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227
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ShareScore release 0.9.0
Dataset results
227 results for “osteoclasts”
Comprehensive transcriptome analysis of osteoclasts with the SIK3 deletion and pterosin B treatment.
GEO Series GSE234221. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation
GEO Series GSE191258. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Comparison expression data from wild-type and NFATc1-deficient osteoclasts
GEO Series GSE37219. Mus musculus. 4 samples. Type: Expression profiling by array.
The microRNA profiles of extracellular vesicles (EVs) from osteoclasts (OCs) co-cultured with prostate cancer (PCa) cell lines [OCEVmiRNA-seq]
GEO Series GSE268548. Mus musculus. 7 samples. Type: Non-coding RNA profiling by high throughput sequencing.
SREBP2 restricts osteoclast differentiation and activity by regulating IRF7 and limits inflammatory bone erosion.
GEO Series GSE172007. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Effect of TET deletion on the global DNA methylation status of osteoclasts (MeDIP-Seq)
GEO Series GSE156128. Mus musculus. 4 samples. Type: Methylation profiling by high throughput sequencing.
Identification of candidate immunity biomarkers associated with age-related variations in osteoclast activity following orthodontic tooth movement
GEO Series GSE299315. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Expression data from cultured macrophages and osteoclasts
GEO Series GSE20850. Mus musculus. 2 samples. Type: Expression profiling by array.
Effects of Immunecomplexes on primary human monocytes and their differentitation towards osteoclasts
GEO Series GSE133210. Homo sapiens. 12 samples. Type: Expression profiling by array.
Expression profiles of BMMs and osteoclasts
GEO Series GSE235773. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
miR-155 role in osteoclast differentiation
GEO Series GSE16749. Mus musculus. 4 samples. Type: Expression profiling by array.
Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin
GEO Series GSE151049. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Gene expression of Dcir-/- osteoclasts induced by M-CSF and RANKL
GEO Series GSE223429. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Medaka Osteoclast
During space flight bone mineral density is decreased by the influence of osteoclast activation which molecular mechanism is expectantly investigated. In the study of medaka bone development we investigated the system of vertebra formation and firstly identified the presence of osteoclasts in medaka. Moreover osteoclast rsorbing activity was affected by hypergravity indicating the possibility that we can investigate the effect of microgravity on osteoclasts in space. To find this effect we examine the alteration of osteoclast activity under microgravity with the histological analysis or the expression analysis by RNA in-situ hybridization. Furthermore since we have succeeded the establishment of the medaka osteoclast-specific transgenic lines we perform the in-vivo imaging analyses for gene expression and cell mobility. Finally to examine the gravity sensing system we employ tooth and bone as the high density organs which are highly sensitive to gravity and perform the histological analysis and the gene expression analysis of such gravity-sensitive tissues at surrounding pharyngeal teeth and supporting bone.
Microarray Profile of Gene Expression during Osteoclast Differentiation in Modeled Microgravity
Microgravity leads to a 10-15% loss of bone mass in astronauts during space flight. Osteoclast is the multinucleated bone resorbing cell. In this study we used NASA developed ground based Rotary Wall Vessel Bioreactor (RWV) Rotary Cell Culture System (RCCS) to simulate microgravity (uXg) conditions and demonstrated a significant increase (2-fold) in osteoclastogenesis compared to ground based control (Xg) mouse bone marrow cultures. We further determined the gene expression profiling of RAW 264.7 osteoclast progenitor cells in microgravity by agilent microarray analysis. Gene expression pattern was functional group clustered by transcriptome analysis using gene ontology tree machine (GOTM) for cell proliferation/survival differentiation and function. We confirm the microgravity modulated gene expression critical for osteoclast differentiation by real-time RT-PCR and Western blot analysis in murine bone marrow cultures. We identify transcription factors such as c-Jun c-Fos PU-1 critical for osteoclast differentiation is up-regulated in microgravity conditions. In addition microgravity resulted in 2.3 and 2.0-fold increase in the level of cathepsin K and MMP-9 matrix metalloproteinase expression in preosteoclast cells involved in the bone resorption process respectively. We also demonstrate a significant increase in the expression levels of M-CSF receptor c-Fms and PLCy2 and S100A8 molecules that play an important role in Ca2+ signaling essential for osteoclast function. Further microgravity stimulated preosteoclast cells showed elevated cytosolic Ca2+ levels compared to ground based control cells. Thus microgravity regulated gene expression profiling in preosteoclast cells provide new insights in to molecular mechanisms and therapeutic targets of osteoclast differentiation/activation responsible for bone loss and fracture risk in astronauts during space flight mission. Microgravity associated with space flight is a challenge for normal bone homeostasis. Astronauts experience 10-15% bone loss during a space flight mission. We aimed to determine the effect of simulated microgravity on osteoclast preosteoclasts cells. RAW264.7 cells (1.5 x 106 /ml) were loaded in RCCS with DMEM containing 10% FBS for 24 h. The cells were stimulated with RANKL (80ng/ml) for 24 h to obtain preosteoclasts in parallel with ground based control cells. Total RNA was isolated using RNAzol reagent (Biotecx Labs Houston TX) from control (Xg) and microgravity (uXg) subjected cells and hybridized with Agilent whole mouse genome 4x44K array system. Slides were washed and scanned on an Agilent G2565 microarray scanner. Data obtained were analyzed with Agilent feature extraction and GeneSpring GX v7.3.1 software packages (Genus biosystem Inc. Northbrook IL USA).
Effect of chaperonin 60 kDa on gene expression during osteoclast differentiation of RAW 264.7 cells
GEO Series GSE227237. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Pre-osteoclast, as an another mechano-sensing cell, has a critical role in mechano-shaping of skeleton
GEO Series GSE246066. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Hypergravity promotes osteoclast differentiation via UPR signaling pathway
GEO Series GSE205024. Mus musculus. 19 samples. Type: Expression profiling by high throughput sequencing.
Single-cell RNA sequencing reveals a distinct profile of bone immune microenvironment and decreased osteoclast differentiation in Type 2 Diabetic Mice
GEO Series GSE212726. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Itaconate mediates a metabolic crosstalk between osteoclasts and osteoblasts
GEO Series GSE236452. Homo sapiens. 27 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.