Find research datasets worth reusing

opencc-by-4.0Oct 2024View details →

3D Printed Bigel: A Novel Delivery System for Cannabidiol-Rich Hemp Extract

<h2>Abstract</h2> <div>The therapeutic potential of Cannabis sativa L. extract has gained significant attention due to its diverse medical applications. Sublingual administration remains a common delivery method of cannabinoids; however, challenges often arise due to the inconvenient form of the extract and its taste. To address these issues, a novel bigel formulation was developed, combining water and oil phases to enhance stability and bioavailability. This formulation incorporates a cannabidiol-rich hemp extract, hyaluronic acid for its moisturizing properties, and a taste-masking agent to improve patient compliance and comfort. Using a standardized hemp extract rich in cannabinoids and a well-characterized terpene profile, the printability of the bigels was evaluated through 3D printing technology. A printout with known cannabidiol (CBD) and cannabidiolic acid (CBDA) content of 11.613 mg ± 0.192 of CBD and 4.732 mg ± 0.280 of CBDA in the printout was obtained. In addition, the release profile of CBD and CBDA was evaluated to determine the delivery efficiency of the active ingredient—dissolved active ingredient levels ranged from 74.84% ± 0.50 to 80.87% ± 3.20 for CBD and from 80.84 ± 1.33 to 98.31 ± 1.70 for CBDA depending on the formulation. Rheological studies were conducted to evaluate the viscosity of the bigels under varying temperature conditions, ensuring their stability and usability. Findings suggest that this 3D-printed bigel formulation could significantly enhance the delivery of cannabis extracts, offering a more convenient and effective therapeutic option for patients. This research underscores the importance of innovation in cannabinoid therapies and paves the way for further advancements in personalized medicine.</div>

opencc-by-4.0Nov 2024View details →

Dataset of the publication: A Novel Banana-Shaped Mixed-Metal Co/Fe Polyoxometalate Cluster

Dataset of the publication: A Novel Banana-Shaped Mixed-Metal Co/Fe Polyoxometalate Cluster DOI: 10.1002/cplu.202400473 J. Quirós-Huerta, J. Troya, M. Clemente-León, J. M. Clemente-Juan, E. Coronado, J. Soriano-López  ChemPlusChem, e202400473 (2024)

opencc-by-4.0Aug 2024View details →

Supplementary dataset for "Phenylacetic acid metabolism in land plants: novel pathways and metabolites"

Supplementary dataset with measured data for publication "Phenylacetic acid metabolism in land plants: novel pathways and metabolites"

opencc-by-4.0Mar 2021View details →

Novel Peptide-Based PET Probe for Non-invasive Imaging of C-X-C Chemokine Receptor Type 4 (CXCR4) in Tumors

These are RAW data datasets of the following final paper Trotta, A.M., Aurilio, M., D'Alterio, C., Ieranò, C., Di Martino, D., Barbieri, A., Luciano, A., Gaballo, P., Santagata, S., Portella, L., Tomassi, S., Marinelli, L., Sementa, D., Novellino, E., Lastoria, S., Scala, S., Schottelius, M., Di Maro, S. Novel Peptide-Based PET Probe for Non-invasive Imaging of C-X-C Chemokine Receptor Type 4 (CXCR4) in Tumors, (2021) Journal of Medicinal Chemistry, 64 (6), pp. 3449-3461. ISSN 00222623 https://doi.org/10.1021/acs.jmedchem.1c00066 Abstract The recently reported CXCR4 antagonist 3 (Ac-Arg-Ala-[DCys-Arg-2Nal-His-Pen]-CO2H) was investigated as a molecular scaffold for a CXCR4-targeted positron emission tomography (PET) tracer. Toward this end, 3 was functionalized with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and 1,4,7-triazacyclononanetriacetic acid (NOTA). On the basis of convincing affinity data, both tracers, [68Ga]NOTA analogue ([68Ga]-5) and [68Ga]DOTA analogue ([68Ga]-4), were evaluated for PET imaging in “in vivo” models of CHO-hCXCR4 and Daudi lymphoma cells. PET imaging and biodistribution studies revealed higher CXCR4-specific tumor uptake and high tumor/background ratios for the [68Ga]NOTA analogue ([68Ga]-5) than for the [68Ga]DOTA analogue ([68Ga]-4) in both in vivo models. Moreover, [68Ga]-4 and [68Ga]-5 displayed rapid clearance and very low levels of accumulation in all nontarget tissues but the kidney. Although the high tumor/background ratios observed in the mouse xenograft model could partially derive from the hCXCR4 selectivity of [68Ga]-5, our results encourage its translation into a clinical context as a novel peptide-based tracer for imaging of CXCR4-overexpressing tumors.

opencc-zeroDec 2021View details →

Genetic background and thermal regime influence adaptation to novel environment in the seed beetle, Callosobruchus maculatus

Climate change is associated with the increase in both mean and variability of thermal conditions. Therefore, the use of more realistic fluctuating thermal regimes is the most appropriate laboratory method for predicting population responses to thermal heterogeneity. However, the long- and short-term implications of evolving under such conditions are not well understood. Here, we examined differences in key life history traits among populations of seed beetles (Callosobruchus maculatus) that evolved under either constant control conditions or in an environment with fluctuating daily temperatures. Specifically, individuals from two distinct genetic backgrounds were kept for 19 generations at one of two temperatures, a constant temperature (T=29°C) or a fluctuating daily cycle (Tmean=33°C, Tmax=40°C, and Tmin=26°C), and were assayed either in their evolved environment or in the other environment. We found that beetles that evolved in fluctuating environments but were then switched to constant 29°C conditions had far greater lifetime reproductive success compared to beetles that were kept in their evolved environments. This increase in reproductive success suggests that beetles raised in fluctuating environments may have evolved greater thermal breadth than control condition beetles. In addition, the degree of sexual dimorphism in body size and development varied as a function of genetic background, evolved thermal environment, and current temperature conditions. These results highlight not only the value of incorporating diel fluctuations into climate research but also suggest that populations that experience variability in temperature may be better able to respond to both short- and long-term changes in environmental conditions.

opencc-zeroDec 2021View details →

Novel disease state model finds most juvenile green turtles develop and recover from fibropapillomatosis

Fibropapillomatosis (FP) is a sea turtle disease characterized by benign tumor development on skin, eyes, and/or internal organs. It primarily affects juvenile green turtles (Chelonia mydas) in coastal foraging sites. The Indian River Lagoon (IRL), Florida, USA, is a coastal green turtle foraging site where the observed FP annual rate averaged 49% between 1983 and 2018. FP is not a major cause of sea turtle mortality and most individuals fully recover; however, the overall dynamics of this disease are poorly understood because prior disease history is unknown for individuals without FP at capture time, and future disease outcome is unknown for individuals with FP at capture time. To better evaluate FP dynamics for green turtles in the IRL, we developed a hierarchical model for predicting disease state change. We used data from 4,149 captures of 3,700 individual green turtles captured in the IRL. The hierarchical disease state model contained two levels: level one modeled whether an individual would develop FP, and level two modeled disease state progression, including states for pre-FP affliction, active FP affliction, and full recovery from FP. From the hierarchical model, we estimated 99.8% (95% credibility intervals 99.1-100%) of juvenile green turtles in the IRL developed FP, indicating that nearly every individual in the IRL is affected by this disease. The model also suggested that turtles quickly developed FP upon recruitment to the IRL and then recovered at different rates, with most completely recovering before emigrating from the IRL as they mature. This is the first analysis of long-term sea turtle data suggesting nearly every turtle in an aggregation both develops and recovers from FP.

opencc-by-4.0Dec 2021View details →

A novel method for objective identification of 3-D potential vorticity anomalies - Visualizations using Met.3D

This video provides 3-D visualizations of the outputs of the Potential Vorticity anomaly identification technique regarding an investigated case study. An in-depth description of the algorithm, as well as evaluations of the visible results are performed in the study.

opencc-by-4.0Jan 2022View details →

Evaluation of a Novel 8-Channel RX Coil for Speech Production at 0.55 T DATASET.

This dataset contains raw imaging MRI data used in SNR evaluation for 4 subjects. For all scans, volumetric data of the upper airway was obtained using a 3D spoiled gradient echo sequence with either a speech coil, a head coil, or an integrated body coil. Imaging parameters were: flip angle = 10, TE = 5 ms, TR = 10 ms, FOV = 32x32x16 cm^3, resolution = 2.5 x 2.5 x 5 mm^3.  Pre-scan noise information for each scan is also included.

opencc-by-4.0Jan 2022View details →

Textual features and metadata for DBNL novels 1800-2000

This dataset contains a corpus of 1346 novels from DBNL. Included are metadata, word counts, and syntactic features for the novels. The metadata includes variables related to canonicity: library information, secondary references, Wikipedia mentions, etc. The titles have been selected using the following criteria: <ul> <li>Novels and novellas</li> <li>Originally written in Dutch</li> <li>First published 1800-2000</li> <li>TEI from titles available on https://www.DBNL.org</li> </ul> Acknowledgements: Information from libraries was contributed by Trudie Stoutjesdijk and Eddie de Kok from Data Warehouse.

Novel polarimetric technique to constrain the magnetic field structure and strength of Gamma-ray burst jets

Gamma-ray bursts (GRBs) are extremely energetic events of cosmological origin. Observed GRBs have high luminosity and rapid variability that requires ultra-relativistic motion in the production mechanism which drive the synchrotron radiation associated with the relativistic jets and their shocked interactions with the local ambient medium. They are broadly divided into two types based on the gamma-ray duration; long GRBs (>2 seconds), and short GRBs (<2 seconds). Long GRBs are thought to be originated from explosions of very massive stars and short GRBs are thought to be produced by the merger of compact binaries. Several key open questions about our understanding of GRB physics remain: What is the driving mechanism of GRB jets? What is the origin and role of magnetic fields in driving the explosion? Since these events happen at cosmological distances, they can not be resolved using traditional astronomical techniques. However, polarimetric observations of GRBs have allowed us to start the exploration of the structure and magnetic field configurations of their relativistic jets. Generally, polarization is measured via the ratio of fluxes by taking consecutive exposures, however for rapidly varying objects such as GRBs, it is not an effective way to observe polarization. Liverpool Telescope (LT) has utilized rapidly rotating polaroids to overcome this problem and created a series of polarimeters that have successfully detected early-time optical polarimetry of various GRBs. I will present photometric and polarimetric results of various GRBs observed by RINGO3. 10 GRBs were bright enough to perform analysis and we were able to perform polarimetric analysis for 7 GRBs. I will discuss how polarimetric detection for a long GRB 191016A along with photometric data constraint the energy injection mechanism for the central engine. In addition, I will present how polarization depends on various properties of GRBs such as photometric decay index, isotropic energy of GRBs, redshift etc.

Word2Vec Models built from a Collection of French 20th-Century Novels

The models were trained using the Gensim library for Python, developed by Radim Rehurek, in 2017. All models are based on the same collection of 20th century French novels that covers the period from 1900 to 2010, with a large range of authors and genres respresented. The collection contains approximately 1,200 novels and about 60 million tokens. The models were created using the SGNS (Skip-Gram with Negative Sampling) architecture, the context window was always of size of 6 + 6 around the target word, and the texts were lemmatised and POS-tagged beforehand. POS-Tags remain attached to each token (as in "souris_nom"). Other parameters vary by model: some have 200, some have 300 dimensional vectors; the minimum frequency of the words in the model varies with values of 50, 100 and 200, something which influences the size of the vocabulary and the size of the model.

opencc-by-4.0Dec 2020View details →

[Data from:] Genetic Analysis Reveals Three Novel QTLs Underpinning a Butterfly Egg-Induced Hypersensitive Response-Like Cell Death in Brassica Rapa

Background Cabbage white butterflies (Pieris spp.) can be severe pests of Brassica crops such as Chinese cabbage, Pak choi (Brassica rapa) or cabbages (B. oleracea). Eggs of Pieris spp. can induce a hypersensitive response-like (HR-like) cell death which reduces egg survival in the wild black mustard (B. nigra). Unravelling the genetic basis of this egg-killing trait in Brassica crops could improve crop resistance to herbivory, reducing major crop losses and pesticides use. Here we investigated the genetic architecture of a HR-like cell death induced by P. brassicae eggs in B. rapa. Results A germplasm screening of B. rapa 56 accessions, representing the genetic and geographical diversity of a B. rapa core collection, showed phenotypic variation for cell death. An image-based phenotyping protocol was developed to accurately measure size of HR-like cell death and was then used to identify two accessions that consistently showed weak (R-o-18) or strong cell death response (L58). Screening of 160 RILs derived from these two accessions resulted in three novel QTLs for Pieris brassicae-induced cell death on chromosomes A02 (Pbc1), A03 (Pbc2), and A06 (Pbc3). The three QTLs Pbc1-3 contain cell surface receptors, intracellular receptors and other genes involved in plant immunity processes, such as ROS accumulation and cell death formation. Synteny analysis with A. thaliana suggested that Pbc1 and Pbc2 are novel QTLs associated with this trait, while Pbc3 contains also LecRK-I.1, a gene of A. thaliana previously associated with cell death induced by a P. brassicae egg extract. Conclusions This study provides the first genomic regions associated with the Pieris egg-induced HR-like cell death in a Brassica crop species. It is a step closer towards unravelling the genetic basis of an egg-killing crop resistance trait, paving the way for breeders to further fine-map and validate candidate genes.

Data files for manuscript "A novel syndrome caused by the constitutional gain-of-function variant p.Glu1099Lys in NSD2"

#2022-02-21 #Summary This ZIP-file contains the data files used for all analyses for the manuscript "A novel syndrome caused by the constitutional gain-of-function variant p.Glu1099Lys in NSD2". #File structure README.txt                                                                    This README file. File S02 ("FileS02_NSD2-clinical-information-and-variants.xlsx")            Clinical data of GoF and LoF inidviduals used for Table 1 and Table 2 and genetic variant data used for Figure 2. File S03 ("FileS03_NSD2-CCLE-analyses.xlsx")                                Tables containing information of the CCLE analyses and depmap results used for Figure 3A-D. File S04 ("FileS04_humanbase_global_1642958821189.tar.gz")                    Tar.gz file of the downlaoded humanbase result files used for Figure 3E. #Files and checksums 5FE613FC7646419C20153068E8D5F463    ./FileS02_NSD2-clinical-information-and-variants.xlsx AC53634E6044469BE42DBBE8F7503275    ./FileS03_NSD2-CCLE-analyses.xlsx 7AE58A28A4D1E1462521A37522BB78B6    ./FileS04_humanbase_global_1642958821189.tar.gz

Concept maps as a novel assessment tool in medical education

This dataset accompanies the manuscript entitled "Concept maps as a novel assessment tool in medical education". The dataset contains data from eight participants in a pilot study investigating the use of Concept Maps (CMs) in medical education. Each participant constructed one CM for three different Problem-Based Learning (PBL) cases. Participant CMs, demographic data, results from  pre-intervention questionnaire on their learning style (VARK Learning Styles Self-Assessment Questionnaire) and post-intervention questionnaire results measuring the level of clinical and critical thinking are included. In addition expert CMs are also provided for each of the three PBL cases.

opencc-by-4.0Mar 2022View details →

A novel strategy for fully automated segmentation of supratentorial meningiomas: Use of pre-trained models and inclusion of normal brain images

This repository is accompanying MRI datasets under the journal, titled: A novel strategy for fully automated segmentation of supratentorial meningiomas: Use of pre-trained models and inclusion of normal brain images.  Nii_data.tar.gz (zipped) file includes MRI images of all patients described in the paper that are formatted as .nii.

opencc-by-4.0Apr 2022View details →

Novel Chromobacterium sp. isolated from mosquitos in Burkina Faso, West Africa

Nov. Chrombacterium sp. isolated in wild caught mosquitos in Burkina Faso, West Africa

opencc-by-4.0Apr 2022View details →

Smartphone imaging repository: a novel method for creating a CT image bank

In a submitted manuscript, test an image capture method using smartphone camera video-derived images of brain computed tomography (CT) scans of traumatic intracranial hemorrhage. The deidentified videos are emailed or uploaded from the emergency department for central adjudication. We measured the time in seconds it took to capture and send the files. The primary outcomes were hematoma volume measured by ABC/2, Marshall Scale, midline shift measurement, image quality by contrast-to-noise ratio (CNR) and time to capture. A radiologist and an imaging scientist applied ABC/2 method, calculated the Marshall scale and midline shift on the data acquired on different smartphones and the PACS in a randomized order. We calculate the intraclass correlation coefficient (ICC). We measured image quality by calculating contrast-to-noise ratio (CNR). We report summary statistics on time to capture in the smartphone group without a comparator.

opencc-zeroNov 2019View details →

Data from: Pop‐off data storage tags reveal niche partitioning between native and non‐native predators in a novel ecosystem

1. Niche partitioning might be predicted to be particularly dynamic in 'novel ecosystems' characterized by human-altered environmental conditions and biological invasions. Restoration efforts for native species in such systems can be informed by detailed characterization of niche partitioning. 2. In Lake Ontario, fishery management agencies have been engaged in a long-term struggle to restore native top predators including lake trout (Salvelinus namaycush). Meanwhile, management agencies continue to stock non-native species like Chinook salmon (Oncorhynchus tshawytscha) into the lake to support a recreational fishery and to help control the abundance of a non-native forage fish, the alewife (Alosa pseudoharengus). 3. We used pop-off data storage tags to study fine scale (9.1M lines of data from 22 animals) behaviour and habitat use by lake trout (native) and Chinook salmon (non-native) in Lake Ontario in terms of depth and temperature, recorded at ≤70 s intervals for periods of up to 12 months. 4. Chinook salmon occupied warmer and shallower waters during summer than did lake trout, and their niche breadth was wider. They achieved greater niche breadth in part because they were much more active vertically, cumulatively traveling 103±1 m hour-1 during summer (model-estimated median), whereas most lake trout were relatively inactive vertically (7±1 m hour-1). In each of our analyses, there was more inter-individual variation among lake trout than among Chinook salmon, driven by some lake trout that spent considerable time making forays into warmer, shallower waters. 5. Synthesis and applications. Our results illustrate the different foraging tactics used by two species in the Great Lakes and reflect their distinct life histories. Vertical and thermal niche partitioning between Chinook salmon and lake trout helps to explain how these species can co-exist in a multi-species fishery even while having substantial overlap in diet. The diversity of behaviours exhibited here by native lake trout have likely helped them persist during dramatic changes to the forage base in recent decades; that flexibility could help underlie their long-term prospects for restoration during future changes to the ecosystem.

opencc-zeroMay 2022View details →

Social information use about novel aposematic prey depends on the intensity of the observed cue

Animals gather social information by observing the behavior of others, but how the intensity of observed cues influences decision-making is rarely investigated. This is crucial for understanding how social information influences ecological and evolutionary dynamics. For example, observing a predator's distaste of unpalatable prey can reduce predation by naïve birds, and help explain the evolution and maintenance of aposematic warning signals. However, previous studies have only used demonstrators that responded vigorously, showing intense beak-wiping after tasting prey. Therefore, here we conducted an experiment with blue tits (Cyanistes caeruleus) informed by variation in predator responses. First, we found that the response to unpalatable food varies greatly, with only few individuals performing intensive beak-wiping. We then tested how the intensity of beak-wiping influences observers' foraging choices using video-playback of a conspecific tasting a novel conspicuous prey item. Observers were provided social information from: (1) no distaste response, (2) a weak distaste response, or (3) a strong distaste response, and were then allowed to forage on evolutionarily novel (artificial) prey. Consistent with previous studies, we found that birds consumed fewer aposematic prey after seeing a strong distaste response, however a weak response did not influence foraging choices. Our results suggest that while beak-wiping is a salient cue, its information content may vary with cue intensity. Furthermore, the number of potential demonstrators in the predator population might be lower than previously thought, although determining how this influences social transmission of avoidance in the wild will require uncovering the effects of intermediate cue salience.