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1,028
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Dataset results
1,028 results for “proton”
Proton Beam Therapy for Treatment of Hepatocellular Carcinoma
ClinicalTrials.gov study NCT00614913. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Concurrent Proton and Chemotherapy in Locally Advanced Stage IIIA/B Non-Small Cell Lung Cancer (NSCLC)
ClinicalTrials.gov study NCT00495170. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Quantification of Intramyocardial Lipid by Proton Magnetic Resonance Spectroscopy
ClinicalTrials.gov study NCT00469911. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Pilot Study To Investigate The Association Between Acid Control And Heartburn Symptoms After Proton Pump Inhibitor Treatment
ClinicalTrials.gov study NCT02708355. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Proton Pump Inhibitors and Dysbiosis in Cirrhosis
ClinicalTrials.gov study NCT01458990. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid Tumors
ClinicalTrials.gov study NCT04343573. IPD Sharing: YES. Countries: 1. Publications: 2.
Proton Therapy for Unresectable Cancer (CA) of Pancreas
ClinicalTrials.gov study NCT00685763. IPD Sharing: UNDECIDED. Countries: 1. Publications: 20.
Data from: Microcanonical kinetics of water-mediated, long range proton transfer in microhydrated 4-aminobenzoic acid
Open the record for dataset details and reuse information.
La and Mn-doped cobalt spinel oxygen evolution catalyst for proton exchange membrane electrolysis
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Data for: Energetics of substrate transport in proton-dependent oligopeptide transporters
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An unusual amino acid substitution within hummingbird cytochrome c oxidase alters a key proton-conducting channel
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Supporting data for "Pressure dependence of proton incorporation and water solubility in olivine"
<p>This is the FTIR and EPMA datasets for the article "Pressure dependence of proton incorporation and water solubility in olivine" by Fei and Katsura.</p>
PROTON deliverable 5.1 dataset
<p>This is the set of simulations used for the <a href="https://www.projectproton.eu/wp-content/uploads/2019/10/D5.1-PROTON-Simulator-Report.pdf">deliverable 5.1 in the PROTON project,</a> for the organized crime. The <a href="https://github.com/LABSS/PROTON-OC">simulation is available on github</a>. In detail:</p> <ul> <li><a href="https://zenodo.org/api/files/d86dce59-43fb-4bf8-abc7-0ba695a2a7dc/OC_rp08.zip?versionId=37b6af36-0b25-4b4c-9b2c-38a9a9d59af9">data used for section 2.7.1</a></li> <li><a href="https://zenodo.org/api/files/d86dce59-43fb-4bf8-abc7-0ba695a2a7dc/OC_all_strong.csv.zip">data used for sections 2.7.2 and 2.7.4</a></li> <li><a href="https://zenodo.org/api/files/d86dce59-43fb-4bf8-abc7-0ba695a2a7dc/OC_rp08e.zip?versionId=f84e6f76-101a-497f-b164-4ef4e49b0e3a">data used for section 2.7.3</a></li> </ul> <p>Reference videos:</p> <p><a href="https://www.youtube.com/watch?v=zJJY0-qj6qs">https://www.youtube.com/watch?v=zJJY0-qj6qs</a></p> <p><a href="https://www.youtube.com/watch?v=rA3aKLaVlR4">https://www.youtube.com/watch?v=rA3aKLaVlR4</a></p>
Heating Rates for Protons and Electrons in Polar Coronal Holes: Empirical Constraints from UVCS/SOHO (Associated Data)
<p>The accompanying files provide some "data behind the figures," as well as some supplementary data (e.g., properties of Monte Carlo trial models), for the paper titled "Heating Rates for Protons and Electrons in Polar Coronal Holes: Empirical Constraints from the Ultraviolet Coronagraph Spectrometer" (by Steven R. Cranmer), which was submitted to the Astrophysical Journal on 25 May 2020, and is currently undergoing revision in response to the referee's report as of 25 June 2020. All files ought to be in standard "Machine Readable Table" format.</p> <p>v1.1 note: The paper has been published as ApJ, vol. 900, paper number 105.<br> ADS link: https://ui.adsabs.harvard.edu/abs/2020ApJ...900..105C/abstract<br> </p>
Cellular bicarbonate accumulation and vesicular proton transport promote calcification in the sea urchin larva
The sea urchin embryo develops a calcitic endoskeleton through intracellular formation of amorphous calcium carbonate (ACC). Intracellular precipitation of ACC, requires HCO3-/CO32- concentrating as well as proton export mechanisms to promote calcification. These processes are of fundamental importance in biological mineralization, but remain largely unexplored. Here we demonstrate that the calcifying primary mesenchyme cells (PMCs) utilize Na+/H+- exchange (NHE) mechanisms to control cellular pH homeostasis during maintenance of the skeleton. During skeleton re-calcification, pHi of PMCs is increased accompanied by substantial elevations in intracellular [HCO3-] mediated by the Na+/HCO3-cotransporter Sp-Slc4a10. However, PMCs lower their pHi regulatory capacities associated with a reduction in NHE activity. Live-cell imaging using GFP reporter constructs in combination with intra-vesicular pH measurements demonstrated alkaline and acidic populations of vesicles in PMCs and extensive trafficking of large V-type H+-ATPase (VHA)-rich acidic vesicles in blastocoelar filopodial cells (BFCs). Pharmacological and gene expression analyses underline a central role of the VHA isoforms Sp-ATP6V0a1, Sp-ATP6V01_1 and Sp-ATPa1-4 for the process of skeleton re-calcification. These results highlight novel pH regulatory strategies in calcifying cells of a marine species with important implications for our understanding of the mineralization process in times of rapid changes in oceanic pH.
Ab initio electronic stopping power for protons in Ga0.5In0.5P/GaAs/Ge triple-junction solar cells for space applications
Motivated by the radiation damage of solar panels in space, firstly, the results of Monte Carlo particle transport simulations are presented for proton impact on triple-junction Ga0.5In0.5P/GaAs/Ge solar cells, showing the proton projectile penetration in the cells as a function of energy. It is followed by a systematic ab initio investigation of the electronic stopping power for protons in different layers of the cell at the relevant velocities via real-time time-dependent density functional theory (RT-TDDFT) calculations. The electronic stopping power is found to depend significantly on different channeling conditions, which should affect the low velocity damage predictions, and which are understood in terms of impact parameter and electron density along the path. Additionally, we explore the effect of the interface between the layers of the multilayer structure on the energy loss of a proton, along with the effect of strain in the lattice-matched solar cell. Both effects are found to be small compared with the main bulk effect. The interface energy loss has been found to increase with decreasing proton velocity, and in one case, there is an effective interface energy gain.
Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte
<p>Aging-associated diseases, including cardiac dysfunction, are increasingly common in the population. However, the mechanisms of physiologic aging in general, and cardiac aging in particular, remain poorly understood. Age-related heart impairment is lacking a clinically effective treatment. Using the model of naturally aging mice and rats, we show direct evidence of increased proton leak in the aged heart mitochondria. Moreover, our data suggested ANT1 as the most likely site of mediating increased mitochondrial proton permeability in old cardiomyocytes. Most importantly, the tetra-peptide SS-31 prevents age-related excess proton entry, decreases the mitochondrial flash activity and mitochondrial permeability transition pore opening, rejuvenates mitochondrial function by direct association with ANT1 and the mitochondrial ATP synthasome, and leads to substantial reversal of diastolic dysfunction. Our results uncover the excessive proton leak as a novel mechanism of age-related cardiac dysfunction and elucidate how SS-31 is able to reverse this clinically important complication of cardiac aging.</p>
Proton-transfer-reaction time-of-flight mass spectrometry (PTR-TOF-MS) as a tool for studying animal volatile organic compound (VOC) emissions
<p>1. Chemical sensing in vertebrates is crucial in their lives, and efforts are undertaken towards deciphering their chemical language. Volatile organic compounds (VOCs) is a group of chemicals believed to play an essential role in a wide variety of animal interactions. Therefore, understanding what animals sense themselves and untangling the ecological role of their volatile cues can be accomplished by analysing VOC emissions. A Proton-Transfer Reaction Time-of-Flight Mass Spectrometer (PTR-TOF-MS) is an instrument that measures VOCs in real-time in an air sample. Since this technique acts as a hyper-sensitive 'nose' it has a similar potential in deciphering the chemical language of vertebrates.</p> <p>2. Here, we validate the use of PTR-TOF-MS as a tool to measure VOCs from vertebrates, which in turn will help resolve vertebrate interactions through VOCs. The instrument monitors and records the full spectrum of VOCs emitted by an individual with a high accuracy and low detection limit, including transient VOC emissions. We propose and test diverse measuring configurations that allow for measurement of VOC emissions from different vertebrates and their exudates: full body, specific parts of the body, urine and femoral pores. In addition, we test configurations for sudden and short-lasting processes as VOCs emitted during adder skin shedding as well as the emissions of skin secretions upon mechanical and physiological stimulation in amphibia. Our configurations work in tandem with Gas Chromatography Mass Spectrometry (GC-MS) to allow compound structure verification.</p> <p>3. We discuss the configurations and methodologies used and conclude with recommendations for further studies, such as the choice of chamber size and flow. We also report the results of the measurements on vertebrates —that are novel to science— and discuss their ecological meaning.</p> <p>4. We argue that PTR-TOF-MS has a high potential to resolve important unanswered questions in vertebrate chemical ecology with great adaptability to a wide range of experimental setups. If combined with a structure verification tool, such as GC-MS, the creative deployment of PTR-TOF-MS in various future study designs will lead to the identification of ecologically relevant VOCs.</p>
Proton Rocket launchpad
This is the launchpad for the proton rocket Source: Objaverse 1.0 / Sketchfab
MD simulation trajectory and related files for POPC bilayer with 30 mol% of protonated pazePC (Berger, Gromacs 4.5.)
<p>Simulation trajectory and related files for POPC bilayer with 30mol% of pazePC in deprotonated form used in "Acyl chain disorder and azelaoyl orientation in lipid membranes containing oxidised lipids" by T. M. Ferreira, et al. https://doi.org/10.1021/acs.langmuir.6b00788</p> <p><br> The simulation with deprotonated pazePC from the same publication available at http://dx.doi.org/10.5281/zenodo.44622</p> <p>90 POPC, 38 pazePC, 7250 water and 38 potassium molecules. Simulation time 167ns.</p> <p> </p> <p>Force field for POPC is based on Berger model and force field for pazePC is modified from H. Khandelia and O. G. Mouritsen, Biophysical Journal, 2009, 96(7), 2734 – 2743, http://dx.doi.org/10.1016/j.bpj.2009.01.007.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.