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183
datasets available to search
ShareScore release 0.9.0
Dataset results
183 results for “secretome”
Radiation-activated secretome of Scgb1a1+ club cells increase the efficacy of immune checkpoint blockade in lung cancer (Bulk048 RNA-seq)
GEO Series GSE157880. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
NAD+ metabolism governs proinflammatory senescence secretome
GEO Series GSE111841. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Ribosomal S6 kinase 1 regulates 'inflammaging' via the senescence secretome III.
GEO Series GSE218684. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing.
Lactobacilli secretome-mediated negative regulator induction in HT-29 human IEC
GEO Series GSE145091. Homo sapiens. 32 samples. Type: Expression profiling by array.
Effect of STAT3-/+ secretome in CD8+ T cells in vitro culture
GEO Series GSE228364. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Radiation-activated secretome of Scgb1a1+ club cells increase the efficacy of immune checkpoint blockade in lung cancer
GEO Series GSE157883. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiling of MDA-MB-231 cells incubated with therapy induced senescence secretome
GEO Series GSE236953. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Safety and Regenerative Properties of Immortalized Human Mesenchymal Stromal Cell Secretome
GEO Series GSE306748. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
The secretome of skin cancer cells activates the mTOR/MYC pathway in healthy keratinocytes and converts them into tumorigenic cells
GEO Series GSE132215. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Response of human corneal epithelial cells to the secretomes of wild-type Serratia marcescens and an eepR mutant strain
GEO Series GSE71320. Homo sapiens. 6 samples. Type: Expression profiling by array.
Modulating SPARC Expression in Mesenchymal Stem Cells Improves Secretome-Mediated Skin Regeneration and Wound Repair
GEO Series GSE301307. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Ribosomal S6 kinase 1 regulates 'inflammaging' via the senescence secretome I.
GEO Series GSE218682. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Radiation-activated secretome of Scgb1a1+ club cells increase the efficacy of immune checkpoint blockade in lung cancer (0Gy4Gy scRNA-seq)
GEO Series GSE157881. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
TP53 deficiency in AML induces resistance to T-cell engagers through an immunosuppressive secretome
GEO Series GSE309028. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Deciphering the determinants of recombinant protein yield across the human secretome
GEO Series GSE225989. Cricetulus griseus. 96 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Oncogenic KRAS-Induced Protein Signature in the Tumor Secretome Identifies Laminin-C2 and Pentraxin-3 as Useful Biomarkers for the Early Diagnosis of Pancreatic Cancer "
<p>This record contains raw data related to article “Oncogenic KRAS-Induced Protein Signature in the Tumor Secretome Identifies Laminin-C2 and Pentraxin-3 as Useful Biomarkers for the Early Diagnosis of Pancreatic Cancer"</p> <p>Abstract</p> <p><em>KRAS</em> mutations characterize pancreatic cell transformation from the earliest stages of carcinogenesis, and are present in &gt;95% of pancreatic ductal adenocarcinoma (PDAC) cases. In search of novel biomarkers for the early diagnosis of PDAC, we identified the proteins secreted by the normal human pancreatic cell line (HPDE) recently transformed by inducing the overexpression of the <em>KRAS<sup>G12V</sup></em> oncogene. We report a proteomic signature of <em>KRAS</em>-induced secreted proteins, which was confirmed in surgical tumor samples from resected PDAC patients. The putative diagnostic performance of three candidates, Laminin-C2 (LAMC2), Tenascin-C (TNC) and Pentraxin-3 (PTX3), was investigated by ELISA quantification in two cohorts of PDAC patients (<em>n</em> = 200) eligible for surgery. Circulating levels of LAMC2, TNC and PTX3 were significantly higher in PDAC patients compared to the healthy individuals (<em>p</em> &lt; 0.0001). The Receiver Operating Characteristics (ROC) curve showed good sensitivity (1) and specificity (0.63 and 0.85) for LAMC2 and PTX3, respectively, but not for TNC, and patients with high levels of LAMC2 had significantly shorter overall survival (<em>p</em> = 0.0007). High levels of LAMC2 and PTX3 were detected at early stages (I-IIB) and in CA19-9-low PDAC patients. In conclusion, pancreatic tumors release LAMC2 and PTX3, which can be quantified in the systemic circulation, and may be useful in selecting patients for further diagnostic imaging.</p>
Endometrial gland secretome maintains the homeostasis of decidualization
GEO Series GSE303741. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Tumor secretome and VEGF-C induce opposite transcriptomic changes in lymphatic endothelial cells
GEO Series GSE171278. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile of human fibroblasts stimulated by breast cancer cell lines secretome
GEO Series GSE80035. Homo sapiens. 15 samples. Type: Expression profiling by array.
Ribosomal S6 kinase 1 regulates 'inflammaging' via the senescence secretome II.
GEO Series GSE218683. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.