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3,584 results for “genomic analysis”
High‐resolution genomic analysis of four local Vietnamese chicken breeds
<p>A total of 96 individuals were sampled from four populations of Vietnamese local chickens (28 Ho, 32 Dong Tao, 18 Mong, and 18 Mia) distributed in four provinces (Bac Ninh, Hung Yen, Ha Nam, and Hanoi, respectively) in the North of Vietnam. All individuals were from the same conservation program in Vietnam, originating from either private farms or public institutions involved in this program. Neither pedigree nor phenotypic information was available. We used stratified sampling for flocks, ensuring a distance of at least 500 m between the selected flocks and random sampling of one or two individuals in each selected flock. Genomic DNA was extracted from the blood samples of all chickens. The HD array for chickens allows for the simultaneous genotyping of approximately 580,000 SNPs. This array comprises SNPs on 28 autosomal chromosomes, two sex chromosomes (Z and W for poultry), and two linkage groups (LGE64 and LGE 22C19W28). Only SNPs on the 28 autosomes were considered in the present study. The SNPs with more than 10% missing genotypes or minor allele frequencies lower than 1% were removed, yielding a consensus panel of 454,297 autosomal SNPs for the analysis of population genetic structure.</p> <p>We applied a second quality control within each breed. Specifically, SNPs with within-breed minor allelic frequencies lower than 0.05 or SNPs with significant (P < 0.0001) deviation from the Hardy-Weinberg equilibrium were filtered out. This second filter led to 368,652, 383,792, 405,535, and 432,631 SNPs for Ho, Dong Tao, Mong, and Mia breeds, respectively. Of note, removing monomorphic SNPs within breeds may lead to the elimination of SNPs that are polymorphic across breeds. Due to the large number of available SNPs, we did not consider the potential effect of these filtered markers as important for subsequent analyses. Genetic diversity analyses were performed on the remaining 308,307 SNPs shared by all four breeds.</p>
Key files for: Comparative genomic analysis of Microcystis strain diversity using conserved marker genes
<p>Key data outputs to accompany the manuscript "Comparative genomic analysis of Microcystis strain diversity using conserved marker genes"</p>
Comparative genomic analysis of chemosensory-related gene families in gastropods
<p>Chemoreception is critical for the survival and reproduction of animals. Except for a reduced group of insects and spiders, the molecular identity of chemosensory proteins is poorly understood in invertebrates. Gastropoda is the extant mollusk class with the greatest species richness, including marine, freshwater, and terrestrial lineages, and likely, highly diverse chemoreception systems. Here, we performed a comprehensive comparative genome analysis taking advantage of the chromosome-level information of two Gastropoda species, one of which belongs to a lineage that underwent a whole genome duplication event. We identified thousands of previously uncharacterized chemosensory-related genes, the majority of them encoding G protein-coupled receptors (GPCR), mostly organized into clusters distributed across all chromosomes. We also detected gene families encoding degenerin epithelial sodium channels (DEG-ENaC), ionotropic receptors (IR), sensory neuron membrane proteins (SNMP), Niemann–Pick type C2 (NPC2) proteins, and lipocalins, although much smaller in size. Our phylogenetic analysis of the GPCR gene family across protostomes revealed: (i) large gene family expansions in Gastropoda; (ii) clades including members from all protostomes; and (iii) species-specific clades with a huge number of receptors. For the first time, we provide new and valuable knowledge into the evolution of the chemosensory gene families in invertebrates other than arthropods.</p>
Sources of coaster brook trout (Salvelinus fontinalis) revealed by genomic analysis of brook trout populations along Minnesota's shoreline with Lake Superior
<p>Knowledge of population-level relationships and how these relationships pertain to different life history forms is critical to developing effective management plans for native trout, char, and salmon. In the Lake Superior basin, identifying effective restoration strategies for coaster brook trout (<em>Salvelinus</em> <em>fontinalis</em>), a lake-inhabiting form of brook trout, is hampered by limited information on genetic connectivity and source-sink dynamics among brook trout populations. Here, we infer these relationships by surveying 8,178 single nucleotide polymorphisms in 234 brook trout from seven rivers along the Minnesota shoreline with Lake Superior, including from reaches above and below natural waterfalls that prevent upstream movement. We identified well-differentiated above-barrier populations that supply brook trout to below-barrier reaches. We also compared within-river brook trout to 26 coaster brook trout from Lake Superior. We identified at least four source populations for these coaster brook trout, three of which were located within rivers. Additionally, we estimated N<sub>E</sub> for within-river populations and detected a decline across recent generations, with the most recent estimates approaching critical thresholds. Finally, comparisons with 94 domestic brook trout representing nine hatchery strains revealed a lack of domestic introgression into wild populations, demonstrating the importance of natural reproduction to population persistence. Our results offer novel insights into sources of coaster brook trout and highlight the role of within-river populations in supporting the coaster life history. Management efforts focused on instream restoration may be more important to rehabilitating coaster brook trout than previously thought, and are urgently needed given the population-level conservation status reported here.</p>
Population genomic analysis of an emerging pathogen Lonsdalea quercina affecting various species of oaks in western North America
<p>Previously unrecognized diseases continue to threaten the health of forest ecosystems globally. Understanding processes leading to disease emergence is important for effective disease management and prevention of future epidemics. Utilizing whole genome sequencing, we studied the phylogenetic relationship and within diversity of two populations of the bacterial oak pathogen <em>Lonsdalea</em> <em>quercina</em> from western North America (Colorado and California) and compared these populations to other <em>Lonsdalea</em> species found worldwide. Phylogenetic analysis separated Colorado and California populations into two well-supported clades within the genus <em>Lonsdalea</em>, with an average nucleotide identity between them near species boundaries (95.31%) for bacteria, suggesting long isolation. Populations comprise distinct patterns in genetic structure and distribution. Genotypes collected from different host species and habitats were randomly distributed within the California cluster, while most Colorado isolates from introduced planted trees were distinct from isolates collected from a natural stand of CO native <em>Q. gambelii,</em> indicating the presence of cryptic population structure. The distribution of clones in California varied, while Colorado clones were always collected from neighboring trees. Despite its recent emergence, the Colorado population had higher nucleotide diversity, possibly due to migrants moving with nursery stock. Overall results suggest independent pathogen emergence in two states likely driven by changes in host-microbe interactions due to ecosystem conditions changing. To our knowledge, this is the first study on <em>L. quercina</em> population structure. Further studies are warranted to understand evolutionary relationships among <em>L. quercina</em> populations from different areas, including the native habitat of red oak in northeastern USA.</p>
Genomic analysis of geographical structure and diversity in the capercaillie (Tetrao urogallus)
<p>The capercaillie is widespread throughout the boreal forests of northern Eurasia but faces serious conservation challenges in the southernmost mountain ranges, where the populations are fragmented and some are critically endangered. To develop effective conservation strategies for these populations, it is essential to have information on both their genetic diversity and the genetic structure of the species. In this work, we used a reduced representation (ddRAD) genomic sequencing technique to analyze the genetic structure of the capercaillie across its European range and to assess the inbreeding levels in some of the most threatened populations. Our population structure analysis suggested the existence of two evolutionarily significant units, one formed by the two populations from the Iberian Peninsula and the other by the populations from the rest of Europe. Genetic diversity showed a significant decrease in the Iberian populations with respect to the other European populations. An isolation-with-migration model supported these results and allowed us to estimate the parameters of the population tree. The inbreeding coefficients estimated for the Iberian capercaillies showed relatively low levels in the Pyrenees. However, some individuals with very high inbreeding values were detected in the Cantabrian Mountains, suggesting that some of its subpopulations are substantially isolated. The population structure results and the genomic monitoring method we used to assess inbreeding levels may be crucial for the conservation and recovery of the most endangered capercaillie populations.</p>
Polytomous radiation revealed in phylogenomic analysis of Allium (Amaryllidaceae) plastid genomes
<p>Alignment of 115 <em>Allium </em>chloroplast genomes plus three outgroups with all sites with missing data masked.</p>
Analysis of genome-wide DNA arrays reveals the genomic population structure and diversity in autochthonous Greek goat breeds
<p>Genotyping data in ped and map format (ped/map) for 72 goats and 53,347 genotypes.</p>
Lifecourse genome-wide association study meta-analysis refines the critical life stages for adiposity’s influence on breast cancer risk
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Comprehensive analysis of mRNA 3′ ends during early zebrafish development reveals dynamics of 3′UTR changes on a genome-wide scale
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Data from: Analysis of chloroplast genomes of ten Central Asian Fritillaria species and their phylogenetic relationships
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Genome content flat files for comparative genomic analysis of seadragons and relatives
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Data from: Assembling microbial communities: a genomic analysis of a natural experiment in neotropical bamboo internodes
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Data from: Genomic analysis of a cardinalfish with larval homing potential reveals genetic admixture in the Okinawa Islands
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Data from: Genomic analysis reveals hidden biodiversity within colugos, the sister group to primates
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Comparative chloroplast genome and phylogenetic analysis of Central Asian Tulips
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High‐resolution genomic analysis of four local Vietnamese chicken breeds
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VCF datasets and analysis scripts for: The combination of genomic offset and niche modelling provides insights into climate change-driven vulnerability
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Methodological challenges in the genomic analysis of an endangered mammal population with low genetic diversity
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Data from: Whole-genome analysis of Mustela erminea finds that pulsed hybridization impacts evolution at high-latitudes
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.