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Dataset results
19,342 results for “sequence”
Dataset - Functional annotation for protein sequences
<p>These are the input and output files for the functional annotation of protein sequences workflow tests.</p>
Neural and behavioral data from: A dynamic sequence of visual processing initiated by gaze shifts
<p>Animals move their head and eyes as they explore and sample the visual scene. Previous studies have demonstrated neural correlates of head and eye movements in rodent primary visual cortex (V1), but the sources and computational roles of these signals are unclear. We addressed this by combining measurement of head and eye movements with high density neural recordings in freely moving mice. V1 neurons responded primarily to gaze shifts, where head movements are accompanied by saccadic eye movements, rather than to head movements where compensatory eye movements stabilize gaze. A variety of activity patterns immediately followed gaze shifts, including units with positive, biphasic, or negative responses, and together these responses formed a temporal sequence following the gaze shift. These responses were greatly diminished in the dark for the vast majority of units, replaced by a uniform suppression of activity, and were similar to those evoked by sequentially flashed stimuli in head-fixed conditions, suggesting that gaze shift transients represent the temporal response to the rapid onset of new visual input. Notably, neurons responded in a sequence that matches their spatial frequency preference, from low to high spatial frequency tuning, consistent with coarse-to-fine processing of the visual scene following each gaze shift. Recordings in foveal V1 of freely gazing head-fixed marmosets revealed a similar sequence of temporal response following a saccade, as well as the progression of spatial frequency tuning. Together, our results demonstrate that active vision in both mice and marmosets consists of a dynamic temporal sequence of neural activity associated with visual sampling.</p>
Small RNA sequencing
<p>The innovation of large-scale, next-generation sequencing has exponentially increased knowledge of RNA biology, with regard to the diversity, abundance, and function of various RNA molecules. <a href="https://rna.cd-genomics.com/small-rna-sequencing.html">Small RNA-seq</a> is a powerful tool for analyzing small RNAs such as miRNAs, siRNAs, and piRNAs in a single sequencing run, allowing the evaluation and discovery of novel small RNA molecules and the prediction of their functions. These RNA-seq methods have provided an even more complete characterization of small RNA and promised further applications.<br><br>Our technologies at single-base resolution allow for small RNA detection from very small amounts of cellular materials, which can help you detect pre-known small RNA, discover new small RNA, and examine all small RNA for differential expression in any sample. We generate small RNA sequencing libraries directly from total RNA and Capture the complete range of small RNAs, to understand the roles they play. this will provide you with a comprehensive and efficient approach to understand post-transcriptional regulation and discovering novel biomarkers.</p>
Pacbio single molecule sequencing
<p>As a leading genomics company, CD Genomics provides next-generation sequencing and bioinformatics services to pharmaceutical and biotech companies, as well as academic and government agencies around the world, relying on advanced sequencing instruments and rich project experience. We are offering long-read sequencing services from PacBio and Oxford Nanopore, giving researchers a wide range of cutting-edge sequencing services to suit the particular needs of any project. Here, we offer long-read sequencing services which are based on <a href="https://longseq.cd-genomics.com/pacbio-smrt-sequencing-technology.html">PacBio single molecule sequencing</a> technology, the Sequel II System. This technology can produce highly accurate (> 99.9% average concordance accuracy) long sequences up to 30 kb long, helping to identify biologically important structural variants, RNA splice site isoforms of cDNA, and provide insights into hard-to-sequence regions of the genome, among others.</p>
18s rRNA sequence
<p>Our eukaryotic <a href="https://www.cd-genomics.com/microbioseq/eukaryotic-18s-rrna-sequencing.html">18S rRNA sequence</a> determines the specific 18S ribosomal RNA (rRNA) genes of eukaryotes and yeast using the next-generation sequencing (NGS) and long-read sequencing platforms. This service helps reveal the microbial community structure, the evolutionary relationship of eukaryotes, and the correlation between eukaryotes and the environment.</p><p> </p>
10x sequencing
<p>Powerful approaches have become more accessible and allow the profiling of rare or heterogeneous populations of cells. The averaging that occurs in Conventional 'bulk' methods of sequencing does not allow the direct assessment of the fundamental biological unit—the cell—or the individual nuclei that package the genome. CD genomics provides access to the genomic and genetic analysis at single-cell level using <a href="https://www.cd-genomics.com/10x-sequencing.html">10x sequencing</a> system and its engineered reagent delivery method. The droplet-based platforms Chromium 10x System, powered by GemCode Technology, enables the biomedical researchers and clinicians to make important new discoveries using this powerful approach as the technologies and tools needed for conducting single-cell studies. Moreover, the droplet-based platforms, maximizing the throughput of cells and meanwhile downscaling the reactions to nanoliter volumes, have been shown to improve detection sensitivity and quantitative accuracy. The droplet-based methods hold advantages, allowing direct analysis of rare cell types or primary cells for which there may be insufficient material for conventional bulk sequencing protocols. It is also ideal to profile interesting subpopulations of cells from a larger heterogeneous population, for example, malignant tumor cells within a tumor mass, or hyper-responsive immune cells within a seemingly homogeneous group. It can even reveal entirely new cell types. 10X genomics also permits to study cellular states in scenarios such as embryonal development, cancer, myoblast and lung epithelium differentiation, and lymphocyte fate diversification.</p>
Mime-seq 2.0: a method to sequence microRNAs from specific mouse cell types
<p>These files contain the raw sequencing data (demultiplexed, unaligned BAM files or FASTQ files) collected as part of following manuscript: "Mime-seq 2.0: a method to sequence microRNAs from specific mouse cell types.". Included are oxidized and unoxidized small RNA sequencing libraries collected from RKO cells (human cell line, timecourse for methyltransferase expression), M. musculus B cells (splenic, CD43 depleted; methyltransferase under Cd79a-Cre driver), M. Musculus Plasma cells (sorted, methyltransferase under Bhlha15-Cre driver). </p><p> </p>
extHomFam v37.0: structural benchmark for protein multiple sequence alignments
<p>extHomFam v37.0 was constructed by combining Homstrad reference alignments (2 December 2023 release) with Pfam 37.0 (UniProt release) families containing at least 200 sequences. Homstrad entries with less than 3 reference sequences and those pointing to dead Pfam families were discarded.</p> <p> </p>
Next Generation Sequencing-Based Stratification of Front Line Treatment of HighGrade Neuroendocrine Carcinoma
ClinicalTrials.gov study NCT04452292. IPD Sharing: NO. Countries: 1. Publications: 1.
LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies
ClinicalTrials.gov study NCT02699190. IPD Sharing: NO. Countries: 1. Publications: 10.
TRIAGE-GS: Towards Reducing Inefficiencies Affecting Genetics Encounters Through Genome Sequencing
ClinicalTrials.gov study NCT06935019. IPD Sharing: YES. Countries: 1. Publications: 1.
Sequenced Treatment Effectiveness for Posttraumatic Stress
ClinicalTrials.gov study NCT04597190. IPD Sharing: YES. Countries: 1. Publications: 1.
Impact of 2 Resuscitation Sequences on Management of Simulated Pediatric Cardiac Arrest
ClinicalTrials.gov study NCT05474170. IPD Sharing: YES. Countries: 1. Publications: 1.
Early Switch From First-Line Docetaxel/Prednisone to Cabazitaxel/Prednisone and the Opposite Sequence, Exploring Molecular Markers in Men With Metastatic Castration-Resistant Prostate Cancer (mCRPC)
ClinicalTrials.gov study NCT01718353. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Enabling Personalized Medicine Through Exome Sequencing in the U.S. Air Force
ClinicalTrials.gov study NCT03276637. IPD Sharing: UNDECIDED. Countries: 1. Publications: 18.
South-seq: Deoxyribonucleic Acid (DNA) Sequencing for Newborn Nurseries in the South
ClinicalTrials.gov study NCT03842995. IPD Sharing: NO. Countries: 1. Publications: 2.
North Carolina Newborn Exome Sequencing for Universal Screening
ClinicalTrials.gov study NCT02826694. IPD Sharing: YES. Countries: 1. Publications: 1.
Sequenced Therapies for Comorbid and Primary Insomnias
ClinicalTrials.gov study NCT01651442. IPD Sharing: Not stated. Countries: 2. Publications: 4.
EmergeNcy Department Apneic Oxygenation Versus Usual Care During Rapid Sequence Intubation
ClinicalTrials.gov study NCT02737917. IPD Sharing: NO. Countries: 1. Publications: 11.
ClinSeq: A Large-Scale Medical Sequencing Clinical Research Pilot Study
ClinicalTrials.gov study NCT00410241. IPD Sharing: YES. Countries: 1. Publications: 5.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.