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1,808 results for “dendritic cells”
Dendritic integration in olfactory bulb granule cells upon simultaneous multi-spine activation: Low thresholds for non-local spiking activity
<p class="CxSpFirst">The inhibitory axonless olfactory bulb granule cells form reciprocal dendrodendritic synapses with mitral and tufted cells via large spines, mediating recurrent and lateral inhibition. As a case in point for dendritic transmitter release, rat granule cell dendrites are highly excitable, featuring local Na<sup>+</sup> spine spikes and global Ca<sup>2+</sup>- and Na<sup>+</sup>-spikes. To investigate the transition from local to global signaling we performed holographic, simultaneous two-photon uncaging of glutamate at up to twelve granule cell spines, along with whole-cell recording and dendritic two-photon Ca<sup>2+</sup> imaging in acute juvenile rat brain slices. Coactivation of less than ten reciprocal spines was sufficient to generate diverse regenerative signals that included regional dendritic Ca<sup>2+</sup>-spikes and dendritic Na<sup>+</sup>-spikes (D-spikes). Global Na<sup>+</sup>-spikes could be triggered in one third of granule cells. Individual spines and dendritic segments sensed the respective signal transitions as increments in Ca<sup>2+</sup> entry. Dendritic integration as monitored by the somatic membrane potential was mostly linear until a threshold number of spines was activated, where often D-spikes along with supralinear summation set in. As to the mechanisms supporting active integration, NMDA receptors strongly contributed to all aspects of supralinearity, followed by dendritic voltage-gated Na<sup>+</sup>- and Ca<sup>2+</sup>-channels, whereas local Na<sup>+</sup> spine spikes as well as morphological parameters barely mattered.</p> <p>Because of the low numbers of coactive spines required to trigger dendritic Ca<sup>2+</sup> signals and thus possibly lateral release of GABA onto mitral and tufted cells, we predict that thresholds for granule cell-mediated bulbar lateral inhibition are low. Moreover, D-spikes could provide a plausible substrate for granule cell-mediated gamma oscillations.</p>
raw data - Regulatory T cells and plasmacytoid dendritic cells in drug rash with eosinophilia and systemic symptoms VS maculopapular drug eruption
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DENDRITIC CELL EFFECT TO cbavd
<p>This is the statistic of test result </p>
treatment using dendritic cell for CBAVD
<p>This is the statistic result of treatemnet of patients with CBAVD using dendritic cells</p>
Data from: Weak sinusoidal electric fields entrain spontaneous Ca transients in the dendritic tufts of CA1 pyramidal cells in rat hippocampal slice preparations
Neurons might interact via electric fields and this notion has been referred to as ephaptic interaction. It has been shown that various types of ion channels are distributed along the dendrites and are capable of supporting generation of dendritic spikes. We hypothesized that generation of dendritic spikes play important roles in the ephaptic interactions either by amplifying the impact of electric fields or by providing current source to generate electric fields. To test if dendritic activities can be modulated by electric fields, we developed a method to monitor local Ca-transients in the dendrites of a neuronal population in acute rat hippocampal slices by applying spinning-disk confocal microscopy and multi-cell dye loading technique. In a condition in which the dendrites of CA1 pyramidal neurons show spontaneous Ca-transients due to added 50 μM 4-aminopyridine to the bathing medium and adjusted extracellular potassium concentration, we examined the impact of sinusoidal electric fields on the Ca-transients. We have found that spontaneously occurring fast-Ca-transients in the tufts of the apical dendrites of CA1 pyramidal neurons can be blocked by applying 1 μM tetrodotoxin, and that the timing of the transients become entrained to sub-threshold 1-4 Hz electric fields with an intensity as weak as 0.84 mV/mm applied parallel to the somato-dendritic axis of the neurons. The extent of entrainment increases with intensity below 5 mV/mm, but does not increase further over the range of 5-20 mV/mm. These results suggest that population of pyramidal cells might be able to detect electric fields with biologically relevant intensity by modulating the timing of dendritic spikes.
Dendritic Cell Therapy With Pembrolizumab for Metastatic or Unresectable Melanoma
ClinicalTrials.gov study NCT03325101. IPD Sharing: YES. Countries: 1. Publications: 0.
A Comparison of Dendritic Cell Content and T-Cell Phenotype Between Granulocyte Colony-Stimulating Factor (G-CSF) or G-CSF + Granulocyte Macrophage (GM)-CSF
ClinicalTrials.gov study NCT00208949. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Multi-Epitope TARP Peptide Autologous Dendritic Cell Vaccination in Men With Stage D0 Prostate Cancer
ClinicalTrials.gov study NCT02362451. IPD Sharing: YES. Countries: 1. Publications: 0.
Polarized Dendritic Cell (aDC1) Based Treatment, Interferon Alpha-2, Rintatolimod, and Celecoxib for the Treatment of HLA-A2+ Refractory Melanoma
ClinicalTrials.gov study NCT04093323. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cyclophosphamide, TAPA-Pulsed Dendritic Cell Therapy and Imiquimod in Progressive and/or Refractory Solid Malignancies
ClinicalTrials.gov study NCT02224599. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Neurofilament Light Chain ,Chitinase-3 Like-1 Proteins and Plasmacytoid Dendritic Cells in Multiple Sclerosis
ClinicalTrials.gov study NCT05451069. IPD Sharing: UNDECIDED. Countries: 0. Publications: 14.
Dendritic Cell Vaccination and Docetaxel for Patients With Prostate Cancer
ClinicalTrials.gov study NCT01446731. IPD Sharing: NO. Countries: 1. Publications: 0.
Dendritic Cell (DC)-Based Vaccines Loaded With Allogeneic Prostate Cell Lines in Combination With Androgen Ablation in Patients With Prostate Cancer
ClinicalTrials.gov study NCT00970203. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Augmentation of Dendritic Cell-Based Vaccines in Melanoma Patients by Depletion of Regulatory T Cells in Stage IV Melanoma Patients
ClinicalTrials.gov study NCT00847106. IPD Sharing: Not stated. Countries: 0. Publications: 8.
Dendritic Cells (DC) Vaccine for Metastatic Melanoma
ClinicalTrials.gov study NCT01042366. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Phase 1 Study of Vaccination With Dendritic Cell (DC)/Multiple Myeloma (MM) Fusions in Combination With Elranatamab in Relapsed or Refractory Multiple Myeloma
ClinicalTrials.gov study NCT06799026. IPD Sharing: YES. Countries: 1. Publications: 0.
Safety Study Of Chemotherapy Combined With Dendritic Cell Vaccine to Treat Breast Cancer
ClinicalTrials.gov study NCT02018458. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Dendritic Cell Vaccination in Patients With Advanced Melanoma
ClinicalTrials.gov study NCT03092453. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Cytomegalovirus (CMV) RNA-Pulsed Dendritic Cells for Pediatric Patients and Young Adults With WHO Grade IV Glioma, Recurrent Malignant Glioma, or Recurrent Medulloblastoma
ClinicalTrials.gov study NCT03615404. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Pilot Study Assessing Intra-Metastasis Administration of Autologous KLH-pulsed Dendritic Cells With Tumoral Radiation Therapy in Patients With Metastatic Pancreatic Carcinoma
ClinicalTrials.gov study NCT00843830. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.