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ShareScore release 0.9.0
Dataset results
231 results for “thrombolysis”
Data from: Intravenous thrombolysis in patients with chronic kidney disease: A systematic review and meta-analysis
Open the record for dataset details and reuse information.
Adjunctive intraarterial thrombolysis in endovascular thrombectomy: a systematic review and meta-analysis
Open the record for dataset details and reuse information.
Artificial Biomarker-based Feedback-regulated Personalized Precise Thrombolysis with Lower Hemorrhagic Risk
GEO Series GSE255147. Rattus norvegicus. 9 samples. Type: Expression profiling by high throughput sequencing.
Data from: Safety and efficacy of dual antiplatelet pretreatment in ischemic stroke patients treated with intravenous thrombolysis: a systematic review and meta-analysis
Objective: Conflicting data exist regarding the safety and efficacy of IV thrombolysis (IVT) in acute ischemic stroke (AIS) patients receiving dual antiplatelet pretreatment (DAPP). The aim of the present systematic review and meta-analysis is to assess the safety and outcome of DAPP history among AIS patients treated with IVT. Methods: We performed a comprehensive literature review to identify studies that investigated the safety and efficacy of DAPP among AIS patients treated with IVT. Results: We identified 9 studies comprising 66,675 patients. In unadjusted analyses, DAPP was associated with higher likelihood of pooled symptomatic intracranial hemorrhage (sICH, OR = 2.26, 95% CI 1.39–3.67) and 3-month mortality (OR = 1.47, 95% CI 1.27–1.73). DAPP was also related to higher odds of sICH according to SITS-MOST (OR = 2.71, 95% CI 2.05–3.59), ECASS II (OR=2.23, 95% CI 1.46–3.40) and NINDS (OR=1.59, 95% CI 1.38–1.83) definitions. There was no association between DAPP and 3-month favorable functional outcome (FFO, mRS 0-1), and 3-month functional independence (FI, mRS 0-2). In adjusted analyses, history of DAPP was not associated with pooled sICH (OR=2.03, 95% CI 0.75–5.25), 3-month mortality (OR=1.11, 95% CI 0.87–1.40), 3-month FFO (OR=0.92, 95% CI 0.77–1.09), and 3-month FI (OR=1.01, 95% CI 0.89–1.15). Conclusions: After adjustment for potential confounders DAPP appears not to be associated with higher risk of adverse outcomes in AIS patients treated with IVT.
Supplement to: Global impact of the COVID-19 pandemic on stroke care and intravenous thrombolysis
<p><span><span><span><span><span><span><span><span><span><span><span><b>Objective: </b></span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span>The objectives of this study were to measure the global impact of the pandemic on the volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with two control 4-month periods. </span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Methods:</b></span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span>We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases. </span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Results:</b></span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span>There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95%CI, -11.7 to - 11.3, p<0.0001) decline. There were 13,334 IVT therapies in the 4 months preceding compared to 11,570 procedures during the pandemic, representing a 13.2% (95%CI, -13.8 to -12.7, p<0.0001) drop. Interfacility IVT transfers decreased from 1,337 to 1,178, or an 11.9% decrease (95%CI, -13.7 to -10.3, p=0.001). Recovery of stroke hospitalization volume (9.5%, 95%CI 9.2-9.8, p<0.0001) was noted over the two later (May, June) versus the two earlier (March, April) pandemic months. There was a 1.48% stroke rate across 119,967 COVID-19 hospitalizations. SARS-CoV-2 infection was noted in 3.3% (1,722/52,026) of all stroke admissions. </span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Conclusions: </b></span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span>The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID19 inpatient volumes experienced steeper declines. Recovery of stroke hospitalization was noted in the later pandemic months.</span></span></span></span></span></span></span></span></span></span></span></p>
Sterotactic Operation Integrating With Thrombolysis in Basal Ganglion Hemorrhage Evacuation
ClinicalTrials.gov study NCT03957707. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Ultrasound-assisted, Catheter-directed Thrombolysis for Acute Intermediate-high-risk Pulmonary Embolism
ClinicalTrials.gov study NCT06143969. IPD Sharing: NO. Countries: 1. Publications: 0.
To Compare "Balloon Occluded Thrombolysis" With "Conventional Catheter Directed Thrombolysis" in Thrombotically Occluded DIPSS Stent in Patients of Budd- Chiari Syndrome.
ClinicalTrials.gov study NCT05117684. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Safety and Efficacy of Levofloxacin Combined With Intravenous Thrombolysis for Acute Ischemic Stroke
ClinicalTrials.gov study NCT05741905. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Thrombolysis Outcome in Ischemic Stroke
ClinicalTrials.gov study NCT04309357. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Early Thrombolysis Guided by AI-Assisted App in Patients With STEMI
ClinicalTrials.gov study NCT07160491. IPD Sharing: NO. Countries: 1. Publications: 0.
Intravenous Thrombolysis Registry for Acute Ischemic Stroke in China
ClinicalTrials.gov study NCT03997292. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Tenecteplase for Intravenous Stroke Thrombolysis in Recent DOAC Users
ClinicalTrials.gov study NCT07092709. IPD Sharing: YES. Countries: 1. Publications: 0.
Thrombolysis in Ischemic Spinal Cord Stroke
ClinicalTrials.gov study NCT02242084. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Early Antiplatelet Therapy After Hemorrhagic Infarction in Acute Ischemic Stroke Treated With Intravenous Thrombolysis (HITs)
ClinicalTrials.gov study NCT04624295. IPD Sharing: NO. Countries: 1. Publications: 0.
Percutaneous Embolectomy, Ultrasound Assisted Thrombolysis or Heparin for Intermediate High Risk Pulmonary Embolism
ClinicalTrials.gov study NCT06453876. IPD Sharing: NO. Countries: 1. Publications: 0.
Efficacy and Safety of Tenecteplase Intravenous Thrombolysis in Acute Posterior Circulation Ischemic Stroke Within 4.5-24 Hours After Onset
ClinicalTrials.gov study NCT07094763. IPD Sharing: NO. Countries: 1. Publications: 0.
Impact of Neutrophil Extracellular Traps (NET) on Thrombolysis in Acute Phase of Cerebral Ischemia
ClinicalTrials.gov study NCT02948465. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety and Effectiveness of Remote Ischemic Conditioning Combined With Intravenous Thrombolysis in Treating Acute Ischemic Stroke
ClinicalTrials.gov study NCT04027621. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of the PS100B for the Diagnostic of Stroke With Patients Out of Delay for Thrombolysis or Thrombectomy
ClinicalTrials.gov study NCT05002400. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.