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746 results for “seizures”
O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans Dataset
<p>Neurodevelopmental disorders such as epilepsy and autism have been linked to an imbalance of excitation and inhibition (E/I) in the central nervous system. The simplicity and tractability of<i> C. elegans</i> allows our electroconvulsive seizure (ES) assay to be used as a behavioral readout of the locomotor circuit and neuronal function. <i>C. elegans</i> possess conserved nervous system features such as gamma-aminobutyric acid (GABA) and GABA receptors in inhibitory neurotransmission, and acetylcholine (Ach) and acetylcholine receptors in excitatory neurotransmission. Our previously published data has shown that decreasing inhibition in the motor circuit, via GABAergic manipulation, will extend the time of locomotor recovery following electroshock. Similarly, mutations in a HECT E3 ubiquitin ligase called EEL-1 leads to impaired GABAergic transmission, E/I imbalance and altered sensitivity to electroshock. Mutations in the human ortholog of EEL-1, called HUWE1, are associated with both syndromic and non-syndromic intellectual disability. Both EEL-1 and its previously established binding protein, OGT-1, are expressed in GABAergic motor neurons, localize to GABAergic presynaptic terminals, and function in parallel to regulate GABA neuron function. In this study, we tested behavioral responses to electroshock in wildtype, <i>ogt-1</i>, <i>eel-1</i> and <i>ogt-1; eel-1</i> double mutants. Both <i>ogt-1 </i>and <i>eel-1 </i>null mutants have decreased inhibitory GABAergic neuron function and increased electroshock sensitivity. Consistent with EEL-1 and OGT-1 functioning in parallel pathways, <i>ogt-1; eel-1 </i>double mutants showed enhanced electroshock susceptibility. Expression of OGT-1 in the <i>C. elegans </i>nervous system rescued enhanced electroshock defects in <i>ogt-1; eel-1 </i>double mutants. Application of a GABA agonist, Baclofen, decreased electroshock susceptibility in all animals. Our <i>C. elegans</i> electroconvulsive seizure assay was the first to model a human X-linked Intellectual Disability (XLID) associated with epilepsy and suggests a potential novel role for the OGT-1/EEL-1 complex in seizure susceptibility.</p>
Dataset to: Isradipine therapy in Cacna1dIle772Met/+ mice with PASNA syndrome (primary aldosteronism, seizures and neurologic abnormalities)
<p>Dataset to:<strong><em> </em></strong><strong><em>Isradipine therapy in Cacna1d<sup>Ile772Met/+</sup> mice with PASNA syndrome (primary aldosteronism, seizures and neurologic abnormalities)</em></strong><strong><em> </em></strong></p>
Comparative Effectiveness of Palliative Surgery Versus Additional Anti-Seizure Medications for Lennox-Gastaut Syndrome
ClinicalTrials.gov study NCT05374824. IPD Sharing: NO. Countries: 1. Publications: 1.
BMI and Its Relationship to Hypoglycemic Seizures in Children With Insulin-requiring Diabetes
ClinicalTrials.gov study NCT00717483. IPD Sharing: NO. Countries: 1. Publications: 4.
Nonconvulsive Seizure Identification on Quantitative EEG by Neuro ICU Nurses
ClinicalTrials.gov study NCT02082873. IPD Sharing: UNDECIDED. Countries: 1. Publications: 14.
Epidemiology Study on Neonatal Seizure
ClinicalTrials.gov study NCT02552511. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Does Short-Term Anti-Seizure Prophylaxis After Traumatic Brain Injury Decrease Seizure Rates?
ClinicalTrials.gov study NCT03054285. IPD Sharing: NO. Countries: 1. Publications: 6.
Assessment of the Emfit Mattress Sensor for Detection and Alarm of Night-time Generalized Tonic-clonic Seizures.
ClinicalTrials.gov study NCT02661919. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Magnetic Seizure Therapy (MST) for the Treatment of Major Depression
ClinicalTrials.gov study NCT00973934. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cognitive Behavioural Therapy in Dissociative Seizures
ClinicalTrials.gov study NCT00688727. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study on Optic Nerve Sheath Diameter Measurements in Prolonged Pediatric Seizures
ClinicalTrials.gov study NCT06451289. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
A Dose Ranging Pilot Study for Intracerebroventricular (ICV) Delivery of Valproate in Subjects With Temporal Seizures
ClinicalTrials.gov study NCT02899611. IPD Sharing: NO. Countries: 1. Publications: 1.
The Impact of Electroencephalographic (EEG) Seizure Treatment in Neonatal Encephalopathy
ClinicalTrials.gov study NCT01027715. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study Evaluating LAMICTAL Extended-Release Therapy Added To Current Seizure Treatments In Patients With Partial Seizures
ClinicalTrials.gov study NCT00113165. IPD Sharing: YES. Countries: 10. Publications: 2.
Magnetic Seizure Therapy for Bipolar Mania
ClinicalTrials.gov study NCT03160664. IPD Sharing: NO. Countries: 1. Publications: 1.
Promoting Implementation of Seizure Detection Devices in Epilepsy Care
ClinicalTrials.gov study NCT03909984. IPD Sharing: YES. Countries: 1. Publications: 1.
NEMO1:NEonatal Seizure Using Medication Off-patent
ClinicalTrials.gov study NCT01434225. IPD Sharing: Not stated. Countries: 4. Publications: 1.
A Study of GWP42006 in People With Focal Seizures - Part B
ClinicalTrials.gov study NCT02365610. IPD Sharing: Not stated. Countries: 6. Publications: 1.
Epileptic Seizure in Epilepsy Patients After SARS-CoV-2 Vaccination
ClinicalTrials.gov study NCT05341713. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Seizure Recurrence After Unprovoked First Seizure
ClinicalTrials.gov study NCT05724719. IPD Sharing: NO. Countries: 1. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.