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4,871 results for “Symptom”
Data for manuscript "The proportion of non-depressed subjects in a study sample strongly affects the results of psychometric analyses of depression symptoms"
<p>Data sets underlying the manuscript "The proportion of non-depressed subjects in a study sample strongly affects the results of psychometric analyses of depression symptoms" (doi: 10.1371/journal.pone.0235272). The file "data_table1.rds" contains the data underlying table 1 of the manuscript, whereas the file "data_figure1.rds" contains the data underlying figure 1. Both files are stored in RDS-format, which is a data format used in the programming language R. RDS-files can be loaded using R with the function readRDS(). Note that "data_figure1.rds" is a list of 22 elements. Elements 1, 21, and 22 are original data sets (depressed subjects, general population, and nondepressed subjects, respectively), while the remaining elements are lists each containing 500 newly generated data sets as described in the method section of the manuscript. For more details about the data please refer to the manuscript.</p>
Supplementary Files-6-extrapyramidal symptoms
<p>Supplementary File to the Cochrane Review “Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis”.</p> <p>Supplementary Files-6-extrapyramidal symptoms_p1-27, Raw data-6-extrapyramidal symptoms</p>
Differences in single positive formal thought disorder symptoms between closely matched acute patients with schizophrenia and mania
<p>Data related to the manuscript "<strong>Differences in single positive formal thought disorder symptoms between closely matched acute patients with schizophrenia and mania"</strong></p>
Data from: Anxiety and depressive symptoms are associated with poor sleep health during a period of COVID-19 induced nation-wide lockdown: a cross-sectional analysis of adults in the Middle East
<p><strong>Background</strong>: Jordan, a Middle Eastern country, declared a state of national emergency due to the novel coronavirus (COVID-19) and a strict nation-wide lockdown on March 17, 2020, banning all travel and movement around the country, potentially impacting mental health. This study sought to investigate the association between mental health (e.g., anxiety and depressive symptoms) and sleep health among a sample of Jordanians living through a state of COVID-19 induced nation-wide lockdown.</p> <p><strong>Methods</strong>: Using Facebook, participants (N=1,240) in Jordan in March 2020 were recruited and direct to a web-based survey measuring anxiety (items from GAD-7 instrument), depressive symptoms (items from DES-10), sleep health (items from the PSQI), and sociodemographic. A modified Poisson regression model with robust error variance. Adjusted prevalence ratios (aPRs) and 95% confidence intervals (CIs) were estimated to examine how anxiety and depressive symptoms may affect different dimensions of sleep health: 1) poor sleep quality, 2) short sleep duration, 3) encountering sleep problems.</p> <p><strong>Results</strong>: The majority of participants reported having experienced mild (33.8%), moderate (12.9%), or severe (6.3%) levels of anxiety during lockdown, and nearly half of respondents reported depressive symptoms during lockdown. Similarly, over 60 percent of participants reported having experienced at least one sleep problem in the last week, and nearly half reported having had short sleep duration. Importantly, Anxiety was associated with poor sleep health outcomes. For example, corresponding to the dose-response relationship between anxiety and sleep health outcomes, those reporting severe anxiety were the most likely to experience poor sleep quality (aPR =8.95; 95% CI =6.12–13.08), short sleep duration (aPR =2.23; 95% CI = 1.91–2.61), and at least one problem sleep problem (aPR = 1.73; 95% CI = 1.54–1.95). Moreover, depressive symptoms were also associated with poor sleep health outcomes. As compared to scoring in the first quartile, scoring fourth quartile was associated with poor sleep quality (aPR = 11.82; 95% CI = 6.64 – 21.04), short sleep duration (aPR = 1.87; 95% CI = 1.58–2.22), and experiencing at least one sleep problem (aPR = 1.90; 95% CI = 1.66 – 2.18).</p> <p><strong>Conclusions</strong>: Increased levels of anxiety and depressive symptoms can negatively influence sleep health among a sample of Jordanian adults living in a state of COVID-19<br> induced nation-wide lockdown.</p>
Mizuki M_Table S1. Cumulative prevalence days of subjective acute gastrointestinal symptoms
<p>The Supplement Table.</p> <p> </p>
Frequency of depressive symptoms in Syrian refugees and Turkish maintenance hemodialysis patients during COVID-19 pandemic
<p><strong>Introduction:</strong> Pneumonia of unknown cause was detected on 30 December 2019 in China. It was categorized as an outbreak and named as COVID-19 by the World Health Organization. The pandemic affects all people, but patient groups such as hemodialysis (HD) patients have been particularly affected. We do not know if refugees suffered more during the outbreak. In this study, we compared depressive symptom frequency between Syrian refugee HD patients and Turkish ones.</p> <p><strong>Methods:</strong> The study had a single-center, cross-sectional design. Demographic and clinical data were collected retrospectively from patients' files containing details about past medical history, demographic variables and laboratory values. Validated Turkish and Arabic forms of Beck Depression Inventory (BDI) were used to assess depressive symptoms. BDI scores were compared according to nationality, demographic features and clinical data. A BDI score more than 14 was accepted as suspicion of depression.</p> <p><strong>Results:</strong> 119 patients were enrolled in the study. After the exclusion of 22 patients, 75 Turkish and 22 Syrian patients were included for further analysis. The median BDI (interquartile range) score for Turkish and Syrian patients were 12 (7-23) and 19.5 (12.7-25.2), respectively (p=0.03). Suspicion of depression was present at 42.7% of Turkish, and 72.7% of Syrian HD patients (p=0.013). Regarding all patients, phosphorus level, Kt/V, and nationality were significantly different between patients with and without suspicion of depression (p=0.023, 0.039, 0.013, respectively).</p> <p><strong>Conclusion:</strong> Syrian patients had higher BDI scores and more depressive symptoms than Turkish patients. Additional national measures for better integration and more mental support to Syrian HD patients are needed. </p>
Data from: Characteristics of patients included and enrolled in studies on the prognostic value of serum biomarkers for prediction of post-concussion symptoms following a mild traumatic brain injury: a systematic review
Objective: Mild traumatic brain injury (mTBI) has been insufficiently researched and its definition remains elusive. Investigators are confronted by heterogeneity in patients, mechanism of injury and outcomes. Findings are thus often limited in generalizability and clinical application. Serum protein biomarkers are increasingly assessed to enhance prognostication of outcomes but their translation into clinical practice has yet to be achieved. A systematic review was performed to describe the adult populations included and enrolled in studies that evaluated the prognostic value of protein biomarkers to predict post-concussion symptoms following a mTBI. Data sources: Searches of MEDLINE, EMBASE, CENTRAL, CINAHL, Web of Science, PsycBITE, and PsycINFO up to October 2016. Data selection and extraction: Two reviewers independently screened for potentially eligible studies, extracted data and assessed the overall quality of evidence by outcome using the Grading of Recommendations Assessment, Development and Evaluation approach. Results: A total of 23,298 citations were obtained from which 166 manuscripts were reviewed. Thirty-six cohort studies (2,812 patients) having enrolled between 7 and 311 patients (median 89) fulfilled our inclusion criteria. Most studies excluded patients based on advanced age (n=10 (28%)), neurologic disorders (n=20 (56%)), psychiatric disorders (n=17 (47%)), substance abuse disorders (n=13 (36%)) or previous TBI (n=10 (28%)). Twenty-one studies (58%) used at least two of these exclusion criteria. The pooled mean age of included patients was 39.3 (SD 4.6) years old (34 studies). The criteria used to define a mTBI were inconsistent. The most frequently reported outcome was post-concussion syndrome (PCS) using the Rivermead Post-Concussion Symptoms Questionnaire (n=18 (50%)) with follow-ups ranging from 7 days to 5 years after the mTBI. Conclusions: Most studies have recruited samples that are not representative and generalizable to the mTBI population. These exclusion criteria limit the potential use and translation of promising serum protein biomarkers to predict post-concussion symptoms.
Data from: Vomiting as a symptom and transmission risk in norovirus illness: evidence from human challenge studies
Background: In the US, noroviruses are estimated to cause 21 million cases annually with economic losses reaching $2 billion. Outbreak investigations frequently implicate vomiting as a major transmission risk. However, little is known about the characteristics of vomiting as a symptom or the amount of virus present in emesis. Methodology and Principal Findings: Emesis samples and symptomology data were obtained from previous norovirus human challenge studies with GI.1 Norwalk virus, GII.2 Snow Mountain virus, and a pilot study with GII.1 Hawaii virus. Viral titers in emesis were determined using strain-specific quantitative RT-PCR. In all four studies, vomiting was common with 40–100% of infected subjects vomiting at least once. However, only 45% of subjects with vomiting also had diarrhea. Most of the emesis samples had detectable virus and the mean viral titers were 8.0 x 105 and 3.9 x 104 genomic equivalent copies (GEC)/ml for GI and GII viruses, respectively (p = 0.02). Sample pH was correlated with GII.2 Snow Mountain virus detection. Conclusions and Significance: Half of all subjects with symptomatic infection experienced vomiting and the average subject shed 1.7 x 108 GEC in emesis. Unlike shedding through stool, vomiting is more likely to result in significant environmental contamination, leading to transmission through fomites and airborne droplets. This quantitative data will be critical for risk assessment studies to further understand norovirus transmission and develop effective control measures. The correlation between sample pH and virus detection is consistent with a single site of virus replication in the small intestine and stomach contents becoming contaminated by intestinal reflux. Additionally, the frequency of vomiting without concurrent diarrhea suggests that epidemiology studies that enroll subjects based on the presence of diarrhea may be significantly underestimating the true burden of norovirus disease.
Data from: Patients with primary biliary cholangitis and fatigue present with depressive symptoms and selected cognitive deficits, but with normal attention performance and brain structure
Background: In primary biliary cholangitis (PBC) fatigue is a major clinical challenge of unknown etiology. By demonstrating that fatigue in PBC is associated with an impaired cognitive performance, previous studies have pointed out the possibility of brain abnormalities underlying fatigue in PBC. Whether structural brain changes are present in PBC patients with fatigue, however, is unclear. To evaluate the role of structural brain abnormalities in PBC patients severely affected from fatigue we, therefore, performed a case-control cerebral magnetic resonance imaging (cMRI) study and correlated changes of white and grey brain matter with the cognitive and attention performance. Methods: 20 female patients with PBC and 20 female age-matched controls were examined in this study. The assessment of fatigue, psychological symptoms, cognitive and attention performance included clinical questionnaires, established cognition tests and a computerized test battery of attention performance. T1-weighted cMRI and diffusion tensor imaging (DTI) scans were acquired with a 3 Tesla scanner. Structural brain alterations were investigated with voxel-based morphometry (VBM) and DTI analyses. Results were correlated to the cognitive and attention performance. Results: Compared to healthy controls, PBC patients had significantly higher levels of fatigue and associated psychological symptoms. Except for an impairment of verbal fluency, no cognitive or attention deficits were found in the PBC cohort. The VBM and DTI analyses revealed neither major structural brain abnormalities in the PBC cohort nor correlations with the cognitive and attention performance. Conclusions: Despite the high burden of fatigue and selected cognitive deficits, the attention performance of PBC patients appears to be comparable to healthy people. As structural brain alterations do not seem to be present in PBC patients with fatigue, fatigue in PBC must be regarded as purely functional. Future studies should evaluate, whether functional brain changes underlie fatigue in PBC.
NLRP3 inflammasome activation and symptom burden in KRAS-mutated CMML patients is reverted by IL-1 blocking therapy
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AN ALLERGY: CAUSES, SYMPTOMS AND TREATMENT
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raw data - Regulatory T cells and plasmacytoid dendritic cells in drug rash with eosinophilia and systemic symptoms VS maculopapular drug eruption
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How patients with mild dementia living in a nursing home benefit from dementia cafés: a case-control study focusing on psychological and behavioural symptoms and caregiver burden
<p><strong>Background: </strong>Dementia is a syndrome, mainly due to neurodegeneration, affecting cognition, behaviour, feelings and relationships. Pharmacological treatment is still challenging and thus different ways to improve/slow down the disease are necessary.</p> <p><strong>Methods: </strong>Twenty-five subjects with mild dementia, living in a nursing home, and their relatives were invited to attend a dementia cafe, a community group which provides support for families affected by dementia. Each patient was evaluated by a neuropsychologist, through the administration of a specific neuropsychological battery, before and at the end of the study. Their outcomes were compared to a matched group of patients with dementia receiving psycho-counselling.</p> <p><strong>Results: </strong>After the dementia cafe meetings, patients showed higher significant changes in mood (P < 0.01), behavioural symptoms (P < 0.001), quality of life (P < 0.001), and caregiver burden (P < 0.001). The control group significantly improved only in quality of life with a reduction of caregiver burden.</p> <p><strong>Conclusions: </strong>Our findings confirm that patients with dementia may benefit from the dementia cafe, especially concerning behavioural symptoms. Moreover, caregivers find these cafés to be welcoming, relaxed places to socialise and access support and information. Future dementia cafés should create programs and comfortable environments answering to the different needs of the patients.</p>
Bacterial QS expands the Xanthomonas campestris pv. campestris invasion of host tissue to trigger host-chlorophagy and maximize disease symptom
<p>Using QS-responsive whole-cell bioreporters of<i> Xcc</i> and cabbage (<i><span>Brassica oleracea</span></i><span>) </span>as a model system and confocal microscopy, we show a detailed chronology of QS-facilitated <i>Xcc</i> colonization in the host mesophyll region. We report the QS-enabled bacterial localization of parenchymal chloroplast within heterogeneously invaded host mesophyll tissue, leading triggered leaf-chlorosis and systemic infection.</p>
Patient with aberrant internal carotid artery in the middle ear presenting with rare symptoms of mixed hearing loss and postauricular pain: a case report
<p>Video of otoscopy of aberrant internal carotid artery in the middle ear</p>
Dataset of Association of depression and anxiety symptoms, and personal factors related to health behavior with tobacco abuse: A secondary data analysis.
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STRICTA Check list for Effects of Electroacupuncture on Cognitive Symptoms in Major Depressive Disorder: A Pilot Study and Randomized Controlled Trial
<p>STRICTA 2010 check list</p>
Fig. 1 in A volunteer-populated online database provides evidence for a geographic pattern in symptoms of black spot infections
Fig. 1. Example photos of a blacknose dace, a stoneroller (Campostoma sp.), a creek chub, and a chub (Nocomis sp.) exhibiting evidence of a black grub infection.
Fig. 3 in A volunteer-populated online database provides evidence for a geographic pattern in symptoms of black spot infections
Fig. 3. If an observation of blacknose dace, creek chub, chubs (Nocomis spp.), or stonerollers (Campostoma spp.) is reported on iNaturalist from the watersheds of Northern Lake Erie or Lake Ontario – Niagara Peninsula it is more likely to exhibit macroscopic signs of infection by metacercariae. Also a high percentage of the observations by user bkorol exhibited symptoms, all from Eastern Georgian Bay which is adjacent to the two other watersheds mentioned. Data were analyzed using conditional information trees in r using package caret to train and tune the model. Percentage of actual observations summarized in bar charts below each split that significantly described the data.
Fig. 2 in A volunteer-populated online database provides evidence for a geographic pattern in symptoms of black spot infections
Fig. 2. Watersheds shaded by the percentage of observations with signs of black spot infection for four groups of fishes, each of which show higher prevalence in the watersheds near Toronto and the northern shoreline of Lake Erie. Watersheds are transparent if only 1 or 2 fish were observed in them, otherwise they increase in opaqueness as sample number increase, those with>15 observations are solid. Refer to Table 1 for numbers.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.