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12,346 results for “derivatives”
Supplementary information of "Chemical and opto-electronic properties of a new indacenodithiophene-carbazole derivative and its use on OLED devices"
<p>This repository contains raw data of experimental measurements for those figures where a X-Y plots are presented and high quality pictures for the article titled "Chemical and opto-electronic properties of a new indacenodithiophene-carbazole derivative and its use on OLED devices".</p> <p> </p>
Fig. 6 in Undescribed phloroglucinol derivatives with antiviral activities from Dryopteris atrata (Wall. Ex Kunze) Ching
Fig. 6. Antivirus activity of compound 7 against HSV-1 by using a fluorescence assay. Compound 7 was added at 20 μM at different times post-infection (1, 2, 4, 6, 8, 12, and 20 h), and acyclovir was used as the positive control. Data were expressed as mean ± SD from three independent experiments (***p <0.001 compared with the viral control group).
Human Embryonic Stem C ells-derived Immature Midbrain Dopaminergic Neurons Transplanted in Parkinsonian Mon-keys Recover Dopamine Levels and Motor Behavior
<p>Supplementary videos of the article "Human Embryonic Stem Cells-derived Immature Midbrain Dopaminergic Neurons Transplanted in Parkinsonian Mon-keys Recover Dopamine Levels and Motor Behavior"</p>
Genetic variation data derived from ferret transmission experiments of avian H3N8 influenza viruses
<p>Supplementary Dataset 1. Genetic variation data derived from ferret transmission experiment of HN/4-10 virus<br> Supplementary Dataset 2. Genetic variation data derived from ferret transmission experiment of CS/1000 virus<br> Supplementary Dataset 3. Genetic variation data derived from ferret transmission experiment of CK/FE12 virus<br> Supplementary Dataset 4. Genetic variation data derived from ferret transmission experiment of CK/F0316 virus</p>
Fig. 5. Key 1H–1H in Sesquiterpenoids and furan derivatives from the Orychophragmus violaceus (L.) O.E. Schulz endophytic fungus Irpex lacteus OV38
Fig. 5. Key 1H–1H COSY () and HMBC () correlations of compounds 1, 5, 9, 10, 11, 12, 13, 16, and 17.
Fig. 5 in Isolation and evaluation of virucidal activities of flavanone glycosides and rosmarinic acid derivatives from Dracocephalum spp. against feline calicivirus
Fig. 5. Feline calicivirus (FCV)-inactivating activities of Dracocephalum spp.-derived compounds. Compounds isolated from D. fruticulosum (A and B), D. nutans (C and D), and D. foetidum (E and F) were incubated with FCV suspensions for 48 h (A, C, and E) and 6 h (B, D, and F), respectively. Viral titer data are presented as the mean ± standard deviation (n = 3–7 per group). *p <0.05; **p <0.01 vs. the dimethyl sulfoxide (DMSO) control group (Student's t-test). TCID50, 50% tissue culture infectious dose.
Fig. 4 in Isolation and evaluation of virucidal activities of flavanone glycosides and rosmarinic acid derivatives from Dracocephalum spp. against feline calicivirus
Fig. 4. Key heteronuclear multiple bonds (HMBC) and nuclear Overhauser effect (NOE) correlations of compounds 19–21.
Fig. 4 in Puerol and pueroside derivatives from Pueraria lobata and their anti-inflammatory activity
Fig. 4. Effects of the tested compounds on the expression of inflammatory factors in LPS-stimulated RAW 264.7 cells. The total RNA was extracted, and Real-time PCR was performed using specific primers to the mRNA expression of TNF-α (A), IL-1β (B) and IL-6 (C). ##P <0.01 and ####P <0.0001, compared to the control group; *P <0.05, **P <0.01, ***P <0.001 and ****P <0.0001, compared to the LPS alone group.
Fig. 4 in The anti-TMV potency of the tobacco-derived fungus Aspergillus versicolor and its active alkaloids, as anti-TMV activity inhibitors
Fig. 4. Docking poses (left) and interactions (right) of compound 10 (yellow) at the binding site of TMV (blue, PDB code 2OM3). The ligand with TMV A chain amino GLY-135 (1.92 Å) form three hydrogen bonds (green dotted line), Hydrogen bonding distance had been hidden for clarity. The binding energy of compound 10 for between ligands and TMV. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 2. The key 1H–1H in The anti-TMV potency of the tobacco-derived fungus Aspergillus versicolor and its active alkaloids, as anti-TMV activity inhibitors
Fig. 2. The key 1H–1H COSY (bold lines), HMBC (solid arrows), and ROESY (dashed arrows) correlations of compounds 1–5.
Fig. 3 in The anti-TMV potency of the tobacco-derived fungus Aspergillus versicolor and its active alkaloids, as anti-TMV activity inhibitors
Fig. 3. Docking poses (left) and interactions (right) of compound 1 (yellow) at the binding site of TMV (blue, PDB code 2OM3). The ligand with TMV. A chain amino ASN-73 (2.81 Å) and TYR-139 (3.04 Å) form four hydrogen bonds (green dotted line), Hydrogen bonding distance had been hidden for clarity. The binding energy of strong affinity between ligands and TMV. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article
Fig. 10 in Benzobicyclic ketones, cycloheptenone oxide derivatives, guaiane-type sesquiterpenes, and alkaloids isolated from Taraxacum mongolicum Hand.-Mazz.
Fig. 10. NO production inhibited by compounds 3 and 11 (A) and IL-6 mRNA levels altered by compounds 3 and 11 (B) after RAW 264.7 macrophages were induced by 100 ng/mL LPS (DMSO was the blank control). The data are presented as the means ± SD (n = 3). Comparisons were made between the DMSO and LPS groups (##p <0.01) and between the LPS and different compound groups (*p <0.05; **p <0.01).
Fig. 1. A in Bioactive terpenoids derived from plant endophytic fungi: An updated review (2011-2020)
Fig. 1. A) The proportions of terpenoids from endophytic fungi; B) the number of terpenoids reported in endophytic fungi; and, C) the most redundant endophytic fungi as terpeoid producers (2011–2020).
Fig. 9 in Bridged cassane derivatives from the seeds of Caesalpinia sappan L. and their cytotoxic activities
Fig. 9. Cell cycle distribution and apoptosis induced by 8 in HepG2 cells. (A) Cell cycle analysis of PI-stained cells treated with different concentrations of 8 for 48 h by flow cytometry. (B) Apoptosis analysis of Annexin V-FITC/PI-stained cells treated with different concentrations of 8 for 48 h by flow cytometry. (C) Apoptosis analysis of Annexin V-FITC/PI-stained cells treated with 8 μM 8 for 6, 12, 24 and 48 h by flow cytometry. (D) Quantification of each stage of the cell cycle after treatment with 8. (E) Quantitative analysis of apoptotic cells treated with 3, 6 and 12 μM 8. (F) Quantitative analysis of apoptotic cells treated with 8 μM 8 for 6, 12, 24 and 48 h **P <0.01, ***P <0.001 versus control group.
Fig. 5 in Decalintetracids A and B, two pairs of unusual 3-decalinoyltetramic acid derivatives with phytotoxicity from Fusarium equiseti D39
Fig. 5. Regression analysis of experimental versus calculated 13C NMR chemical shifts of 1a and 2a, linear fitting is shown as a line.
Fig. 10. Previously undescribed homogentisic acid derivatives isolated from G in Non-volatile constituents from Monimiaceae, Siparunaceae and Atherospermataceae plant species and their bioactivities: An up-date covering 2000-2021
Fig. 10. Previously undescribed homogentisic acid derivatives isolated from G. Brevipes in the Siparunaceae family.
Fig. 4 in Polychlorinated cyclopentenes from a marine derived Periconia sp. (strain G1144)
Fig. 4. ΔδH values (Δδ = δS – δR) obtained for (S)- and (R)-MTPA esters of 1, 3 and 4 in pyridine-d5.
Fig. 5 in Polyketide-derived macrobrevins from marine macroalga-associated Bacillus amyloliquefaciens as promising antibacterial agents against pathogens causing nosocomial infections
Fig. 5. (A) Molecular docking interfaces of 41-hydroxy-macrobrevin-31-acetate (compound 3) with S. aureus peptide deformylase (SaPDF). 3D docking analysis of the titled macrobrevin analogue (ligand) and S. aureus PDF crystal structure (PDB ID: 1LQW) were conformationally structured (Swiss-Pdb Viewer, SPDBV, version 4.1.0). The primary algorithm used by AutoDock for conformational searching was the Lamarckian Genetic Algorithm (LGA) showing four hydrogen bonds each (displayed as red and bluecoloured lines) in the binding site, whereas USCF Chimera (University of California, San Francisco, ver. 1.11.2) software reinforced the visualizations of the best molecular docking positions of the compound and target protein. The contact residues were shown and labeled by type and number in the background. Compound 3 exhibited least binding energy among the titled compounds. (B) Illustrative representation of 41-hydroxy-macrobrevin-31-acetate (compound 3) forming hydrogen bond interactions with the amino acyl residues in the active site of SaPDF. Compound (3) displayed maximum number of hydrogen bond interactions (GLN141 at 3.118 Å, LYS84 at 3.789 Å and 3.388 Å, and ARG143 at 3.483 Å). (C) Drug-likeness score obtained for the compound (3) with molsoft software. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 4 in Polyketide-derived macrobrevins from marine macroalga-associated Bacillus amyloliquefaciens as promising antibacterial agents against pathogens causing nosocomial infections
Fig. 4. Proposed biosynthesis of 21- membered macrocyclic lactones classified as macrobrevin analogues (1–4) in B. amyloliquefaciens through successive decarboxylative Claisen condensation between acetyl-S-KS domain and malonate-SACP units. Claisen condensation was activated by acyl carrier protein (ACP), ketoreductase (KR), ketosynthase (KS), thioesterase (TE), dehydratase (DH), methyl transferase (MT), acyl transferase (AT), enoyl reductase (ER) and S-adenosyl-methionine (SAM). The elongation process comprised of 16 modules with KS, KR and ACP domains. The initial step includes the decarboxylative Claisen condensation between 2-methylbutanethioic-S-KS and malonate-S-ACP. The final step of macrobrevin formation could occur through the cyclization of linear chain of 21-membered carbon framework by TE. Consequently, alterations of 21-membered carbon framework classified as macrobrevin scaffold could result in the formation of macrobrevin analogues 1–4.
Fig. 3 in Polyketide-derived macrobrevins from marine macroalga-associated Bacillus amyloliquefaciens as promising antibacterial agents against pathogens causing nosocomial infections
Fig. 3. (A) Biosynthetic gene cluster coding for biosynthesis of macrobrevin analogues in B. amyloliquefaciens showing 46% similarity with macrobrevin biosynthetic gene cluster BGC0001470 (as elucidated by Known-Cluster-Blast prediction, the gene cluster also had 32% similarity with aurantinine and bacillaene with 100% similarity), (B) organization of genes in macrobrevin biosynthetic gene cluster of Brevibacillus sp. (C) Domain organization of the modules of trans-AT PKS gene cluster coding for bacillaene, which is 46% similar to macrobrevin biosynthetic gene cluster is shown. (D) The proposed functions of genes (1–16) contained in the biosynthetic gene cluster has been listed out, and are described as: (1) Biosynthetic additional (smcogs) SMCOG1170: metallo-β-lactamase family protein (score: 203; E-value: 5.4e-62); (2) biosynthetic trans-AT-PKS:PKS_AT biosynthetic additional SMCOG1021: malonyl CoA-acyl carrier protein transacylase (score: 400.8; E-value: 1.8e-121); (3) biosynthetic trans AT-PKS:PKS_AT biosynthetic additional SMCOG1021: malonyl CoA-acyl carrier protein transacylase (score: 232.8; E-value: 1.5e-70); (4) biosynthetic trans-AT-PKS:PKS_AT biosynthetic additional SMCOG1021:malonyl CoA-acyl carrier protein transacylase (score: 481.1; E-value: 9e-146); (5) biosynthetic additional PP-binding; (6) biosynthetic T3PKS:Chal_sti_synt_N biosynthetic additional SMCOG1043:hydroxymethylglutaryl-CoA synthase (score: 496.9; E-value: 6.5e-151); (7) biosynthetic additional SMCOG1023: enoyl-CoA hydratase (score: 228.4; E-value: 1.3e-69); (8) biosynthetic trans-AT-PKS:PP-binding biosynthetic trans-AT-PKS:tra_KS-biosynthetic trans AT-PKS:ATd-biosynthetic NRPS:AMP-binding biosynthetic-NRPS: condensation biosynthetic additional adh_short biosynthetic additional SMCOG1127: condensation domain-containing protein (score: 295.3; E-value: 1.6e-89); (9) biosynthetic additional-tra_KS biosyntheticadditional SMCOG1022: β-ketoacyl synthase (score: 160.9; E-value: 8.3e-49); (10) biosynthetic-trans-AT-PKS:PP-binding-biosynthetic-trans-AT-PKS:tra_KS-biosynthetic-trans-AT-KS:ATd-biosynthetic-additional-adh_short-biosynthetic-additional-SMCOG1001:short-chain-dehydrogenase/reductase SDR (score: 48.7; E-value: 1.2e-14); (11) biosynthetic-trans-AT-PKS:PP-binding-biosynthetic-trans-AT-PKS:tra_KS-biosynthetic-trans-AT-PKS:ATd-biosynthetic-additional-adh_short-biosynthetic-additional SMCOG1093: β-ketoacyl synthase (score: 73.2; E-value: 2.8e-22); (12) biosynthetic trans AT-PKS: PP-binding-biosynthetic-trans-AT-PKS:tra_KSbiosynthetic-trans-AT-PKS:ATd-biosynthetic-additional-adh biosynthetic-additional SMCOG1022: β-ketoacyl synthase (score: 222.6; E-value: 1.5e-67); (13) biosynthetic-additional-condensation biosynthetic-additional SMCOG1127:condensation domain-containing protein (score: 196.8; E-value: 1.3e-59); (14) biosynthetic-trans-AT-PKS:PP-binding-biosynthetic-trans-AT-PKS:tra_KS-biosynthetic-trans-AT-PKS:ATd-biosynthetic-NRPS-like:AMP-binding-biosynthetic-NRPS-like:PPbinding-biosynthetic-additional adh_short-biosynthetic-additional SMCOG1002: AMP-dependent synthetase and ligase (score: 373.7; E-value: 1.9e-113); (15) biosynthetic-additional-PP-binding-biosynthetic-additional-tra_KS-biosynthetic-additional MCOG1022: β-ketoacyl (score: 73.2; E-value: 2.8e-22); (16) biosynthetictrans-AT-PKS-like:tra_KS-biosynthetic-trans-AT-PKS-like:ATd-biosynthetic-additional-PP-binding-biosynthetic-additional SMCOG1022: β-ketoacyl synthase (score: 207.7; E-value: 5.1e-63).
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.