Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
2,952
datasets available to search
ShareScore release 0.9.0
Dataset results
2,952 results for “limb”
A Study to Compare the Safety and Efficacy of Dysport® and Botox® in Adults With Upper Limb Spasticity.
ClinicalTrials.gov study NCT04936542. IPD Sharing: YES. Countries: 4. Publications: 1.
Efficacy And Safety Of Dysport In The Treatment Of Upper Limb Spasticity In Children
ClinicalTrials.gov study NCT02106351. IPD Sharing: YES. Countries: 8. Publications: 2.
Study to Evaluate Effects of DYSPORT® Injected in Lower and Upper Limb Combined With Guided Self-Rehabilitation Contract (GSC)
ClinicalTrials.gov study NCT02969356. IPD Sharing: YES. Countries: 4. Publications: 1.
Safety and Pharmacokinetics Study of DU-176b Administered to Patients With Severe Renal Impairment Undergoing Orthopedic Surgery of The Lower Limbs
ClinicalTrials.gov study NCT01857583. IPD Sharing: YES. Countries: 1. Publications: 1.
Dysport® Adult Lower Limb Spasticity Follow-on Study
ClinicalTrials.gov study NCT01251367. IPD Sharing: YES. Countries: 11. Publications: 4.
Dysport® Adult Upper Limb Spasticity Extension Study
ClinicalTrials.gov study NCT01313312. IPD Sharing: YES. Countries: 9. Publications: 1.
Dysport® Adult Lower Limb Spasticity Study
ClinicalTrials.gov study NCT01249404. IPD Sharing: YES. Countries: 11. Publications: 3.
Study to Assess Impact of Dysport Injections Early After Stroke on Upper Limb Spasticity Progression
ClinicalTrials.gov study NCT02321436. IPD Sharing: YES. Countries: 4. Publications: 1.
Dysport® Adult Upper Limb Spasticity
ClinicalTrials.gov study NCT01313299. IPD Sharing: YES. Countries: 9. Publications: 4.
Snow flies self-amputate freezing limbs to sustain behavior at sub-zero temperatures
Open the record for dataset details and reuse information.
Early diversification of avian limb morphology and the role of modularity in the locomotor evolution of crown birds
Open the record for dataset details and reuse information.
Patterns of girdle shape and their correlates in Australian limb-reduced skinks
Open the record for dataset details and reuse information.
Data from: Frog limbs in deep time: is jumping locomotion at the roots of the anuran Bauplan?
Open the record for dataset details and reuse information.
Data from: Nerve-dependent regulation of H3K27me3 during the induction of patterning competency in regenerating axolotl limb cells
Open the record for dataset details and reuse information.
Post-stroke upper limb kinematics of a set of daily living tasks
<p>This dataset contains upper limb kinematics of twenty chronic stroke-subjects and five healthy control subjects that were collected within a cross-sectional, observational study (Clinicaltrials.gov Identifier: NCT03135093). Participants were measured when performing a set of 30 daily living activities, including gesture movements, grasping actions and tool-mediated upper limb activities. Kinematic parameters were captured by use of inertial sensing and stored in software specific XML file format (.mvnx) allowing import to programs such as MATLAB and Microsoft Excel. Each mvnx-file represents one trial execution and is named according to the participant ID, task number, tested upper limb and repetition.</p> <p>This data collection is part of a large multimodal dataset collected and shared between collaborators of a European project under grant agreement No.688857.</p>
Data from: Non-consumptive predator effects modify crayfish induced bioturbation as mediated by limb loss: field and mesocosm experiments
1. We addressed the implications of limb loss and regeneration for multi-species interactions and their impacts on ecosystem engineering in freshwater stream environments. 2. We included regenerative and non-regenerative crayfish as well as fish predators in a 2x2 factorial design to assess the effects on water turbidity of interactions between crayfish ecosystem engineers differing in regenerative status and their fish predators. 3. We demonstrated that crayfish limb loss and predation risks lead to more turbidity in field and mesocosm conditions. Moreover, ongoing regeneration of crayfish increased turbidity, while fish presence seemed to hinder crayfish turbidity-inducing behaviors (such as tail-flipping and burrowing) in the mesocosm experiment. 4. We confirmed that greater numbers of crayfish produce a greater amount of turbidity in-situ in streams. 5. Although mechanical burrowing crayfish capacities may depend on crayfish burrowing classification (primary, secondary, or tertiary), our work emphasizes the implication for turbidity levels of crayfish autotomy in freshwater streams.
Limb work and joint work minimisation reveal an energetic benefit to the elbows-back, knees-forward limb design in parasagittal quadrupeds. Supplementary material including data, simulation code and simulation results
<p>Quadrupedal animal locomotion is energetically costly. We explore two forms of mechanical work that may be relevant in imposing these physiological demands. Limb work, due to the forces and velocities between the stance foot and the centre of mass, could theoretically be zero given vertical limb forces and horizontal centre of mass path. To prevent pitching, skewed vertical force profiles would then be required, with forelimb forces high in late stance and hindlimb forces high in early stance. By contrast, joint work – the positive mechanical work performed by the limb joints – would be reduced with forces directed through the hip or shoulder joints. Measured quadruped kinetics show features consistent with compromised reduction of both forms of work, suggesting some degree of, but not perfect, inter-joint energy transfer. The elbows-back, knees-forward design reduces the joint work demand of a low limb-work, skewed, vertical force profile. This geometry allows periods of high force to be supported when the distal segment is near vertical, imposing low moments about the elbow or knee, while the shoulder or hip avoids high joint power despite high moments because the proximal segment barely rotates – translation over this period is due to rotation of the distal segment.</p>
Differing limb functions and their potential influence upon the diversification of the mustelid hindlimb skeleton
<p>Though form-function relationships of the mammalian locomotor system have been investigated for over a century, recent models of trait evolution have hitherto been seldom used to identify likely evolutionary processes underlying the locomotor system's morphological diversity. Using mustelids, an ecologically diverse carnivoran lineage, I investigated whether variation in hindlimb skeletal morphology functionally coincides with climbing, digging, swimming, and generalized locomotor habits by using 15 linear traits of the femur, tibia, fibula, calcaneum, and metatarsal III across 44 species in a principal components analysis. I subsequently fit different models of Brownian motion and adaptive trait diversification individually to each trait. Climbing, digging, and swimming mustelids occupy distinct regions of phenotypic space characterized by differences in bone robustness. Models of adaptive and neutral evolution are, respectively, the best fits for long bone lengths and muscle in-levers, suggesting that different kinds of traits may be associated with different evolutionary processes. However, simulations based upon models of best fit reveal low statistical power to rank the models. Though differences in mustelid hindlimb skeletal morphology appear to coincide with locomotor habits, further study, with sampling expanded beyond Mustelidae, is necessary to better understand to what degree adaptive evolution shapes morphological diversity of the locomotor system.</p>
Supplemental Material for "Biomechanical analyses of Cambrian euarthropod limbs reveal their effectiveness in mastication and durophagy"
<p>Durophagy arose in the Cambrian and greatly influenced the diversification of biomineralised defensive structures throughout the Phanerozoic. Spinose gnathobases on protopodites of Cambrian euarthropod limbs are considered key innovations for shell-crushing, yet few studies have demonstrated their effectiveness with biomechanical models. Here we present finite element analysis models of two Cambrian trilobites with prominent gnathobases—<i>Redlichia rex</i> and <i>Olenoides serratus</i>—and compare these to the protopodites of the Cambrian euarthropod <i>Sidneyia inexpectans</i> and the modern American horseshoe crab, <i>Limulus polyphemus</i>. Results show that <i>L. polyphemus</i>, <i>S. inexpectans</i> and <i>R. rex</i> have broadly similar microstrain patterns, reflecting effective durophagous abilities. Conversely, low microstrain values across the <i>O. serratus</i> protopodite suggest that the elongate gnathobasic spines transferred minimal strain, implying that this species was less well-adapted to masticate hard prey. These results confirm that Cambrian euarthropods with transversely elongate protopodites bearing short, robust gnathobasic spines were likely durophages. Comparatively, taxa with shorter protopodites armed with long spines, such as <i>O. serratus</i>, were more likely restricted to a soft food diet. The prevalence of Cambrian gnathobase-bearing euarthropods and their various feeding specialisations may have accelerated the development of complex trophic relationships within early animal ecosystems, especially the 'arms race' between predators and biomineralised prey.</p>
Anuran limbs reflect microhabitat and distal, later-developing bones are more evolutionarily labile
Tetrapod limbs have been used as a model system to investigate how selective pressures and constraints shape morphological evolution. Anurans have had many independent transitions to various microhabitats, allowing us to dissect how these factors influence limb morphology. Furthermore, anurans provide a unique system to test the generality of developmental constraints proposed in mammals, namely that later-developing limb bones are under less constraint and show more variation. We used micro-computed tomography scans of 236 species from 52 of 55 families, geometric morphometrics, and modern phylogenetic comparative methods to examine how limb bones are related to microhabitat, phylogeny, allometry, and developmental timing. Although there was significant phylogenetic signal, anuran limb shape showed a relationship with microhabitat and to a lesser extent, body size. We found that distal bones had higher evolutionary rates than proximal bones, providing evidence that developmental constraints are reduced in later-developing bones. Distal bones also showed increased selection related to allometry and microhabitat, providing an additional explanation for higher evolutionary rates. By looking at the evolution of limb shape across a diverse clade, we demonstrated that multiple factors have shaped anuran limbs and that greater evolutionary lability in later-developing limb bones is likely a general trend among tetrapods.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.