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5,472 results for “mouse cells”
Dataset related to article: "Fluoxetine increases brain MeCP2 immuno-positive cells in a female Mecp2 heterozygous mouse model of Rett syndrome through endogenous serotonin. "
<pre>Dataset related to article: "Fluoxetine increases brain MeCP2 immuno-positive cells in a female Mecp2 heterozygous mouse model of Rett syndrome through endogenous serotonin." </pre>
RNA sequencing of sorted conducting airway epithelial cells from FGF9-overexpressing and control mouse lungs at 1 day post-infection with IAV
<p><span>Influenza A virus (IAV) preferentially infects conducting airway and alveolar epithelial cells in the lung. The outcome of these infections is impacted by the host response, including the production of various cytokines, chemokines, and growth factors. Fibroblast growth factor-9 (FGF9) is required for lung development, can display antiviral activity <em>in vitro</em>, and is upregulated in asymptomatic patients during early IAV infection. We therefore hypothesized that FGF9 would protect the lungs from respiratory virus infection and evaluated IAV pathogenesis in mice that overexpress FGF9 in club cells in the conducting airway epithelium (FGF9-OE mice). However, we found that FGF9-OE mice were highly susceptible to IAV and Sendai virus infection compared to control mice. FGF9-OE mice displayed elevated and persistent viral loads, increased expression of cytokines and chemokines, and increased numbers of infiltrating immune cells as early as 1 day post-infection (dpi). Gene expression analysis showed an elevated type I interferon (IFN) signature in the conducting airway epithelium and analysis of IAV tropism uncovered a dramatic shift in infection from the conducting airway epithelium to the alveolar epithelium in FGF9-OE lungs. These results demonstrate that FGF9 signaling primes the conducting airway epithelium to rapidly induce a localized, protective IFN and proinflammatory cytokine response during viral infection. Although this response protects the airway epithelial cells from IAV infection, it allows for early and enhanced infection of the alveolar epithelium, ultimately leading to increased morbidity and mortality. Our study illuminates a novel role for FGF9 in regulating respiratory virus infection and pathogenesis.</span></p>
Conservation and divergence of cortical cell organization in human and mouse revealed by MERFISH
<p>Please contact Rongxin Fang (r3fang@fas.harvard.edu) for any question about the dataset.</p> <p>The human cerebral cortex has tremendous cellular diversity. How different cell types are organized in the human cortex and how cellular organization varies across species remain unclear. In this study, we performed spatially resolved single-cell profiling of 4000 genes using multiplexed error-robust fluorescence in situ hybridization (MERFISH), identified more than 100 transcriptionally distinct cell populations, and generated a molecularly defined and spatially resolved cell atlas of the human middle and superior temporal gyrus. We further explored cell-cell interactions arising from soma contact or proximity in a cell type–specific manner. Comparison of the human and mouse cortices showed conservation in the laminar organization of cells and divergence in somatic interactions across species. Our data revealed human-specific cell-cell proximity patterns and a marked increase in interaction enrichment between neurons and non-neuronal cells in the human cortex.</p>
Dataset related to article "Neonicotinoid pesticides affect developing neurons in experi-mental mouse models and in human induced pluripotent stem cell (iPSC)-derived neural cultures and organoids"
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Neonicotinoid pesticides affect developing neurons in experi-mental mouse models and in human induced pluripotent stem cell (iPSC)-derived neural cultures and organoids
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Data from: Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion
Hippocampal place cells represent the cellular substrate of episodic memory. Place cell ensembles reorganize to support learning but must also maintain stable representations to facilitate memory recall. Despite extensive research, the learning-related role of place cell dynamics in health and disease remains elusive. Using chronic two-photon Ca2+ imaging in hippocampal area CA1 of wild-type and Df(16)A+/− mice, an animal model of 22q11.2 deletion syndrome, one of the most common genetic risk factors for cognitive dysfunction and schizophrenia, we found that goal-oriented learning in wild-type mice was supported by stable spatial maps and robust remapping of place fields toward the goal location. Df(16)A+/− mice showed a significant learning deficit accompanied by reduced spatial map stability and the absence of goal-directed place cell reorganization. These results expand our understanding of the hippocampal ensemble dynamics supporting cognitive flexibility and demonstrate their importance in a model of 22q11.2-associated cognitive dysfunction.
Localisation of oestrogen receptors in stem cells and in stem cell derived neurons of the mouse
<p>This dataset is linked to a publication in the Journal of Neuroendocrinology with the following DOI: 10.1111/jne.13220</p> <p>The Readme file gives details of the organisation of this dataset. All data here are raw data obtained from image analyses using the EZcoloc plugin for Fiji (Image J) and this raw data was used to construct the data graphs that are shown in the paper. In some graphs that involve ratios, integrated density values from Fiji were used.</p> <p>The softwares used are EZcoloc plugin and Image J referenced in the Readme file.</p>
Data for paper "MDM2 inhibitors, nutlin-3a and navtemadlin, retain efficacy in human and mouse cancer cells cultured in hypoxia"
<p>This repository contains data for manuscript with DOI: 10.1038/s41598-023-31484-0</p>
Microscopy data of RNA polymerase II clusters during RHB differentiation of cultured mouse embryonic stem cells
<p>Main repository containing the analysis scripts and results: 10.5281/zenodo.8013242</p>
Microscopy data of RNA polymerase II clusters during -LIF differentiation of cultured mouse embryonic stem cells
<p>Main repository containing the analysis scripts and results: 10.5281/zenodo.8013242</p>
Figure 1 in The study of exposure times and dose-escalation of tick saliva on mouse embryonic stem cell proliferation
Figure 1. Effect of H. marginatum SGE (0-160 µg/ml) on mouse embryonic stem cell proliferation and viability. Values represent relative fold change of cell viability normalized to untreated negative control. The Geisser –Greenhouse correction and Dunnett´s test on multiple comparison were used. The results are mean ± standard deviation (SD) from a representative experiment carried out in triplicate and were seeded in equal amount in 3 different 96 -well cultured plates.
Data from: An increase in immature β-cells lacking Glut2 precedes the expansion of β-cell mass in the pregnant mouse
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Data from: The functional diversity of retinal ganglion cells in the mouse
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RNA sequencing of sorted conducting airway epithelial cells from FGF9-overexpressing and control mouse lungs at 1 day post-infection with IAV
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Data from: A four-component model of the action potential in mouse detrusor smooth muscle cell
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Data from: Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion
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Conservation and divergence of cortical cell organization in human and mouse revealed by MERFISH
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single cell-RNA sequencing for Immune cells from mouse brain tumor post control diet
GEO Series GSE200533. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Zfp57 inactivation illustrates the relationship between DNA methylation and imprinted gene expression in mouse neural precursor cells
GEO Series GSE164669. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Generation of transcriptional regulatory network of Lgr5+ small and large intestinal stem cells from mouse [scRNA-seq]
GEO Series GSE196915. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.