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423 results for “spatial use”
Test dataset for "Spatial Integration of Multi-Omics Data from Serial Sections using the novel Multi-Omics Imaging Integration Toolset"
<p>The uploaded tar file contains anonymized and reduced test data for the paper "Spatial Integration of Multi-Omics Data from Serial Sections using the novel Multi-Omics Imaging Integration Toolset". (doi: https://doi.org/10.1101/2024.06.11.598306; https://github.com/mwess/miit)</p> <p>Dataset description:<br>- 9 serial histology sections with the following stains: (HES, HE, HES, HES, HES, MTS, IHC, IHC, HES)<br>- Sections are indexed in the following way (due to some sections not being part of this project): 1,2,3,6,7,8,9,10,11<br>- Each serial section contains: <br> - landmarks with matching labels across all sections.<br> - semi-manually generated tissue masks <br>- Section 2 contain spatial transcriptomics data and one annotation file in geojson format.<br>- Sections 6 and 7 contain imzml data that were generated with MALDI-MSI in positive ion mode (section 6) and negative ion mode (section 7) and additional histology annotations.<br>- MALDI-MSI is reduced. The positive ion data contains only intensities and spectra for spermine. The negative ion mode data contains only intensities and spectra for citrate and zinc.<br>- ST data contains only locations of spots and scalefactors. (I.e. no count data is included.). Barcode ids are randomly generated. <br>- In addition, for each ST spot histopathological annotations and GSEA scores for the Citrate-Spermine Secretion gene signature are provided.</p> <p>Abbreviations:</p> <p>- HES = Hematoxylin-Erythrosine-Saffron<br>- HE = Hematoxylin-Eosin<br>- MTS = Masson's Trichrome Staining<br>- IHC = Immunohistochemistry<br>- ST = Spatial Transcriptomics, here refers to Visium10X arrays.<br>- MALDI-MSI = Matrix-Assisted Laser Desorption Ionization - Mass Spectrometry Imaging.</p> <p> </p>
R script used for: Telomeres in a spatial context: a tool for understanding ageing pattern variation in wild populations
<p><span><span><span><span><span><span><span><span><span><span><span>Ageing refers to the loss of organismal functionality with age, a process that is characterised by decreased reproduction and survival probability. In natural populations, it is expected that environmental conditions influence an individual's ageing trajectory. Understanding the role of environmental heterogeneity on ageing variation could provide criticleinsights into population resilience and species distribution but remains overlooked. Telomeres, the end cap of chromosomes, are a promising integrative physiological marker of an individual's health and a possible proxy to aid the understanding of variation in ageing trajectories. Here, we review the existing information on telomere length and its dynamics in wild populations distributed across spatial scales. Despite a relative scarcity of information, there is evidence for divergence in telomere length between populations facing contrasting environments. Nonetheless, a higher spatial resolution and temporal replication is needed to fully understand the role that environmental conditions play on telomere length variation. Since most of the existing studies are correlational, future field and laboratory experiments are required. For the first time, we demonstrate the use of population telomere data to predict species habitat suitability through Species Distribution Models (SDMs). This represents a promising new research area in the study of ageing pattern variation in wild populations. Furthermore, the inclusion of telomere data in future physiological-SDMs may improve our understanding of species distribution and population resilience. However, the use of telomeres within this context could be limited if no previous knowledge on the relevance of telomeres as markers of health and survival at the species level is available. Finally, we suggest some key practical and theoretical considerations that, ideally, future studies combining biogeographic and telomere data should pay attention. </span></span></span></span></span></span></span></span></span></span></span></p>
Using seabird and whale distribution models to estimate spatial consumption of krill to inform fishery management
<p>Ecosystem dynamics at the north-west Antarctic Peninsula are driven by interactions between physical and biological processes. For example, baleen whale populations are recovering from commercial harvesting against the backdrop of rapid climate change, including reduced sea-ice extent and changing ecosystem composition. Concurrently, the commercial harvesting of Antarctic krill is increasing, with the potential to increase the likelihood for competition with and between krill predators and the fishery. However, understanding the ecology, abundance, and spatial distribution of krill predators is often limited, outdated, or at spatial scales that do not match those desired for effective fisheries management. We update current knowledge of predator dependence on krill by integrating telemetry-based data, at-sea observational surveys, estimates of predator abundance, and physiological data to estimate the spatial distribution of krill consumption during the austral summer by three species of Pygoscelis penguin, 11 species of flying seabirds, one species of pinniped and two species of baleen whale. Our models show that the majority of important areas for krill-predator foraging are close to penguin breeding colonies in nearshore areas where humpback whales also regularly feed, and along the shelf-break, though we caution that not all known krill predators are included in these analyses. We show that krill consumption is highly variable across the region, and often concentrated at fine spatial scales, emphasising the need for management of the local krill fishery at relevant temporal and spatial scales. We also note that krill consumption by recovering populations of krill predators provides further evidence in support of the krill surplus hypothesis, and highlight that despite less than comprehensive data, cetaceans are likely to consume a significant proportion of the krill consumed by natural predators but are not currently considered directly in the management of the krill fishery. If management of the krill fishery is to be precautionary and operate in a way that minimises the risks to krill predator populations, it will be necessary in future analyses, to include up-to-date and precise abundance and consumption estimates for pack-ice seals, finfish, squid, and other baleen whale species not currently considered.</p>
Source data and codes for the paper "Inviting atomic mechanics to macro-continua: A study on monocrystalline Si using a spatial multilevel coarsening model"
<p>Source data and codes for the paper "Inviting atomic mechanics to macro-continua: A study on monocrystalline Si using a spatial multilevel coarsening model"</p> <p>This file includes </p> <p>- Source data for Figs 1-5 and Supplementary Materials</p> <p>- LAMMPS codes and raw log files used to produce the results of this study</p> <p> </p>
Data from: Evaluating otter reintroduction outcomes using genetic spatial capture-recapture modified for dendritic networks
<p>River otters (Lontra canadensis) were extirpated from New Mexico by the 1950s. A limited reintroduction occurred during 2008–2010 in which 33 otters sourced from Washington (WA) were translocated to the Upper Rio Grande Basin (URG) of New Mexico. We conducted a noninvasive genetic capture-recapture survey during the winter of 2018 by collecting fecal DNA samples from river otter scats found at latrines in the URG dendritic network of perennial waterways. Our objectives were to: 1) estimate genetic diversity and effective population size; 2) genetic divergence from the WA source population and potential connectivity with regionally proximal populations; 3) spatially explicit population density and size; and 4) population growth rate since the founder event. Between February and April 2018, we collected 1,184 fecal DNA samples from 622 individual scats at 20 latrines; genotyping was attempted at 10 otter-specific microsatellite loci for a subsample of 543 samples. A bottlenecking founder effect was strongly supported, which, combined with genetic drift, reduced genetic diversity and effective population size by 20–26% and 106–170%, respectively, compared with the WA source population. Estimated population density from spatial capture-recapture models was 0.23–0.28 otter/km of waterway, or 1 otter/3.57–4.35 km of waterway, corresponding to a total population size of 83–100 otters across 359 km of the perennial dendritic network from La Mesilla, New Mexico to Alamosa National Wildlife Refuge, Colorado. Estimated average annual population growth rate since the founder event was 1.12–1.15/year. Despite successful population establishment, the URG river otter population remains small, is genetically degraded, and does not yet meet the criteria for long-term reintroduction success. Projections suggested that the population could reach the recommended minimum viable population size of ≥400 otters by the years 2030–2033, though sufficient habitat may not exist in the URG Basin to support that many otters. </p>
Data for: Inferring spatially-varying animal movement characteristics using a hierarchical continuous-time velocity model
<p>Understanding the spatial dynamics of animal movement is an essential component of maintaining ecological connectivity, conserving key habitats, and mitigating the impacts of anthropogenic disturbance. Altered movement and migratory patterns are often an early warning sign of the effects of environmental disturbance, and a precursor to population declines. Here, we present a hierarchical Bayesian framework based on Gaussian processes for analysing the spatial characteristics of animal movement. At the heart of our approach is a novel covariance kernel that links the spatially-varying parameters of a continuous-time velocity model with GPS locations from multiple individuals. We demonstrate the effectiveness of our framework by first applying it to a synthetic dataset, then by analysing telemetry data from the Serengeti wildebeest migration. Through application of our approach, we are able to identify the key pathways of the wildebeest migration as well as revealing the impacts of environmental features on movement behaviour.</p>
Supplementary material 1 from: Nedkov S, Zhiyanski M, Dimitrov S, Borisova B, Popov A, Ihtimanski I, Yaneva R, Nikolov P, Bratanova-Doncheva S (2017) Mapping and assessment of urban ecosystem condition and services using integrated index of spatial structure. One Ecosystem 2: e14499. https://doi.org/10.3897/oneeco.2.e14499
Figure representing examples of catalogues used during the identification built and land cover types.
Supplementary material 2 from: Nedkov S, Zhiyanski M, Dimitrov S, Borisova B, Popov A, Ihtimanski I, Yaneva R, Nikolov P, Bratanova-Doncheva S (2017) Mapping and assessment of urban ecosystem condition and services using integrated index of spatial structure. One Ecosystem 2: e14499. https://doi.org/10.3897/oneeco.2.e14499
Table representing all combinations of the integrated index of spatial structute in urban ecosystems in Bulgaria
Multimodal contrastive learning for spatial gene expression prediction using histology images
<p>we employed two human breast cancer datasets and one human cutaneous squamous cell carcinoma (cSCC) dataset.</p>
Supplementary material 1 from: Underwood E, Taylor K, Tucker G (2018) The use of biodiversity data in spatial planning and impact assessment in Europe. Research Ideas and Outcomes 4: e28045. https://doi.org/10.3897/rio.4.e28045
Biodiversity data sources at the EU level comprise the biodiversity and landuse-related EU reporting and monitoring programmes, and global or regional data portals which include data from European countries. Also gives an overview of spatial planning and data sources for biodiversity impact assessment in a selection of EU Member States: UK, Bulgaria, Netherlands, Germany, Sweden, Denmark and the Baltic Sea.
Data for Speedy component resolution using spatially encoded diffusion NMR data
Open the record for dataset details and reuse information.
Data from: Using spatial capture–recapture to elucidate population processes and space-use in herpetological studies
The cryptic behavior and ecology of herpetofauna make estimating the impacts of environmental change on demography difficult; yet, the ability to measure demographic relationships is essential for elucidating mechanisms leading to the population declines reported for herpetofauna worldwide. Recently developed spatial capture–recapture (SCR) methods are well suited to standard herpetofauna monitoring approaches. Individually identifying animals and their locations allows accurate estimates of population densities and survival. Spatial capture–recapture methods also allow estimation of parameters describing space-use and movement, which generally are expensive or difficult to obtain using other methods. In this paper, we discuss the basic components of SCR models, the available software for conducting analyses, and the experimental designs based on common herpetological survey methods. We then apply SCR models to Red-backed Salamander (Plethodon cinereus), to determine differences in density, survival, dispersal, and space-use between adult male and female salamanders. By highlighting the capabilities of SCR, and its advantages compared to traditional methods, we hope to give herpetologists the resource they need to apply SCR in their own systems.
Data from: Using a 'time machine' to test for local adaptation of aquatic microbes to temporal and spatial environmental variation
Local adaptation occurs when different environments are dominated by different specialist genotypes, each of which is relatively fit in its local conditions and relatively unfit under other conditions. Analogously, ecological species sorting occurs when different environments are dominated by different competing species, each of which is relatively fit in its local conditions. The simplest theory predicts that spatial, but not temporal, environmental variation selects for local adaptation (or generates species sorting), but this prediction is difficult to test. Although organisms can be reciprocally transplanted among sites, doing so among times seems implausible. Here we describe a reciprocal transplant experiment testing for local adaptation or species sorting of lake bacteria in response to both temporal and spatial variation in water chemistry. The experiment used a −80 °C freezer as a 'time machine'. Bacterial isolates and water samples were frozen for later use, allowing transplantation of older isolates 'forward in time' and newer isolates 'backward in time'. Surprisingly, local maladaptation predominated over local adaptation in both space and time. Such local maladaptation may indicate that adaptation, or the analogous species sorting process, fails to keep pace with temporal fluctuations in water chemistry. This hypothesis could be tested with more finely-resolved temporal data.
Data from: Unraveling conflicting density- and distance-dependent effects on plant reproduction using a spatially-explicit approach
1. Density- and distance-dependent (DDD) mechanisms are important determinants of plant reproductive success (PRS). Different components of sequential PRS can operate either in the same or in different directions and thus reinforce or neutralize each other, and they may also operate at different spatial scales. Thus, spatially-explicit approaches are needed to detect such complex DDD effects across multiple PRS components and spatial scales. 2. To reveal DDD effects of different components of early PRS of the Iberian pear (Pyrus bourgaeana) sampled over three consecutive years, we used marked point pattern analysis. Our special interest is to identify conflicting processes that regulate populations at different spatial scales, e.g. whether DDD on fruit initiation and on fruit development acted in opposite directions. To evaluate the significance of observed mark correlation functions based on empirical data (e.g. fruiting success) we compared them to expectations given by spatially-explicit null models. 3. Diverse DDD processes affected several aspects of PRS in a variable extent over the three seasons. First, early fruit set was higher for individuals with more neighbors at small distances (i.e. up to 40m). However, late P. bourgaeana fruit set decreased with increasing number of nearby neighbors, but these effects canceled for overall fruit set that did not show DDD effects. Second, the absolute number of fruits produced (crop sizes) by trees showed positive density dependence in 2011 and 2012 but not in 2013. Finally, the total number of seeds produced did not show DDD effects, indicating that conflicting demographic processes can disrupt the initial spatial pattern of tree investment in reproduction. 4. Synthesis: Understanding complex spatial effects of density- and distance-dependent (DDD) processes requires dissection of component processes to attain the complete picture since contrasting DDD processes may be hidden behind a single cumulative measure of reproductive success. The combination of novel and classic mark correlation functions used here constitute a powerful spatially-explicit tool that can be broadly applied to unravel conflicting mechanisms of DDD regulating the persistence of sessile organisms at a range of spatial scales. Our findings help to explain why some authors failed to find expected DDD of PRS and highlight the importance of detailed multi-year field studies on plant reproductive success.
Data from: Spatial dynamics and mixing of bluefin tuna in the Atlantic Ocean and Mediterranean Sea revealed using next generation sequencing
The Atlantic bluefin tuna is a highly migratory species emblematic of the challenges associated with shared fisheries management. In an effort to resolve the species' stock dynamics, a genome-wide search for spatially informative single nucleotide polymorphisms (SNPs) was undertaken, by way of sequencing reduced representation libraries. An allele frequency approach to SNP discovery was used, combining the data of 555 larvae and young-of-the-year (LYOY) into pools representing major geographical areas and mapping against a newly assembled genomic reference. From a set of 184,895 candidate loci, 384 were selected for validation using 167 LYOY. A highly discriminatory genotyping panel of 95 SNPs was ultimately developed by selecting loci with the most pronounced differences between western Atlantic and Mediterranean Sea LYOY. The panel was evaluated by genotyping a different set of LYOY (n= 326) and from these 77.8% and 82.1% were correctly assigned to western Atlantic and Mediterranean Sea origins, respectively. The panel revealed temporally persistent differentiation among LYOY from the western Atlantic and Mediterranean Sea (FST = 0.008, p=0.034). The composition of six mixed feeding aggregations in the Atlantic Ocean and Mediterranean Sea was characterized using genotypes from medium (n = 184) and large (n = 48) adults, applying population assignment and mixture analyses. The results provide evidence of persistent population structuring across broad geographic areas and extensive mixing in the Atlantic Ocean, particularly in the mid-Atlantic Bight and Gulf of St. Lawrence. The genomic reference and genotyping tools presented here constitute novel resources useful for future research and conservation efforts.
Spatial reconstruction of the early hepatic transcriptomic landscape after an acetaminophen overdose using single-cell RNA sequencing
<p>We leveraged single-cell RNA sequencing to understand the early molecular events that define the hepatocyte response to acetaminophen exposure at a subpopulation level. We spatially assigned hepatocytes along the portol-central vein axis by using established landmark genes. By spatially assigning the hepatocytes were were able to account for innate differences in gene expression that existed along this gradient. The excel files herein provide the full list of differentially expressed genes between key subpopulations of interest. Additionally, we classified genes as either pericentral zonated, periportal zonated, or non-zonated, the full list of genes and their spatial assignments are included in the appropriate excel file. </p>
Health service use_spatial_ dataset
<p>This data set was used for the manuscript submitted to PLoS Global Public Health Journal. It is aggregate data from 54 kebeles (lowest administrative unit in Ethiopia) from two rural districts in Sidama region, southern Ethiopia. The study design was an ecological type.</p>
Experimental variation in the spatial deposition of trace metals in feathers revealed using synchrotron x-ray fluorescence
<p>Feathers can be used to investigate exposure to pollution in birds because they are a secondary route for the excretion of trace elements. Evidence based on analytical imaging and spectroscopy suggests that the spatial distribution of the essential trace element zinc within feathers is related to melanin pigmentation. However, our understanding of how trace elements are deposited into growing feathers is poor and has been hampered by a lack of analytical tools to examine the localization of trace elements within a feather. Here, synchrotron micro X-ray fluorescence spectroscopy was used to map zinc directly within the barb and barbules of lesser scaup (<em>Aythya affinis</em>) feathers grown after experimental increases in dietary zinc. The results showed distinct spatial variation in zinc within barbs and barbules, with higher levels observed in the latter. Furthermore, increases in dietary zinc were found to increase the relative levels of zinc throughout the barbules from the base to the tip of the feather. Finally, analysis of feather cross sections revealed that regions of the feather barb and barbules with higher melanosome density also contained higher levels of zinc. These results provide a more detailed understanding of zinc and melanosome arrangement within the feather barb and barbules. Moreover, these results provide further support for the use of feathers as a noninvasive tool to study exposure to trace elements and highlight the utility of X-ray spectroscopy in studies investigating impacts of a rapidly changing environment on<br> wild bird health. </p>
Processed data used for spatial analysis of DMD mouse models
<p>This repository contains seurat objects and .H5AD files that were used in the analysis described in the paper titled <strong>"Spatial transcriptomics reveal markers of histopathological changes in Duchenne muscular dystrophy mouse models"</strong> Authors: L.G.M. Heezen, T. Abdelaal, M. van Putten, A. Aartsma-Rus, A. Mahfouz and P. Spitali</p> <p>It contains datafiles obtained from spatial transcriptomics (Visium, 10x Genomics) experiments on skeletal muscle samples from two wildtypes: C57BL10 and DBA/2J and two DMD mouse models: mdx and D2-mdx. All ten weeks old male mice, 10micron thick sections of the quadriceps.</p>
Multiplying the impact of biodiversity conservation funding using spatial exchange rates
<p>Funding available to support conservation must be invested effectively given declines in biodiversity and ecosystem services. Unfortunately, conservation dollars often come with restrictions on where they can be spent. We introduce a method to demonstrate to supporters of conservation how much more could be achieved if they allow greater flexibility over conservation funding. Specifically, we calculate conservation exchange rates that summarize gains in conservation outcomes available if funding originating in one location can be invested elsewhere. We illustrate our approach by considering NGO funding and major federal programs within the United States and a range of conservation objectives focused on biodiversity and ecosystem services. We show that large improvements in biodiversity and ecosystem service provision are available if geographic restrictions on conservation funding can be loosened. We demonstrate how conservation exchange rates can be used to spotlight promising opportunities for relaxing geographic funding restrictions.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.