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184 results for “variability analysis”
Fig. 5 in Several Subspecies or Phenotypic Plasticity? A Geometric Morphometric and Molecular Analysis of Variability of the Mayan Cichlid Mayaheros urophthalmus in the Yucatan
Fig. 5. Topology of haplotypic relationships of 15 populations of the M. urophthalmus complex inferred at a network based on two concatenated mitochondrial protein gene fragments (cytb and COI, 1677 bp) and showing the north and south components.
Outcomes of Cesarean Section vs Vaginal Delivery: Instrumental Variable Adjusted Analysis
ClinicalTrials.gov study NCT02866058. IPD Sharing: NO. Countries: 0. Publications: 0.
Utility of Dynamic Variables Measured by Calibrated Pulse Contour Analysis of Oesophageal Doppler Monitor for Predicting Fluid Responsiveness During Robot-Assisted Laparoscopic Prostatectomy
ClinicalTrials.gov study NCT02886546. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Analysis of Pseudomonas aeruginosa evolving in the cystic fibrosis lung uncovers limited evidence that mutator lineages are more genetically variable than non-mutator lineages
GEO Series GSE25481. Pseudomonas aeruginosa. 10 samples. Type: Genome variation profiling by array.
Fermi All-Sky Variability Analysis Second Catalog of Flaring Gamma-Ray Sources
The Fermi All-sky Variability Analysis (FAVA) is an analysis technique that searches for flaring sources in data collected by the Large Area Telescope (LAT) onboard NASA's Fermi Gamma-ray Space Telescope. It uses a photometric approach to blindly search for flares over the entire sky, and a likelihood analysis to precisely locate them and to measure their spectra. This catalog contains the flares and sources detected by running FAVA over the first 7.4 years of Fermi mission, from Modified Julian Date (MJD) 54682 (2008-08-04) to 57391 (2016-01-04). The analysis has been run in weekly time bins and in two independent energy bands, 100-800 MeV and 0.8-300 GeV. The detection threshold applied to the catalog flares is equivalent to 6 sigma (pre trials). The sources in the 2FAV are identified as clusters of flares. Their position and the corresponding error are derived from a weighted average of the best localized flares in the cluster. Likely gamma-ray counterparts, based on positional coincidence, are provided for the sources. This database table was first ingested by the HEASARC in July 2017 using electronic data obtained from the Fermi Science Support Center (FSSC). That data is available at <a href="http://fermi.gsfc.nasa.gov/ssc/data/access/lat/fava_catalog/">http://fermi.gsfc.nasa.gov/ssc/data/access/lat/fava_catalog/</a>. This is a service provided by NASA HEASARC .
Discovery and verification of liver cancer marker genes and variable scission based on second-generation sequencing data analysis
GEO Series GSE136846. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
How does servant leadership impact employee performance in a stateowned construction company? An analysis with organizational citizenship behavior as an intervening variable
<p>This study examines the pivotal role of leadership in organizational functioning, specifically examining its impact on enhancing employee performance. The research focuses on understanding and analyzing the influence of Servant Leadership on Employee Performance, with Organizational Citizenship Behavior (OCB) serving as the intervening variable. Employing a descriptive quantitative research design, the study encompasses employees from a State-Owned Construction Company in Jakarta, Indonesia. The research uses 100 samples. The research draws upon primary and secondary data derived from field studies and library research. Using path analysis, hypothesis testing, and the coefficient of determination as analytical tools, the findings reveal the significant influence of Servant Leadership (X) on both Employee Performance (Y) and Organizational Citizenship Behavior (Z) at 10.1% and 58.2%, respectively. Furthermore, OCB (Z) exhibits a noteworthy effect on Employee Performance (Y) at 7.6%, while Servant Leadership (X) significantly impacts Employee Performance (Y) through OCB (Z) at 27.9%. The research results show that servant leadership has a significant and positive impact on employee performance, both directly and through OCB, highlight the potential to enhance organizational outcomes even beyond the percentages demonstrated in this study.</p>
High-resolution transcriptional analysis of immunoglobulin variable regions reveals the absence of direct relationships between somatic hypermutation, nascent transcription and epigenetic marks [MutPE
GEO Series GSE202039. Homo sapiens; Mus musculus. 36 samples. Type: Other.
High-resolution transcriptional analysis of immunoglobulin variable regions reveals the absence of direct relationships between somatic hypermutation, nascent transcription and epigenetic marks
GEO Series GSE202042. Drosophila melanogaster; Mus musculus; Homo sapiens. 78 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
High-resolution transcriptional analysis of immunoglobulin variable regions reveals the absence of direct relationships between somatic hypermutation, nascent transcription and epigenetic marks [ChIP-
GEO Series GSE202038. Homo sapiens; Drosophila melanogaster. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
High-resolution transcriptional analysis of immunoglobulin variable regions reveals the absence of direct relationships between somatic hypermutation, nascent transcription and epigenetic marks [PRO-c
GEO Series GSE202040. Homo sapiens; Mus musculus; Drosophila melanogaster. 11 samples. Type: Other.
High-resolution transcriptional analysis of immunoglobulin variable regions reveals the absence of direct relationships between somatic hypermutation, nascent transcription and epigenetic marks [ATAC-
GEO Series GSE202037. Homo sapiens. 1 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Decomposing the complexity of heart-rate variability by the multifractal–multiscale approach to detrended fluctuation analysis: an application to low-level spinal cord injury
<p>Raw data for reproducing (figure 2) and the main results of the paper: doi: 10.1088/1361-6579/ab2b4a</p>
Analysis of heart-rate variability during angioedema attacks in patients with hereditary c1-inhibitor deficiency
<p>Database from the article Perego F, De Maria B, Bova M, Petraroli A, Marcelli Cesoni A, De Grazia V, Zingale LC, Porta A, Spadaro G, Dalla Vecchia LA. Analysis of Heart-Rate Variability during Angioedema Attacks in Patients with Hereditary C1-Inhibitor Deficiency. Int J Environ Res Public Health. 2021 Mar 12;18(6):2900. doi: 10.3390/ijerph18062900. PMID: 33809031; PMCID: PMC8002127.</p> <p>Abstract</p> <p>C1-inhibitor hereditary angioedema (C1-INH-HAE) is a rare disease characterized by self-limiting edema associated with localized vasodilation due to increased levels of circulating bradykinin. C1-INH-HAE directly influences patients' everyday lives, as attacks are unpredictable in frequency, severity, and the involved anatomical site. The autonomic nervous system could be involved in remission. The cardiac autonomic profile has not yet been evaluated during the attack or prodromal phases. In this study, a multiday continuous electrocardiogram was obtained in four C1-INH-HAE patients until attack occurrence. Power spectral heart rate variability (HRV) indices were computed over the 4 h preceding the attack and during the first 4 h of the attack in three patients. Increased vagal modulation of the sinus node was detected in the prodromal phase. This finding may reflect localized vasodilation mediated by the release of bradykinin. HRV analysis may furnish early markers of an impending angioedema attack, thereby helping to identify patients at higher risk of attack recurrence. In this perspective, it could assist in the timing, titration, and optimization of prophylactic therapy, and thus improve patients' quality of life.</p>
Symbolic Analysis of the Heart Rate Variability During the Plateau Phase Following Maximal Sprint Exercise.
<p>Dataset from Storniolo JL, Cairo B, Porta A, Cavallari P. Symbolic Analysis of the Heart Rate Variability During the Plateau Phase Following Maximal Sprint Exercise. Front Physiol. 2021 Mar 23;12:632883. doi: 10.3389/fphys.2021.632883. PMID: 33833687; PMCID: PMC8021730.</p> <p>Cardiac autonomic control is commonly assessed <em>via</em> the analysis of fluctuations of the temporal distance between two consecutive R-waves (RR). Cardiac regulation assessment following high intensity physical exercise is difficult due to RR non-stationarities. The very short epoch following maximal sprint exercise when RR remains close to its lowest value, i.e., the PLATEAU, provides the opportunity to evaluate cardiac regulation from stationary RR sequences. The aim of the study is to evaluate cardiac autonomic control during PLATEAU phase following 60-m maximal sprint and compare the results to those derived from sequences featuring the same length as the PLATEAU and derived from pre-exercise and post-exercise periods. These sequences were referred to as PRE and POST sequences. RR series were recorded in 21 subjects (age: 24.9 ± 5.1 years, 15 men and six women). We applied a symbolic approach due to its ability to deal with very short RR sequences. The symbolic approach classified patterns formed by three RRs according to the sign and number of RR variations. Symbolic markers were compared to more classical time and frequency domain indexes. Comparison was extended to simulated signals to explicitly evaluate the suitability of methods to deal with short variability series. A surrogate test was applied to check the null hypothesis of random fluctuations. Over simulated data symbolic analysis was able to separate dynamics with different spectral profiles provided that the frame length was longer than 10 cardiac beats. Over real data the surrogate test indicated the presence of determinism in PRE, PLATEAU, and POST sequences. We found that the rate of patterns with two variations with unlike sign increased during PLATEAU and in POST sequences and the frequency of patterns with no variations remained unchanged during PLATEAU and decreased in POST compared to PRE sequences. Results indicated a sustained sympathetic control along with an early vagal reactivation during PLATEAU and a shift of the sympathovagal balance toward vagal predominance in POST compared to PRE sequences. Time and frequency domains markers were less powerful because they were dominated by the dramatic decrease of RR variance during PLATEAU.</p>
How the first years of motherhood impact the cardiac autonomic profile of female healthcare professionals: a study by heart rate variability analysis.
<p>Dataset from Dalla Vecchia LA, De Maria B, Cassetti G, Clementi L, De Grazia V, Perego F, Porta A. How the first years of motherhood impact the cardiac autonomic profile of female healthcare professionals: a study by heart rate variability analysis. Sci Rep. 2021 Apr 14;11(1):8161. doi: 10.1038/s41598-021-87596-y. PMID: 33854133; PMCID: PMC8047021.</p> <p>Abstract</p> <p>The conciliation between career and family is a relevant issue for working women, in particular during the first years of motherhood. Data about the state of the cardiac autonomic regulation in working women with preschoolers are lacking. Aim of this study was to compare the cardiac autonomic profile of female healthcare professionals with and without preschoolers via the analysis of the variability of the time distance between two consecutive R-wave peaks (RR) from standard 24-h Holter electrocardiogram (ECG). Fifty healthy active female healthcare professionals were enrolled: 25 with at least one preschooler (W_KID) and 25 without (W_NOKID). A standard Holter ECG was obtained during a regular working day. Segments of 5000 consecutive RRs were selected during daytime (DAY) and nighttime (NIGHT). Heart rate variability analysis was performed and the following parameters were considered for comparison between the two groups: mean (μ<sub>RR</sub>), variance (σ<sup>2</sup><sub>RR</sub>), and the absolute power in high frequency component (HF) of RR (HF<sub>RR</sub>) series. HF<sub>RR</sub> was considered as a marker of vagal cardiac modulation. Only µ<sub>RR</sub> significantly increased from DAY to NIGHT in both groups (699 ± 88 vs 887 ± 140 ms in W_KID and 728 ± 90 vs 942 ± 166 ms in W_NOKID). Instead, σ<sup>2</sup><sub>RR</sub> and HF<sub>RR</sub> increased from DAY to NIGHT only in W_NOKID (from 3334 ± 2153 to 4816 ± 4063 ms<sup>2</sup> and from 356 ± 334 to 1397 ± 1629 ms<sup>2</sup>, respectively). W_KID showed lower σ<sup>2</sup><sub>RR</sub> and HF<sub>RR</sub> during NIGHT, compared to W_NOKID (2336 ± 3170 vs 4816 ± 4063 ms<sup>2</sup> and 556 ± 950 vs 1397 ± 1629 ms<sup>2</sup>, respectively). The perceived stress according to the visual analogue scale was similar in the two groups (4.7 ± 2.1 in W_KID, 5.7 ± 2.1 in W_NOKID). The presence of preschoolers lowered nocturnal cardiac vagal modulation in female healthcare professionals. This might represent an adaptation with a finalistic purpose, scilicet the facilitation of a prompt reaction in case of a child's need.</p>
Optimizing phase variability threshold for automated synchrogram analysis of cardiorespiratory interactions in amateur cyclists
<p>Cairo B, de Abreu RM, Bari V, Gelpi F, De Maria B, Rehder-Santos P, Sakaguchi CA, da Silva CD, De Favari Signini É, Catai AM, Porta A. Optimizing phase variability threshold for automated synchrogram analysis of cardiorespiratory interactions in amateur cyclists. Philos Trans A Math Phys Eng Sci. 2021 Dec 13;379(2212):20200251. doi: 10.1098/rsta.2020.0251. Epub 2021 Oct 25. PMID: 34689616.</p> <p>Abstract</p> <p>We propose a procedure suitable for automated synchrogram analysis for setting the threshold below which phase variability between two marker event series is of such a negligible amount that the null hypothesis of phase desynchronization can be rejected. The procedure exploits the principle of maximizing the likelihood of detecting phase synchronization epochs and it is grounded on a surrogate data approach testing the null hypothesis of phase uncoupling. The approach was applied to assess cardiorespiratory phase interactions between heartbeat and inspiratory onset in amateur cyclists before and after 11-week inspiratory muscle training (IMT) at different intensities and compared to a more traditional approach to set phase variability threshold. The proposed procedure was able to detect the decrease in cardiorespiratory phase locking strength during vagal withdrawal induced by the modification of posture from supine to standing. IMT had very limited effects on cardiorespiratory phase synchronization strength and this result held regardless of the training intensity. In amateur athletes training, the inspiratory muscles did not limit the decrease in cardiorespiratory phase synchronization observed in the upright position as a likely consequence of the modest impact of this respiratory exercise, regardless of its intensity, on cardiac vagal control. This article is part of the theme issue 'Advanced computation in cardiovascular physiology: new challenges and opportunities'.</p>
Autonomic cardiac profile in male and female healthcare professionals with and without preschoolers: differences evidenced by heart rate variability analysis
<p>De Maria B, Cassetti G, Clementi L, De Grazia V, Parati M, Perego F, Porta A, Dalla Vecchia LA. Autonomic cardiac profile in male and female healthcare professionals with and without preschoolers: differences evidenced by heart rate variability analysis. Sci Rep. 2022 Aug 25;12(1):14499. doi: 10.1038/s41598-022-18744-1. PMID: 36008506; PMCID: PMC9411539.</p> <p>Abstract</p> <p>A reduced nocturnal cardiac vagal modulation has been observed in working women with preschoolers. Whether this adaptation also occurs in men remains an open question. The aim of this study was to analyze the cardiac autonomic profile of two groups of healthcare male professionals, one with and one without preschoolers, to be compared to females. Twenty-five working men with preschoolers (M_KID, age 35.41 ± 4.01 years) and 25 without (M_NOKID, 34.48 ± 6.00 years) were compared with 25 working women with preschoolers (W_KID, 37.7 ± 5.6 years) and 25 without (W_NOKID, 35.4 ± 7.2 years). A 24-h Holter electrocardiogram was performed for time and frequency domain analysis of the beat-to-beat variations of RR interval (RR) variability, during daytime (DAY) and nighttime (NIGHT). The power of RR variability in the high frequency band (HF<sub>RR</sub>) was considered as an index of cardiac vagal modulation. RR variability indices were similar in M_KID and M_NOKID during both DAY and NIGHT. In contrast, W_KID showed a reduced nocturnal HF<sub>RR</sub> compared to W_NOKID. The comparison of working men with and without preschoolers revealed no differences in the cardiac autonomic profile, in contrast with women. This suggests that sex and/or gender may represent a crucial factor in the cardiac neural control in the parental condition.</p>
Improvement of Sympathovagal Balance by Regular Exercise May Counteract the Ageing Process. A Study by the Analysis of QT Variability
<p>De Maria B, Lucini D, Gois MO, Catai AM, Perego F, Malacarne M, Pagani M, Porta A, Dalla Vecchia LA. Improvement of Sympathovagal Balance by Regular Exercise May Counteract the Ageing Process. A Study by the Analysis of QT Variability. Front Physiol. 2022 Apr 20;13:880250. doi: 10.3389/fphys.2022.880250. PMID: 35514344; PMCID: PMC9065681.</p> <p>Abstract</p> <p>QT interval (QT) variability analysis provides pathophysiological and prognostic information utilized in cardiac and non-cardiac diseases, complementary to those obtained from the analysis of heart period (HP) variability. An increased QT variability has been associated to a higher risk for cardiac events and poorest prognosis. Autonomic cardiovascular adaptation to internal and external challenges, such those occurring in athletes exposed to high levels of physical stress and in ageing could also be deepen by analyzing QT variability, searching for early prognostic signatures. The aim of the study was to analyze the QT variability and cardiac control complexity in a group of middle-aged half-marathon runners at baseline (B) and at a 10-year follow-up (FU). We found that the overall QT variability decreased at FU, despite the inescapable increase in age (52.3 ± 8.0 years at FU). This change was accompanied by an increase of the HP variability complexity without changes of the QT variability complexity. Of notice, over the years, the group of athletes maintained their regular physical activity by switching to a moderate intensity rather than strenuous. In conclusion, regular and moderate exercise over the years was beneficial for this group of athletes, as reflected by the decreased overall QT variability that is known to be associated to lower cardiovascular risk. The concomitant enhanced cardiac control complexity also suggests a trend opposite to what usually occurs with ageing, resulting in a more flexible cardiac control, typical of younger people.</p>
High-resolution transcriptional analysis of immunoglobulin variable regions reveals the absence of direct relationships between somatic hypermutation, nascent transcription and epigenetic marks [PRO-s
GEO Series GSE202041. Mus musculus; Homo sapiens; Drosophila melanogaster. 18 samples. Type: Other.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.