Find research datasets worth reusing

Study of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Adacel® in Healthy Subjects

ClinicalTrials.gov study NCT02992418. IPD Sharing: YES. Countries: 1. Publications: 1.

Study on an Investigational Yellow Fever Vaccine Compared With YF-VAX in Adults in the USA

ClinicalTrials.gov study NCT04942210. IPD Sharing: YES. Countries: 1. Publications: 0.

COVID-19 Vaccine Hesitancy Counseling Intervention for Pharmacists

ClinicalTrials.gov study NCT05926544. IPD Sharing: YES. Countries: 1. Publications: 5.

Immunogenicity and Safety of a Tetravalent Dengue Vaccine Booster Injection in Subjects Who Previously Completed a 3-dose Schedule

ClinicalTrials.gov study NCT02824198. IPD Sharing: YES. Countries: 1. Publications: 2.

Lot-to-lot Consistency of 3 Lots of Tetravalent Dengue Vaccine (TDV) in Non-endemic Country(Ies) for Dengue

ClinicalTrials.gov study NCT03423173. IPD Sharing: YES. Countries: 1. Publications: 2.

Immunogenicity and Safety of a Quadrivalent Meningococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers in the US

ClinicalTrials.gov study NCT03537508. IPD Sharing: YES. Countries: 2. Publications: 1.

Study on a Quadrivalent Meningococcal Conjugate Vaccine (MenACYW Conjugate Vaccine) Compared to a Meningococcal Reference Vaccine, and When Given Alone or With Two Other Vaccines in Healthy Adolescent

ClinicalTrials.gov study NCT04490018. IPD Sharing: YES. Countries: 4. Publications: 1.

publicJan 2025View details →

Data and code from: Cost-effectiveness Analysis of Alternative Infant and Neonatal Rotavirus Vaccination Schedules in Malawi

Open the record for dataset details and reuse information.

publicNov 2019View details →

Fluorescent biomarkers demonstrate prospects for spreadable vaccines to control disease transmission in wild bats

Open the record for dataset details and reuse information.

publicOct 2023View details →

Characterization of the anti-spike IgG immune response to COVID-19 vaccines in people with a wide variety of immunodeficiencies

Open the record for dataset details and reuse information.

publicJan 2023View details →

Data and code for: Local infectious disease experience influences vaccine refusal rates: a natural experiment

Open the record for dataset details and reuse information.

publicSep 2022View details →

Optimal vaccination at high reproductive numbers: sharp transitions and counterintuitive allocations

Open the record for dataset details and reuse information.

opencc-by-4.0Apr 2018View details →

List of journal articles on vaccination and autism

List of open access journal articles, dois, Altmetric.com IDs and public dates on the topic of vaccination and autism. Article titles and dois were collected from January 2016 to June 2017 using purposive and snowball sampling. Altmetric IDs were collected in April 2018 using the Altmetric Explorer. The data were used to study the use of open access journal articles by the anti-vaccination movement in the social media.

opencc-by-4.0Dec 2019View details →

Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon vaccination

Data set accompanying the publication "Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon vaccination". In this study, we utilize high-throughput sequencing to profile the memory CD4 TCRβ repertoire and track vaccine-specific and epitope-specific TCRβ clonotypes following the de novo administration of hepatitis B (HepB) vaccine in healthy HepB-naïve individuals. The data set is comprised out of the following parts: <ul> <li>repTCRb: Folder containing CD4+ TCR repertoire data from volunteers. Some of these samples are also available in ImmuneAccess (https://clients.adaptivebiotech.com/pub/deneuter-2018-cmvserostatus).</li> <li>peptideTCRab: Folder containing peptide-specific or peptide-pool-specific TCR data</li> <li>df_all: Meta and FC data for samples and volunteers</li> <li>freqCD154: CD154-based group definitions</li> <li>groups.csv: Group definitions used for classes</li> </ul>

opencc-by-4.0Nov 2020View details →

English Vaccine-related Twitter data (Tweet IDs) 2018-07-01 to 2020-09-30

Twitter data collected through the Crowdbreaks platform [1]. Between July 1st, 2017 and October 1st, 2020 a total of 57.5M tweets (including 39.7M retweets) in English language by 9.9M unique users were collected using the public filter stream endpoint of the Twitter API. The tweets matched one or more of the keywords "vaccine", "vaccination", "vaxxer", "vaxxed", "vaccinated", "vaccinating", "vacine", "overvaccinate", "undervaccinate", "unvaccinated". The data can be considered complete with respect to these keywords.   The files contain a single column which corresponds to the Tweet ID (one file per day). Using the IDs the full tweet objects can be restored.

dryad36/100

Code and scripts used to generate results for: Designing transmissible viral vaccines for evolutionary robustness and maximum efficiency

The danger posed by infectious agents necessitates the development of new tools to both predict and manage emerging diseases. One promising approach is the development of recombinant viral vaccines that are themselves infectious. Transmissible vaccines have been shown to greatly reduce the effort required to control the spread of zoonotic pathogens in their animal reservoirs, thereby limiting the chances of human infection. While this approach can be immensely useful in combating emerging diseases, the ability to self-replicate exposes vaccines to evolutionary change. As a recombinant transmissible vaccine mutates, selection is expected to favor variants with reduced efficacy against the pathogen and increased transmission rates. This creates a trade-off in vaccine design priorities between efficacy, reduction in transmission, and evolutionary stability. Here we ask how such trade-offs influence the overall performance of transmissible vaccines. We find that evolutionary instability can dramatically reduce performance, even for vaccine candidates with ideal efficacy and transmission dynamics. One method to increase functional stability is through the inclusion of multiple redundant antigens. We show that the inclusion of a second antigen can increase functional stability in the face of evolutionary pressures. However, the benefit of genetic redundancy plus any gain in efficacy must outweigh the reduction in transmission for dual-gene designs to be effective. Our results suggest that the successful application of recombinant transmissible vaccines will require consideration of evolutionary dynamics and epistatic effects, as well as basic measurements of epidemiological features.

opencc-zeroNov 2020View details →

dryad36/100

Implementation and adherence of routine pertussis vaccination (DTP) in a low-resource urban birth cohort

Introduction: Reliable information on rates of up-to-date coverage and timely administration of routine childhood immunizations is critical for guiding public health efforts worldwide, yet prospective observation of vaccination programs within individual communities is rare. Here we provide a longitudinal analysis of the directly-observed administration of a 3-dose primary vaccination series to infants in a low-resource community in Lusaka, Zambia. Methods: Throughout 2015, we recruited a longitudinal birth cohort of mother/infant pairs (initial enrollment, 1,981 pairs; attending, 1,497 pairs) from the peri-urban informal settlement of Chawama compound, located in Lusaka, Zambia. We prospectively monitored the administration of scheduled Diphtheria-Tetanus-Pertussis (DTP) vaccinations across the first 14-18 weeks of life. We analyzed study attendance and vaccine coverage, both overall and stratified by age group. We employed Kaplan-Meier analyses to estimate delays in age-appropriate administration of vaccine doses. We also assessed schedule timing violations, including early and compressed dose administration. Results: At study completion, first dose (DTP1) rates were high (92.9% of attending), whereas third dose completion (DTP3) rates were far lower (61.9%). Missed vaccinations and study dropout both contributed to the low DTP3 completion rates. DTP1 was administered very late (at or after 10 weeks) to 61 infants (4.1%). DPT1 was administered too early to 64 infants (4.3%), and 77 (5.1%) received consecutive doses below the minimum recommended spacing of 28 days. Conclusions: We observe substantial individual variation in the timing of early childhood DTP doses, though following this birth cohort proved challenging. Our results indicate that timely administration of both DTP1 and DPT3 remains a challenge in this community. These directly-observed, individual-based results provide an important counterpoint to more course-grained, survey-based national and province estimates of up-to-date vaccine coverage. This study also highlights the challenges of vaccine hesitancy and sub-optimal utilization of (no-cost) healthcare services in a low-resource urban setting.

opencc-zeroDec 2020View details →

dryad36/100

Data from: Age-appropriate vaccination coverage and its associated factors for pentavalent 1-3 and measles vaccine doses, in northeast Ethiopia: A community-based cross-sectional study

Background: In Ethiopia, there are no studies on age-appropriate vaccinations that children received at the recommended specific ages. Therefore, we assessed age appropriate vaccination coverage and its associated factors among children 12 to 23 months of age in Menz Lalo district, northeast Ethiopia. Methods: A community based cross sectional study was conducted in Menz Lalo district from March to April, 2018 among 417 mothers/caregivers with children 12 to 23 months of age using simple random sampling technique. Data were collected using pretested structured Amharic questionnaire. Age appropriate vaccination coverage was measured using World Health Organization vaccination schedule recommendation. Information about children vaccination status was collected from children vaccination cards. Data was entered into Epi-Info7 software and exported to SPSS-20 for analysis. Logistic regression analysis was carried out to identify factors associated with age inappropriate vaccinations. A p-value of < 0.05 was considered to sate statistically significant association. Results: Age appropriate vaccination coverage were 39.1% (95% CI: 34.1-43.6) for Pentavalent 1, 36.3% (95% CI: 30.5-40) for Pentavalent 2, 30.3% (95% CI: 23.5-32.4) for Pentavalent 3 and 26.4% (95% CI: 18-29.4) for measles vaccine doses. Age inappropriate Pentavalent 1-3 vaccinations was associated with being male child (AOR: 0.47, 95% CI: 0.29-0.74), absence of telephone (AOR: 2.2, 95% CI: 1.4-3.6), absence of usual caretaker (AOR: 2.6, 95% CI: 1.3-5.2), unplanned pregnancy (AOR: 1.9, 95% CI: 1.1-3.5), missing antenatal conference participation (AOR: 2.7, 95% CI: 1.3-5.7), first birth order (AOR: 0.34, 95% CI: 0.17-0.68) and insufficient knowledge (AOR: 2.7, 95% CI: 1.6-4.4). Conclusion: The proportion of age appropriate vaccinations coverage was low in the study area. Modifiable factors were associated with age inappropriate vaccinations. Vaccination interventions should consider identified modifiable factors to improve age appropriate vaccinations coverage.

opencc-zeroAug 2019View details →

opencc-by-4.0Oct 2023View details →

Manifestation of Health Denialism in Attitudes Toward COVID-19 Vaccination: A Qualitative Study

The transcripts of the in-depth interviews used for the qualitative analysis of the manifestations of denializm in attitudes toward COVID-19 preventive measures and other opinions about the pandemic.