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485 results for “photodynamic therapy,”
Data from: Quantitative multi-parametric magnetic resonance imaging of tumor response to photodynamic therapy
Objective: The aim of this study was to characterize response to photodynamic therapy (PDT) in a mouse cancer model using a multi-parametric quantitative MRI protocol and to identify MR parameters as potential biomarkers for early assessment of treatment outcome. Methods: CT26.WT colon carcinoma tumors were grown subcutaneously in the hind limb of BALB/c mice. Therapy consisted of intravenous injection of the photosensitizer Bremachlorin, followed by 10 min laser illumination (200 mW/cm2) of the tumor 6 h post injection. MRI at 7 T was performed at baseline, directly after PDT, as well as at 24 h, and 72 h. Tumor relaxation time constants (T1 and T2) and apparent diffusion coefficient (ADC) were quantified at each time point. Additionally, Gd-DOTA dynamic contrast-enhanced (DCE) MRI was performed to estimate transfer constants (Ktrans) and volume fractions of the extravascular extracellular space (ve) using standard Tofts-Kermode tracer kinetic modeling. At the end of the experiment, tumor viability was characterized by histology using NADH-diaphorase staining. Results: The therapy induced extensive cell death in the tumor and resulted in significant reduction in tumor growth, as compared to untreated controls. Tumor T1 and T2 relaxation times remained unchanged up to 24 h, but decreased at 72 h after treatment. Tumor ADC values significantly increased at 24 h and 72 h. DCE-MRI derived tracer kinetic parameters displayed an early response to the treatment. Directly after PDT complete vascular shutdown was observed in large parts of the tumors and reduced uptake (decreased Ktrans) in remaining tumor tissue. At 24 h, contrast uptake in most tumors was essentially absent. Out of 5 animals that were monitored for 2 weeks after treatment, 3 had tumor recurrence, in locations that showed strong contrast uptake at 72 h. Conclusion: DCE-MRI is an effective tool for visualization of vascular effects directly after PDT. Endogenous contrast parameters T1, T2, and ADC, measured at 24 to 72 h after PDT, are also potential biomarkers for evaluation of therapy outcome.
Local Monitoring of Photosensitizer Transient States Provides Feedback for Enhanced Efficiency and Targeting Selectivity in Photodynamic Therapy.
<p><strong>This folder contains all raw data underlying the results presented in a manuscript, accepted for publication in Scientifc Reports, entitled:</strong></p> <p><strong>Local Monitoring of Photosensitizer Transient States Provides Feedback for Enhanced Efficiency and Targeting Selectivity in Photodynamic Therapy.</strong></p> <p><strong>Authored by:</strong></p> <p>Elin Sandberg <sup>1</sup>, Chinmaya V Srambickal <sup>1</sup>, Joachim Piguet <sup>1</sup>, Haichun Liu <sup>1</sup> and Jerker Widengren <sup>1,</sup>*</p> <p><sup>1</sup> Experimental Biomolecular Physics, Department of Applied Physics, Royal Institute of Technology (KTH), Stockholm, Sweden</p> <p><sup>* </sup>To whom correspondence should be addressed. Email: jwideng@kth.se. Tel: +46-8-7907813</p> <p> </p> <p><strong>The data files are grouped with respect to the figures/tables in the manuscript where the extracted results are presented. </strong></p> <p><strong>ABSTRACT</strong></p> <p>Photodynamic therapy (PDT) fundamentally relies on local generation of PDT precursor states in added photosensitizers (PS), particularly triplet and photo-radical states. Monitoring these states <em>in situ</em> can provide important feedback but is difficult in practice. The states are strongly influenced by local oxygenation, pH and redox conditions, often varying significantly at PDT treatment sites. To overcome this problem, we followed local PDT precursor state populations of PS compounds, via their fluorescence intensity response to systematically varied excitation light modulation. Thereby, we could demonstrate local monitoring of PDT precursor states of methylene blue (MB) and IRdye700DX (IR700), and determined their transitions rates under different oxygenation, pH and redox conditions. By fiber-optics, using one fiber for both excitation and fluorescence detection, the triplet and photo-radical state kinetics of locally applied MB and IR700 could then be monitored in a tissue sample. Finally, potassium iodide and ascorbate were added as possible PDT adjuvants, enhancing intersystem crossing and photoreduction, respectively, and their effects on the PDT precursor states of MB and IR700 could be locally monitored. Taken together, the presented procedure overcomes current methodological limitations and can offer feedback, guiding both excitation and PDT adjuvant application, and thereby more efficient and targeted PDT treatments.</p>
Photodynamic Therapy Using Topical Aminolevulinic Acid in Treating Patients With Actinic Keratosis
ClinicalTrials.gov study NCT00524485. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Treatment of Chronic Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy
ClinicalTrials.gov study NCT02734784. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Bevacizumab in Combination With Visudyne Photodynamic Therapy (PDT)
ClinicalTrials.gov study NCT00729846. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Endobronchial Ultrasound Guided Interstitial Photodynamic Therapy in Treating Patients With Locally Advanced Lung Cancer
ClinicalTrials.gov study NCT03735095. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Randomized Study of Photodynamic Therapy Using Dihematoporphyrin in Patients With Corneal Neovascularization
ClinicalTrials.gov study NCT00004430. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Treatment of Actinic Keratoses of the Face With Imiquimod 3.75% Cream Followed by Photodynamic Therapy
ClinicalTrials.gov study NCT01203878. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Intra-individual Comparison of Efficacy and Safety of Metvix® Natural Daylight Photodynamic Therapy Versus Conventional Metvix® Photodynamic Therapy in Subject With Mild Actinic Keratoses
ClinicalTrials.gov study NCT01475071. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Photodynamic Therapy (PDT) With Methyl Aminolevulinate (MAL) Cream in Moderate to Severe Acne
ClinicalTrials.gov study NCT00594425. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy And Safety Of Illumination Dose Reduction In Red Light Photodynamic Therapy For Actinic Keratoses
ClinicalTrials.gov study NCT06545396. IPD Sharing: NO. Countries: 0. Publications: 11.
Porfimer Sodium Interstitial Photodynamic Therapy With or Without Standard of Care Chemotherapy in Treating Patients With Locally Advanced or Recurrent Head and Neck Cancer
ClinicalTrials.gov study NCT03727061. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy and Safety of Photodynamic Therapy for CIN3
ClinicalTrials.gov study NCT07009327. IPD Sharing: NO. Countries: 1. Publications: 0.
Combination Therapy With 5-Fluorouracil and Photodynamic Therapy in Post-transplant Premalignant Skin Disease
ClinicalTrials.gov study NCT01525329. IPD Sharing: NO. Countries: 1. Publications: 0.
Gemcitabine/Oxaliplatin and Photodynamic Therapy in Cholangiocarcinoma
ClinicalTrials.gov study NCT00713687. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Comparative Study of Endoscopic Submucosal Dissection and Photodynamic Therapy for Early Esophageal Cancer
ClinicalTrials.gov study NCT05208775. IPD Sharing: NO. Countries: 0. Publications: 9.
Study of Daylight Photodynamic Therapy With Aminolevulinic Acid for Actinic Keratoses
ClinicalTrials.gov study NCT03327831. IPD Sharing: NO. Countries: 1. Publications: 0.
Photodynamic Therapy in Treating Patients With Resectable Non-Small Cell Lung Cancer That Has Spread to the Pleura
ClinicalTrials.gov study NCT00601848. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Photodynamic Therapy With HPPH Compared to Standard of Care Surgery in Treating Patients With Oral Cavity Cancer
ClinicalTrials.gov study NCT03090412. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Novel Light Delivery Methods for Lung Cancer Photodynamic Therapy - A Pilot Study
ClinicalTrials.gov study NCT04753918. IPD Sharing: NO. Countries: 0. Publications: 3.
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OpenNeuro
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