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394
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ShareScore release 0.9.0
Dataset results
394 results for “oligodendrocyte”
Oligodendrocyte differentiation alters tRNA modifications and codon-dependent mRNA decay [RiboSeq]
GEO Series GSE182810. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing; Other.
RNA-seq profiles of WT and Qk-KO freshly isolated oligodendrocytes
GEO Series GSE125581. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation [ChIP-seq]
GEO Series GSE203293. Mus musculus. 14 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Oligodendrocyte progenitor cells become regionally diverse and heterogeneous with age
GEO Series GSE121083. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional convergence of oligodendrocyte lineage progenitors during development
GEO Series GSE95093. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Sequentially Acting SOX Proteins Orchestrate Astrocyte and Oligodendrocyte Specific Gene Expression
GEO Series GSE117997. Mus musculus. 19 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Genome-wide identification of target genes for the transcription factor Klf13 in differentiated primary mouse oligodendrocytes.
GEO Series GSE212736. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
The histone methyltransferases EHMT1 and EHMT2 repress the expression of genes related to excitability and cell death in oligodendrocyte progenitors [RNA-seq]
GEO Series GSE276334. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Accelerated evolution of oligodendrocytes in human brain
GEO Series GSE123936. Pan troglodytes; Macaca mulatta; Homo sapiens. 95 samples. Type: Expression profiling by high throughput sequencing.
TREX1 is required for microglial cholesterol homeostasis and subsequent oligodendrocyte maturation during brain development [bulk RNA-seq]
GEO Series GSE216702. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival.
GEO Series GSE277705. Mus musculus. 57 samples. Type: Expression profiling by high throughput sequencing.
Parvalbumin expression in oligodendrocyte-like CG4 cells causes a reduction in mitochondrial volume, attenuation in reactive oxygen species production and a decrease in cell processes' length and branching
<p>Forebrain glial cells - ependymal cells and astrocytes -acquire upon injury- a “reactive” phenotype associated with parvalbumin (PV) upregulation. Since free radicals, e.g. reactive oxygen species (ROS) play a role in the pathogenesis of multiple sclerosis, and that PV-upregulation in glial cells is inversely correlated with the level of oxidative stress, we hypothesized that PV-upregulation might also protect oligodendrocytes by decreasing ROS production. Lentiviral transduction techniques allowed for PV overexpression in CG4 oligodendrocyte progenitor cells (OPCs). Depending on the growth medium CG4 cells can be maintained in an OPC-like state, or induced to differentiate into an oligodendrocyte (OLG)-like phenotype. While increased levels of PV had no effect on cell proliferation and invasiveness <em>in vitro</em>, PV decreased the mitochondria volume in CG4 cell bodies, as well as the mitochondrial density in CG4 processes in both OPC-like and OLG-like states. In line with the PV-induced global decrease in mitochondrial volume, elevated PV levels reduced transcript levels of mitochondrial transcription factors involved in mitochondria biogenesis. In differentiated PV-overexpressing CG4 cells with a decreased mitochondrial volume, UV-induced ROS production was lower than in control CG4 cells hinting towards a possible role of PV in counteracting oxidative stress. Unexpectedly, PV also decreased the length of processes in undifferentiated CG4 cells and moreover diminished branching of differentiated CG4 cell processes, strongly correlated with the decreased density of mitochondria in CG4 cell processes. Thus besides conferring a protective role against oxidative stress, PV in a cell autonomous fashion additionally affects process’ growth and branching in CG4 cells.</p>
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participants With Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease
ClinicalTrials.gov study NCT05271409. IPD Sharing: YES. Countries: 11. Publications: 0.
UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells
ClinicalTrials.gov study NCT02254863. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Reduced Oligodendrocyte-specific Cytotoxicity and Ofatumumab Treatment
ClinicalTrials.gov study NCT05171972. IPD Sharing: NO. Countries: 1. Publications: 0.
Oligodendrocyte Progenitor Cell Culture From Human Brain
ClinicalTrials.gov study NCT00283023. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety and Efficacy of Tocilizumab in Patients With Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease
ClinicalTrials.gov study NCT06452537. IPD Sharing: NO. Countries: 1. Publications: 0.
RNA-seq profiles of WT and Qk-KO corpus callosum and oligodendrocytes
GEO Series GSE106468. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile in the mouse primary oligodendrocytes during the differentiation
GEO Series GSE228241. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation [RNA-seq]
GEO Series GSE203294. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.