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787 results for “conjugation”
Trial to Evaluate the Safety and Immunogenicity of a Multivalent Pneumococcal Conjugate Vaccine in Adults 60 Through 64 Years of Age
ClinicalTrials.gov study NCT03313037. IPD Sharing: YES. Countries: 1. Publications: 1.
Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' 10-valent Pneumococcal Conjugate Vaccine
ClinicalTrials.gov study NCT00344318. IPD Sharing: YES. Countries: 2. Publications: 3.
Ospemifene vs. Conjugated Estrogens in the Treatment of Postmenopausal Sexual Dysfunction
ClinicalTrials.gov study NCT03018106. IPD Sharing: NO. Countries: 1. Publications: 1.
Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Meningococcal Conjugate Vaccine (GSK134612) When Co-administered With Boostrix® in Subjects Between 11 and 25 Years of Age
ClinicalTrials.gov study NCT01767376. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Wyeth Study To Evaluate a 13-valent Pneumococcal Conjugate Vaccine in Infants
ClinicalTrials.gov study NCT00464945. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety, Tolerability, and Immunogenicity Study of a 24-Valent Pneumococcal Conjugate Vaccine (VAX-24) in Older Adults
ClinicalTrials.gov study NCT05297578. IPD Sharing: YES. Countries: 1. Publications: 1.
20-valent Pneumococcal Conjugate Vaccine Safety and Immunogenicity Study of a 4-Dose Series in Healthy Infants
ClinicalTrials.gov study NCT04382326. IPD Sharing: YES. Countries: 2. Publications: 3.
Study Response of 13-valent Conjugate Pneumococcal Vaccine in Patients With End Stage Renal Disease
ClinicalTrials.gov study NCT01974817. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety, Tolerability, and Immunogenicity of a Polyvalent Pneumococcal Conjugate Vaccine (V116) in Japanese Adults (V116-002)
ClinicalTrials.gov study NCT04665050. IPD Sharing: YES. Countries: 1. Publications: 1.
Study of a Booster Dose of Meningococcal Diphtheria Toxoid Conjugate Vaccine in Adolescents
ClinicalTrials.gov study NCT00777790. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Temperature-Dependent Dynamics of Molecular Dopant in Conjugated Polymer
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Tuning transport via interaction strength in cationic conjugated polyelectrolytes
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A streamlined approach for fluorescence labelling of low copy-number plasmids for determination of conjugation frequency by flow cytometry
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Data for: A cell surface-binding antibody atlas nominates a MUC18-directed antibody-drug conjugate for targeting melanoma
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Tuning interdomain conjugation toward in situ population modification in yeasts
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Resonant Soft X-ray Scattering Reveals the Distribution of Dopants in Semicrystalline Conjugated Polymers
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Data from: Charge state-dependent ion condensation near conjugated polymer backbones
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Data from: Electrostatic complexation of conjugated and bottlebrush polyelectrolytes forms printable conductive inks
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Data from: Aquatic animals promote antibiotic resistance gene dissemination in water via conjugation: role of different regions within the zebra fish intestinal tract, and impact on fish intestinal microbiota
The aqueous environment is one of many reservoirs of antibiotic resistance genes (ARGs). Fish, as important aquatic animals which possess ideal intestinal niches for bacteria to grow and multiply, may ingest antibiotic resistance bacteria from aqueous environment. The fish gut would be a suitable environment for conjugal gene transfer including those encoding antibiotic resistance. However, little is known in relation to the impact of ingested ARGs or antibiotic resistance bacteria (ARB) on gut microbiota. Here, we applied the cultivation method, qPCR, nuclear molecular genetic marker and 16S rDNA amplicon sequencing technologies to develop a plasmid-mediated ARG transfer model of zebrafish. Furthermore, we aimed to investigate the dissemination of ARGs in microbial communities of zebrafish guts after donors carrying self-transferring plasmids that encode ARGs were introduced in aquaria. On average, 15% of faecal bacteria obtained ARGs through RP4-mediated conjugal transfer. The hindgut was the most important intestinal region supporting ARG dissemination, with concentrations of donor and transconjugant cells almost 25 times higher than those of other intestinal segments. Furthermore, in the hindgut where conjugal transfer occurred most actively, there was remarkable upregulation of the mRNA expression of the RP4 plasmid regulatory genes, trbBp and trfAp. Exogenous bacteria seem to alter bacterial communities by increasing Escherichia and Bacteroides species, while decreasing Aeromonas compared with control groups. We identified the composition of transconjugants and abundance of both cultivable and uncultivable bacteria (the latter accounted for 90.4%–97.2% of total transconjugants). Our study suggests that aquatic animal guts contribute to the spread of ARGs in water environments.
Data from: Amphotericin B-conjugated polypeptide hydrogels as a novel innovative strategy for fungal infections
The present work is focused on design and development of novel Amphotericin B-conjugated biocompatible and biodegradable poly-peptide hydrogels to improve the antifungal activity. Using three kinds of promoting self-assembly groups (2-naphthalene acetic acid, Naproxen and Dexamethasone) and poly-peptide sequence (Phe-Phe-Asp-Lys-Tyr, FFDKY), we successfully synthesized the Nap-FFDK (AmB) Y gels, Npx-FFDK (AmB) Y gels and Dex-FFDK (AmB) Y gels. The Amphotericin B-conjugated hydrogelators are highly soluble in different aqueous solutions. The Cryo-transmission electron microscopy (TEM) and scanning electron microscopy (SEM) micrographs of hydrogels afford nanofibers with width of 20~50 nm. Powder X-ray diffraction (PXRD) analyses demonstrate that the crystalline structure of the AmB and Dex are changed into amorphous structure after formation of hydrogels. Circular dichroism (CD) spectra of the solution of blank carriers and the corresponding drug deliveries further help elucidate the molecular arrangement in gel phase, indicating the existence of turn features. The in vitro drug releases suggest that the Amphotericin B-conjugated hydrogels are suitable as drug-controlled release vehicles for hydrophobic drug. The antifungal effect of AmB-conjugated hydrogels significantly exhibits the antifungal activity against Candida albicans. The results of present study indicated that the Amphotericin B-conjugated hydrogels are suitable carriers for poorly water soluble drugs and for enhancement of therapeutic efficacy of antifungal drugs.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.