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173
datasets available to search
ShareScore release 0.9.0
Dataset results
173 results for “vasculature”
Molecular Characterization of the Vasculature of Patients with Infiltrating Ductal Carcinoma generates a Gene Signature predictive of Breast Cancer Survival
GEO Series GSE43379. Homo sapiens. 40 samples. Type: Expression profiling by array.
AGO2 slicing of a domesticated retrotransposon is necessary for normal mammalian vasculature [RNA-Seq]
GEO Series GSE291207. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Diabetic hyperglycemia-induced glycation regulates tumor vasculature integrity via NF-κB-mediated GM-CSF secretion by tumor cells
GEO Series GSE285474. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Endoglin regulates the integrity of the bone marrow vasculature
GEO Series GSE271409. Mus musculus. 17 samples. Type: Expression profiling by high throughput sequencing.
Zebrafish Brain Vasculature and EC Nuclei 3dpf Light-Sheet (For StarDist)
<p>Small dataset of the zebrafish brain vasculature and endothelial cell nuclei acquired at 3 days post fertilization (dpf) with a Zeiss Z.2 light-sheet microscope. Transgenic reporter lines used: blood vessels <em>Tg(kdrl:HRAS-mCherry)</em><sup><em>s916</em></sup> labels EC membrane (Chi et al., 2008) and EC nuclei <em>Tg(kdr:nls-eGFP)</em><sup><em>zf109</em></sup> labels EC nuclei (Blum et al., 2008).</p> <p>Data were acquired by Elisabeth Kugler in 2018 at the University of Sheffield conforming to UK Home Office regulations and were performed under Home Office Project Licence 70/8588 held by TJAC. - Data are part of the publication: Kugler et al., 2019 as well as Dr Kugler's thesis.</p> <p>Dataset consists only of 3 samples and is used as a sample dataset to train students on StarDist (https://github.com/stardist/; Schmidt, et al. 2018; Weigert, et al. 2020).</p> <p>Image Acquisition Details:<br> Datasets in Sheffield were obtained using a Zeiss Z.1 light sheet microscope with a water-dipping detection objective (Plan-Apochromat 20×/1.0 Corr nd = 1.38) and a scientific complementary metal-oxide semiconductor (sCMOS) detection unit. Data were acquired with activated pivot scan, dual-sided illumination and online fusion; properties of acquired data are as follows: 0.7× zoom, 16bit image depth, 1,920 × 1,920px image size and minimum z-stack interval (approx. 0.33 × 0.33× 0.5 μm). Green and red fluorophores were excited using 488 nm and 561 nm laser, respectively. Used filters in sequential tracks for multi-colour images were LP560 for both and BP505-545 and LP585, respectively. Samples were embedded in 1% or 2% LMP-agarose containing 200 mg/l Tricaine (MS-222, Sigma). The image acquisition chamber was filled with E3 plus Tricaine (200 mg/ml) and maintained at 28°C.</p>
Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex
GEO Series GSE201991. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
AGO2 slicing of a domesticated retrotransposon is necessary for normal mammalian vasculature [smRNA-Seq]
GEO Series GSE291208. Mus musculus. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity
GEO Series GSE29733. Rattus norvegicus. 44 samples. Type: Expression profiling by array.
Multi-omics profiling of human endothelial differentiation reveals gene regulatory program in vasculature-related dysfunctions [in situ Hi-C]
GEO Series GSE281670. Homo sapiens. 16 samples. Type: Other.
Effect of Maternal Separation (MatSep) on renal vasculature isolated from male neonates (Postnatal day 10) and adult (Postnatal day 180)
GEO Series GSE151402. Rattus norvegicus. 20 samples. Type: Expression profiling by array.
Data set related to the article: "Transfer of the longevity-associated variant of BPIFB4 gene rejuvenates immune system and vasculature by a reduction of CD38+ macrophages and NAD+ decline"
<p>As we age, our body experiences chronic, systemic inflammation contributing to the morbidity and mortality of the elderly. The senescent immune system has been described to have a causal role in driving systemic aging and therefore may represent a key therapeutic target to prevent pathological consequences associated with aging and extend a healthy lifespan. Previous studies from our group associated a polymorphic haplotype variant in the BPIFB4 gene (LAV-BPIFB4) with exceptional longevity. Transfer of the LAV-BPIFB4 in preclinical models halted the progression of cardiovascular diseases (CVDs) and frailty by counterbalancing chronic inflammation. In the present study, we aimed to delineate the action of systemic adeno-associated viral vector-mediated LAV-BPIFB4 gene transfer (AAV-LAV-BPIFB4) on the deleterious age-related changes of the immune system and thereby the senescence-associated events occurring in C57BL/6J mice aged 26 months. Our in vivo data showed that 26-months-old mice had a higher frequency of CD45+SA-beta Gal+ immune cells in peripheral blood than young (4-months-old) C57BL/6J mice. Notably, AAVLAV-BPIFB4 gene transfer in aged mice reduced the pool of peripheral immunosenescent cells that were shown to be enriched in the spleen. In addition, the proper tuning of the immune secretory phenotype (IL1βlow, IL6low, IL10high) associated with a significant reduction in SA-beta Gal-positive area of aorta from AAV-LAV treated mice. At the functional level, the reduction of senescenceassociated inflammation ensured sustained NAD+ levels in the plasma of AAV-LAV-BPIFB4 old mice by preventing the NADase CD38 increase in F4/80+ tissue-resident macrophages and Ly6Chigh pro-inflammatory monocytes of the spleen and bone marrow. Finally, to validate the clinical implication of our findings, we showed that Long-living-individuals (LLIs, >95 years), which delay CVDs onset, especially if LAV-carriers, were characterized by high NAD+ levels. In conclusion, the new senotherapeutic action of LAV-BPIFB4 may offer a valuable therapeutic tool to control aging and reduce the burden of its pathophysiological disorders, such as CVDs.</p>
Vasculature creation v. 1.0
<p>Figure 1.</p> <p>HUVEC cells cultivated in T25 flask with Cellbiologics M1168 endothelial basal medium (containing essential and non-essential amino acids, vitamins, organic and inorganic compounds, trace minerals) supplemented with 0.1% hydrocortisone and 0.1% EGF, 10% FBS, and penicillin/streptomycin at 37 °C in an atmosphere of 5% CO<sub>2</sub>. HUVEC cells failed to thrive in this environment that was tested for future co-culture with functionalized silk fibers, other cytotypes, and brain slice-cultures. Scale bar 100 μm.</p> <p>Figure 2.</p> <p>HUVEC cells cultivated in T25 flask with Cellbiologics M1168 endothelial basal medium (described in Fig. 1), supplemented with 0.1% hydrocortisone, 0.1% EGF, 0.1% VEGF, 0.1% ECGS, 0.1% Heparin and 5% FBS, penicillin/streptomycin at 37 °C in an atmosphere of 5% CO<sub>2</sub>. HUVEC cells were able to thrive with the addition of the supplements but failed to acquire an adequate morphology. Scale bar 100 μm.</p> <p>Figure 3.</p> <p>HUVEC cells cultivated in a gelatin-coated Petri dish (Cellbiologics Gelatin-Based Coating Solution cat. 6950) with Cellbiologics M1168 endothelial supplemented medium (described in Fig. 2) at 37 °C in an atmosphere of 5% CO<sub>2</sub>. HUVEC cells were able to thrive and acquire endothelial morphology with preliminary tube formation. Scale bar 100 μm.</p> <p>Figure 4</p> <p>Functionalized silk fiber scaffold. The arrangement of the fibers is mostly parallel. However, differences in thickness and uncontrolled crossing are observed. Air bubbles are trapped by the meshes. No difference between the control and functionalized (VEGF and IKVAV) groups are observed. Scale bar 100 μm.</p> <p>Figure 5.</p> <p>C57BL/6 Mouse Embryonic Brain Endothelial Cells (Cellbiologics C57-6023E) seeded on gelatin-coated functionalized silk fiber scaffold (meshes). The cell vials arrived at room temperature for shipping delay from the US and were immediately seeded using the endothelial supplemented medium. Air bubbles traps are removed by coating the wells with gelatin. No difference is reported among control and (VEGF and IKVAV) functionalized meshes. Scale bar 100 μm.</p>
Reverse Remodelling of the Lung Vasculature after Hypoxia
GEO Series GSE183908. Mus musculus. 38 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.