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249
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ShareScore release 0.9.0
Dataset results
249 results for “infection tolerance”
Data from: Nonlinear disease tolerance curves reveal distinct components of host responses to viral infection
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Data from: Genotype and diet shape resistance and tolerance across distinct phases of bacterial infection
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Data from: Effects of protein malnutrition on tolerance to helminth infection
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Data from: Sexual antagonism for resistance and tolerance to infection in Drosophila melanogaster
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Data from: Health trajectories reveal the dynamic contributions of host genetic resistance and tolerance to infection outcome
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Reprogramming of disease tolerance is necessary for infection defense during aging
GEO Series GSE178878. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Differential gene expression differences between tolerant and susceptible avocado rootstocks in response to Rosellinia necatrix infection
GEO Series GSE119140. Persea americana. 8 samples. Type: Expression profiling by array.
The molecular programs underpinning 'tolerance' and 'resistance' in health and viral infection
GEO Series GSE174253. Influenza A virus (A/Puerto Rico/8/1934(H1N1)); Mus musculus. 198 samples. Type: Expression profiling by high throughput sequencing.
Mycobacterium avium ssp. paratuberculosis Infection Induces an Immune Tolerance Phenotype in Primary Bovine Macrophages from Johne’s Disease Cows (Agriculture and Agri-Food Canada_N.Bissonnette_J00007
GEO Series GSE98363. Bos taurus. 72 samples. Type: Expression profiling by high throughput sequencing.
Titanium nanoparticles activate a transcriptional response in Arabidopsis that enhances tolerance to low phosphate, osmotic stress and pathogen infection
GEO Series GSE208223. Arabidopsis thaliana. 24 samples. Type: Expression profiling by high throughput sequencing.
Defining the responses governing disease tolerance during Citrobacter rodentium infection of mice by deep RNA sequencing
GEO Series GSE100546. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Transgenerational tolerance to abiotic stresses induced by plant virus infection
GEO Series GSE214636. Nicotiana benthamiana. 12 samples. Type: Expression profiling by high throughput sequencing.
JAK/STAT inhibition restores disease tolerance in malaria-infected glucocorticoid receptor knockout mice.
GEO Series GSE268268. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Pulmonary ketogenesis promotes tolerance to bacterial infection
GEO Series GSE203352. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Arhgdia regulates disease tolerance in IAV-infected epithelial cells
GEO Series GSE193160. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
A type 1 immune-stromal cell network mediates disease tolerance and barrier protection against intestinal infection
GEO Series GSE292516. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Data from: The effect of diet and time after bacterial infection on fecundity, resistance, and tolerance in Drosophila melanogaster
Mounting and maintaining an effective immune response in the face of infection can be costly. The outcome of infection depends on two host immune strategies: resistance and tolerance. Resistance limits pathogen load, while tolerance reduces the fitness impact of an infection. While resistance strategies are well studied, tolerance has received less attention, but is now considered to play a vital role in host–pathogen interactions in animals. A major challenge in ecoimmunology is to understand how some hosts maintain their fitness when infected while others succumb to infection, as well as how extrinsic, environmental factors, such as diet, affect defense. We tested whether dietary restriction through yeast (protein) limitation affects resistance, tolerance, and fecundity in Drosophila melanogaster. We predicted that protein restriction would reveal costs of infection. Because infectious diseases are not always lethal, we tested resistance and tolerance using two bacteria with low lethality: Escherichia coli and Lactococcus lactis. We then assayed fecundity and characterized bacterial infection pathology in individual flies at two acute phase time points after infection. As expected, our four fecundity measures all showed a negative effect of a low-protein diet, but contrary to predictions, diet did not affect resistance to either bacteria species. We found evidence for diet-induced and time-dependent variation in host tolerance to E. coli, but not to L. lactis. Furthermore, the two bacteria species exhibited remarkably different infection profiles, and persisted within the flies for at least 7 days postinfection. Our results show that acute phase infections do not necessarily lead to fecundity costs despite high bacterial loads. The influence of intrinsic variables such as genotype are the prevailing factors that have been studied in relation to variation in host tolerance, but here we show that extrinsic factors should also be considered for their role in influencing tolerance strategies.
A Study to Evaluate the Safety and Tolerability of Eravacycline in Pediatric Patients Aged 8 to 17 With Complicated Intra-abdominal Infections (cIAI)
ClinicalTrials.gov study NCT06794541. IPD Sharing: YES. Countries: 1. Publications: 0.
Benefit and Tolerability of IQP-AS-105 in Reducing Susceptibility to Upper Respiratory Tract Infections
ClinicalTrials.gov study NCT01964885. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study Testing the Efficacy, Safety, and Tolerability of EDI048 in Cryptosporidium Infection Model in Healthy Adults
ClinicalTrials.gov study NCT07249463. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.