Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,880
datasets available to search
ShareScore release 0.9.0
Dataset results
1,880 results for “Dimensionality”
Bystander response to 2.5 Gy of protons in a human 3-dimensional skin model in 16 h after exposure
Bystander mechanisms that originate in the areas surrounding a tissue damage presumably play an important role participating in wound healing and tissue remodeling. Thus identification and characterization of bystander mechanisms will help to development of new treatments of patients with a radiation exposure. In the present study we irradiated 3-dimensional tissue model of human epidermis Epi-200 (Mat-Tek Ashland MA) with 2.5 Gy protons. By exposing only a thin strip across the center of the EPI-200 tissue we have been able to measure global gene expression responses in directly irradiated and bystander cells located at 0.125-0.375 0.375-0.625 0.625-875 mm from the irradiation line. The data were analyzed using BRB-Array Tools (NIH) and further gene ontology analysis and network analysis was performed with Panther (Applied Biosystems) and IPA (Ingenuity) accordingly. Significantly responding genes were identified at all distances and included sets common to both direct and bystander responses. False discovery rate in bystander samples did not exceed 20% (p=0.001) and was sufficiently low in the samples obtained after the whole tissue exposure (0.06-1.16%). Analysis of the fragments cut at the same distance revealed 52 54 and 88 differentially expressed genes. These gene lists overlapped each other had from 3 to 12 genes in common including CLED2 S100A7A. Samples obtained after the whole tissue exposure discovered 949 differentially expressed genes. Moreover the performed gene ontology analysis showed there overrepresentation of TP53 pathway (pathways p=2.04E-02) a common marker of direct irradiation response and also overrepresentation of the following groups of genes: signal transduction (p=4.52E-04) cell communication (p=1.24E-04) and cell cycle in the category of biological processes; DNA helicase activity (p=2.54E-07) receptor binding (p=6.19E-04) calcium ion binding proteins (p=2.57E-03) as the molecular functions. Differentially expresses genes of bystander samples had few categories in common such as cell communication (p=2.36E-03) and signal transduction (p=2.42E-03) among the biological processes and receptor activity (p=4.54E-03) among the molecular functions. Categories specific for the bystander samples included G-protein coupled receptors (p=7.24E-03) and ligand-gated ion channels (p=4.16E-03) suggesting a role of external stimulation and ion trafficking in bystander mechanisms. Radiation induced gene expression in 3-dimensional tissue model Epi-200 was measured in 16 hours after exposure to 2.5 Gy of protons. Four independent experiments were performed for the samples collected at different distances from the irradiation line (125-375 375-625 and 625-875 micrometers) using three tissue fragments per a data point. Moreover three sets of whole tissue irradited samples were also generated for 0 and 2.5 Gy (6 samples total) and used for comparison of bystander and direct responses.
STEREO-B In-Situ Measurements of Particles and CME Transients (IMPACT) Solar Wind Electron Analyzer (SWEA) 3-Dimensional Electron Distributions, Level 1 (L1), 30 s Data
The file contains Level 1 3D electron distributions from the In-situ Measurements of Particles and CME Transients, IMPACT, SWEA instrument on the STEREO Behind spacecraft. For important usage caveats see https://cdaweb.gsfc.nasa.gov/stereo_swea_caveats.html.
Detection and Prognostics on Low Dimensional Systems
This paper describes the application of known and novel prognostic algorithms on systems that can be described by low dimensional, potentially nonlinear dynamics. The methods rely on estimating the conditional probability distribution of the output of the system at a future time given knowledge of the current state of the system. We show how to estimate these conditional probabilities using a variety of techniques, including bagged neural networks and kernel methods such as Gaussian Process Regression (GPR). The results are compared with standard method such as the nearest neighbor algorithm. We demonstrate the algorithms on a real-world data set and a simulated data set. The real-world data set consists of the intensity of an NH3 laser. The laser data set has been shown by other authors to exhibit low-dimensional chaos with sudden drops in intensity. The simulated data set is generated from the Lorenz attractor and has known statistical characteristics. On these data sets, we show the evolution of the estimated conditional probability distribution, the way it can act as a prognostic signal, and its use as an early warning system. We also review a novel approach to perform Gaussian Process Regression with large numbers of data points.
STEREO-B In-Situ Measurements of Particles and CME Transients (IMPACT) Solar Wind Electron Analyzer (SWEA) 3-Dimensional Electron Distributions, Burst Mode, Level 1 (L1), 2 s Data
The file contains Level 1 3D electron distributions in burst mode from the In-situ Measurements of Particles and CME Transients, IMPACT, SWEA instrument on the STEREO Behind spacecraft. For important usage caveats see https://cdaweb.gsfc.nasa.gov/stereo_swea_caveats.html.
STEREO-A In-Situ Measurements of Particles and CME Transients (IMPACT) Solar Wind Electron Analyzer (SWEA) 3-Dimensional Electron Distributions, Burst Mode, Level 1 (L1), 2 s Data
The file contains Level 1 3D electron distributions in burst mode from the In-situ Measurements of Particles and CME Transients, IMPACT, SWEA instrument on the STEREO Ahead spacecraft. For important usage caveats see https://cdaweb.gsfc.nasa.gov/stereo_swea_caveats.html.
STEREO-A In-Situ Measurements of Particles and CME Transients (IMPACT) Solar Wind Electron Analyzer (SWEA) 3-Dimensional Electron Distributions, Level 1 (L1), 30 s Data
The file contains Level 1 3D electron distributions from the In-situ Measurements of Particles and CME Transients, IMPACT, SWEA instrument on the STEREO Ahead spacecraft. For important usage caveats see https://cdaweb.gsfc.nasa.gov/stereo_swea_caveats.html.
In vitro throughput screening of anticancer drugs by patient-derived cell lines cultured on vascularized three-dimensional stromal tissues
GEO Series GSE248026. Homo sapiens. 2 samples. Type: Expression profiling by array.
Transient histone deacetylase inhibition induces cellular memory of gene expression and three-dimensional genome folding
GEO Series GSE281151. Mus musculus. 259 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other.
Bystander responses to 0.5Gy of alpha-particles in a human 3-dimensional skin model in 4h after exposure to ionizing radiation
GEO Series GSE23903. Homo sapiens. 6 samples. Type: Expression profiling by array.
Gene expression in a three dimensionally cultivated human hepatocytes
GEO Series GSE44580. Homo sapiens. 8 samples. Type: Expression profiling by array.
Gene expression profiling of response to Everolimus in a three-dimensional (3D) model of oral mucosa
GEO Series GSE182066. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Reprogramming of three-dimensional chromatin architecture drives human dilated cardiomyopathy
GEO Series GSE165303. Homo sapiens. 177 samples. Type: Expression profiling by high throughput sequencing; Other; Genome binding/occupancy profiling by high throughput sequencing.
Three-Dimensional Matrix Stiffness Modulates Mechanosensitive and Phenotypic Alterations in Oral Squamous Cell Carcinoma Spheroids
GEO Series GSE262142. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
constructing condylar organoid to explore its difference to the traditional two-dimensional (2D) culture condylar chondrocyte
GEO Series GSE230630. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
Biological response to low dose of alpha-particles in a human 3-dimensional skin model, in 1 and 16h after exposure to ionizing radiation.
GEO Series GSE23901. Homo sapiens. 12 samples. Type: Expression profiling by array.
Pseudogenes contribute to the evolution of topological domains across species via forming three-dimensional genome [Hi-C]
GEO Series GSE246661. Homo sapiens. 4 samples. Type: Other.
Transcriptomics based multi-dimensional characterization and drug screen in esophageal squamous cell carcinoma
GEO Series GSE167488. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Three dimensional sectioning and full length gene expression profiling of Patiria miniata
GEO Series GSE214723. Patiria miniata. 46 samples. Type: Expression profiling by high throughput sequencing.
Extracellular glutamate drives glioblastoma invasion through NMDA receptor signaling in a three-dimensional engineered biomaterial platform
GEO Series GSE308404. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
High-dimensional analysis of single neurosphere molecular states reveals an ethanol-mediated shift in distribution along maturation trajectories
GEO Series GSE167604. Mus musculus. 264 samples. Type: Expression profiling by RT-PCR.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.