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1,952
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ShareScore release 0.9.0
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1,952 results for “actionality”
Circulating Exosomal miR-20b-5p is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle.
GEO Series GSE102295. Homo sapiens. 6 samples. Type: Expression profiling by array.
NAC controls nascent chain fate through tunnel sensing and chaperone action[RNA]
GEO Series GSE263659. Caenorhabditis elegans. 12 samples. Type: Expression profiling by high throughput sequencing.
Insights into selective action of microsecond pulsed electric fields on healthy and cancer stem cells (D283)
GEO Series GSE248599. Homo sapiens. 8 samples. Type: Expression profiling by array.
Histone Arginine Methylation in Cocaine Action: Essential Role of Src Signaling in the Nucleus Accumbens
GEO Series GSE85310. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment
GEO Series GSE76606. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Anthocyanin-rich extract from black beans exert anti-diabetic effects in rats through multi-genomic mode of action in adipose tissue
GEO Series GSE215903. Rattus norvegicus. 9 samples. Type: Expression profiling by high throughput sequencing.
Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma
GEO Series GSE63420. Homo sapiens. 30 samples. Type: Genome variation profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Action Potential
Drawing uploaded to scidraw.io on: 14 October 2019
Action Potential
Drawing uploaded to scidraw.io on: 14 October 2019
FIGURE 6. Aphanius iconii, FSJF 2325 in Neotype designation of Aphanius iconii, first reviser action to stabilise the usage of A. fontinalis and A. meridionalis and comments on the family group names of fishes placed in Cyprinodontidae (Teleostei: Cyprinodontiformes)
FIGURE 6. Aphanius iconii, FSJF 2325, female, 30 mm SL; Turkey: Karaot; FSJF 2476, male, 25 mm SL; Turkey: Çayköy.
FIGURE 3. Aphanius meridionalis, ZMH 3502 in Neotype designation of Aphanius iconii, first reviser action to stabilise the usage of A. fontinalis and A. meridionalis and comments on the family group names of fishes placed in Cyprinodontidae (Teleostei: Cyprinodontiformes)
FIGURE 3. Aphanius meridionalis, ZMH 3502, from the top, 39 mm SL, 28 mm SL, 27 mm SL, 25 mm SL; Lake Gölhisar.
CIC-DUX4 chromatin prolfiling reveals new epigenetic dependencies and actionable therpaeutic targets in CIC-rearranged sarcomas
<p>CIC-DUX4-rearranged sarcoma (CDS) is a rare and aggressive soft tissue tumor that occurs most frequently in young adults. The key oncogenic driver of this disease is the expression of the CIC-DUX4 fusion protein as a result of chromosomal rearrangements. CIC-DUX4 displays chromatin binding properties, and is therefore believed to function as an aberrant transcription factor. However, the chromatin remodeling events induced by CIC-DUX4 are not well understood, limiting our ability to identify new mechanism-based therapeutic strategies for these patients. Here we generated a genome wide profile of CIC-DUX4 DNA occupancy and associated chromatin states in human CDS cell models and primary tumors. Combining chromatin profiling, proximity ligation assays, as well as genetic and pharmacological perturbations, we show that CIC-DUX4 operates as a potent transcriptional activator at its binding sites. This property is in contrast with the repressive function of the wild type CIC protein, and is mainly mediated through the direct interaction of CIC-DUX4 with the acetyltransferase p300. In keeping with this, we show p300 to be essential for CDS tumor cell proliferation, and its pharmacological inhibition to significantly impact tumor growth in vitro and in vivo. Taken together, our study elucidates the mechanisms underpinning CIC-DUX4-mediated transcriptional regulation and suggests a potential therapeutic approach for the clinical management of CDS patients. </p>
Public space for public health: a call to action
<p>Korsakow film</p>
Abbreviations: ILK: indigenous and local knowledge; IPLCs: indigenous peoples and local communities; NBSAPs: national biodiversity strategies and action plans. a Strategic Plan for Biodiversity 2011–2020. Figure 6. Summary of progress towards the Aichi Targets. Scores are based on quantitative analysis of indicators, a systematic review of the literature, fifth National Reports to the CBD, and available information on countries' stated intentions to implement additional actions by 2020. Progress towards target elements is scored as "Good" (substantial positive trends at a global scale relating to in Summary for policymakers of the global assessment report on biodiversity and ecosystem services - unedited advance version
Abbreviations: ILK: indigenous and local knowledge; IPLCs: indigenous peoples and local communities; NBSAPs: national biodiversity strategies and action plans. a Strategic Plan for Biodiversity 2011–2020. Figure 6. Summary of progress towards the Aichi Targets. Scores are based on quantitative analysis of indicators, a systematic review of the literature, fifth National Reports to the CBD, and available information on countries' stated intentions to implement additional actions by 2020. Progress towards target elements is scored as "Good" (substantial positive trends at a global scale relating to
Data from: Striatal lateral inhibition regulates action selection in a mouse model of levodopa-induced dyskinesia
<p>Data from: Twedell, Bair-Marshall, Girasole, Scaria, Sridhar, & Nelson (2024) <span>Striatal lateral inhibition regulates action selection in a mouse model of levodopa-induced dyskinesia </span><span>(preprint version).</span></p>
An Actionable Framework for Understanding and Improving Talent Retention as a Competitive Advantage in IT Organizations
<p>We provided a public link with coded interview data.<br> We opted not to provide the full interview transcripts in order to adhere to double-blind guidelines.</p>
Fig. 7 in Astragalus species: Phytochemistry, biological actions and molecular mechanisms underlying their potential neuroprotective effects on neurological diseases
Fig. 7. Mechanisms underlying the effects of saponins and AS-IV on cognitive dysfunction. They attenuate amyloid β-protein (Aβ) aggregation and tauopathy (Tau), modulate cholinergic and other neurotransmitter abnormalities, protect against neuronal apoptosis (Pei et al., 2020).
Fig. 5 in Antihypertensive phytocomplexes of proven efficacy and well-established use: Mode of action and individual characterization of the active constituents
Fig. 5. Isolated components of Elettaria cardamomum (L.) Maton extract characterized for antihypertensive activity.
Prospective, Observational Study of Biomarkers in Liver Cancer - Identification of Actionable Events
ClinicalTrials.gov study NCT01963949. IPD Sharing: Not stated. Countries: 0. Publications: 0.
The Children in Action Feasibility Study
ClinicalTrials.gov study NCT01697124. IPD Sharing: Not stated. Countries: 0. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.