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5,031 results for “MiRNA”
A combined transcriptome - miRNAome approach revealed that a kinesin gene is differentially targeted by a novel miRNA in an apomictic genotype of Eragrostis curvula
<p>Weeping lovegrass (<em>Eragrostis curvula</em> [Shrad.] Nees) is a perennial grass typically established in semi-arid regions, with good adaptability to dry conditions and sandy soils. This polymorphic complex includes both sexual and apomictic cytotypes, with different ploidy levels (2x-8x). Diploids are known to be sexual, while most polyploids are facultative apomicts, and full apomicts have also been reported. Plant breeding studies throughout the years have focused on achieving the introgression of apomixis into species of agricultural relevance, but, given the complexity of the trait, a deeper understanding of the molecular basis of regulatory mechanisms of apomixis is still required. Apomixis is thought to be associated with silencing or disruption of the sexual pathway, and studies have shown it is influenced by epigenetic mechanisms. In a previous study, we explored the role of miRNA-mRNA interactions using two contrasting <em>E. curvula</em> phenotypes. Here, the sexual OTA-S, the facultative Don Walter and the obligate apomictic Tanganyika cDNA and sRNA libraries were inquired, searching for miRNA discovery and miRNA expression regulation of genes related to the reproductive mode. This allowed for the characterization of seven miRNAs and the validation of their miRNA-target interactions. Interestingly, a <em>kinesin</em> gene was found to be repressed in the apomictic cultivar Tanganyika, targeted by a novel miRNA that was found to be overexpressed in this genotype, suggestive of an involvement in the reproductive mode expression. Our work provided additional evidence of the contribution of the epigenetic regulation of the apomictic pathway.</p>
m6A modification inhibits miRNA intracellular function favouring their extracellular export and the cell-to-cell communication
<p>Epitranscriptomics represents a new layer of gene expression regulation. Specifically, N6-methyladenosine (m6A) regulates RNA maturation, stability, degradation, and translation. Regarding miRNAs, while it has been reported that m6A impact their biogenesis, no evidence is yet provided on their function. Here we show that m6A modification on specific miRNAs weakens their coupling to AGO2, impairs their function on target mRNAs, determines their delivery into extracellular vesicles (EVs) and provides functional information to receiving cells. Mechanistically, the intracellular functional impairment is caused by m6A-mediated inhibition of AGO2/miRNA interaction, the EV-loading is favoured by m6A-mediated recognition by the RBP hnRNPA2B1, the EV-miRNAs function in the receiving cell requires their FTO-mediated demethylation. Consequently, cells express specific miRNAs that do not impact endogenous transcripts but provide regulatory information for cell-to-cell communication. This highlights that a further level of complexity should be considered when relating cellular dynamics to specific miRNAs.</p>
Data from: miRglmm: a generalized linear mixed model of isomiR-level counts improves estimation of miRNA-level differential expression and uncovers variable differential expression between isomiRs
<p>These datasets can be used to reproduce all analyses from the publication "miRglmm: a generalized linear mixed model of isomiR-level counts improves estimation of miRNA-level differential expression and uncovers variable differential expression between isomiRs" in conjunction with codes found at https://github.com/mccall-group/miRglmm_paper. </p> <p>"Monocyte_data_subset.rda", "monocyte_exact_subset_filtered2.rda" and "sims_N100_m2_s1_rtruncnorm.rda" can be used to reproduce the simulation analysis. </p> <p>"panel_B_SE.rda" and "ERCC_filtered.rda" can be used to reproduce the ERCC synthetic data analysis with known ground truth.</p> <p>"study89_data_subset.rda" and "study89_data_subset_filtered2.rda" can be used to reproduce the immune cell-type analysis. </p> <p>"bladder_testes_data_subset.rda" and "bladder_testes_data_subset_filtered2.rda" can be used to reproduce the bladder vs testes tissue analysis.</p>
miRNAs targeting AQP3 - mirDIP
<p>This data was collected via the mirDIP website when searching for miRNAs that would target AQP3.</p>
Fig. 36 in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 36: PCA of 14 morphometric parameters (females) and six parameters (males). Brown dot = A. fratella; red dot: A mirna. Abbreviations of biplot parameters see Table 1.
Fig. 34 in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 34: PCA of seven morphometric parameters (females) and 8 parameters (males). Brown dot = A. fratella; blue dot: A cyanomicans. Abbreviations of biplot parameters see Table 1.
Fig. 27 in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 27: Morphometric analyses (females) of head width (HW), HL/HW index, interocellar distance (IOD), labrum process width (LPW), mesosoma width (MSW), metasoma width (MTW).
Fig. 22a-f in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 22a-f: Mesoscutum of the males: (a) Andrena cyanomicans (Photo: ZOBODAT, 2021/25/03); (b) A. fratella (Photo: ZOBODAT, 2021/25/03); (c) A. maderensis (Photo: L. Haitzinger, OLML); (d) A. mirna (Photo: M. Schwarz, OLML); (e) A. notata (Photo: ZOBODAT, 2021/25/03); (f) A. portosanctana (Photo: V. Smith, CAS).
Fig. 15a-f in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 15a-f: Mesoscutum of the females: (a) Andrena cyanomicans (Photo: ZOBODAT, 2021/25/03); (b) A. fratella (Photo: ZOBODAT, 2021/25/03); (c) A. maderensis (Photo: L. Haitzinger, OLML); (d) A. mirna (Photo: ZOBODAT, 2021/25/03); (e) A. notata (Photo: ZOBODAT, 2021/25/03); (f) A. portosanctana (Photo: V. Smith, CAS).
Fig. 9a-b in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 9a-b: Dorsal view of the holotype (a) and paratype (b) specimens of Andrena notata with labels; female (OLML Nr. 6953082); male (OLML Nr. 6953081). Photos: ZOBODAT, 2021/25/03.
Fig. 28 in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 28: Morphometric analyses (females) of ocelloccipital distance (OCD), ocellular distance (OOD), propodeum basal area length (PBAL), pterostigma length (PSL), wing length (WL).
Fig. 31 in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 31: Morphometric analyses (males) of labrum process width (LPW), mesosoma width (MSW), metasoma width (MTW), ocelloccipital distance (OCD), ocellular distance (OOD), propodeum basal area length (PBAL).
Fig. 4a-b in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 4a-b: Dorsal view of the type specimen of Andrena cyanomicans with labels. (a) female (OLML Nr. 6952279); (b) male; labels (OLML Nr. 6952278). Photos: ZOBODAT, 2021/25/03.
Fig. 11a-b in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 11a-b: Paralectotype of Andrena portosanctana (female) deposited in the NMNH (USNM 24656, barcode number 00533697); (a) dorsal view; (b) lateral view. First label written by Wilmatte Porter Cockerell with pencil; the two other labels written by Cockerell with ink. Photos: Department of Entomology, NMNH, Smithsonian Institution.
Fig. 2a-b in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 2a-b: Dorsal and lateral view of the lectotype type specimen of Andrena cyanomicans with labels. Photos: B. F. Santos & A. Touret-Alby © MNHN 2021.
Fig. 1 in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 1: Areas and structures on the female labrum. a) basal area, b) margin of the basal area, c) apical (distal) process of the basal area, d) apical margin of the process, e) vertical area of the labrum.
Fig. 20a-f in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 20a-f: Head of the males: (a) Andrena cyanomicans (Photo: ZOBODAT, 2021/25/03); (b) A. fratella (Photo: ZOBODAT, 2021/25/03); (c) A. maderensis (Photo: L. Haitzinger, OLML); (d) A. mirna (Photo: M. Schwarz, OLML); (e) A. notata (Photo: ZOBODAT, 2021/25/03); (f) A. portosanctana (Photo: V. Smith, CAS).
Fig. 26 in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 26: Morphometric analyses (females) of FL1/FL3 and FL3/Fl3 index, fovea length (FVL), fovea width (FVW), FVL/FVW index, head length (HL).
Fig. 16a-f in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 16a-f: Puncturing of the mesoscutum of the females: (a) Andrena cyanomicans (Photo: ZOBODAT, 2021/25/03); (b) A. fratella (Photo: ZOBODAT, 2021/25/03); (c) A. maderensis (Photo: L. Haitzinger, OLML); (d) A. mirna (Photo: ZOBODAT, 2021/25/03); (e) A. notata (Photo: ZOBODAT, 2021/25/03); (f) A. portosanctana (Photo: V. Smith, CAS).
Fig. 25 in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 25: Morphometric analyses (females) of body length (BL), clypeus length (CL), length of flagellomeres 1–3 (FL1–Fl3), and Fl1/Fl2 index.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.