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15,733 results for “article”
Data for article "Brønsted and Lewis acid adducts of triazenes"
<p>This upload contains raw data (NMR, IR, X-Ray) files for the article: </p> <p>Landman, I. R.; Suleymanov, A. A.; Scopelliti, R.; Fadaei-Tirani, F.; Chadwick, F. M.; Severin, K.</p> <p>"Brønsted and Lewis Acid Adducts of Triazenes." <em>Dalton Transactions</em> <strong>2020, </strong>DOI: <a href="https://doi.org/10.1039/D0DT00049C">10.1039/D0DT00049C</a></p>
Data supplementing the article "Aquatic biofilms as passive environmental DNA samplers: application to benthic macroinvertebrate communities in rivers" - raw MiSeq data inventories
<p>These data supplement the article “Aquatic biofilms as passive environmental DNA samplers: application to benthic macroinvertebrate communities in rivers” Sinziana F. Rivera, Valentin Vasselon, Nathalie Mary, Olivier Monnier, Fréderic Rimet & Agnès Bouchez submitted to “Molecular Ecology Resources” journal.</p> <p>The directory is composed of: “38_samples_fastq:files”: contains raw demultiplexed fastq files (R1. fastq and R2. fastq) for each of the 38 samples used in this study to produce OTUs and taxonomic inventories.</p> <p>“Samples id.xlsx”: contains the samples ID of the fastq files</p> <p>“Inventories.xlsx”: contains single and multi-habitat morphological inventories as well as molecular inventories resulting from the study</p>
Dataset for the article "Optomechanics of Chiral Dielectric Metasurfaces"
<p>This folder contains the raw data from which the graphs in the paper "Optomechanics of Chiral Dielectric Metasurfaces", DOI 10.1002/adom.201901507 have been obtained.</p>
Supplementary Information Table for J. Geophys. Res. article: A Survey of Small-Scale Waves and Wave-Like Phenomena in Jupiter's Atmosphere Detected by JunoCam
<p>Text version of the Table in the Supplementary Information file associated with the J. Geophys. Res. article by Orton et al. (2020) A Survey of Small-Scale Waves and Wave-Like Phenomena in Jupiter’s Atmosphere Detected by JunoCam. The columns provide values for various sizes and orientations associated with waves detected by the Juno spacecraft's JunoCam visible imaging instrument. The values include the perijove, PJ (orbit close approach), image number, number of wave crests detected, the mean longitude and latitude, the length and width of the wave packet, the wavelength (mean distance between wave crests), and the tilt (angle of the wave crest with respect to the direction of the wave).</p>
Dataset related to the article "Arrhythmogenic cardiomyopathy: what blood can reveal?"
<p>This record contains raw data related to the article “Arrhythmogenic cardiomyopathy: what blood can reveal?”</p> <p>Blood, serum and plasma represent accessible sources of data about physiological and pathologic status. In arrhythmogenic cardiomyopathy (ACM), circulating nucleated cells are routinely used for detection of germinal genetic mutations. In addition, different biomarkers have been proposed for diagnostic purposes and for monitoring disease progression, including inflammatory cytokines, markers of myocardial dysfunction and damage, and microRNAs. This review summarizes the current information that can be retrieved from the blood of ACM patients and considers the future prospects. Improvements in current knowledge of circulating factors may provide noninvasive means to simplify and improve the diagnosis, prognosis prediction, and management of ACM patients.</p>
Dataset related to article "Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells"
<p>Cancer induces alteration of hematopoiesis to fuel disease progression. We report that in tumor-bearing mice the macrophage colony-stimulating factor elevates the myeloid cell levels of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the NAD salvage pathway, which acts as negative regulator of the CXCR4 retention axis of hematopoietic cells in the bone marrow. NAMPT inhibits CXCR4 through a NAD/Sirtuin 1-mediated inactivation of HIF1α-driven <em>CXCR4</em> gene transcription, leading to mobilization of immature myeloid-derived suppressor cells (MDSC) and enhancing their production of suppressive nitric oxide. Pharmacologic inhibition or myeloid-specific ablation of NAMPT prevented MDSC mobilization, reactivated specific antitumor immunity, and enhanced the antitumor activity of immune checkpoint inhibitors. Our findings identify NAMPT as a metabolic gate of MDSC precursor function, providing new opportunities to reverse tumor immunosuppression and to restore clinical efficacy of immunotherapy in patients with cancer. SIGNIFICANCE: These findings identify NAMPT as a metabolic gate of MDSC precursor function, providing new opportunities to reverse tumor immunosuppression and to restore clinical efficacy of immunotherapy in cancer patients.</p>
Dataset related to article "Lymphatic endothelium contributes to colorectal cancer growth via the soluble matrisome component GDF11."
<p>Colorectal cancer (CRC) is one of the most malignant tumors worldwide. Stromal cells residing in the tumor microenvironment strongly contribute to cancer progression through their crosstalk with cancer cells and extracellular matrix. Here we provide the first evidence that CRC-associated lymphatic endothelium displays a distinct matrisome-associated transcriptomic signature, which distinguishes them from healthy intestinal lymphatics. We also demonstrate that CRC-associated human intestinal lymphatic endothelial cells regulate tumor cell growth via growth differentiation factor 11, a soluble matrisome component which in CRC patients was found to be associated with tumor progression. Our data provide new insights into lymphatic contribution to CRC growth, aside from their conventional role as conduits of metastasis.</p> <p> </p> <p>The extension of the set is in Prism form, we attach a pdf information to this format and a link where download a version of it</p>
Dataset and link to dataset related to article "MicroRNA-127-3p controls murine hematopoietic stem cell maintenance by limiting differentiation."
<p>The balance between self-renewal and differentiation is crucial to ensure the homeostasis of the hematopoietic system, and is a hallmark of hematopoietic stem cells. However, the underlying molecular pathways, including the role of micro-RNA, are not completely understood. To assess the contribution of micro-RNA, we performed micro-RNA profiling of hematopoietic stem cells and their immediate downstream progeny multi-potent progenitors from wild-type control and Pbx1-conditional knockout mice, whose stem cells display a profound self-renewal defect. Unsupervised hierarchical cluster analysis separated stem cells from multi-potent progenitors, suggesting that micro-RNA might regulate the first transition step in the adult hematopoietic development. Notably, Pbx1-deficient and wild-type cells clustered separately, linking micro-RNAs to self-renewal impairment. Differential expression analysis of micro-RNA in the physiological stem cell-to-multi-potent progenitor transition and in Pbx1-deficient stem cells compared to control stem cells revealed miR-127-3p as the most differentially expressed. Furthermore, miR-127-3p was strongly stem cell-specific, being quickly down-regulated upon differentiation and not re-expressed further downstream in the bone marrow hematopoietic hierarchy. Inhibition of miR-127-3p function in Lineage-negative cells, achieved through a lentiviral-sponge vector, led to severe stem cell depletion, as assessed with serial transplantation assays. miR-127-3p-sponged stem cells displayed accelerated differentiation, which was uncoupled from proliferation, accounting for the observed stem cell reduction. miR-127-3p overexpression in Lineage-negative cells did not alter stem cell pool size, but gave rise to lymphopenia, likely due to lack of miR-127-3p physiological downregulation beyond the stem cell stage. Thus, tight regulation of miR-127-3p is crucial to preserve the self-renewing stem cell pool and homeostasis of the hematopoietic system.</p> <p> </p> <p>Raw data relative to Figure 1 have been deposited in NCBI's Gene Expression Omnibus and are accessible through GEO Series accession number GSE113062, <a href="https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE113062">https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE113062</a></p>
Dataset related to article "The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell-mediated resistance to metastasis."
<p>The plasma membrane tetraspan molecule MS4A4A is selectively expressed by macrophage-lineage cells, but its function is unknown. Here we report that MS4A4A was restricted to murine and human mononuclear phagocytes and was induced during monocyte-to-macrophage differentiation in the presence of interleukin 4 or dexamethasone. Human MS4A4A was co-expressed with M2/M2-like molecules in subsets of normal tissue-resident macrophages, infiltrating macrophages from inflamed synovium and tumor-associated macrophages. MS4A4A interacted and colocalized with the β-glucan receptor dectin-1 in lipid rafts. In response to dectin-1 ligands, Ms4a4a-deficient macrophages showed defective signaling and defective production of effector molecules. In experimental models of tumor progression and metastasis, Ms4a4a deficiency in macrophages had no impact on primary tumor growth, but was essential for dectin-1-mediated activation of macrophages and natural killer (NK) cell-mediated metastasis control. Thus, MS4A4A is a tetraspan molecule selectively expressed in macrophages during differentiation and polarization, essential for dectin-1-dependent activation of NK cell-mediated resistance to metastasis.</p>
Dataset related to article "The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance."
<p>CCRL2 is a nonsignaling seven-transmembrane domain receptor. CCRL2 binds chemerin, a protein that promotes chemotaxis of leukocytes, including macrophages and natural killer (NK) cells. In addition, CCRL2 controls the inflammatory response in different pathologic settings, such as hypersensitivity, inflammatory arthritis, and experimental autoimmune encephalitis. Here, we investigated the role of CCRL2 in the regulation of lung cancer-related inflammation. The genetic deletion of <em>Ccrl2</em> promoted tumor progression in urethane-induced and in <em>Kras</em> <sup>G12D/+</sup>/<em>p53</em> <sup>LoxP</sup> lung tumor mouse models. Similarly, a <em>Kras</em>-mutant lung tumor displayed enhanced growth in <em>Ccrl2</em>-deficient mice. This phenotype was associated with a reduced inflammatory infiltrate characterized by the impaired recruitment of several leukocyte populations including NK cells. Bone marrow chimeras showed that CCRL2 expression by the nonhematopoietic cell compartment was responsible for the increased tumor formation observed in <em>Kras</em>-mutant <em>Ccrl2</em>-deficient mice. In human and mouse lungs, CCRL2 was expressed by a fraction of CD31<sup>+</sup> endothelial cells, where it could control NK infiltration. Elevated CCRL2 expression in biopsies from human lung adenocarcinoma positively correlated with clinical outcome. These results provide evidence for a crucial role of CCRL2 in shaping an anti-lung tumor immune response.</p>
Link to dataset related to article "Development, application and computational analysis of high-dimensional fluorescent antibody panels for single-cell flow cytometry"
<p>The interrogation of single cells is revolutionizing biology, especially our understanding of the immune system. Flow cytometry is still one of the most versatile and high-throughput approaches for single-cell analysis, and its capability has been recently extended to detect up to 28 colors, thus approaching the utility of cytometry by time of flight (CyTOF). However, flow cytometry suffers from autofluorescence and spreading error (SE) generated by errors in the measurement of photons mainly at red and far-red wavelengths, which limit barcoding and the detection of dim markers. Consequently, development of 28-color fluorescent antibody panels for flow cytometry is laborious and time consuming. Here, we describe the steps that are required to successfully achieve 28-color measurement capability. To do this, we provide a reference map of the fluorescence spreading errors in the 28-color space to simplify panel design and predict the success of fluorescent antibody combinations. Finally, we provide detailed instructions for the computational analysis of such complex data by existing, popular algorithms (PhenoGraph and FlowSOM). We exemplify our approach by designing a high-dimensional panel to characterize the immune system, but we anticipate that our approach can be used to design any high-dimensional flow cytometry panel of choice. The full protocol takes a few days to complete, depending on the time spent on panel design and data analysis.</p> <p> </p> <p> </p> <p>link related to dataset: https://flowrepository.org/id/FR-FCM-ZYV3</p>
Dataset for the article entitled "Macroalgal metabolism and lateral carbon flows can create significant carbon sinks"
<p>The dataset for the article entitled “Macroalgal metabolism and lateral carbon flows can create significant carbon sinks” by Watanabe et al., 2020</p>
Aligned DNA sequence matrix for phylogenetic analyses in the article "Description and phylogenetic relationships of a new trans-Andean species of Elachistocleis Parker 1927 (Amphibia, Anura, Microhylidae)"
<p>Aligned DNA sequence matrix for phylogenetic analyses in the article "Description and phylogenetic relationships of a new trans-Andean species of <em>Elachistocleis</em> Parker 1927 (Amphibia, Anura, Microhylidae)"</p> <p>Gene partitions are arranged as follows (tRNAs are included as part of larger adjacent genes):</p> <p>16S = 1-1165;<br> BDNFcodonPos1 = 1166 - 1874\3;<br> BDNFcodonPos2 = 1167 - 1875\3;<br> BDNFcodonPos3 = 1168 - 1876\3;<br> cmyccodonPos1 = 1878 - 2319\3;<br> cmyccodonPos2 = 1879 - 2320\3;<br> cmyccodonPos3 = 1877 - 2318\3;<br> CO1codonPos1 = 2321 - 2981\3;<br> CO1codonPos2 = 2322 - 2979\3;<br> CO1codonPos3 = 2323 - 2980\3;<br> histcodonPos1 = 2983 - 3307\3;<br> histcodonPos2 = 2984 - 3308\3;<br> histcodonPos3 = 2982 - 3309\3;<br> siacodonPos1 = 3311 - 3704\3;<br> siacodonPos2 = 3312 - 3705\3;<br> siacodonPos3 = 3310 - 3706\3;<br> tyrcodonPos1 = 3708 - 4263\3;<br> tyrcodonPos2 = 3709 - 4264\3;<br> tyrcodonPos3 = 3707 - 4262\3;<br> 28S = 4265-5084;<br> 12S = 5085-6171;</p> <p> </p>
Dataset for Article Titled Benchmarking Multiphysics Software
<p>Software files containing input and output data for the article titled "Benchmarking multiphysics software for mantle convection."</p>
Supplemental data for "Initial land use/cover distribution substantially affects global carbon and local temperature projections in the integrated Earth System Model." Article published as Global Biogeochemical Cycles publication 2019B006383
<p>These are supporting data for Global Biogeochemical Cycles publication 2019B006383: "Initial land use/cover distribution substantially affects global carbon and local temperature projections in the integrated Earth System Model." They include data for all of the regular and supplemental figures.</p>
Raw data for Article "Copper-Catalyzed Oxyalkynylation of C−S Bonds in Thiiranes and Thiethanes with Hypervalent Iodine Reagents"
<p>Raw data for the Article "Copper-Catalyzed Oxyalkynylation of C−S Bonds in Thiiranes and Thiethanes with Hypervalent Iodine Reagents" published in <em>Org. Lett.</em> <strong>2020</strong>, <em>22</em>, 422-427. <a href="https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.9b04157">https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.9b04157</a></p> <p>The number of the folders correspond to compounds numbers in the article. All details concerning conditions and equipment for measurements can be found in the supporting information of the article.</p>
Open Data Articles of Journal of Contemporary Administration (Jul2018-Dec2020)
<p>This table shows the list of articles with Open Data published by The Journal of Contemporary Administration between Jul2018-Dec2020. All of them are Open, without any kind of fee/cost.</p>
TAAG 2020 Article Replication Data
<p>This zipfile contains data files necessary to replicate the results of the article "A Toponym-Based Approach to the Automated Georeferencing of Physically Mapped Documents: The TAAG Algorithm", by Karim Bahgat and Dan Runfola (2020). </p> <p>For the replication code as well as instructions on where to extract the data files contained in this zipfile, see https://github.com/karimbahgat/AutoMap. </p>
Raw Data for Article "Access to Vinyl Ethers and Ketones with Hypervalent Iodine Reagents as Oxy-Allyl Cation Synthetic Equivalents"
<p>NMR, IR and MS raw data for the article "Access to Vinyl Ethers and Ketones with Hypervalent Iodine Reagents as Oxy-Allyl Cation Synthetic Equivalents" published in Angewandte Chemie in 2020, DOI: 10.1002/anie.202006707 and 10.1002/ange.202006707</p> <p>The number of the folders correspond to compounds numbers in the article. All details concerning conditions and equipment for measurements can be found in the supporting information of the article.</p>
Raw Data for Article "Oxidative Fluorination of Cyclopropylamides via Organic Photoredox Catalysis"
<p>NMR, MS and IR raw data for article "Oxidative Fluorination of Cyclopropylamides via Organic Photoredox Catalysis" published in 2020 in Angewandte Chemie: DOI: 10.1002/anie.202007864 and 10.1002/ange.202007864</p> <p>The number of the folders correspond to compounds numbers in the article. All details concerning conditions and equipment for measurements can be found in the supporting information of the article.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.