Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
54,099
datasets available to search
ShareScore release 0.9.0
Dataset results
54,099 results for “Expression”
Pea aphid winged and wingless males exhibit reproductive, gene expression, and lipid metabolism differences
<p><span>Alternative, intraspecific phenotypes offer an opportunity to identify the mechanistic basis of differences associated with distinctive life-history strategies. Wing dimorphic insects, in which both flight-capable and flight-incapable individuals occur in the same population, are particularly well-studied in terms of why and how the morphs trade-off flight for reproduction. Yet despite a wealth of studies examining the differences between female morphs, little is known about male differences, which could arise from different causes than those acting on females. Here we examined reproductive, gene expression, and biochemical differences between pea aphid (<em>Acyrthosiphon pisum</em>) winged and wingless males. We find that winged males are competitively superior in one-on-one mating circumstances, but wingless males reach reproductive maturity faster and have larger testes. We suggest that males </span><span>tradeoff increased local matings with concurrent possible inbreeding for outbreeding and increased ability to find mates. At the mechanistic level, differential gene expression between the morphs revealed a possible role for activin and insulin signaling in morph differences; it also highlighted genes not previously identified as being functionally important in wing polymorphism, such as genes likely involved in sperm production. Further, we find that winged males have higher lipid levels, consistent with their use as flight fuel, but we find no consistent patterns of different levels of activity among five enzymes associated with lipid biosynthesis. Overall, our analyses provide evidence that winged versus wingless males exhibit differences at the reproductive, biochemical, and gene expression levels, expanding the field's understanding of the functional aspects of morph differences.</span></p>
Supplementary information for 'Distinct gene expression dynamics in developing and regenerating crustacean limbs', by Sinigaglia et al.
<p>Supplementary data and code for the manuscript <em>'Distinct gene expression dynamics in developing and regenerating crustacean limbs'</em>, by Sinigaglia et al.</p>
Additive genetic variation, but not temperature, influences warning signal expression in Amata nigriceps moths (Lepidoptera: Arctiinae)
<p>Many aposematic species show variation in their colour patterns even though selection by predators is expected to stabilise warning signals towards a common phenotype. Warning signal variability can be explained by trade-offs with other functions of colouration, such as thermoregulation, that may constrain warning signal expression by favouring darker individuals. Here, we investigated the effect of temperature on warning signal expression in aposematic <em>Amata nigriceps</em> moths that vary in their black and orange wing patterns. We sampled moths from two flight seasons that differed in the environmental temperatures and also reared different families under controlled conditions at three different temperatures. Against our prediction that lower developmental temperatures would reduce the warning signal size of the adult moths, we found no effect of temperature on warning signal expression in either wild or laboratory-reared moths. Instead, we found sex- and population-level differences in wing patterns. Our rearing experiment indicated that ~70% of the variability in the trait is genetic but understanding what signalling and non-signalling functions of wing colouration maintain the genetic variation requires further work. Our results emphasise the importance of considering both genetic and plastic components of warning signal expression when studying intraspecific variation in aposematic species.</p>
Data of FigS2, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of FigS2, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_FigS2.PNG). The corresponding raw data and subsequent data analysis obtained from proteomics analysis are provided as nine files in CSV format (31003A-179400_10.3390-cancers14133074_SS_SA_DHRS7_5_1-3_M1-3.csv). All further experiment related information provided as one meta-data-file (31003A-179400_10.3390-cancers14133074_SS_SA_DHRS7_5_1_M .txt) in txt format.</p>
Data of FigS4, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of FigS4, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_FigS4.PNG). The Corresponding raw data and subsequent data analysis obtained from western blot analysis contains the original figures of the raw blots and antibody dilutions as PDF-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_6_M1.pdf), data analysis (densitometry) and all further experiment related information provided as one meta-data-file in txt format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_6_M.txt) and three files in CSV-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_6_1-3.csv).</p>
Data of Fig7, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig7, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_Fig7.PNG). The Corresponding raw data and subsequent data analysis obtained for TCGA analysis contains one file in txt-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_1_M.txt), and all further related information provided as one meta-data-file in pdf-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_1_M1.pdf)</p> <p> </p>
Data of Fig8, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig8, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_Fig8.PNG). The Corresponding raw data and subsequent data analysis obtained for immunohistochemistry contains one file in txt-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_12_1_M .txt) and one file in csv-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_12_1.csv), and all further related information provided as one meta-data-file in pdf-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_12_1_M1 .pdf)</p> <p> </p>
Data of Fig4, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig4, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_Fig4.PNG). The Corresponding raw data and subsequent data analysis obtained from western blot analysis contains the original figures of the raw blots and antibody dilutions as PDF-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_3_M_1.pdf), data analysis (densitometry) and all further experiment related information provided as one meta-data-file in txt format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_3_M.txt). Corresponding raw data and subsequent data analysis obtained from RT-PCR analysis provided as one files in TXT format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_4_M.txt), all further experiment related information provided as one meta-data-file in pdf format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_4_M_1.pdf).</p>
Data of Fig2, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig2, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_Fig2.PNG). The corresponding raw data and subsequent data analysis obtained from proteomics analysis are provided as three files in CSV format (31003A-179400_10.3390-cancers14133074_SS_SA_DHRS7_5_1-3.csv). All further experiment related information provided as one meta-data-file (31003A-179400_10.3390-cancers14133074_SS_SA_DHRS7_5_1_M .txt) in txt format. Corresponding raw data and subsequent data analysis obtained from western blot analysis contains the original figures of the raw blots and antibody dilutions as PDF-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_1_M_1 .pdf), data analysis (densitometry) and all further experiment related information provided as one meta-data-file in txt format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_1_M.txt). Corresponding raw data and subsequent data analysis obtained from RT-PCR analysis provided as one files in TXT format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_2_M.txt), all further experiment related information provided as one meta-data-file in pdf format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_2_M_1.pdf).</p>
Data of Fig5, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig5, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_Fig5.PNG). The Corresponding raw data and subsequent data analysis obtained from western blot analysis contains the original figures of the raw blots and antibody dilutions as PDF-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_4_M_1.pdf), data analysis (densitometry) and all further experiment related information provided as one meta-data-file in txt format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_4_M.txt) and three files in CSV-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_4_3.csv). Corresponding raw data and subsequent data analysis obtained from RT-PCR analysis provided as one files in TXT format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_5_M .txt) and three files in CSV format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_5-1-3.csv), all further experiment related information provided as three meta-data-files in pdf format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_5_M_1-3.pdf).</p>
Data of Fig6, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig6, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_Fig6.PNG). The Corresponding raw data and subsequent data analysis obtained from western blot analysis contains the original figures of the raw blots and antibody dilutions as PDF-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_5_M1.pdf), data analysis (densitometry) and all further experiment related information provided as one meta-data-file in txt format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_5_M.txt) and three files in CSV-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_5_1-3.csv).</p> <p> </p>
Data of Fig3, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig3, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_Fig3.PNG). The Corresponding raw data and subsequent data analysis obtained from western blot analysis contains the original figures of the raw blots and antibody dilutions as PDF-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_2_M_1.pdf), data analysis (densitometry) and all further experiment related information provided as one meta-data-file in txt format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_2_M.txt). Corresponding raw data and subsequent data analysis obtained from RT-PCR analysis provided as one files in TXT format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_3_M.txt), all further experiment related information provided as one meta-data-file in pdf format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_3_M_1.pdf).</p>
Data of Fig1, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig1, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (doi: 10.3390/cancers14133074) contains the original figures as PNG-format (10.3390-cancers14133074_Fig1.PNG). Raw data and related Meta data are provides as one file in TXT format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_1_M.txt) and one file in PDF-Format (31003A-179400_10.3390-cancers14133074_SSDHRS7_1_1_M_1.pdf).</p>
Data of Fig9, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of Fig9, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_Fig9.PNG). The Corresponding raw data and subsequent data analysis obtained for immunohistochemistry contains one file in txt-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_12_1_M.pdf) and one file in csv-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_12_1.csv), and all further related information provided as one meta-data-file in pdf-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_1_M .txt)</p> <p> </p>
Data of FigS3, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of FigS3, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_FigS3.PNG). The Corresponding raw data and subsequent data analysis obtained for TCGA analysis contains one file in txt-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_3_M .txt), six files in csv-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_3-1-6 .csv) and one file in sps-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_3-4 .sps). All further related information provided as one meta-data-file in pdf-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_2_M 1.pdf).</p>
Data of FigS5, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of FigS5, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_FigS5.PNG). The Corresponding raw data and subsequent data analysis obtained from western blot analysis contains the original figures of the raw blots and antibody dilutions as PDF-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_7_M1.pdf), data analysis (densitometry) and all further experiment related information provided as one meta-data-file in txt format (31003A-179400_10.3390-cancers14133074_SSDHRS7_2_7_M.txt).</p> <p> </p>
Data of FigS6, "The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples"
<p>Data of FigS6, “The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples”</p> <p>The Dataset (original publication: doi: 10.3390/cancers14133074) contains the original figure as PNG-format (10.3390-cancers14133074_FigS6.PNG). The Corresponding raw data and subsequent data analysis obtained for TCGA analysis contains two files in txt-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_1-2_M.txt). All further related information provided as one meta-data-file in pdf-format (31003A-179400_10.3390-cancers14133074_SSDHRS7_23_1_M1.pdf).</p> <p> </p>
Transcriptomic analysis of deceptively pollinated Arum maculatum (Araceae) reveals association between terpene synthase expression in floral trap chamber and species-specific pollinator attraction
<p>A compressed folder containing the R script and input files required to replicate the results in our manuscript entitled "Transcriptomic analysis of deceptively pollinated <em>Arum maculatum</em> (Araceae) reveals association between terpene synthase expression in floral trap chamber and species-specific pollinator attraction".</p> <p>Note: Raw Illumina sequencing files associated with this study have been uploaded to NCBI SRA, under the BioProject accession PRJNA856436.</p> <p><strong>ABSTRACT</strong></p> <p>Deceptive pollination often involves volatile organic compound (VOC) emissions that mislead insects into performing non-rewarding pollination. Among deceptively pollinated plants, <em>Arum maculatum</em> is particularly well-known for its potent dung-like VOC emissions and specialized floral chamber, which traps pollinators – mainly <em>Psychoda phalaenoides</em>and <em>P. grisescens</em> – overnight. However, little is known about the genes underlying the production of many <em>A. maculatum</em>VOCs, and their influence on variation in pollinator attraction rates. Therefore, we performed <em>de novo</em> transcriptome sequencing of <em>A. maculatum</em> appendix and male floret tissue collected during- and post-anthesis, from ten natural populations across Europe. These RNA-seq data were paired with GC-MS analyses of floral scent composition and pollinator data collected from the same inflorescences. Differential expression analyses revealed candidate transcripts in appendix tissue linked to malodourous VOCs including indole, <em>p</em>-cresol, and 2-heptanone. Additionally, we found that terpene synthase expression in male floret tissue during anthesis significantly covaried with sex- and species-specific attraction of <em>Psychoda phalaenoides</em> and <em>P.</em> <em>grisescens</em>. Taken together, our results provide the first insights into molecular mechanisms underlying pollinator attraction patterns in <em>A. maculatum</em>, and highlight floral chamber sesquiterpene (<em>e.g.</em>bicyclogermacrene) synthases as interesting candidate genes for further study.</p>
Data and script files: Gene expression in response to estrone sulfate in Trachemys scripta
<p>Variation in developmental conditions can affect a variety of embryonic processes and shape a number of phenotypic characteristics that can affect offspring throughout their lives. This is particularly true of oviparous species where development typically occurs outside of the female, and studies have shown that traits such as survival and behavior can be altered by both temperature and exposure to steroid hormones during development. In species with temperature-dependent sex determination (TSD), the fate of gonadal development can be affected by temperature and by maternal estrogens present in the egg at oviposition and there is evidence that these factors can affect gene expression patterns. Here, we explore how thermal fluctuations and exposure to an estrogen metabolite, estrone sulfate, affect the expression of several genes known to be involved in sexual differentiation; <em>Kdm6b, Dmrt1, Sox9, FoxL2, </em>and <em>Cyp19A1</em>. We found that most of the genes responded to both temperature and estrone sulfate exposure, but that the responses to these factors was not identical in that estrone sulfate effects occur downstream of temperature effects. Our findings demonstrate that conjugated hormones such as estrone sulfate are capable of influencing temperature dependent pathways to potentially alter how embryos respond to temperature and highlight the importance of studying the interaction of maternal hormone and temperature effects.</p>
Seasonal but not sex-biased gene expression of the carotenoid ketolase, CYP2J19, in the sexually dichromatic southern red bishop (Euplectes orix)
<p>Intense red colors in birds are often due to ketocarotenoids (KCs). In many land birds, KCs are oxidized from dietary yellow precursors, presumably by the avian carotenoid ketolase CYP2J19, the regulation and constraints of which have important implications for condition-dependence and honest signaling of carotenoid color displays. Here we investigate hepatic CYP2J19 gene expression in the seasonally and sexually dichromatic southern red bishop (Euplectes orix) in relation to season, sex, progression of the prenuptial moult, testis size, body condition, reflectance-based redness (hue), and circulating sex steroids. A coloration function of CYP2J19 is supported by seasonal upregulation prior to and during the carotenoid-depositing stage of the male prenuptial moult. However, upregulation was similar in females (which do not moult prenuptially), and remained high in males after moult, suggesting additional or alternative functions of hepatic CYP2J19 or its products, such as detoxification or antioxidants, respectively. In males, the CYP2J19 upregulation preceded and was unrelated to the rise in plasma testosterone, but was correlated with androstenedione, likely of adrenal origin and compatible with luteinizing hormone-induced and (in females) estrogen-suppressed moult. Finally, contrary to ideas that carotenoid ketolation rate mediates honest signaling, CYP2J19 expression was not related to male body condition or plumage redness.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.