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1,723 results for “Reactivation”
Dataset related to article "Antigen Reactivity and Clinical Significance of Autoantibodies Directed Against the Pyruvate Dehydrogenase Antigen Complex in Patients With Connective Tissue Disease "
<p>This record contains raw data related to article "Antigen Reactivity and Clinical Significance of Autoantibodies Directed Against the Pyruvate Dehydrogenase Antigen Complex in Patients With Connective Tissue Disease "</p> <p><strong>Introduction: </strong> Antimitochondrial antibodies (AMAs) are the hallmark of primary biliary cholangitis (PBC) but can be identified also in patients with connective tissue disease, namely, systemic sclerosis (SSc). Protein immunoprecipitation (IP) and IP-Western blot (WB) can be used to confirm AMA positivity directed at the pyruvate dehydrogenase complex (PDC) subunits E1α, E1β, E2/E3, and E3BP in patients showing a cytoplasmic reticular pattern at indirect immunofluorescence when performed in a screening setting before the onset of overt cholestasis in rheumatic patients.</p> <p><strong>Patients and methods: </strong> We studied sera from 285 patients affected by connective tissue disease [SSc, n = 144; dermato/polymyositis (DM/PM), n = 56; and undifferentiated connective tissue disease (UCTD), n = 85] by indirect immunofluorescence (IIF), protein-IP, and IP-WB to identify specific PDC subunits recognized by AMA.</p> <p><strong>Results: </strong> Twenty percent (57/285) of sera from patients with connective tissue disease had a cytoplasmic reticular pattern at IIF, and in 77% (44/57, including 20 SSc, 12 PM/DM, and 12 UCTD) of these, we detected different titers of autoantibodies against the PDC subunits, specifically against PDC-E2. Among these sera, 4 (9%) tested positive for anti-E1α, 15 (34%) for anti-E1β, and 16 (36%) for anti-E3BP. Four of the 20 AMA-positive SSc cases (20%) had been already diagnosed with PBC, and all were positive for autoantibodies against the subunits PDC-E2, E3, and E3BP.</p> <p><strong>Conclusions: </strong> Using IIF and IP, we confirm that autoantibodies against the PDC components are detected in rheumatic patients with PBC or without liver dysfunction. In view of the strong predictive value of AMA for PBC, a strict follow-up of these latter patients is warranted for an early diagnosis of the disease</p>
Fig. 4. Experimental and calculated ECD for 3 in Bond reactivity indices approach analysis of the [2+2] cycloaddition of jatrophane skeleton diterpenoids from Euphorbia gaditana Coss to tetracyclic gaditanone
Fig. 4. Experimental and calculated ECD for 3.
Genetics and Cardiovascular Reactivity in Young Twins
ClinicalTrials.gov study NCT00083850. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Sustained epigenetic reactivation in fragile X neurons with an RNA-binding small molecule [RNA-seq]
GEO Series GSE272192. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Lipid-accumulated reactive astrocytes promote seizure activity in epilepsy
GEO Series GSE190453. Mus musculus; Homo sapiens. 79 samples. Type: Expression profiling by high throughput sequencing.
Detecting Tumor Specific Antigen-Reactive T cells from Tumor Infiltrating Lymphocytes via Interaction Dependent Fucosyl-biotinylation [TCR-seq]
GEO Series GSE154604. Mus musculus. 12 samples. Type: Other.
Antigen-reactive CD4 T cells after SARS-CoV-2 vaccination show divergent phenotypic states with or without restimulation [separate samples]
GEO Series GSE310441. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Dynamics of reactive astrocytes fosters tissue regeneration after cuprizone-induced demyelination
GEO Series GSE236929. Mus musculus. 21 samples. Type: Expression profiling by high throughput sequencing.
Astrocyte-Derived Estrogen Regulates Reactive Astrogliosis and is Neuroprotective Following Ischemic Brain Injury
GEO Series GSE154383. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
CD39 Identifies Tumor-Reactive CD8 T cells in Patients With Lung Cancer [FB]
GEO Series GSE218259. Homo sapiens. 2 samples. Type: Other.
Lipid-accumulated reactive astrocytes promote seizure activity in epilepsy [single-cell RNA-seq]
GEO Series GSE190452. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Kaposi’s Sarcoma-associated Herpesvirus Reactivation by Bacteria Promotes the Hypoxia Response and Epigenetic Regulation
GEO Series GSE67532. Human betaherpesvirus 6; Cucumber mosaic virus; Human gammaherpesvirus 8; Homo sapiens; Simian-Human immunodeficiency virus; Human alphaherpesvirus 1; Human alphaherpesvirus 2; Human alphaherpesvirus 3; Human betaherpesvirus 7; human papillomavirus 72. 7 samples. Type: Expression profiling by array.
Gene expression profiles of T cell fraction enriched for donor antigen-reactive T cells in skin allografted recipient mice (I)
GEO Series GSE32952. Mus musculus. 8 samples. Type: Expression profiling by array.
Lysophosphatidylcholine acyltransferase 1 controls the mitochondrial reactive oxygen species generation and survival of the retinal photoreceptor cells [P8 photoreceptor]
GEO Series GSE184817. Mus musculus. 8 samples. Type: Expression profiling by array.
The influence of highly recurrent EBV reactivation on genetic copy number alterations
GEO Series GSE6472. Homo sapiens. 6 samples. Type: Genome variation profiling by genome tiling array.
Reactivity of the corticotrope axis in rainbow trout (Oncorhynchus mykiss) exposed to chronic environmental stress
GEO Series GSE126748. Oncorhynchus mykiss. 31 samples. Type: Expression profiling by array.
Pien Tze Huang induces reactive oxygen species to inhibit colorectal cancer growth
GEO Series GSE245680. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Reactivation of an Embryonic Cardiac Neural Crest Transcriptional Subcircuit During Zebrafish Heart Regeneration [scRNA-seq]
GEO Series GSE287811. Danio rerio. 1 samples. Type: Expression profiling by high throughput sequencing.
Control of brain tumor growth by reactivating monocytes and macrophages with niacin
GEO Series GSE103381. Homo sapiens. 6 samples. Type: Expression profiling by array.
Sustained epigenetic reactivation in fragile X neurons with an RNA-binding small molecule [CUT&RUN]
GEO Series GSE272191. Homo sapiens. 15 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.