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175
datasets available to search
ShareScore release 0.9.0
Dataset results
175 results for “Single-molecule”
Single-molecule simultaneous profiling of DNA methylation and DNA-protein interactions with Nanopore-DamID
GEO Series GSE203109. Homo sapiens; Mus musculus. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
The data of "Understanding the Extraordinary Flexibility of Polydimethylsiloxane through Single-molecule Mechanics"
<p>The data set is the Raw data of the Paper titled "Understanding the Extraordinary Flexibility of Polydimethylsiloxane through Single-molecule Mechanics".</p>
Single-molecule detection and super-resolution imaging with a portable and adaptable 3D-printed microscopy platform (Brick-MIC)
<p>Supplementary Videos, CAD 3D-printing templates and assembly instructions</p>
Single-molecule fingerprinting of protein-drug interaction using a funneled biological nanopore
<p>This dataset belongs to “Single-molecule fingerprinting of protein-drug interaction using a funneled biological nanopore” and describes the raw micrograph dataset from negative-stain electron microscopy for YaxAB-C8, -C9, -C10.</p>
Single-molecule analysis of RNA:protein interactions reveals sequential binding of different YTHDF proteins to the same mRNA molecules [RIP-Seq]
GEO Series GSE201540. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing; Other.
Tracking live-cell single-molecule dynamics enables measurements of heterochromatin-associated protein-protein interactions
GEO Series GSE263472. Schizosaccharomyces pombe. 5 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The human transcription factor occupancy landscape viewed using high-resolution in situ base-conversion strand-specific single-molecule chromatin accessibility mapping
GEO Series GSE301497. Homo sapiens. 8 samples. Type: Other.
Single-molecule analysis of RNA:protein interactions reveals sequential binding of different YTHDF proteins to the same mRNA molecules.
GEO Series GSE200713. Homo sapiens. 136 samples. Type: Other; Expression profiling by high throughput sequencing.
Simultaneous identification of m6A and m5C reveals coordinated RNA modification at single-molecule resolution [HeLa cells]
GEO Series GSE211759. Homo sapiens. 6 samples. Type: Other.
Exploring in vivo cholesterol-mediated interactions between activated EGF receptors in plasma membrane with single-molecule optical tracking
<p><strong>Background</strong>:: The first step in many cellular signaling processes occurs at various types of receptors in the plasma membrane. Membrane cholesterol can alter these signaling pathways of living cells. However, the process in which the interaction of activated receptors is modulated by cholesterol remains unclear.</p> <p><strong>Methods</strong>:: In this study, we measured single-molecule optical trajectories of epidermal growth factor receptors moving in the plasma membranes of two cancerous cell lines and one normal endothelial cell line. A stochastic model was developed and applied to identify critical information from single-molecule trajectories.</p> <p><strong>Results</strong>:: We discovered that unliganded epidermal growth factor receptors may reside nearby cholesterol-riched regions of the plasma membrane and can move into these lipid domains when subjected to ligand binding. The amount of membrane cholesterol considerably affects the stability of correlated motion of activated epidermal growth factor receptors.</p> <p><strong>Conclusions</strong>:: Our results provide single-molecule evidence of membrane cholesterol in regulating signaling receptors. Because the three cell lines used for this study are quite diverse, our results may be useful to shed light on the mechanism of cholesterol-mediated interaction between activated receptors in live cells. </p>
Simultaneous identification of m6A and m5C reveals coordinated RNA modification at single-molecule resolution [mouse frontal cortex]
GEO Series GSE211760. Mus musculus. 15 samples. Type: Other.
Methylation pseudotime analysis for label-free profiling of the temporal chromatin landscape with long-read and single-molecule resolution [ATAC-seq]
GEO Series GSE290974. Homo sapiens. 16 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Simultaneous identification of m6A and m5C reveals coordinated RNA modification at single-molecule resolution
GEO Series GSE211762. Homo sapiens; Mus musculus. 21 samples. Type: Other.
Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device
<p>Supplementary data and code to accompany "Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device".</p>
Supplemental Material for "Single-molecule dynamics of DNA methyltransferase DnmA are regulated by DNA methylation and RNA-DNA hybrids"
<p>Raw data for single-particle tracking analysis.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.