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176
datasets available to search
ShareScore release 0.9.0
Dataset results
176 results for “gene fusion”
The novel ZBTB5::JAK2 fusion gene reveals a new mechanism of kinase activation in Ph-like acute lymphoblastic leukemia
GEO Series GSE296703. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
A novel gene fusion RUNX1/ZNF423 promotes leukemic relapse of NUP98-rearranged AML
GEO Series GSE222098. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Expanded Access to Provide Selitrectinib for the Treatment of Cancers With a NTRK Gene Fusion
ClinicalTrials.gov study NCT03206931. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Expanded Access to Provide Larotrectinib for the Treatment of Cancers With a NTRK Gene Fusion
ClinicalTrials.gov study NCT03025360. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Afatinib (GILOTRIF®) in Patients Suffering From Tumors Harboring Neuregulin 1 (NRG1) Gene Alterations (Specifically NRG1 Gene Fusion-positive Advanced Solid Tumors)
ClinicalTrials.gov study NCT05107193. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Effect of knockdown PHF8 on the transcriptional regulation of BCR-ABL1 fusion gene on CML cell line K562
GEO Series GSE235463. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
T47D cell line transfected with various ESR1 fusion genes (or with estrogen treatment), vs. YFP transfection alone
GEO Series GSE69774. Homo sapiens. 37 samples. Type: Expression profiling by array.
Vanished MDM2 amplification in a poorly differentiated sarcoma with amplified TERT-TRIO fusion gene: a targeted effect of radiotherapy?
GEO Series GSE200434. Homo sapiens. 4 samples. Type: Genome variation profiling by SNP array.
RBPJ::ALK : a novel fusion gene amplified in a metastatic sarcomatoid chromophobe renal cell carcinoma
GEO Series GSE224415. Homo sapiens. 3 samples. Type: Genome variation profiling by SNP array.
Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas
GEO Series GSE77205. Homo sapiens; Mus musculus. 35 samples. Type: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing.
PML-RARA fusion gene requires Dnmt3a to induce acute promyelocytic leukemia in mice
GEO Series GSE68844. Mus musculus. 19 samples. Type: Expression profiling by array.
RNA_seq Analysis of Murine Leukemias for Identifying Potential Leukemia Fusion Targets and JAK1 regulated genes
GEO Series GSE164181. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
A novel gene fusion RUNX1/ZNF423 promotes leukemic relapse of NUP98-rearranged AML [RNAseq]
GEO Series GSE221767. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
The leukemia-specific fusion gene ETV6/RUNX1 perturbs distinct key biological functions primarily by gene repression
Background: ETV6/RUNX1 (E/R) (also known as TEL/AML1) is the most frequent gene fusion in childhood acute lymphoblastic leukemia (ALL) and also most likely the crucial factor for disease initiation, whereas its role in leukemia propagation and maintenance remains largely elusive. To address this issue we performed a shRNA-mediated knock-down (KD) of the E/R fusion gene and investigated the ensuing consequences on genome-wide gene expression patterns and deducible regulatory functions in two E/R-positive leukemic cell lines. Findings: Microarray analyses identified 777 genes whose expression was substantially altered. Although approximately equal proportions were either up- (KD-UP) or down-regulated (KD-DOWN), the effects on biological processes and pathways differed considerably. The E/R KD-DOWN set was significantly enriched for genes included in the cell activation, immune response, apoptosis, signal transduction and development and differentiation categories, whereas in the E/R KD-UP set only the PI3K/AKT/mTOR signaling and hematopoietic stem cells categories became evident. Comparable expression signatures obtained from primary E/R-positive ALL samples underline the relevance of these pathways and molecular functions. We also validated six differentially expressed genes representing the categories stem cell properties, B-cell differentiation, immune response, cell adhesion and DNA damage with RT-qPCR. Conclusion: The results of our analyses provide the first preliminary evidence that the continuous expression of the E/R fusion gene interferes with regular B-cell development by repressing key functions that are necessary under physiological circumstances. E/R may thus constitute also the essential driving force for the propagation and maintenance of the leukemic process irrespective of potential consequences of associated secondary changes. Finally, these findings may also provide a valuable source of potentially attractive therapeutic targets.
Transcriptomic analysis and fusion gene identification of Exos, MPs, MBRs
GEO Series GSE244455. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Gene Expression Profiling of Fusion Negative Rhabdomyosarcoma Cell Lines
GEO Series GSE84629. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.