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8,038 results for “validation.”
FIGURE 2 in Dolichochorus Strobl 1904: a valid genus of Mesochorinae (Hymenoptera: Ichneumonidae: Mesochorinae)
FIGURE 2. Dolichochorus longiceps (specimen NHMUK010880738) head, frontal view (left) and side view (right).
Validation and Stabilization of a Prophage Lysin of Clostridium perfringens by Using Yeast Surface Display and Coevolutionary Models
<p>Bacteriophage lysins are compelling antimicrobial proteins whose biotechnological utility and evolvability would be aided by elevated stability. Lysin catalytic domains, which evolved as modular entities distinct from cell wall binding domains, can be classified into one of several families with highly conserved structure and function, many of which contain thousands of annotated homologous sequences. Motivated by the quality of these evolutionary data, the performance of generative protein models incorporating coevolutionary information was analyzed to predict the stability of variants in a collection of 9,749 multimutants across 10 libraries diversified at different regions of a putative lysin from a prophage region of a Clostridium perfringens genome. Protein stability was assessed via a yeast surface display assay with accompanying highthroughput sequencing. Statistical fitness of mutant sequences, derived from secondorder Potts models inferred with different levels of sequence homolog information, was predictive of experimental stability with areas under the curve (AUCs) ranging from 0.78 to 0.85. To extract an experimentally derived model of stability, a logistic model with site-wise score contributions was regressed on the collection of multimutants. This achieved a cross-validated classification performance of 0.95. Using this experimentally derived model, 5 designs incorporating 5 or 6 mutations from multiple libraries were constructed. All designs retained enzymatic activity, with 4 of 5 increasing the melting temperature and with the highest-performing design achieving an improvement of 4°C.</p>
FIGURE 1 in Tolmerus calceatus (Meigen) confirmed as a valid species separate from Tolmerus atricapillus (Fallén) (Diptera: Asilidae)
FIGURE 1. Neighbour-Joining tree of the genus Machimus with Eutolmus rufibarbis as outgroup, inferred from COI DNA barcodes. Bootstrap values above 75 (1000 replicates) are given at the nodes.
FIGURE 10. Magelona minuta, USNM 52510 in Redescription of Magelona minuta Eliason, 1962 (Annelida), with discussions on the validity of Magelona filiformis minuta
FIGURE 10. Magelona minuta, USNM 52510, slide mounted specimen, slide 4 (medial and posterior fragments), gut contents (dorsal views) (A) silicoflagellate (Dictyocha speculum?); (B) girdle view of a diatom, ostracod fragment?; (C) sand grain mass; (D) diatom, Lyrella?; (E) bivalve/scallop larva? and large fragment presumed to be of animal origin; (F) centric diatom?; (G) unidentified; (H) diatom.
FIGURE 9 in Redescription of Magelona minuta Eliason, 1962 (Annelida), with discussions on the validity of Magelona filiformis minuta
FIGURE 9. Magelona minuta (A, B) USNM 52510, fluid preserved specimen, (C–D) NMW.Z.2005.014.0111; E: NMW.Z.2005.014.0122: (A–B) anterior (dorso-lateral and ventral views respectively; (C) anterior (dorso-lateral view); (D) anterior (ventro-lateral view); (E) chaetigers 7–13 (ventral view). All stained with methyl green.
FIGURE 7 in Redescription of Magelona minuta Eliason, 1962 (Annelida), with discussions on the validity of Magelona filiformis minuta
FIGURE 7. Magelona minuta (NMW.Z.1991.075.1584a after sonification): (A–B) parapodia of chaetigers 16, 19 (anterolateral views); (C–D) 35 and 39 (posterolateral views) respectively; (E–H) abdominal bidentate hooded hooks from chaetigers 30, 21, 23 and 29 respectively (lateral views).
FIGURE 6 in Redescription of Magelona minuta Eliason, 1962 (Annelida), with discussions on the validity of Magelona filiformis minuta
FIGURE 6. Magelona minuta (NMW.Z.1991.075.1584a): (A) left-hand parapodia of chaetigers 1–3 (posterior view); (B) lefthand parapodia of chaetiger 1 (dorso-lateral view); (C) left-hand parapodia of chaetiger 4 (anterior view); (D) left-hand parapodia of chaetigers 6–9 (anterior view); (E) left-hand parapodia of chaetigers 8–9 (anterior view); (F–H) left-hand neuropodial fascicle of chaetigers 2, 3, 8 respectively (anterior views).
FIGURE 5 in Redescription of Magelona minuta Eliason, 1962 (Annelida), with discussions on the validity of Magelona filiformis minuta
FIGURE 5. Live photographs of an individual of relaxed (MgCl2) Magelona minuta collected from Jennycliff Bay, Plymouth Sound, UK: (A) whole animal (dorso-lateral view); (B) anterior end and palps (photos by Andrew Mackie).
FIGURE 4. Magelona minuta—USNM 52510 in Redescription of Magelona minuta Eliason, 1962 (Annelida), with discussions on the validity of Magelona filiformis minuta
FIGURE 4. Magelona minuta—USNM 52510, slide mounted specimen: (A) left-hand notopodia of chaetiger 1 (anterior view); (B) neuropodia of same chaetiger; (C–D) left-hand parapodia of chaetigers 4 and 5 respectively (anterior views, chaetiger 5 original drawn by Eliason); (E) notopodia of chaetiger 35 (3rd hook from lamella, tridentate); (F–G) abdominal hooded hooks from medial abdominal chaetigers (outermost left-hand hook of F, tridentate). N.B. assigned chaetiger number assumes that parapodia were mounted consecutively by Eliason.
FIGURE 3. Magelona minuta—USNM 52510, A–K in Redescription of Magelona minuta Eliason, 1962 (Annelida), with discussions on the validity of Magelona filiformis minuta
FIGURE 3. Magelona minuta—USNM 52510, A–K, fluid preserved specimen; L–Q slide mounted specimen: (A) anterior (dorsal view); (B) prostomium (dorsal view); (C–M) parapodia of chaetigers 1–10, 35 respectively; (N–O) bidentate abdominal hooded hooks (lateral and frontal views respectively), (P–Q) sporadic tridentate hooded hooks of medial abdominal chaetigers (lateral and frontal views respectively).
FIGURE 1 in Redescription of Magelona minuta Eliason, 1962 (Annelida), with discussions on the validity of Magelona filiformis minuta
FIGURE 1. Measurement of the angle between the main fang and secondary tooth/teeth of abdominal hooded hooks. Dotted line: baseline from the apical tip of the secondary tooth (A) to base of the same tooth (B). Solid line: from tip of the main fang (C) to the base of the secondary tooth (B).
FIGURE 2 in Redescription of Magelona minuta Eliason, 1962 (Annelida), with discussions on the validity of Magelona filiformis minuta
FIGURE 2. Magelona minuta—slide mounted anterior fragment (USNM 52510). Slide 1, left-hand parapodia of chaetigers 1– 4 respectively; Slide 2, left-hand parapodia of chaetigers 5–8 respectively; Slide 3, parapodia of chaetigers 9, 10, 16, 35 (both sides for the former two, right-hand and left-hand parapodia respectively for the latter two); Slide 4, majority of specimen dissected into three fragments: 1) prostomium and 8 thoracic chaetigers; 2) 26 medial abdominal chaetigers and 3) 8 posteriormost abdominal chaetigers N.B. label of slide 1 mounted underneath, shown here on top for clarity. Chaetiger numbers assume that parapodia were mounted consecutively, although are comparable with other material herein examined.
FIGURE 3 in Validation of the status of a species with high CO1 and low nuclear genetic divergences: the scab mite Caparinia ictonyctis stat. res. (Acariformes: Psoroptidae) parasitizing the African hedgehog Atelerix albiventris
FIGURE 3. Details of Caparinia spp. A—Position of seta si, female of C. ictonyctis stat. res.; B—Same, female of C. tripilis; C—Coxal field III, male of C. ictonyctis stat. res.; D—Same, females of C. tripilis; E - Anal region, female of C. tripilis; F— Adanal shields, male of C. tripilis.
FIGURE 6. Caparinia ictonyctis Lawrence, 1955, protonymph. A in Validation of the status of a species with high CO1 and low nuclear genetic divergences: the scab mite Caparinia ictonyctis stat. res. (Acariformes: Psoroptidae) parasitizing the African hedgehog Atelerix albiventris
FIGURE 6. Caparinia ictonyctis Lawrence, 1955, protonymph. A—dorsal view; B—ventral view; C—tarsus I in dorsal view, D—same in ventral view; E—tarsus II in dorsal view; F—same in ventral view; G—leg III in ventral view; H—leg IV in ventral view. Scale bars: 100 µm = A, B; 50 µm = C–H.
FIGURE 5. Caparinia ictonyctis Lawrence, 1955, larva. A in Validation of the status of a species with high CO1 and low nuclear genetic divergences: the scab mite Caparinia ictonyctis stat. res. (Acariformes: Psoroptidae) parasitizing the African hedgehog Atelerix albiventris
FIGURE 5. Caparinia ictonyctis Lawrence, 1955, larva. A—dorsal view; B—ventral view; C—leg I in dorsal view, D—same in ventral view; E—leg II in dorsal view; F—same in ventral view; G—leg III in ventral view. Scale bars: 100 µm = A, B; 50 µm = C–G.
FIGURE 2 in Validation of the status of a species with high CO1 and low nuclear genetic divergences: the scab mite Caparinia ictonyctis stat. res. (Acariformes: Psoroptidae) parasitizing the African hedgehog Atelerix albiventris
FIGURE 2. SEM images of Caparinia ictonyctis stat. res. A—Tibia and tarsus IV of male, dorsal view; B—Tarsus IV of male, ventral view; C—Female, dorsal view; D—Posterior opisthosoma, dorsal view; E—Trochanter I, dorsal view; F—Tibia and tarsus III, dorsal view.
FIGURE 4 in Validation of the status of a species with high CO1 and low nuclear genetic divergences: the scab mite Caparinia ictonyctis stat. res. (Acariformes: Psoroptidae) parasitizing the African hedgehog Atelerix albiventris
FIGURE 4. Anal region of females (left column) and adanal shields of males (right column) of Caparinia spp. A and B—C. setifera; C and D—C. erinacei; E and F—C. algirus; G and H—C. lophiomys.
FIGURE 16 in Validity of Lepadichthys misakius (Tanaka 1908) and redescription of Lepadichthys frenatus Waite 1904 (Gobiesocidae: Diademichthyinae)
FIGURE 16. Relationships of number of rows of papillae on disc regions A (A) and B (B) to standard length (mm) in Lepadichthys frenatus (blue circles) and L. misakius (red triangles).
FIGURE 12 in Validity of Lepadichthys misakius (Tanaka 1908) and redescription of Lepadichthys frenatus Waite 1904 (Gobiesocidae: Diademichthyinae)
FIGURE 12. Head sensory canal pores of Lepadichthys misakius. (A–C), CMNH-ZF 15415, 21.2 mm SL; (D–F), KAUM–I. 56686, 41.5 mm SL. (A, D), dorsal views; (B, E), lateral views; (C, F), ventral views. Abbreviations as in Fig. 5. Bar indicates 1 mm.
FIGURE 11 in Validity of Lepadichthys misakius (Tanaka 1908) and redescription of Lepadichthys frenatus Waite 1904 (Gobiesocidae: Diademichthyinae)
FIGURE 11. CT scanned skeleton of Lepadichthys misakius, CMNH-ZF 7652, 20.1 mm SL. (A–C), overall shape; (D–F), close up of head. (A, D), dorsal view; (B, E), lateral view; (C, F), ventral view.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.