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453 results for “iron deficiency”
TO ASSESS THE FREQUENCY OF IRON DEFICIENCY ANEMIA AND HELICOBACTER PYLORI INFECTION AMONG SCHOOL-AGE CHILDREN WITH CHRONIC GASTRODUODENAL PATHOLOGY
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Data from: Systems and trans-system level analysis identifies conserved iron deficiency responses in the plant lineage
We surveyed the iron nutrition-responsive transcriptome of Chlamydomonas reinhardtii using RNA-Seq methodology. Presumed primary targets were identified in comparisons between visually asymptomatic iron-deficient versus iron-replete cells. This includes the known components of high-affinity iron uptake as well as candidates for distributive iron transport in C. reinhardtii. Comparison of growth-inhibited iron-limited versus iron-replete cells revealed changes in the expression of genes in chloroplastic oxidative stress response pathways, among hundreds of other genes. The output from the transcriptome was validated at multiple levels: by quantitative RT-PCR for assessing the data analysis pipeline, by quantitative proteomics for assessing the impact of changes in RNA abundance on the proteome, and by cross-species comparison for identifying conserved or universal response pathways. In addition, we assessed the functional importance of three target genes, VITAMIN C 2 (VTC2), MONODEHYDROASCORBATE REDUCTASE 1 (MDAR1), and CONSERVED IN THE GREEN LINEAGE AND DIATOMS 27 (CGLD27), by biochemistry or reverse genetics. VTC2 and MDAR1, which are key enzymes in de novo ascorbate synthesis and ascorbate recycling, respectively, are likely responsible for the 10-fold increase in ascorbate content of iron-limited cells. CGLD27/At5g67370 is a highly conserved, presumed chloroplast-localized pioneer protein and is important for growth of Arabidopsis thaliana in low iron.
IRON DEFICIENCY ANEMIA - AN OVERVIEW
<p>The most common nutritional issue worldwide, particularly in underdeveloped nations, is iron deficiency. Pregnant women, newborns, young children, and adolescents have particularly high needs since they are at a higher risk of iron deficiency. Low dietary iron bioavailability is a major contributor to iron insufficiency in underdeveloped nations. The effects of iron deficiency are numerous and severe, having an impact not only on an individuals health but also on the growth of civilizations and nations. Coordinating several approaches is necessary for the prevention and treatment of anemia and iron deficiency in all populations with varying needs for iron. The most prevalent type of anemia in the world is iron deficiency anemia and the most frequent cause of iron deficiency anemia in men and postmenopausal women is blood loss from gastrointestinal tract lesions. Iron deficiency anemia is brought on by either iron malabsorption or blood loss. Individualized treatment plans may be necessary for certain patient populations, including premenopausal women, people with low-normal ferritin levels, and people with iron deficiency but not anemia. Despite normal endoscopies returning negative results, a tiny percentage of patients nevertheless develop recurrent or persistent iron deficiency anemia. Patients must get intravenous iron because oral iron is ineffective in treating anemia. The response to iron supplementation by parenteral route varies but typically causes Hb levels to rise over time compared to people with acquired iron deficiency, the anemia is only partially corrected, and the process is more slower. Additionally, microcytosis persists, Hb levels rarely return to normal, and transferrin saturation is still below the ideal range. Contrarily, serum ferritin rises after iron injections, albeit in a dose-dependent way. </p><p> </p>
Iron-fortified Flavoured Skimmed Milk With or Without Vitamin D in Iron Deficient Women
ClinicalTrials.gov study NCT01739907. IPD Sharing: Not stated. Countries: 0. Publications: 6.
Short Term Oral Iron Supplementation in Systolic Heart Failure Patients Suffering From Iron Deficiency Anemia
ClinicalTrials.gov study NCT02998697. IPD Sharing: NO. Countries: 0. Publications: 4.
Iron Deficiency in Heart Failure Patients
ClinicalTrials.gov study NCT03883854. IPD Sharing: Not stated. Countries: 0. Publications: 1.
A Pilot Study of KRX-0502 (Ferric Citrate, Administered Without Food, in Treating Iron-deficiency Anemia
ClinicalTrials.gov study NCT02128074. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study to Assess Feasibility and Safety of Iron Repletion With Feraheme in Iron Deficient Patients With Durable Ventricular Assist Device Support
ClinicalTrials.gov study NCT04080908. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Daily Versus Alternate Day Iron Supplementation for the Treatment of Iron Deficiency Anemia in Pregnancy
ClinicalTrials.gov study NCT04594070. IPD Sharing: NO. Countries: 1. Publications: 0.
Ferric Carboxymaltose to Improve Skeletal Muscle Metabolism in Heart Failure Patients With Functional Iron Deficiency
ClinicalTrials.gov study NCT03218384. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Prevalence Study of Iron Deficiency in Patients With Cancer
ClinicalTrials.gov study NCT03924271. IPD Sharing: NO. Countries: 0. Publications: 1.
Epidemiological Study on Anemia and Iron Deficiency in Pregnancy in Medical Institutions in Some Areas of China
ClinicalTrials.gov study NCT04486456. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Impact of Iron Deficiency on Arrhythmic Events and Resting ECG Abnormalities in Patients Hospitalized With Heart Failure
ClinicalTrials.gov study NCT07277140. IPD Sharing: YES. Countries: 0. Publications: 7.
Clinical Observational Study: IBD Patients With Restless-legs-syndrome and Iron Deficiency Syndrome
ClinicalTrials.gov study NCT03457571. IPD Sharing: NO. Countries: 0. Publications: 1.
A Trial of Ferumoxytol for the Episodic Treatment of Iron Deficiency Anemia in Pediatric Participants With Chronic Kidney Disease
ClinicalTrials.gov study NCT01264679. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Heavy Menstrual Bleeding and Iron Deficiency Anemia
ClinicalTrials.gov study NCT05079815. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Iron Sucrose in Adolescents With Iron Deficiency and Postural Orthostatic Tachycardia Syndrome (POTS)
ClinicalTrials.gov study NCT01978535. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety and Tolerability of FCM vs Standard of Care in Treating Iron Deficiency Anemia in Chronic Kidney Disease Patients
ClinicalTrials.gov study NCT00548691. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluate the Safety and Efficacy of Ferric Maltol Oral Suspension vs. Ferrous Sulfate Oral Liquid in Children and Adolescents Aged 2 to 17 Years With Iron-deficiency Anaemia, With a Single Arm Study i
ClinicalTrials.gov study NCT05126901. IPD Sharing: NO. Countries: 3. Publications: 0.
Alternative vs. Once-Daily Oral Iron Supplementation in Iron Deficiency Anemia (IDA)
ClinicalTrials.gov study NCT07014371. IPD Sharing: NO. Countries: 1. Publications: 0.
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