affect nest survival of the endangered Yellow-headed Parrot in Belize, Central America
<p>The endangered Yellow-headed Parrot (<em>Amazona oratrix</em>) has experienced a considerable reduction in abundance and distribution. Identifying natural and anthropogenic causes of nest failure is a critical step towards developing conservation actions that increase nest survival. In this study, we examined daily nest survival in relation to temporal, habitat and anthropogenic factors, as well as nest site properties. We monitored nests (<em>n </em>= 124) across six study sites in Belize during 2017 and 2018 and independently modeled the effects of predation, abandonment and poaching on daily nest survival rates. Overall, the estimated cumulative nest survival probability was 0.18 (95% CI = 0.12 – 0.25). Predation was the main cause of nest failure, followed by abandonment and poaching. Our results showed that nest predation and abandonment usually occurred early in the nesting cycle. Day within the nesting season negatively influenced daily survival for abandoned nests and had a quadratic effect on survival for poached nests.<strong> </strong>Poaching events occurred at a specific date range later in the season, with nests farther from the nearest human settlement having higher daily survival. Findings from this study highlight the additive mortality effect that nest poaching is having on Yellow-headed Parrot populations in Belize and show that managers can anticipate the timing and location of nests most vulnerable to poaching.<span> </span></p>
THE IMPORTANCE OF KNOWING THE HUMAN FACTOR IN MANAGEMENT ACTIVITIES
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ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.