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Fig 3 in An activity-integrated strategy of the identification, screening and determination of potential neuraminidase inhibitors from Radix Scutellariae
Fig 3. Chromatogram of activity-integrated fingerprints of RS extracts. Chromatography (A) and total ion chromatography (B) of 26 compounds with NA inhibitory activity. Colored bar means the fraction collection purity> 98%. https://doi.org/10.1371/journal.pone.0175751.g003
Fig 2 in An activity-integrated strategy of the identification, screening and determination of potential neuraminidase inhibitors from Radix Scutellariae
Fig 2. Typical chromatogram. (A) RS extracts, (B) 9 standards mixture. Scutellarin (5), scutellarein (10), baicalin (11), chrysin-7-Oglucuronide (15), baicalein (19), wogonoside (22), wogonin (23), chrysin (24) and oroxylin A (25). https://doi.org/10.1371/journal.pone.0175751.g002
Fig 1 in An activity-integrated strategy of the identification, screening and determination of potential neuraminidase inhibitors from Radix Scutellariae
Fig 1. The principle of an activity integrated strategy method. The UPLC system with auto-fraction was used to separate, quantify collect and enrich the active compounds in fraction were performed by an. The fractions were used to test the bioactive analysis. https://doi.org/10.1371/journal.pone.0175751.g001
Fig 5 in An activity-integrated strategy of the identification, screening and determination of potential neuraminidase inhibitors from Radix Scutellariae
Fig 5. The cellular toxicity of baicalin, baicalein, wogonoside and wogonin. PLF and HIEC-6 cells were treated with indicated drugs with different concentrations as indicated for 24 hours and collected to evaluate cellular viability. https://doi.org/10.1371/journal.pone.0175751.g005
Fig 4 in An activity-integrated strategy of the identification, screening and determination of potential neuraminidase inhibitors from Radix Scutellariae
Fig 4. The NA inhibitory activity of compounds isolated from RS. The IC50 of Radix scutellariae extract scutellarin, scutellarein, baicalin, baicalein, wogonoside, wogonin, chrysin-7-O-glucuronideand chrysin by an NA inhibitory screening kit. https://doi.org/10.1371/journal.pone.0175751.g004
Dataset for RNA-binding protein FUS antibody screening study
<p><strong>This antibody characterization dataset is related to the F1000 research article openly available at F1000Research.</strong></p> <p><em>This project contains the following underlying data included in a study aiming at characterizing antibodies for the RNA-binding protein FUS protein. Version 2 contains the FUS FSC file describing the experimental set up used for the Flow Cytometry experiment. The original study is also available on the Zenodo YCharOS community (<a href="https://doi.org/10.5281/zenodo.5259945">https://doi.org/10.5281/zenodo.5259945</a>).</em></p>
Data for Stable isotope composition of long and short term carbon pools can screen drought tolerance in cassava
<p>This repository contains data and scripts to reproduce results that are presented in the article: Van Laere, J., Martinez Maya, M.A., Selvaraj M.G., Becerra Lopez-Lavalle, L.A., Guzman, D., Casas, J.A., Merckx, R., Hood-Nowotny, R., Dercon, G. (2024)<strong> Stable isotope composition of long and short term carbon pools can screen drought tolerance in cassava</strong>. <em>Field Crops Research. </em>https://doi.org/10.1016/j.fcr.2024.109586</p>
A scalable CRISPR-Cas9 gene editing system facilitates CRISPR screens in the malaria parasite Plasmodium berghei - sequencing data
<p>This holds raw sequencing data, and extracted sgRNA counts </p>
UV mutagenesis conjugated to high throughput screening as a tool to generate new phenotypic diversity in wine yeast
<p><strong>The current global changes, societal and climatic, strongly challenge the wine industry. Multiple methods are applied in the development of new strains for the industry, but many are based on the existing phenotypic and genetic diversities. UV mutagenesis, as an untargeted strategy, has been successfully used for years, with significant examples on wine. Here we developed and validated a UV-mutant generation strategy coupled with a high throughput screening in wine-like conditions. This strategy led to the production of a 502 mutant’s library for which concentrations of eight primary metabolites after fermentation were assessed. This data paper presents the resulting data.</strong></p>
Data and scripts used in the paper entitled "Led Color Gradient As A New Screening Tool For Rapid Phenotyping Of Plant Responses To Light Quality" by Pierre LEJEUNE et al.
<p>Images, script and data used in the paper entitled "Led Color Gradient As A New Screening Tool For Rapid Phenotyping Of Plant Responses To Light Quality" by Pierre LEJEUNE, Anthony FRATAMICO, Frédéric BOUCHÉ, Samuel HUERGA-FERNÁNDEZ, Pierre TOCQUIN, Claire PÉRILLEUX</p>
BonMOLière: Small-Sized Libraries of Readily Purchasable Compounds, Optimized to Produce Genuine Hits in Biological Screens across the Protein Space
<p>BonMOLière is a set of small-sized libraries of readily purchasable compounds, optimized to produce genuine hits in biological screens across the protein space. The corresponding research article has been published in <em>Int. J. Mol. Sci.</em> 2021, 22(15), 7773, DOI: <a href="https://doi.org/10.3390/ijms22157773">https://doi.org/10.3390/ijms22157773</a></p>
In silico study for screening of natural phytochemicals and metformin as a potential inhibitor of interleukin 6 as target for covid-19
<p>Interleukin 6 is considered the corner stone at treatment of covid-19 specially the severe cases and it is the marker of severe inflammation and the gate of cytokine storm , so the future studies for this important proinflammatory cytokine storm , the first target for speed recovery from sars cov2 it is overcoming this cytokine which is immune response to virus , it is responsible about the fever and most sypmtoms of severity of covid-19 also may has role at smell and taste , so this study target this interleukin-6 by discovering natural potential inhibitors of IL-6. We do molecular docking for some natural phytochemicals like EGCG , bromelain , luteolin , vitexin and isovitexin , in adding to metformin and polyetheylene glycocl </p>
Data set: Genome scale CRISPR Cas9a knockout screen reveals genes that controls glioblastoma susceptibility to the alkylating agent temozolomide (TMZ).
<p>Glioblastoma is the deadliest of all primary brain tumor with a very poor survival outcome. Alkylating agent such as temozolomide is used as a mainstay drug used in treating of glioblastoma patients including radiation, tumor treating field and surgery. However, this drug offers little to no benefit for the glioblastoma patients. Hence, the objective of the generation of this data is to understand and unravel genes that controls glioblastoma susceptibility and resistance to temozolomide using an unbiased genome scale CRISPR Cas9a knockout screen</p>
Dataset: Wood retention at inclined bar screens: effect of wood characteristics on backwater rise and bedload transport
<p>This dataset includes flow and bedload transport measurements and wood accumulation characteristics of flume experiments conducted at the Laboratory of Hydraulics, Hydrology and Glaciology (VAW), ETH Zurich.</p>
A suspect screening list of 1310 persistent and mobile (PM) candidates
<p>PM Suspect List from UFZ and HSF</p>
Arabidopsis HapMap screen for salt-induced changes in root:shoot ratio - data for all experimental batches
<p>Quantified root and shoot area of the 360 Arabidopsis accessions exposed to salt stress / control treatment. The data were collected during PhD of Magdalena Julkowska at University of Amsterdam, under supervision of Dr. Christa Testerink. The quantification of root system architecture was performed at University of Amsterdam, under supervision of Dr. Christa Testerink, and was used for the publication of Julkowska et al., 2017 (<a href="https://doi.org/10.1105/tpc.16.00680">https://doi.org/10.1105/tpc.16.00680</a>). The quantification of the root and shoot data was performed with custom developed tool at King Abdullah University of Science and Technology, during Magdalena Julkowska's Postdoc, under supervision of Dr. Mark Tester. </p>
Arabidopsis HapMap screen for salt-induced changes in root architecture and root:shoot ratio - images BA4 experiment
<p>Images of scanned agar plates collected for Arabidopsis accessions exposed to salt stress / control treatment. The data were collected during PhD of Magdalena Julkowska at University of Amsterdam, under supervision of Dr. Christa Testerink. </p>
Arabidopsis HapMap screen for salt-induced changes in root architecture and root:shoot ratio - images BA5 experiment
<p>Images of scanned agar plates collected for Arabidopsis accessions exposed to salt stress / control treatment. The data were collected during PhD of Magdalena Julkowska at University of Amsterdam, under supervision of Dr. Christa Testerink. </p>
Screen of Arabidopsis mutants homologous to Cowpea GWAS peaks
<p>This dataset was collected for T-DNA insertion mutants of Arabidopsis that were selected based on the sequence homology with the candidate genes in cowpea (<em>Vigna unguiculata</em>) identified through GWAS for drought induced changes in growth, evapotranspiration and photosynthetic efficiency. The T-DNA insertion lines were germinated on agar plates and transferred to soil - where the seedlings were exposed to drought stress (10% soil water-holding capacity). </p>
Data from: Cost-saving population genomic investigation of Daphnia longispina complex resting eggs using whole genome amplification and pre-sequencing screening
<p>This dataset contains all paired MiSeq sequences that were generated for the study "Cost-saving population genomic investigation of<em> Daphnia longispina</em> complex resting eggs using whole genome amplification and pre-sequencing screening" by Nickel and Cordellier.</p> <p>The sample names used in the study and the associated file names are explained in the table<strong> </strong>"Study_sample_names.xlsx"</p> <p> </p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.