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337
datasets available to search
ShareScore release 0.9.0
Dataset results
337 results for “cell shape”
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment. [bulk RNA-Seq]
GEO Series GSE128781. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Single-cell RNA-seq analysis of a soft-tissue sarcoma model reveals the critical role of tumor expressed MIF in shaping macrophage heterogeneity. [CITE-Seq 2]
GEO Series GSE201618. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing; Other.
Constrained pioneering and partner factor redirection by PU.1 shape early T-cell gene regulation
GEO Series GSE93755. Mus musculus. 188 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other.
Human Skeletal Development and Regenerative Capacity is Shaped by Skeletal Stem Cell Diversity
GEO Series GSE234040. Homo sapiens. 39 samples. Type: Expression profiling by high throughput sequencing.
STAT5 and STAT3 balance shapes dendritic cell function and tumor immunity
GEO Series GSE289764. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Molecular and epistatic interactions between pioneer transcription factors shape nucleosome dynamics and cell differentiation [MNase-seq]
GEO Series GSE268717. Mus musculus. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Bap1 shapes the bone marrow niche for lymphopoiesis by fine-tuning epigenetic profiles in endosteal mesenchymal stromal cells [RNA-Seq]
GEO Series GSE198823. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Seeding of visceral adipose tissue with perinatally generated regulatory T cells shapes the metabolic tenor in mice
GEO Series GSE300181. Mus musculus. 50 samples. Type: Expression profiling by high throughput sequencing.
Ezh2 shapes T cell plasticity to drive atherosclerosis
GEO Series GSE283002. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Poverty shapes the transcriptome of immune cells
GEO Series GSE221766. Homo sapiens. 408 samples. Type: Expression profiling by high throughput sequencing.
Crosstalk between myeloid and B cells shapes the distinct microenvironments of primary and secondary liver cancer
GEO Series GSE243245. Homo sapiens. 123 samples. Type: Expression profiling by high throughput sequencing.
An alternative transcriptome shapes cell fate transitions in yeast (MNase-seq)
GEO Series GSE137709. Saccharomyces cerevisiae. 36 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The Tumor Microenvironment Shapes Innate Lymphoid Cells in Patients with Hepatocellular Carcinoma
GEO Series GSE179746. Homo sapiens. 58 samples. Type: Expression profiling by high throughput sequencing.
The miR-183/96/182 cluster is a checkpoint for resident immune cells and shapes the cellular landscape of the cornea.
GEO Series GSE249384. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
The mitotic STAG3–cohesin complex shapes male germline nucleome [single-cell RNA-seq]
GEO Series GSE274225. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity
GEO Series GSE30227. Homo sapiens. 89 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Inflammation-dependent differentiation of two distinct regulatory T cell populations in the visceral adipose tissue shapes systemic metabolism [RNA-seq III]
GEO Series GSE237835. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Recruitment to the nuclear periphery enhances repression of H3K9me2-marked genes and transposons to shape cell fate [RNAseq_epilc]
GEO Series GSE264599. Mus musculus. 40 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic dynamics shaping melanophore and iridophore cell fate in zebrafish
GEO Series GSE181287. Danio rerio. 24 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Tuning cell behavior with nanoparticle shape
We investigated how the shape of polymeric vesicles, made by the exact same material, impacts the replication activity and metabolic state of both cancer and non-cancer cell types. First, we isolated discrete geometrical structures (spheres and tubes) from a heterogeneous sample using density-gradient centrifugation. Then, we characterized the cellular internalization and the kinetics of uptake of both types of polymersomes in different cell types (either cancer or non-cancer cells). We also investigated the cellular metabolic response as a function of the shape of the structures internalized and discovered that tubular vesicles induce a significant decrease in the replication activity of cancer cells compared to spherical vesicles. We related this effect to the significant up-regulation of the tumor suppressor genes p21 and p53 with a concomitant activation of caspase 3/7. Finally, we demonstrated that combining the intrinsic shape-dependent effects of tubes with the delivery of doxorubicin significantly increases the cytotoxicity of the system. Our results illustrate how the geometrical conformation of nanoparticles could impact cell behavior and how this could be tuned to create novel drug delivery systems tailored to specific biomedical application.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.