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143 results for “neurodegenerative diseases”
Subject-specific features of excitation/inhibition profiles in neurodegenerative diseases
<p>Brain pathologies are based on microscopic changes in neurons and synapses that reverberate into large scale networks altering brain dynamics and functional states. An important yet unresolved issue concerns the impact of patients excitation/inhibition (E/I) profiles on neurodegenerative diseases including Alzheimer’s disease (AD), Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS). In this work we used a simulation platform, The Virtual Brain (TVB), to simulate brain dynamics in healthy controls (HC) and in AD, FTD and ALS patients. The brain connectome and functional connectivity were extracted from 3T-MRI scans and the TVB nodes were represented by a Wong-Wang neural mass model endowing an explicit representation of the E/I balance. The integration of cerebro-cerebellar loops improved the correlation between experimental and simulated functional connectivity, and hence TVB predictive power, in all pathological conditions. The TVB biophysical parameters differed between clinical phenotypes, predicting higher global coupling and inhibition in AD and stronger NMDA receptor-dependent excitation in ALS. These physio-pathological parameters allowed an advanced analysis of patients’ state.</p> <p>This database includes structural and functional connectivity matrices estimated from tractography and rs-fMRI time-series of each subject analyzed (15 HC, 15 AD, 15 FTD, 15 ALS). An ad-hoc grey matter (GM) parcellation atlas has been created combining 93 cerebral (including cortical/subcortical structures) and 31 cerebellar labels. Each GM parcellation is reported as a node in the connectivity matrices. Two types of SC matrices are reported: a distance matrix containing the length of tracts connecting each pair of nodes and a weight matrix in which connections strengths (number of streamlines) are normalized by the maximum value per each subject. The time-course of BOLD signals has been extracted for each node and the experimental FC matrix (expFC) is computed as the Pearson’s correlation coefficient (PCC) of the time-courses between each pair of brain regions. </p> <p> </p>
Dataset for the project "LRRK2 as a novel pharmacological target for treatment of neurodegenerative diseases" (GR-2016-02362548)
<p>Dataset for the project "LRRK2 as a novel pharmacological target for treatment of neurodegenerative diseases" (GR-2016-02362548).</p> <p><strong>Aim 1:</strong></p> <p>Understanding whether LRRK2 mediates neuroinflammation triggered by PD and AD misfolded proteins using in vitro and in vivo models.</p> <p><strong>Aim 2:</strong></p> <p>Exploring whether and how LRRK2-related neuroinflammation affects hiPSC-derived neuronal function.</p> <p><strong>Aim 3:</strong></p> <p>Exploring whether hiPSC-derived neurons carrying LRRK2 mutation/variant are more vulnerable to neuroinflammation.</p> <p> </p> <p>The present dataset contains the following folders:</p> <p><strong>1- Aim 1</strong></p> <p>- In vitro</p> <p> - Attivazione infiammazione</p> <p> - Generazione proteina amiloide</p> <p> - LRRK2 infiammazione</p> <p>- In vivo</p> <p> - Generazione proteina amiloidi</p> <p> - Infiammazione abeta</p> <p> - Infiammazione asyn</p> <p> - Microglia-Astrociti abeta</p> <p> - Microglia-Astrociti asyn </p> <p> </p> <p><strong>2- Aim 2</strong></p> <p>- hiPSC Col RNASeq</p> <p>- hiPSC DA RNASEq</p> <p>- Neuroni colinergici</p> <p>- Neuroni dopaminergici</p> <p> </p> <p><strong>3- Aim 3</strong></p> <p>- Gentotyping human cells</p>
Semiology and determinants of apathy across neurodegenerative motor disorders: A comparison between amyotrophic lateral sclerosis, Parkinson's and Huntington's disease
<p>Dataset associated with the paper: "Semiology and determinants of apathy across neurodegenerative motor disorders: A comparison between amyotrophic lateral sclerosis, Parkinson’s and Huntington’s disease".</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.