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555 results for “albumin”
Data from: Identification and mapping of linear antibody epitopes in human serum albumin using high-density peptide arrays
We have recently developed a high-density photolithographic, peptide array technology with a theoretical upper limit of 2 million different peptides per array of 2 cm2. Here, we have used this to perform complete and exhaustive analyses of linear B cell epitopes of a medium sized protein target using human serum albumin (HSA) as an example. All possible overlapping 15-mers from HSA were synthesized and probed with a commercially available polyclonal rabbit anti-HSA antibody preparation. To allow for identification of even the weakest epitopes and at the same time perform a detailed characterization of key residues involved in antibody binding, the array also included complete single substitution scans (i.e. including each of the 20 common amino acids) at each position of each 15-mer peptide. As specificity controls, all possible 15-mer peptides from bovine serum albumin (BSA) and from rabbit serum albumin (RSA) were included as well. The resulting layout contained more than 200.000 peptide fields and could be synthesized in a single array on a microscope slide. More than 20 linear epitope candidates were identified and characterized at high resolution i.e. identifying which amino acids in which positions were needed, or not needed, for antibody interaction. As expected, moderate cross-reaction with some peptides in BSA was identified whereas no cross-reaction was observed with peptides from RSA. We conclude that high-density peptide microarrays are a very powerful methodology to identify and characterize linear antibody epitopes, and should advance detailed description of individual specificities at the single antibody level as well as serologic analysis at the proteome-wide level.
Figure 2 from: Abarova S, Stoitchkova K, Tzonev S, Argirova M, Yancheva D, Anastassova N, Tenchov B (2024) Spectroscopic and thermodynamic characterization of the interaction of a new synthesized antitumor drug candidate 2H4MBBH with human serum albumin. Pharmacia 71: 1-5. https://doi.org/10.3897/pharmacia.71.e112385
Figure 2 Fluorescence titration curve of HSA (4 µM) with the 2H4MBBH in saline at 15 °C and 25 °C. Different curves correspond to 2H4MBBH concentrations of 0, 10, 20, 30, 40, 50 µM, respectively.
Figure 3 from: Abarova S, Stoitchkova K, Tzonev S, Argirova M, Yancheva D, Anastassova N, Tenchov B (2024) Spectroscopic and thermodynamic characterization of the interaction of a new synthesized antitumor drug candidate 2H4MBBH with human serum albumin. Pharmacia 71: 1-5. https://doi.org/10.3897/pharmacia.71.e112385
Figure 3 Stern-Volmer plots for quenching of different 2H4MBBH concentrations (10–50 µM) to HSA (4 µM) in saline at 15 and 25 °C.
Dataset: Modification of Gradient HPLC Method for Determination of Small Molecules' Affinity to Human Serum Albumin under Column Safety Conditions: Robustness and Chemometrics Study
<p>Dataset for publication.</p> <p> </p>
Simultaneous Determination of Glucose and Albumin in Human Urine for Diagnosing Albuminuria using Attenuated Total Reflection Fourier-Transform Infrared Spectroscopy
<p>The manuscript has not yet been published.</p> <p> </p>
Albumin - nitroacetic acid
<p>Data included in the manuscript</p>
Phase II/III of Recombinant Human Albumin Injection
ClinicalTrials.gov study NCT06411743. IPD Sharing: NO. Countries: 1. Publications: 0.
Compare the Diuretic Effect With Furosemide vs Furosemide and Albumin Combined in Cirrhotic Patients
ClinicalTrials.gov study NCT04216784. IPD Sharing: NO. Countries: 1. Publications: 0.
C-reactive Protein & Albumin Ratio IN AKI
ClinicalTrials.gov study NCT07335757. IPD Sharing: UNDECIDED. Countries: 0. Publications: 2.
Use of Lactate-to-Albumin, CRP-to-Albumin, and Procalcitonin-to-Albumin Ratios to Predict Mortality in ICU Patients
ClinicalTrials.gov study NCT07242027. IPD Sharing: NO. Countries: 1. Publications: 0.
Recombinant Fusion Protein Linking Coagulation Factor IX With Albumin (rIX-FP) in Chinese Subjects With Hemophilia B Previously Treated With FIX Therapy
ClinicalTrials.gov study NCT06399289. IPD Sharing: YES. Countries: 1. Publications: 0.
Pertuzumab, Trastuzumab, and Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With HER2-Positive Advanced Breast Cancer
ClinicalTrials.gov study NCT01730833. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of Albumin Bound-Paclitaxel for Treatment of Recurrent or Metastatic Head and Neck Cancer With Cetuximab
ClinicalTrials.gov study NCT00319839. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy and Safety of Plasma Exchange With 5% Albumin in Beta-amyloid Peptide Clearance in Cerebral Spinal Fluid
ClinicalTrials.gov study NCT00742417. IPD Sharing: Not stated. Countries: 2. Publications: 0.
A Comparison Between Child-Pugh and Albumin-Bilirubin Scores
ClinicalTrials.gov study NCT03534843. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.
Ipromlimab and Tuvonralimab Combined With Albumin-Bound Paclitaxel and Nedaplatin as Neoadjuvant Therapy for Locally Advanced Resectable Esophageal Squamous Cell Carcinoma
ClinicalTrials.gov study NCT07374003. IPD Sharing: YES. Countries: 1. Publications: 0.
Mechanistic Inflammatory Sub-study Embedded Within the Albumin vs Balanced Crystalloid Trial
ClinicalTrials.gov study NCT04963569. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Short-term Survival of Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Albumin 5%
ClinicalTrials.gov study NCT03702920. IPD Sharing: NO. Countries: 10. Publications: 0.
Carboplatin and Paclitaxel Albumin-Stabilized Nanoparticle Formulation Followed by Radiation Therapy and Erlotinib in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed
ClinicalTrials.gov study NCT00553462. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Sargramostim and Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Advanced Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer That Did Not Respond to P
ClinicalTrials.gov study NCT00466960. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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