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183
datasets available to search
ShareScore release 0.9.0
Dataset results
183 results for “secretome”
A secretome CRISPR screen identifies SFRP1 as a regulator of epidermal self-renewal [ATAC-seq]
GEO Series GSE269626. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Early senescence-induced immunosuppressive β-cell secretome prevents type 1 diabetes
GEO Series GSE239947. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Yes-Associated Protein (YAP) Induces a Secretome Phenotype and Transcriptionally Regulates Plasminogen Activator Inhibitor-1 (PAI-1) Expression in Hepatocarcinogenesis
GEO Series GSE128043. Mus musculus. 6 samples. Type: Expression profiling by array.
ADSC secretome constrains NK cell activity by attenuating IL-2–mediated JAK-STAT and AKT signaling pathway via upregulation of CIS and DUSP4
GEO Series GSE237253. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Secretome from human placenta–derived mesenchymal stem cells rescues ovarian function and circadian rhythm in mice with cyclophosphamide-induced primary ovarian insufficiency
GEO Series GSE247568. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
ENRICHMENT IN C-KIT IMPROVES STEM CELL POTENTIAL OF FOETAL HUMAN AMNIOTIC FLUID CELLS: CHARACTERIZATION FROM SINGLE CELL ANALYSIS TO THE SECRETOME EFFECT [Bulk RNA-Seq]
GEO Series GSE219024. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
The human amniotic fluid stem cell secretome counteracts doxorubicin-induced cardiotoxicity
GEO Series GSE74513. Mus musculus. 2 samples. Type: Expression profiling by array.
Mesenchymal stromal cell secretome in preserving myocardial transcriptome profile following ex vivo cold storage
GEO Series GSE208341. Mus musculus. 21 samples. Type: Expression profiling by high throughput sequencing.
ER reprogramming promotes a select pro-metastatic secretome in high FOXA1-expressing ER-positive endocrine-resistant and metastatic breast cancer
GEO Series GSE175420. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Analysis of The Senescence Secretome During Zebrafish Retina Regeneration
GEO Series GSE277792. Danio rerio. 18 samples. Type: Expression profiling by high throughput sequencing.
ER reprogramming promotes a select pro-metastatic secretome in high FOXA1-expressing ER-positive endocrine-resistant and metastatic breast cancer [ChIP-seq]
GEO Series GSE175418. Homo sapiens. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Fig. 5 in Suspension cell secretome of the grain legume Lathyrus sativus (grasspea) reveals roles in plant development and defense responses
Fig. 5. Functional annotation of the grasspea suspension secretome. (A) GO classification of proteins reveals the abundance of proteins associated with (B) response to abiotic stress, (C) response to biotic stress and (D) phytohormone signaling.
Investigating the Safety and Regenerative Potential of MSC-Derived Secretome Combined With PRGF in Knee Osteoarthritis
ClinicalTrials.gov study NCT07157891. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Umbilical Cord Mesenchymal Stem Cell Secretome in Severe Erectile Dysfunction Non-responsive to Sildenafil
ClinicalTrials.gov study NCT06839651. IPD Sharing: Not stated. Countries: 0. Publications: 0.
The Human Blastocyst Secretome and Implantome
ClinicalTrials.gov study NCT00505115. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Biomarkers and Outcome Predictors of Pediatric Nephrotic Syndrome: A Genetic, Transcriptomic, and Secretome Multiomics Study
ClinicalTrials.gov study NCT06792448. IPD Sharing: NO. Countries: 0. Publications: 0.
Renal cancer secretome induces migration of mesenchymal stromal cells
GEO Series GSE232951. Homo sapiens. 9 samples. Type: Expression profiling by array.
Altered Quorum Sensing and Physiology of Staphylococcus aureus During Spaceflight Detected by Multi-omics Data Analysis (BRIC-23: Secretomics)
Staphylococcus aureus colonizes the nares of approximately 30% of humans, a risk factor for opportunistic infections. Because of the potential threat of S. aureus to astronaut health, the effect of spaceflight conditions on this pathogen is of great interest. To gain insight into the virulence potential of S. aureus in the spaceflight environment, we performed differential expression (DE) analysis of RNA-Seq and cellular proteomics data from the “Biological Research in Canisters-23” (BRIC-23) GeneLab spaceflight experiment, a mission designed to measure the response of S. aureus to growth in low earth orbit (LEO) on the international space station (ISS). This experiment used Biological Research in Canisters-Petri Dish Fixation Units (BRIC-PDFUs) to grow asynchronous ground controls (GCs) and spaceflight cultures of S. aureus for 48 hours. Analysis of the RNA-Seq data revealed that RNAIII, the effector of the Accessory Gene Regulator (Agr) quorum sensing system, was the most highly upregulated gene in spaceflight cultures (~88-fold) relative to GCs. Genes of the agr operon (~14 fold) were also highly upregulated during spaceflight, followed by genes encoding secreted phenol-soluble modulins (PSMs) and secreted proteases, all of which are positively regulated by Agr. Upregulated spaceflight genes/proteins also had functions related to urease activity, Ess secretion, and copper transport. We also performed a secretome analysis of culture supernatant samples from BRIC-23. In line with the other BRIC-23 omics data, spaceflight supernatants displayed significantly increased abundance of several known secreted virulence factors, including Agr-regulated proteases (SspA, SspB), staphylococcal nuclease (Nuc), and EsxA, a small protein secreted by the type VII-like Ess secretion system. These data also suggested that S. aureus metabolism is altered in space flight conditions relative to the ground controls (increased amino acid metabolism, TCA cycle and PTS systems, and decreased glycolysis/fermentation and translation machinery). Collectively, these data suggest that S. aureus experiences increased quorum sensing and altered expression of virulence factors in response to the spaceflight environment that may impact its pathogenic potential.
The administration of amnion-derived multipotent cell secretome ST266 protects against necrotizing enterocolitis in mice and piglets
GEO Series GSE193177. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Radiation-activated secretome of Scgb1a1+ club cells increase the efficacy of immune checkpoint blockade in lung cancer (iDTR scRNA-seq)
GEO Series GSE157882. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.