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Dataset results
308 results for “Early age”
Risk Factors for Bowel Dysfunction at Preschool and Early Childhood Age in Children With Hirschsprung Disease
ClinicalTrials.gov study NCT05655845. IPD Sharing: NO. Countries: 1. Publications: 1.
Language and Motor Skills of Preterm Infants in Pre-school Age: Diagnosis and Early Intervention
ClinicalTrials.gov study NCT01426659. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Exclusive Human-milk in Preterm NEOnates and Early VASCular Aging Risk Factors (NEOVASC)
ClinicalTrials.gov study NCT04413994. IPD Sharing: NO. Countries: 1. Publications: 1.
Laser Intervention in Early Age-Related Macular Degeneration Study
ClinicalTrials.gov study NCT01790802. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Selective Early Medical Treatment of Patent Ductus Arteriosus in Extremely Low Gestational Age Infants: A Pilot RCT
ClinicalTrials.gov study NCT05011149. IPD Sharing: YES. Countries: 2. Publications: 1.
Early Vascular Ageing in the YOUth
ClinicalTrials.gov study NCT04598685. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Early Oseltamivir Treatment of Influenza in Children 1-3 Years of Age
ClinicalTrials.gov study NCT00593502. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Study to Learn About the Safety of BIIB122 Tablets and Whether They Can Slow the Worsening of Early-Stage Parkinson's Disease in Adults Between the Ages of 30 and 80
ClinicalTrials.gov study NCT05348785. IPD Sharing: YES. Countries: 13. Publications: 1.
ExclUsive endocRine Therapy Or Radiation theraPy for Women Aged ≥70 Years Early Stage Breast Cancer
ClinicalTrials.gov study NCT04134598. IPD Sharing: NO. Countries: 1. Publications: 3.
Parental age does not influence offspring telomeres during early life in common gulls (Larus canus)
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How fitness consequences of early-life conditions vary with age in a long-lived seabird: a Bayesian multivariate analysis of age-specific reproductive values
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No evidence of early life resource pulse effects on age-specific variation in survival, reproduction and body mass of female Siberian flying squirrels
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Data from: Atolchelys lepida, a new side-necked turtle from the Early Cretaceous of Brazil and the age of crown Pleurodira
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Ageing as early-life inertia: disentangling life-history trade-offs along a lifetime of an individual
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Data from: Do environmental conditions experienced in early life affect recruitment age and performance at first breeding in common goldeneye females?
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Supplementary data and bibliography to "The distribution of querns and millstones of Mayen lava in the Early Middle Ages (c. 500 to 1050 A.D.)"
<p>Supplementary data and bibliography to “The distribution of querns and millstones of Mayen lava in the Early<br> Middle Ages (c. 500 to 1050 A.D.)”; list of findspots for the following maps:</p> <p>fig. 1. Findspots of basalt-like lava (tephrite) dating from c. 30 BC to 275 AD.</p> <p>fig. 2 Findspots of basalt-like lava (tephrite) dating from c. 275 AD to 500 AD.</p> <p>fig. 3 Findspots of basalt-like lava (tephrite) dating from c. 500 AD to 750 AD.</p> <p>fig. 5 Findspots of basalt-like lava (tephrite) dating from c. 750 AD to 1050 AD.</p>
Data from: Perturbations in growth trajectory due to early diet affect age-related deterioration in performance
Fluctuations in early developmental conditions can cause changes in growth trajectories that subsequently affect the adult phenotype. Here, we investigated whether compensatory growth has long-term consequences for patterns of senescence. Using three-spined sticklebacks (Gasterosteus aculeatus), we show that a brief period of dietary manipulation in early life affected skeletal growth rate not only during the manipulation itself, but also during a subsequent compensatory phase when fish caught up in size with controls. However, this growth acceleration influenced swimming endurance and its decline over the course of the breeding season, with a faster decline in fish that had undergone faster growth compensation. Similarly, accelerated growth led to a more pronounced reduction in the breeding period (as indicated by the duration of sexual ornamentation) over the following two breeding seasons, suggesting faster reproductive senescence. Parallel experiments showed a heightened effect of accelerated growth on these age-related declines in performance if the fish were under greater time stress to complete their compensation prior to the breeding season. Compensatory growth led to a reduction in median life span of 12% compared to steadily growing controls. While life span was independent of the eventual adult size attained, it was negatively correlated with the age-related decline in swimming endurance and sexual ornamentation. These results, complementary to those found when growth trajectories were altered by temperature rather than dietary manipulations, show that the costs of accelerated growth can last well beyond the time over which growth rates differ and are affected by the time available until an approaching life-history event such as reproduction.
Data from: Age and early social environment influence guppy social learning propensities
Social learning, learning from others, allows animals to quickly and adaptively adjust to changing environments, but only if social learning provides reliable, useful information in that environment. Early life conditions provide a potential cue to the reliability of social information later in life. Here, we addressed whether direct early life experience of the utility of social learning influences later social learning propensities. We reared guppy, Poecilia reticulata, fry for 45 days in three different social conditions which involved the presence of adult demonstrators providing cues about feeding locations in the tanks ('follow adults' and 'avoid adults' treatments), or their absence ('no adults' treatment). In the 'follow adults' treatment, juveniles that swam in the same direction as the adult demonstrators found food, whereas in the 'avoid adults' treatment, subjects that swam in the opposite direction to the demonstrators found food. We then tested the fish with a social learning task, to examine whether prior experience had influenced the social learning tendencies of the juveniles. After another 45 days of rearing under common-garden conditions with no adult fish present in the tanks, subjects were retested with the same social learning task, to investigate whether early experiences had effects persisting into adulthood. After 45 days of rearing we found no evidence for social learning in any of the experimental groups. However, after 90 days of rearing, we found evidence of social learning, but only in the 'follow adults' treatment. These results suggest that social learning propensities may develop over life, and that prior exposure to conspecifics providing useful foraging information during early life can shape the degree of reliance on social learning in adulthood.
Data from: Early-life inflammation, immune response and ageing
Age-related diseases are often attributed to immunopathology, which results in self-damage caused by an inappropriate inflammatory response. Immunopathology associated with early-life inflammation also appears to cause faster ageing, although we lack direct experimental evidence for this association. To understand the interactions between ageing, inflammation and immunopathology, we used the mealworm beetle Tenebrio molitor as a study organism. We hypothesized that phenoloxidase, an important immune effector in insect defence, may impose substantial immunopathological costs by causing tissue damage to Malpighian tubules (MTs; functionally equivalent to the human kidney), in turn accelerating ageing. In support of this hypothesis, we found that RNAi knockdown of phenoloxidase (PO) transcripts in young adults possibly reduced inflammation-induced autoreactive tissue damage to MTs, and increased adult lifespan. Our work thus suggests a causative link between immunopathological costs of early-life inflammation and faster ageing. We also reasoned that if natural selection weakens with age, older individuals should display increased immunopathological costs associated with an immune response. Indeed, we found that while old infected individuals cleared infection faster than young individuals, possibly they also displayed exacerbated immunopathological costs (larger decline in MT function) and higher post-infection mortality. RNAi-mediated knockdown of PO response partially rescued MTs function in older beetles and resulted in increased lifespan after infection. Taken together, our data are consistent with a direct role of immunopathological consequences of immune response during ageing in insects. Our work is also the first report that highlights the pervasive role of tissue damage under diverse contexts of ageing and immune response.
Age-induced midbrain-striatum assembloid models early phenotypes of Parkinson's disease
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.