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278
datasets available to search
ShareScore release 0.9.0
Dataset results
278 results for “metabolic modeling”
Transcriptome and proteome profiling reveals TREM2-dependent and -independent glial response and metabolic perturbation in an Alzheimer’s mouse model
GEO Series GSE279164. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Impaired adult hippocampal neurogenesis in a mouse model of familial hypercholesterolemia: a role for the LDL receptor and cholesterol metabolism in adult neural precursor cells (LDL treatment)
GEO Series GSE136792. Mus musculus. 6 samples. Type: Expression profiling by array.
Gene expression profile at single cell level of non-parenchymal cells from Fibrosis and Tumor (FAT) Metabolic Dysfunction-Associated Steatohepatitis (MASH) model vs healthy liver at 12- and 24-week ti
GEO Series GSE261088. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Mannose reduces fructose metabolism and reverses MASH in human liver slices and murine models in vivo
GEO Series GSE287943. Mus musculus. 25 samples. Type: Expression profiling by high throughput sequencing.
A hollow fiber membrane-based liver organoid-on-a-chip model for examining drug metabolism and transport
GEO Series GSE269150. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
Intersection of Immunity, Metabolism, and Muscle Regeneration in an Autoimmune-Prone MRL Mouse Model
GEO Series GSE252436. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Multi-omic Analysis of an Mucolipidosis II Neuronal Cell Model Uncovers Involvement of Pathways Related to Neurodegeneration and Drug Metabolism
GEO Series GSE273794. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Improving genome-scale metabolic model simulations by measuring exchange fluxes during exponential growth phase
GEO Series GSE293588. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Expression of metabolic hormone signalling genes in the brain of a triprolyl-human amylin transgenic mouse model of type 2 diabetes
GEO Series GSE132940. Mus musculus. 192 samples. Type: Other.
Banxia Xiexin decoction promotes gastric lymphatic pumping by regulating lymphatic smooth muscle cell contraction and energy metabolism in a stress-induced gastric ulceration rat model
GEO Series GSE252116. Rattus norvegicus. 9 samples. Type: Expression profiling by high throughput sequencing.
Mature Polarized Hepatocyte Organoids Derived from Human Embryonic Stem Cells for Modeling the Pathogenesis and Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease and Therapeutic
GEO Series GSE303090. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
A Mouse Model for Metabolic Dysfunction-associated Steatotic Liver Disease and Hepatocellular Carcinoma [RNA-seq]
GEO Series GSE246221. Mus musculus; Homo sapiens. 148 samples. Type: Expression profiling by high throughput sequencing.
Mice model for 15q11-13 duplication syndrome show late onset obesity and altered lipid metabolism
GEO Series GSE58191. Mus musculus. 6 samples. Type: Expression profiling by array.
Lamin A/C regulates lipid metabolism and inflammation: insights from models of familial partial lipodystrophy 2 sub1
GEO Series GSE311533. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome [polyA RNA-seq]
GEO Series GSE126358. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Alpha-ketoglutarate mitigates insulin resistance and metabolic inflexibility in a mouse model of Ataxia-Telangiectasia
GEO Series GSE222655. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Metabolic responses of the model archaeon Halobacterium sp. NRC-1 to oxygen limitation
GEO Series GSE38374. Halobacterium salinarum NRC-1. 5 samples. Type: Expression profiling by array.
Integrated metabolic modelling reveals cell-type specific epigenetic control points of the macrophage metabolic network
GEO Series GSE68798. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Data from: From the cover: three-dimensional (3d) heparg spheroid model with physiologically relevant xenobiotic metabolism competence and hepatocyte functionality for liver toxicity screening.
Effective prediction of human responses to chemical and drug exposure is of critical importance in environmental toxicology research and drug development. While significant progress has been made to address this challenge using invitro liver models, these approaches often fail due to inadequate tissue model functionality. Herein, we describe the development, optimization, and characterization of a novel three-dimensional (3D) spheroid model using differentiated HepaRG cells that achieve and maintain physiologically relevant levels of xenobiotic metabolism (CYP1A2, CYP2B6, and CYP3A4/5). This invitro model maintains a stable phenotype over multiple weeks in both 96- and 384-well formats, supports highly reproducible tissue-like architectures and models pharmacologically- and environmentally important hepatic receptor pathways (ie AhR, CAR, and PXR) analogous to primary human hepatocyte cultures. HepaRG spheroid cultures use 50–100× fewer cells than conventional two dimensional cultures, and enable the identification of metabolically activated toxicants. Spheroid size, time in culture and culture media composition were important factors affecting basal levels of xenobiotic metabolism and liver enzyme inducibility with activators of hepatic receptors AhR, CAR and PXR. Repeated exposure studies showed higher sensitivity than traditional 2D cultures in identifying compounds that cause liver injury and metabolism-dependent toxicity. This platform combines the well-documented impact of 3D culture configuration for improved tissue functionality and longevity with the requisite throughput and repeatability needed for year-over-year toxicology screening.
Strain specific Genome scale metabolic models for 1011 Saccharomyces cerevisiae
<p>This is generated strain specific genome scale metabolic models for 1011 S. cerevisiae strains. This is linked with paper: Lu, H. et al. <em>A consensus S. cerevisiae metabolic model Yeast8 and its ecosystem for comprehensively probing cellular metabolism.</em> Nature Communications 10, 3586 (2019). <a href="https://doi.org/10.1038/s41467-019-11581-3">doi:10.1038/s41467-019-11581-3</a></p> <p> </p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.