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308
datasets available to search
ShareScore release 0.9.0
Dataset results
308 results for “Rhesus Macaque”
RNA-Seq of TET2 uniallelic mutated and wild type CFU colonies from rhesus macaque HSPCs
GEO Series GSE148132. Macaca mulatta. 6 samples. Type: Expression profiling by high throughput sequencing.
Cannabinoid attenuation of intestinal inflammation in chronic simian immunodeficiency virus (SIV)-infected rhesus macaques involves differential modulation of pro-inflammatory microRNA/gene expression
GEO Series GSE121439. Macaca mulatta. 16 samples. Type: Expression profiling by array.
Data from: Increased soluble IL-7 receptor concentrations associate with improved IL-7 therapy outcomes in SIV-infected ART-treated Rhesus macaques
The use of interleukin-7 (IL-7) as an immunorestorative therapeutic has proven effective in HIV infection, cancer and bone marrow transplantation. Mediating its activity through membrane-bound IL-7 receptor α (mCD127), IL-7 therapy increases T-cell numbers and survival. A soluble form, sCD127, is found in plasma, and we have previously identified increased plasma sCD127 concentrations in HIV infection. Furthermore, patients with high sCD127 exhibited the best viral control, implicating a role for IL-7 or sCD127 directly in improved virologic/immunologic outcomes. The role of the cytokine IL-7 in elevating sCD127 levels was addressed here through assessment of retrospective samples obtained from SIV-infected antiretroviral (ART)-treated Rhesus macaques. IL-7 was administered in clustered weekly doses, allowing for an assessment prior, during and following IL-7 administration. The levels of sCD127 remained relatively unchanged during both early SIV infection and following initiation of ART. However, treatment with IL-7 increased sCD127 concentrations in most animals, transiently or persistently, paralleling increased T-cell numbers, correlating significantly with CD8+ T-cell levels. In addition, proliferating CD4+ or CD8+ T-cells (measured by Ki67) increased in association with elevated sCD127 concentrations. Finally, a high concentration of sCD127 in IL7-treated animals was associated with increased retention of T-cells (measured by BrDU). In addition, a lack, or loss of viral control was associated with more pronounced and frequent elevations in plasma sCD127 concentrations with IL-7 therapy. In summary, plasma sCD127 levels in SIV-infected ART-treated macaques was associated with therapeutic IL-7 administration, with higher sCD127 levels in macaques demonstrating the best T-cell responses. This study furthers our knowledge regarding the interrelationship between increased IL-7 levels and elevated sCD127 levels that may have implications for future IL-7 immunotherapeutic approaches in HIV-infected patients.
Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques [RNA-Seq]
GEO Series GSE159213. Macaca mulatta. 24 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profiles of unfractionated lymph nodes cells obtained from completely protected, non protected and unvaccinated control rhesus macaques seven days prior to, and four and fourteen days
GEO Series GSE39967. Macaca mulatta; Homo sapiens. 85 samples. Type: Expression profiling by array.
MicroRNA-130a and miR-212 disrupt the intestinal epithelial barrier through modulation of peroxisome proliferator-activated receptor gamma and occludin expression in chronic SIV-infected rhesus macaqu
GEO Series GSE104771. Macaca mulatta. 8 samples. Type: Expression profiling by array.
The effects of periodic restricted feeding on Rhesus Macaques
GEO Series GSE235769. gut metagenome. 140 samples. Type: Other.
Rhesus macaque rhadinovirus (RRV) gene expression in vivo
GEO Series GSE12608. Macaca mulatta; Macaca mulatta rhadinovirus 17577. 1 samples. Type: Expression profiling by array.
Nascent transcription upon interferon-α2 stimulation on human and rhesus macaque lymphoblastoid cell lines
GEO Series GSE214304. Macaca mulatta; Homo sapiens. 12 samples. Type: Other.
Data from: Increased soluble IL-7 receptor concentrations associate with improved IL-7 therapy outcomes in SIV-infected ART-treated Rhesus macaques
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Dramatic effects of social behavior on gene regulation in rhesus macaques [Cell type_expression]
GEO Series GSE34127. Macaca mulatta; Homo sapiens. 20 samples. Type: Expression profiling by array.
Single-nuclei sequencing of late gestation rhesus macaques exposed to chorioamnionitis
GEO Series GSE205001. Macaca mulatta. 4 samples. Type: Expression profiling by high throughput sequencing.
A homologous or variant booster vaccine after Ad26.COV2.S immunization enhances SARS-CoV-2-specific immune responses in rhesus macaques
GEO Series GSE193264. Macaca mulatta. 50 samples. Type: Expression profiling by high throughput sequencing.
Vascular Disease and Thrombosis in SARS-CoV-2 Infected Humans and Rhesus Macaques
GEO Series GSE156701. Macaca mulatta. 123 samples. Type: Expression profiling by high throughput sequencing.
In utero exposure of delta-9-tetrahydrocannabinol (THC) affects vascular transcriptome in rhesus macaques
GEO Series GSE244644. Macaca mulatta. 30 samples. Type: Expression profiling by high throughput sequencing.
On the Relationships in Rhesus Macaques between Chronic Ethanol Consumption and the Brain Transcriptome (Cortical Area 32 - A32)
GEO Series GSE96731. Macaca mulatta. 30 samples. Type: Expression profiling by high throughput sequencing.
Dramatic effects of social behavior on gene regulation in rhesus macaques [Bisulfite seq]
GEO Series GSE34128. Macaca mulatta. 6 samples. Type: Methylation profiling by high throughput sequencing.
Immunotyping of microglia and macrophages in the CNS during acute SIV infection: a single-cell study of rhesus macaque brains
GEO Series GSE253835. Macaca mulatta. 20 samples. Type: Expression profiling by high throughput sequencing.
Blood transcriptome following BCG vaccination administered via different routes in rhesus macaques
GEO Series GSE218157. Macaca mulatta. 144 samples. Type: Expression profiling by high throughput sequencing.
Maternal Immune Activation Induces Long-Term, Cell-Specific Transcriptomic Changes in the Amygdala of Rhesus Macaque Offspring
GEO Series GSE307538. Macaca mulatta. 16 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.