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175 results for “lipidomic”
Lipin-1 inhibition alters the transcriptome and lipidome of castration-resistant prostate cancer cells
GEO Series GSE247919. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Integrative analysis of the lipidome and transcriptome in Chinese Kazakh patients with esophageal squamous cell carcinoma
GEO Series GSE253171. Homo sapiens; solid waste metagenome. 6 samples. Type: Non-coding RNA profiling by array.
Transcriptomic and lipidomic analyses unravel the responses of Faecalibacterium prausnitzii to calcium palmitate
GEO Series GSE225701. Faecalibacterium prausnitzii. 12 samples. Type: Expression profiling by high throughput sequencing.
Coordinated changes of gut microbiome and lipidome differentiates nonalcoholic steatohepatitis (NASH) from isolated steatosis
GEO Series GSE126790. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
MASLD metabolomics -- SWATH -- ReversePhase -- Lipidomics
<p>We analyzed liver tissues, liver secretome (conditioned medium), and blood plasma samples from 109 obese patients undergoing bariatric surgery spanning early stages of metabolic dysfunction-associated steatotic liver diseases (MASLD). We used a combination of data-dependent acquisition (DDA) and data-independent acquisition (DIA or SWATH-MS) on SCIEX TripleTOF 6600.</p> <p>Metabolites and lipids were extracted using modified chloroform-methanol biphasic extraction methods for both biological matrices. Organic and aqueous fractions were separated using RRHD Eclipse Plus C18 and SeQuant ZIC-cHILIC columns prior to DDA and DIA acquisitions, respectively.</p> <p>All mzML files are deposited with ZENODO.</p> <p>*** RP - Lipids - SWATH is deposited in this dataset repository ***</p>
Human IVD lipidomics
<p>Human intervertebral disc cells lipidomic LC-MS dataset.</p>
Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodelling.
GEO Series GSE290509. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
LC/MS-Based Lipidomics and Transcriptomics Reveal Lipid Diversity and Regulatory Networks Underlying Intramuscular Fat Differences in Xingguo Grey Geese
GEO Series GSE291139. Anser cygnoides. 12 samples. Type: Expression profiling by high throughput sequencing.
Low input lipidomics analysis reveals remodeling of lipid metabolism and saturation during mouse and human preimplantation embryo development
GEO Series GSE213782. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Sub-5 min RP-UHPLC-TIMS for high-throughput untargeted lipidomics and its application to multiple matrices
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Dataset related to the article "Lipidomics analysis of monocytes from patients with acute myocardial infarction reveals lactosylceramide as a new player in monocyte migration"
<p>this record contains raw data related to the article " Lipidomic analysis of monocytes from patients with acute myocardial infarction reveals lactosylceramide as a new player in monocyte migration,"</p> <p>Abstract. Monocyte recruitment after vascular injury and their migration through the vessel wall represent crucial events in the initiation, progression, and destabilization of atherosclerotic plaque. Circulating monocytes are exposed to stimuli that alter their physiological state, and among them, lipids play a key role. Several studies investigated the mechanisms by which lipids affect monocyte functions promoting coronary atherosclerotic plaque initiation, but information on the relationship between lipid composition and function of monocyte is scant. We aimed at studying the migration of circulating monocytes isolated from patients with acute myocardial infarction (AMI) at hospital presentation and investigating its correlation with cellular lipid profile. The migration of monocytes was tested using both fetal bovine serum (FBS) and autologous serum as chemoattractant stimuli. Monocyte lipid profile was evaluated through an untargeted lipidomics approach, using a liquid chromatography/time-of-flight mass spectrometry platform. We observed that AMI patients' monocytes showed a significant increase in FBS and autologous serum-mediated migration compared to controls. Moreover, a different monocyte lipidomic profile between the two study groups was detected. In particular, AMI patients' monocytes showed an altered composition in ceramides, with an increase in lactosylceramide and in phospholipids (ie, phosphatidylethanolamine and lisophosphatidylethanolamine). Of note, a positive correlation between lactosylceramide levels and monocyte migration was observed. Furthermore, the lactosylceramide synthase inhibition significantly reduced FBS-induced monocyte migration. Our results highlight the influence of lactosylceramide on the monocyte migration capacity, pointing out a new possible mechanism of lipids in the onset of atherothrombosis and, hence, in AMI.</p>
Lipidomic data
<p>Lipidomic data SH-SY5Y KO -SPG11, SPG15, SPG31</p>
Lipidomics in Rett Syndrome Patients
<p>Lipidomics analysis of CSF and plasma samples obtained from Rett syndrome (RS) patients and controls using UHPLC-MS/MS. Raw data (Panasonic raw image) obtained from analysis in positive and negative ionisation mode. Processed results files from each sample are shown in separate excel files. </p> <p>Enclosed meta file provides sample information. </p>
Raw data to "Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome"
<p>Background: Impairments in timely resolving inflammation is now considered a key hallmark of chronic inflammation and the development of neurodegenerative diseases such as multiple sclerosis (MS). Lipoxins are among the mediators of resolution of inflammation and their role in MS is scarce.</p> <p>Results: We treated experimental autoimmune encephalomyelitis (EAE) mice, the experimental model of MS, with lipoxin A4 (LXA4) daily and intraperitoneally either mimicking a prophylactic treatment (from day 8 post immunization, namely before the acute phase) or a therapeutic treatment (from day 21 post immunization, namely at the peak of disease) and both until the end of the experiment with 100 ng/mouse of LXA4 or vehicle. When given in a prophylactic setting, LXA4 treatment significantly ameliorated EAE clinical scores (Fig.1A), counteracted the reduction in the body weight (Fig.1B) and reduced disease severity (Fig.1C) compared to EAE vehicle-treated mice. Moreover, histological examination of the spinal cord at the peak of the disease revealed a profound reduction of CD45+ inflammatory cells in LXA4-treated as compared to vehicle-treated EAE mice (Fig. 1D). However, LXA4 treatment in a therapeutic setting, slightly reduced EAE clinical scores (Fig. 1E) and did not modify body weight compared to the EAE-vehicle treaded mice (Fig.1F).</p> <p>Conclusions: These data suggest that boosting resolution of inflammation in vivo can halt clinical symptoms in experimental MS and eventually reduce or halt disease progression.</p>
Dataset for the paper Plasma metabolomics and lipidomics profiling reveal signatures of Hepatocellular carcinoma.
<p>The following dataset contains data from MS metabolome and lipidome profiling of HCV patients </p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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