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SUINK project presentation
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Can eDNA Present in Aquatic Environments of Rural Areas Help Identify Species Diversity in the Family Anura?
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Medieval church patrocinia in the present-day province of Belgian Limburg
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Model files and output seismograms for Seismic Wavefield Modelling of Enceladus: challenges and opportunities presented by a 3D ice shell (Dapré & Irving)
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Linked collectors and determiners for: Modelación de la distribución geográfica de las especies del género Abies presentes en México.
Natural history specimen data linked to collectors and determiners held within, "Modelación de la distribución geográfica de las especies del género Abies presentes en México". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="https://bionomia.net/dataset/772b065f-0b77-4557-934b-81efba7f4610">https://bionomia.net/dataset/772b065f-0b77-4557-934b-81efba7f4610</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/772b065f-0b77-4557-934b-81efba7f4610">https://gbif.org/dataset/772b065f-0b77-4557-934b-81efba7f4610</a>. Formatted as a Frictionless Data package.
Data from: Age of heart disease presentation and dysmorphic nuclei in patients with LMNA mutations
Nuclear shape defects are a distinguishing characteristic in laminopathies, cancers, and other pathologies. Correlating these defects to the symptoms, mechanisms, and progression of disease requires unbiased, quantitative, and high-throughput means of quantifying nuclear morphology. To accomplish this, we developed a method of automatically segmenting fluorescently stained nuclei in 2D microscopy images and then classifying them as normal or dysmorphic based on three geometric features of the nucleus using a package of Matlab codes. As a test case, cultured skin-fibroblast nuclei of individuals possessing LMNA splice-site mutation (c.357-2A>G), LMNA nonsense mutation (c.736 C>T, pQ246X) in exon 4, LMNA missense mutation (c.1003C>T, pR335W) in exon 6, Hutchinson-Gilford Progeria Syndrome, and no LMNA mutations were analyzed. For each cell type, the percentage of dysmorphic nuclei, and other morphological features such as average nuclear area and average eccentricity were obtained. Compared to blind observers, our procedure implemented in Matlab codes possessed similar accuracy to manual counting of dysmorphic nuclei while being significantly more consistent. The automatic quantification of nuclear defects revealed a correlation between in vitro results and age of patients for initial symptom onset. Our results demonstrate the method's utility in experimental studies of diseases affecting nuclear shape through automated, unbiased, and accurate identification of dysmorphic nuclei.
FIGURE 4 in The smaller arachnid orders: diversity, descriptions and distributions from Linnaeus to the present (1758 to 2007)*
FIGURE 4. Pseudoscorpion species diversity plotted against log country area.
FIGURE 3 in The smaller arachnid orders: diversity, descriptions and distributions from Linnaeus to the present (1758 to 2007)*
FIGURE 3. Proportion of pseudoscorpion species described by various authors, 1758–2007.
Source data of main figures of the effect of splicing inhibition on antigen presentation
<p>The success of cancer immunotherapy relies on the induction of an immunoprotective response targeting tumor antigens (TAs) presented on MHC-I molecules. We demonstrated that the splicing inhibitor isoginkgetin and its water-soluble and non-toxic derivative IP2 act at the production stage of the Pioneer Translation Products (PTPs). We showed that IP2 increases PTP-derived antigen presentation in cancer cells <i>in vitro </i>and impairs tumor growth <i>in vivo</i>. IP2 action is long-lasting and dependent on the CD8<sup>+</sup> T cell response against TAs. We observed that the antigen repertoire displayed on MHC-I molecules at the surface of MCA205 fibrosarcoma is modified upon treatment with IP2. In particular, IP2 enhances the presentation of an exon-derived epitope from the tumor suppressor nischarin. The combination of IP2 with a peptide vaccine targeting the nischarin-derived epitope showed a synergistic antitumor effect. These findings identify the spliceosome as a druggable target for the development of epitope-based immunotherapies.<b> </b></p>
Figure 1 in Hitchhiking with the Vikings? The anthropogenic bumblebee fauna of Iceland - past and present
Figure 1. Distribution records of bumblebee species in Iceland.
FIG. 34. Limatula demiradiata. Sta. z398 in The Recent species of the genera Limatula and Limea (Bivalvia, Limacea) present in the Atlantic, with particular reference to those in deep water
FIG. 34. Limatula demiradiata. Sta. z398, dorsal view of shell. Scale bar: 1 mm.
FIG. 29. Limatula laminifera. Sta. 118 in The Recent species of the genera Limatula and Limea (Bivalvia, Limacea) present in the Atlantic, with particular reference to those in deep water
FIG. 29. Limatula laminifera. Sta. 118, lateral view of shell from the left side. Scale bar: 1 mm.
FIG. 26. Limatula thalassae. Sta. z387 in The Recent species of the genera Limatula and Limea (Bivalvia, Limacea) present in the Atlantic, with particular reference to those in deep water
FIG. 26. Limatula thalassae. Sta. z387, lateral view of shell from left side. Scale bar: 1 mm.
FIG. 23 in The Recent species of the genera Limatula and Limea (Bivalvia, Limacea) present in the Atlantic, with particular reference to those in deep water
FIG. 23. Limatula celtica. Sta. Incal DS16, dorsal view of shell. Scale bar: 1 mm.
FIG. 18. Limatula smithi. Sta. 189 in The Recent species of the genera Limatula and Limea (Bivalvia, Limacea) present in the Atlantic, with particular reference to those in deep water
FIG. 18. Limatula smithi. Sta. 189, dorsal view of shell. Scale bar: 1 mm.
FIG. 6 in The Recent species of the genera Limatula and Limea (Bivalvia, Limacea) present in the Atlantic, with particular reference to those in deep water
FIG. 6. Limatula subovata. Sta. DS 02, detail of right demibranch. Scale bar: 1 mm.
FIG. 17. Limatula smithi. Sta. 191 in The Recent species of the genera Limatula and Limea (Bivalvia, Limacea) present in the Atlantic, with particular reference to those in deep water
FIG. 17. Limatula smithi. Sta. 191, lateral view of shell from right side. Scale bar: 1 mm.
FIG. 1. Limatula subovata. Sta. 87 in The Recent species of the genera Limatula and Limea (Bivalvia, Limacea) present in the Atlantic, with particular reference to those in deep water
FIG. 1. Limatula subovata. Sta. 87, lateral view of a shell from the left side. Scale bar: 1 mm.
Frontal tau pathology underlies behavioural/dysexecutive presentations of Alzheimer's disease
<p><b>Objective: </b>To determine the associations between amyloid-PET, tau-PET and atrophy with the behavioural/dysexecutive presentation of Alzheimer's disease (AD) and how these differ from amnestic AD.</p> <p><b>Background:</b> The behavioural/dysexecutive variant of AD is a rare clinical syndrome presenting with behavioural changes, apathy and/or executive dysfunction, similar to frontotemporal dementia. Small autopsy studies provide conflicting reports of frontal pathology and recent studies challenge the notion of frontal involvement in this condition. We tested the hypothesis that patterns of cortical tau pathology differentiate behavioural/dysexecutive AD from amnestic AD and correlate to clinical symptoms.</p> <p><b>Methods:</b> We assessed 15 cases of behavioural/dysexecutive AD recruited from a tertiary care memory clinic, all of whom had biologically defined AD. They were compared with 25 disease severity- and age-matched amnestic AD patients and a group of 131 cognitively unimpaired (CU) elderly individuals. All subjects were evaluated with amyloid-PET, tau-PET, MRI and neuropsychological testing.</p> <p><b>Results:</b> Voxelwise contrasts identified patterns of frontal cortical tau aggregation in behavioural/dysexecutive AD, with peaks in medial prefrontal, anterior cingulate and frontal insular cortices. No differences were observed in the distribution of amyloid-PET. Voxelwise area under the ROC curve analyses revealed that tau-PET uptake in the medial prefrontal, anterior cingulate and frontal insular cortices were best able to differentiate between behavioural/dysexecutive and amnestic AD (AUC=0.87). Voxelwise regressions demonstrated relationships between frontal cortical tau load and degree of executive dysfunction.</p> <p><b>Conclusions:</b> Our results provide evidence of frontal cortical involvement of tau pathology in behavioural/dysexecutive AD and highlight the need for consensus clinical criteria in this syndrome.</p>
Figure 2 from: Kilian N (2012) Two new mountainous species of Lactuca (Cichorieae, Asteraceae) from Iran, one presenting a new, possibly myrmecochorous achene variant. PhytoKeys 11: 61-77. https://doi.org/10.3897/phytokeys.11.2563
Figure 2 - Lactuca hazaranensis – A habit, left plant of holotype sheet B–G capitula, all to the same scale, before flowering (B–C), at fruiting (D–E), after fruiting (F–G); H plant in natural habitat A–G from the holotype H plant in the natural habitat at the type locality; photograph by M. Eskandari, 10 Aug 2010.
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.