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537 results for “Pharmaceuticals”
Interviews for New Business Models for Pharmaceutical Innovation and Access to Medicines - Pandemic Preparedness
<p>These supplementary materials represent the partial dataset in the form of semi-structured interviews, collected and analyzed in the research article "Unlocking global access to medicines for pandemics: the potential and limits of alternative innovation models". This article is one of the outcomes of the "New Business Models for Pharmaceutical Innovation and Global Access to Medicines" research project, conducted at the Global Health Center, within the Geneva Graduate Institute. The dataset contains 8/11 interviews collected and used in this article, which are published with the informed consent of the interviewees.</p> <p>Details about the research project can be found at: <a href="https://www.graduateinstitute.ch/NBM">https://www.graduateinstitute.ch/NBM</a></p>
Interviews for New Business Models for Pharmaceutical Innovation and Access to Medicines - Neglected Diseases
<p>These supplementary materials represent the partial dataset in the form of semi-structured interviews, collected and analyzed in the research article "Alternative pharmaceutical innovation models for neglected diseases: How can they continue to thrive?". This article is one of the outcomes of the "New Business Models for Pharmaceutical Innovation and Global Access to Medicines" research project, conducted at the Global Health Center, within the Geneva Graduate Institute. The dataset contains 8/21 interviews collected and used in this article, which are published with the informed consent of the interviewees.</p> <p>Details about the research project can be found at: <a href="https://www.graduateinstitute.ch/NBM">https://www.graduateinstitute.ch/NBM</a></p>
Interactions of pharmaceutical companies with world countries, cancers and rare diseases from Wikipedia network analysis
<p>Using the English Wikipedia network of more than 5 million articles we analyze interactions and interlinks between the 34 largest pharmaceutical companies, 195 world countries, 47 rare renal diseases and 37 types of cancer. The recently developed algorithm using a reduced Google matrix (REGOMAX) allows us to take account both of direct Markov transitions between these articles and also of indirect transitions generated by the pathways between them<br> via the global Wikipedia network. This approach therefore provides a compact description of interactions between these articles that allows us to determine the friendship networks between them, as well as the PageRank sensitivity<br> of countries to pharmaceutical companies and rare renal diseases. We also show that the top pharmaceutical companies in terms of their Wikipedia PageRankvare not those with the highest market capitalization.</p>
Mas Pharmaceuticals Biotechnical Audit Report
<p>The Biotechnical Valuation Report Performed by Praxity Alliance ; The irreversibly attorned exclusive rights for 128 Bioceutical Patents invented by Erdal Can Alkoclar and Metehan Yesil.</p> <p>Monthly license rights value pre-approved by Turkish Technology Transfer Office.</p>
Appendix to 'Digital Marketing in Indian Pharmaceuticals: Strategies for Prescription Products Targeting Healthcare Professionals
<p>This appendix supplements the scoping review on digital marketing strategies in the Indian pharmaceutical industry from 2014 to 2024. It includes additional data, case studies, reference tables, and detailed analyses that support the main paper, providing further insights into the adoption and effectiveness of digital tools among healthcare professionals. The appendix also incorporates supplementary materials that expand on the use of AI, social media, omnichannel marketing, and key theoretical frameworks, such as the Unified Theory of Acceptance and Use of Technology (UTAUT) and Customer Journey Mapping (CJM), used in the main study.</p>
Frog nest foams exhibit pharmaceutical foam-like properties
<p>Foams have frequently been used as systems for the delivery of cosmetic and therapeutic molecules; however, there is high variability in the foamability and long-term stability of synthetic foams. The development of pharmaceutical foams that exhibit desirable foaming properties, delivering appropriate amounts of the active pharmaceutical ingredient (API) and that have excellent biocompatibility is of great interest. The production of stable foams is rare in the natural world; however, certain species of frogs have adopted foam production as a means of providing a protective environment for their eggs and larvae from a predators and parasites, to prevent desiccation, to control gaseous exchange, temperature extremes, and to reduce UV damage. These foams show great stability (up to 10 days in tropical environments) and are highly biocompatible due to the sensitive nature of amphibian skin. This work demonstrates for the first time, that nests of the Túngara frog (<i>Engystomops pustulosus</i>) is stable <i>ex situ</i> with useful physiochemical and biocompatible properties and is capable of encapsulating a range of compounds, including antibiotics. These protein foam mixtures share some properties with pharmaceutical foams and may find utility in a range of pharmaceutical applications such as a topical drug delivery systems (DDS).</p>
Data for "Vaccinations or Non-Pharmaceutical Interventions:Safe Reopening of Schools in England"
<p>This dataset contains the output files generated with the JUNE epidemiological model use to produce the paper "Vaccinations or Non-Pharmaceutical Interventions:Safe Reopening of Schools in England" https://doi.org/10.1101/2021.09.07.21263223</p>
LC-MS/MS data of pharmaceutical compounds for lIbrary building
<p>Dataset used for MergeION package testing are provided by Janssen Pharmaceutica. It consists of known standard pharmaceutical compounds for which high quality Q-Exactive MS/MS data is provided. Details about these compounds can be found in Metadata_Library.txt. All datasets were acquired in positive ion mode through either DDA (data-dependent acquisition) or targeted MS/MS. Raw data in profile mode were converted into centroid-mode mzML or mzXML files using MSConvertGUI</p> <p> </p>
DATA: molecularly enhanced proof of concept for targeting cocrystals at molecular scale in continuous pharmaceuticals cocrystallization - part 2
<p>This is the cleansed files for CoCryM project carried out at the University of Limerick, Ireland for a MSCA postdoctoral fellowship. </p> <p>Link to PNAS paper <a href="https://www.pnas.org/doi/10.1073/pnas.2114277119">https://www.pnas.org/doi/10.1073/pnas.2114277119</a> </p> <p>(molecularly enhanced proof of concept for targeting cocrystals at molecular scale in continuous pharmaceuticals cocrystallization) </p> <p>Original uploaded files on 10 September 2021: </p> <ol> <li><a href="https://doi.org/10.5281/zenodo.6164838">https://doi.org/10.5281/zenodo.6164838</a></li> <li><a href="https://doi.org/10.5281/zenodo.6189068">https://doi.org/10.5281/zenodo.6189068</a></li> <li><a href="https://doi.org/10.5281/zenodo.6189100">https://doi.org/10.5281/zenodo.6189100</a></li> <li><a href="https://doi.org/10.5281/zenodo.6189715">https://doi.org/10.5281/zenodo.6189715</a></li> <li><a href="https://doi.org/10.5281/zenodo.6189885">https://doi.org/10.5281/zenodo.6189885</a></li> </ol> <p> </p> <p>Inhouse: https://sites.google.com/view/makhansary/publications </p>
Small intestinal microbiota data of pigs receiving control or pharmaceutical levels of ZincOxide
<p>To improve our understanding of host and intestinal microbiome interaction, this research investigated the effects of a high level zinc oxide in the diet as model intervention on the intestinal microbiome and small intestinal functionality in clinically healthy post-weaning piglets.</p> <p>In study 1 piglets received either a high concentration of zinc as zinc oxide (Zn, 2690 mg/kg) or a low Zn concentration (100 mg/kg) in the diet during the post weaning period (d 14-23). We investigated the effects on the piglet’s small intestinal microbiome and functionality of intestinal tissue. In study 2 we investigated the impact of timing of the dietary zinc intervention, i.e. between d 0-14 and/or d 14-23 post weaning, and the consecutive effects on the piglet’s intestinal functionality. We acquired data on the microbiota composition in small intestinal digesta and gene expression profiles of both jejunum and ileum tissue.</p> <p>Overall, we observed differences in the small intestinal functionality during the post weaning period between piglets receiving a diet with a low or high concentration ZnO content.</p>
Datasets for the manuscript "Metabolomic and Sphingolipidomic Profiling of Human Hepatoma Cells Exposed to Widely Used Pharmaceuticals"
<p>See experimental details on the main text of the manuscript "Metabolomic and Sphingolipidomic Profiling of Human Hepatoma Cells Exposed to Widely Used Pharmaceuticals" <a title="Persistent link using digital object identifier" href="https://doi.org/10.1016/j.jpba.2024.116378" target="_blank" rel="noreferrer noopener"><span><span>https://doi.org/10.1016/j.jpba.2024.116378</span></span></a></p> <h2><strong>Data description</strong></h2> <p>This study investigates the impact of three commonly used pharmaceuticals (amoxicillin, carbamazepine, and trazodone) on human liver cells. To mimic real-world conditions, liver cells were encapsulated in spheroids and exposed to various concentrations of these drugs for 24 hours. The study employs metabolomic and sphingolipid analyses to identify metabolic changes induced by drug exposure.</p> <div></div> <p></p> <div> <div> <div> <h3>LC-MS/MS Method for Sphingolipid Analysis</h3> <p>Targeted sphingolipid analysis was conducted using a Waters ACQUITY UPLC System coupled to a Waters Xevo TQ-S system equipped with an Electrospray Ion Source (ESI) and ScanWave™ collision cell technology, operating in positive mode [16]. Sphingolipids were quantified using a Zorbax Rapid Resolution RRHD C18 Column (80 Å, 1.8 µm, 2.1 mm × 100 mm).</p> <h3>LC-HRMS Method for Semi-Targeted Metabolomic Analysis</h3> <p>LC-HRMS analysis was performed on an Agilent 1290 Affinity II HPLC system coupled to an Agilent 6550 iFunnel QTOF mass spectrometer equipped with a dual AJS electrospray ionization source operating in both positive and negative modes. Polar metabolite screening was conducted using a SeQuant® ZIC®-pHILIC 5 µm polymer 100 × 2.1 mm column.</p> </div> </div> </div> <p> </p> <h2><strong>Funding</strong></h2> <p>The research leading to these results has received funding from the Spanish Ministry of Science and Innovation MCIN/AEI/ 10.13039/501100011033, Grants CTQ2017-82598-P and CEX2018-000794-S. The authors also want to grant support from the Catalan Agency for Management of University and Research Grants (AGAUR, Grant 2017SGR753). Miriam Pérez-Cova acknowledges a predoctoral FPU 16/02640 scholarship from the Spanish Ministry of Education and Vocational Training (MEFP), and Post-graduate department from CSIC for the funding of the research stay in Karolinska Institute, <em>via</em> the award to best outreach video in the YoInvestigoYosoyCsic contest, 2019 edition. </p>
Efficacy of Online CBT for GAD Compared to Pharmaceutical Interventions
ClinicalTrials.gov study NCT04478526. IPD Sharing: NO. Countries: 1. Publications: 1.
Pilot Study of Pharmaceutical and Behavioral Interventions to Treat Anxiety Disorders
ClinicalTrials.gov study NCT01631682. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effect of Pharmaceutical Care in Patients With Bipolar I Disorder (BD I)
ClinicalTrials.gov study NCT01750255. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Impact of Pharmaceutical Care in Diabetics Patients
ClinicalTrials.gov study NCT01580904. IPD Sharing: NO. Countries: 1. Publications: 1.
Pharmaceutical Care Program for Pharmacological Treatment of Depression in Primary Care
ClinicalTrials.gov study NCT00794196. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Safety, Tolerability and Pharmacokinetics of Oral Doses of RP3128 of Rhizen Pharmaceuticals
ClinicalTrials.gov study NCT02958982. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Pharmaceutical pollution alters the cost of bacterial infection and its relationship to pathogen load
Open the record for dataset details and reuse information.
Frog nest foams exhibit pharmaceutical foam-like properties
Open the record for dataset details and reuse information.
Pharmaceutical effects on biofilm functioning quantified via contaminant exposure substrates presented in Rosi et al. 2018.
An ongoing component of the Baltimore urban long-term ecological research (LTER) project (Baltimore Ecosystem Study, BES) is the use of the watershed approach and monitoring of stream water quality to evaluate the impacts of multiple chemical stressors on urban stream ecosystem functioning within Baltimore. The LTER research has focused on the Gwynns Falls watershed, which spans a gradient from highly urban, urban-residential, and suburban zones. In addition, a forested watershed serves as a reference. The long-term sampling network includes four longitudinal sampling sites along the Gwynns Falls mainstem, as well as several small (40-100 ha) watershed within or near the Gwynns Falls, providing data on water quality in different land use zones of the watersheds. Each study site is continuously monitored for discharge and is sampled weekly for water chemistry. Those data are available elsewhere on the BES website. We are interested in studying the effects of pharmaceuticals and personal care products (PPCPs) on stream biofilm functioning within urban streams. We constructed and deployed contaminant exposure substrates (CES) in four streams within the greater Baltimore, Maryland, USA area to measure the responses of biofilms in each of the four streams to caffeine, ciprofloxacin, cimetidine, diphenhydramine, and no PPCPs. We incubated CES for 2 weeks in the four different streams, with five replicate CES for each treatment being randomly placed on plastic L-bars within each stream. After the two-week deployment, we used the light-dark incubation approach to estimate gross primary production and community respiration via change in dissolved oxygen (DO) for biofilms colonizing substrates (either cellulose sponges to select heterotrophic biofilms or fritted glass disks to select for autotrophic biofilms) topping each CES. This dataset includes all of the raw data for the light-dark incubations used to calculate gross primary production and community respiration for the v
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.