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1,670 results for “FORCE”
Promiscuous CRE-CRE interaction that acts as a causative force driving de novel methylation in cis-regulatory elements in plants [AGeRdDM BSseq]
GEO Series GSE228425. Arabidopsis thaliana. 5 samples. Type: Methylation profiling by high throughput sequencing.
Adhesion-mediated mechanosignaling forces mitohormesis
GEO Series GSE171076. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Influence of Sex Hormones on Nervous System and Musculoskeletal Health in Micro and Martian Fractional Gravity in Rat Analogues (Force Plate; Soleus)
Gonadal hormones, such as testosterone and estradiol, modulate muscle size and strength in males and females. However, the influence of sex hormones on muscle strength in micro- and partial-gravity environments (e.g., the Moon or Mars) is not fully understood. The purpose of this study was to determine the influence of gonadectomy (castration/ovariectomy) on progression of muscle atrophy in both micro- and partial-gravity environments in male and female rats. Male and female Fischer rats (n equals 120) underwent castration/ovariectomy (CAST/OVX) or sham surgery (SHAM) at 11 weeks of age. After 2 weeks of recovery, rats were exposed to hindlimb unloading (0g), partial weight bearing at 40% of normal loading (0.4g, Martian gravity), or normal loading (1.0g) for 28 days. In males, CAST did not exacerbate body weight loss or other metrics of musculoskeletal health. In females, OVX animals tended to have greater body weight loss and greater gastrocnemius loss. Within 7 days of exposure to either microgravity or partial gravity, females had detectable changes to estrous cycle, with greater time spent in low-estradiol phases diestrus and metestrus (∼47% in 1g vs. 58% in 0g and 72% in 0.4g animals, P equals 0.005). We conclude that in males testosterone deficiency at the initiation of unloading has little effect on the trajectory of muscle loss. In females, initial low estradiol status may result in greater musculoskeletal losses. This study derives results from Force Plate.
DeepDrill Forced Photometry Catalog
The DeepDrill team presents a catalog of multi-band forced photometry in the CDFS and XMM-LSS fields. They used The Tractor image-modeling software to produce de-blended photometry across 13 to 15 optical/infrared bands and determine photometric redshifts. The Catalog contains ~1.5 million sources covering a total area of ~9 square degrees.
Influence of gonadectomy on muscle health in micro- and partial-gravity environments in rats (Grip; force transducer)
Gonadal hormones, such as testosterone and estradiol, modulate muscle size and strength in males and females. However, the influence of sex hormones on muscle strength in micro- and partial-gravity environments (e.g., the Moon or Mars) is not fully understood. The purpose of this study was to determine the influence of gonadectomy (castration/ovariectomy) on progression of muscle atrophy in both micro- and partial-gravity environments in male and female rats. Male and female Fischer rats (n equals 120) underwent castration/ovariectomy (CAST/OVX) or sham surgery (SHAM) at 11 weeks of age. After 2 weeks of recovery, rats were exposed to hindlimb unloading (0g), partial weight bearing at 40% of normal loading (0.4g, Martian gravity), or normal loading (1.0g) for 28 days. In males, CAST did not exacerbate body weight loss or other metrics of musculoskeletal health. In females, OVX animals tended to have greater body weight loss and greater gastrocnemius loss. Within 7 days of exposure to either microgravity or partial gravity, females had detectable changes to estrous cycle, with greater time spent in low-estradiol phases diestrus and metestrus (∼47% in 1g vs. 58% in 0g and 72% in 0.4g animals, P equals 0.005). We conclude that in males testosterone deficiency at the initiation of unloading has little effect on the trajectory of muscle loss. In females, initial low estradiol status may result in greater musculoskeletal losses. This study derives results from Grip (Force Transducer).
SnowEx20 Boise River Basin SnowMicroPen (SMP) Raw Penetration Force Profiles V001
This data set contains raw penetration force profiles from the SnowEx 2020 Time Series campaign in the Boise River Basin in Idaho. Measurements were taken using the SnowMicroPen (SMP), a digital snow penetrometer, from three snow pits. The data files contain force measurements of the snowpack from the top of the snow surface to the ground. Measurements took place approximately weekly between 18 December 2019 and 24 January 2020.
SnowEx20 SnowMicroPen (SMP) Raw Penetration Force Profiles V001
This data set contains raw penetration force profiles from the SnowEx 2020 Intensive Observation Period in Grand Mesa, Colorado. Measurements were taken using the SnowMicroPen (SMP), a digital snow penetrometer. The data files contain force measurements (in Newtons) at various snow depths. Data are available from 28 January 2020 through 12 February 2020.
Soil Moisture Active Passive (SMAP) L4 Carbon Ancillary Surface Meteorological Forcing Data V001
This ancillary SMAP product contains dynamic surface meteorological forcing data. The meteorological model is derived from the Modern-Era Retrospective Analysis for Research and Applications (MERRA) data set and used as an input in the SMAP L4 Carbon algorithm. The forcing data is processed from hourly GEOS-5 files into daily values. Daily files are processed every eight days.
Effects of 32 Days Aboard the ISS on Gastrocnemius Tendon Nanomechanics (Gastrocnemius tendon, RR-1 and Atomic Force Microscopy)
Collagen is an essential component of connective tissue and plays a crucial role in elasticity, stability, and force distribution. While the adaptations of tendon to internal stimuli have been extensively researched, the impact of environmental factors (such as microgravity) on its structure and function at the nanoscopic scale (i.e., fibril level) remains largely unexplored. The purpose of this study was to determine the effects of 32 days (d) aboard the International Space Station (ISS) on murine tendon collagen fibril morphology and nanomechanics (Young’s Modulus, YM). Gastronemius tendon samples from 16wk old female C57BL/6J mice aboard NASA Rodent Research-1 underwent chemical processing and mechanical isolation. Subsequently, collagen fibrils (n equals 17) were studied via atomic force microscopy (AFM, JPK NanoWizard 4a) to compare the morphology (diameter, height) and nanomechanics (average YM) between spaceflight (SF) and ground control (GC) mouse tendon samples. The qp-BioAC-CB1 cantilever (spring constant: 0.3 N/m, tip radius: 10µm) was used under quantitative imaging mode (Qi) for all force and morphological measurements. The data from 17 micrographs (SF n equals 5; GC n equals 12) was processed via the JPK Data Processing Software (Version 6.4.5.), and finally analyzed via Gwyddion (Version 2.62). To our knowledge, this is the first investigation to use AFM QI-mode on tendon collagen fibrils after spaceflight. Mean fibril size and YM were similar between Space Flight (SF) and Ground Control (GC) mouse tendon fibrils after 32 days of space flight; these results suggest that collagen fibrils may require more time to adapt to changes in their environment, and/or more rapid changes may take place at different levels of the collagen hierarchy. This data provides valuable insights into mammalian tissue adaptations during spaceflight, and future research should continue these investigations with longer-duration missions to build a time-course of tendon adaptations to microgravity. This dataset includes results from atomic force microscopy using gastronemius tendon tissue.
SnowEx17 SnowMicroPen (SMP) Raw Penetration Force Profiles V001
This data set contains raw penetration force profiles measured at snow pits and along linear transects at Grand Mesa, Colorado using the SnowMicroPen (SMP), a digital snow penetrometer. The data files contain force measurements (in Newtons) at various snow depths.
SnowEx17 Senator Beck SnowMicroPen (SMP) Raw Penetration Force Profiles V001
This data set consists of raw penetration force profiles measured at 8 different snow pits located in Senator Beck, Colorado using the SnowMicroPen (SMP), a digital snow penetrometer. The data files contain force measurements (in Newtons) at various snow depths.
Effects of 32 Days Aboard the ISS on Quadricep Tendon Nanomechanics (Quadricep femoris tendon, RR-1 and Atomic Force Microscopy)
Collagen is an essential component of connective tissue and plays a crucial role in elasticity, stability, and force distribution. While the adaptations of tendon to internal stimuli have been extensively researched, the impact of environmental factors (such as microgravity) on its structure and function at the nanoscopic scale (i.e., fibril level) remains largely unexplored. The purpose of this study was to determine the effects of 32 days (d) aboard the International Space Station (ISS) on murine tendon collagen fibril morphology and nanomechanics (Young’s Modulus, YM). Quadriceps tendon samples from 16wk old female C57BL/6J mice aboard NASA Rodent Research-1 underwent chemical processing and mechanical isolation. Subsequently, collagen fibrils (n equals 38) were studied via atomic force microscopy (AFM, JPK NanoWizard 4a) to compare the morphology (diameter, height) and nanomechanics (average YM) between spaceflight (SF) and ground control (GC) mouse tendon samples. The qp-BioAC-CB1 cantilever (spring constant: 0.3 N/m, tip radius: 10µm) was used under quantitative imaging mode (Qi) for all force and morphological measurements. The data from 17 micrographs (SF n equals 23; GC n equals 15) was processed via the JPK Data Processing Software (Version 6.4.5.), and finally analyzed via Gwyddion (Version 2.62). To our knowledge, this is the first investigation to use AFM QI-mode on tendon collagen fibrils after spaceflight. Mean fibril size and YM were similar between SF and GC mouse tendon fibrils after 32 days of space flight; these results suggest that collagen fibrils may require more time to adapt to changes in their environment, and/or more rapid changes may take place at different levels of the collagen hierarchy. This data provides valuable insights into mammalian tissue adaptations during spaceflight, and future research should continue these investigations with longer-duration missions to build a time-course of tendon adaptations to microgravity. All results derived are from atomic force microscopy using quadriceps femoris tendon tissue.
Long non-coding RNA expression profile of mouse cementoblasts under compressive force
GEO Series GSE116785. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Effect of surface waters from Eglin Air Force Base on gene expression in fathead minnow (Pimephales promelas)
GEO Series GSE23521. Pimephales promelas. 38 samples. Type: Expression profiling by array.
Lamin B1 and LAP2β resist cytoskeletal force to maintain lamin A/C meshwork organization and preserve nuclear integrity
GEO Series GSE289252. Homo sapiens. 46 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome analysis of virulence factors in Vibrio parahaemolyticus FORC_022, isolated from a soy sauce marinated crab
GEO Series GSE100267. Vibrio parahaemolyticus. 4 samples. Type: Expression profiling by high throughput sequencing.
Dynamic magneto-mechanical force in lysosomes instructs durable macrophage repolarization for antitumor immunity.
GEO Series GSE273977. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Cellular and Transcriptomic Analyses Identify the Source and Lineage of Regenerated Neurons in the Adult Zebrafish Telencephalon following Blunt-Force Traumatic Brain Injury
GEO Series GSE278446. Danio rerio. 28 samples. Type: Expression profiling by high throughput sequencing.
Gravitational and mechanical forces shape mitochondrial translation
GEO Series GSE222998. Mus musculus; Caenorhabditis elegans; Homo sapiens. 84 samples. Type: Expression profiling by high throughput sequencing; Other.
Connexin 43 Suppression Enhances Contractile Force in Human iPSC-derived Cardiac Tissues
GEO Series GSE304132. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.